Tdp2: A Means to Fixing the Ends

PLoS Genetics

Volumn 9, Issue 3, 2013, Pages

  Nitiss, John L ^a   Nitiss, Karin C ^a,b  

^a ILLINOIS COLLEGE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CD40 ANTIGEN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); EAPII PROTEIN; ETOPOSIDE; PHOSPHODIESTERASE; REGULATOR PROTEIN; SINGLE STRANDED DNA; SMAD3 PROTEIN; SMALL INTERFERING RNA; TDP2 PROTEIN; TTRAP PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 75; UNCLASSIFIED DRUG;

ARTICLE; DNA ADDUCT; DNA PROTEIN COMPLEX; DNA REPAIR; DNA STRAND BREAKAGE; DNA STRUCTURE; ENZYME ACTIVITY; HUMAN; NONHUMAN; PROTEIN FUNCTION;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; GENOMIC INSTABILITY; PHOSPHORIC DIESTER HYDROLASES; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

EID: 84875993330     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003370     Document Type: Article

References (26)

1. Nitiss JL, (2009) Targeting DNA topoisomerase II in cancer chemotherapy. Nature reviews Cancer 9: 338-350.
2. Nitiss JL, Nitiss KC, Rose A, Waltman JL, (2001) Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage. J Biol Chem 276: 26708-26714.
3. Nitiss JL (1998) DNA topoisomerases in DNA repair and DNA damage tolerance. In: Nockoloff, JA and Hoekstra, MF, editors. DNA damage and repair: Vol. 2, DNA repair in higher eukaryotes. Totowa: Humana. pp. 517-538.
4. Kim N, Huang SN, Williams JS, Li YC, Clark AB, et al. (2011) Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science 332: 1561-1564.
5. Kingma PS, Osheroff N, (1997) Apurinic sites are position-specific topoisomerase II poisons. J Biol Chem 272: 1148-1155.
6. Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, et al. (2006) A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 312: 1798-1802.
7. Pouliot JJ, Yao KC, Robertson CA, Nash HA, (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286: 552-555.
8. Nitiss KC, Malik M, He X, White SW, Nitiss JL, (2006) Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A 103: 8953-8958.
9. Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, et al. (2005) SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity. EMBO J 24: 2224-2233.
10. Murai J, Huang SY, Das BB, Dexheimer TS, Takeda S, et al. (2012) Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells. J Biol Chem 287: 12848-12857.
11. Gómez-Herreros F, Romero-Granados R, Zeng Z, Álvarez-Quilón A, Quintero C, et al. (2013) TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. PLoS Genet 9: e1003226 doi:10.1371/journal.pgen.1003226.
12. Cortes-Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW, (2009) A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature 461: 674-678.
13. Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, et al. (2000) TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. J Biol Chem 275: 18586-18593.
14. Zeng Z, Cortes-Ledesma F, El Khamisy SF, Caldecott KW, (2011) TDP2/TTRAP is the major 5′-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. J Biol Chem 286: 403-409.
15. Zeng Z, Sharma A, Ju L, Murai J, Umans L, et al. (2012) TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Res 40: 8371-8380.
16. Shi K, Kurahashi K, Gao R, Tsutakawa SE, Tainer JA, et al. (2012) Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2. Nat Struct Mol Biol 19: 1372-7.
17. Schellenberg MJ, Appel CD, Adhikari S, Robertson PD, Ramsden DA, et al. (2012) Mechanism of repair of 5′-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nat Struct Mol Biol 19: 1363-71.
18. Gao R, Huang SY, Marchand C, Pommier Y, (2012) Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. J Biol Chem 287: 30842-30852.
19. Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, et al. (2012) MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open 1: 863-873.
20. Hartsuiker E, Neale MJ, Carr AM, (2009) Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Molecular Cell 33: 117-123.
21. Hamilton NK, Maizels N, (2010) MRE11 function in response to topoisomerase poisons is independent of its function in double-strand break repair in Saccharomyces cerevisiae. PLoS ONE 5: e15387 doi:10.1371/journal.pone.0015387.
22. Mao Y, Desai SD, Ting CY, Hwang J, Liu LF, (2001) 26 S proteasome-mediated degradation of topoisomerase II cleavable complexes. J Biol Chem 276: 40652-40658.
23. Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, et al. (2003) EAPII interacts with ETS1 and modulates its transcriptional function. Oncogene 22: 2699-2709.
24. Li C, Fan S, Owonikoko TK, Khuri FR, Sun SY, et al. (2011) Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway. Oncogene 30: 3802-3812.
25. Esguerra CV, Nelles L, Vermeire L, Ibrahimi A, Crawford AD, et al. (2007) Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development 134: 4381-4393.
26. Li C, Sun SY, Khuri FR, Li R, (2011) Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond. Cell Cycle 10: 3274-3283.