TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 4, 2009, Pages 716-720

  Jones, Ronald N ^a   Moet, Gary J ^a   Sader, Helio S ^a   Mendes, Rodrigo E ^a   Castanheira, Mariana ^a  

^a JMI LABORATORIES   (United States)

Author keywords

Cfr; Mutation studies; Oxazolidinones; TR 701

Indexed keywords

BACTERIAL PROTEIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; ERYTHROMYCIN; GENTAMICIN; LINEZOLID; MIKAMYCIN B; OXACILLIN; OXAZOLIDINONE DERIVATIVE; PLEUROMUTILIN; RNA 23S; TEICOPLANIN; TETRACYCLINE; TR 700; UNCLASSIFIED DRUG; VANCOMYCIN;

ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BROTH DILUTION; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; EUROPE; FAR EAST; GENE MUTATION; GENUS; GEOGRAPHIC ORIGIN; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MUTATION RATE; NONHUMAN; NORTH AMERICA; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOUTH AMERICA; SPECIES DIFFERENCE; STAPHYLOCOCCUS AUREUS; WILD TYPE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; EUROPE; FAR EAST; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; NORTH AMERICA; OXAZOLIDINONES; POINT MUTATION; POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; SEQUENCE ANALYSIS, DNA; SOUTH AMERICA; STAPHYLOCOCCUS; STREPTOCOCCUS; TRNA METHYLTRANSFERASES;

EID: 62549148632     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp021     Document Type: Article

References (8)

1. Diekema DJ, Jones RN. Oxazolidinone antibiotics. Lancet 2001; 358: 1975-82.
2. Jones RN, Ross JE, Castanheira M et al. United States resistance surveillance results for linezolid (LEADER Program for 2007). Diagn Microbiol Infect Dis 2008; 62: 416-26.
3. Meka VG, Gold HS. Antimicrobial resistance to linezolid. Clin Infect Dis 2004; 39: 1010-5.
4. Mendes RE, Deshpande LM, Castanheira M et al. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother 2008; 52: 2244-6.
5. Bae SK, Yang SH, Shin KN et al. Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats. J Pharm Pharmacol 2007; 59: 955-63.
6. Im W, Choi S, Rhee J. Structure-activity relationship of substituted pyridyl phenyl oxazolidinone derivatives, including TR-700 (DA-7157). In: Abstracts of the Forty-seventh Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, 2007. Abstract F1-1686, p. 249. American Society for Microbiology, Washington, DC, USA.
7. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Eighteenth Informational Supplement M100-S18. CLSI, Wayne, PA, USA, 2008.
8. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically - Seventh Edition: Approved Standard M7-A7. CLSI, Wayne, PA, USA, 2006.