Pickpocket1 is an ionotropic molecular sensory transducer

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 39878-39886

  Boiko, Nina ^a   Kucher, Volodymyr ^a   Stockand, James D ^a   Eaton, Benjamin A ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; NEURONS; TRANSDUCERS;

ACID-SENSING ION CHANNELS; EXTERNAL STIMULUS; ION CHANNEL; NEURAL ACTIVITY; SENSORY NEURONS;

SENSORY PERCEPTION;

ACID SENSING ION CHANNEL; DEGENERIN SODIUM CHANNEL; DROSOPHILA PROTEIN; NERVE PROTEIN; PPK1 PROTEIN, DROSOPHILA; SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DENDRITE; DROSOPHILA MELANOGASTER; EMBRYO; GAIN OF FUNCTION MUTATION; GENE; GENE ACTIVATION; GENE FUNCTION; NONHUMAN; PICKPOCKET1 GENE; PRIORITY JOURNAL; SENSORY NERVE CELL; STIMULUS; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; SENSORY RECEPTOR;

ACTION POTENTIALS; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MUTATION; NERVE TISSUE PROTEINS; SENSORY RECEPTOR CELLS; SODIUM CHANNELS;

EID: 84873949877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.411736     Document Type: Article

References (35)

1. Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., and Patapoutian, A. (2010) Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55-60
2. Kim, S. E., Coste, B., Chadha, A., Cook, B., and Patapoutian, A. (2012) The role of Drosophila Piezo in mechanical nociception. Nature 483, 209-212
3. Geffeney, S. L., Cueva, J. G., Glauser, D. A., Doll, J. C., Lee, T. H., Montoya, M., Karania, S., Garakani, A. M., Pruitt, B. L., and Goodman, M. B. (2011) DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor. Neuron 71, 845-857
4. O'Hagan, R., Chalfie, M., and Goodman, M. B. (2005) The MEC-4 DEG/ ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat. Neurosci. 8, 43-50
5. Hong, K., Mano, I., and Driscoll, M. (2000) In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit. J. Neurosci. 20, 2575-2588
6. Chatzigeorgiou, M., Yoo, S., Watson, J. D., Lee, W. H., Spencer, W. C., Kindt, K. S., Hwang, S. W., Miller, D. M., 3rd, Treinin, M., Driscoll, M., and Schafer, W. R. (2010) Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat. Neurosci. 13, 861-868
7. Walker, R. G., Willingham, A. T., and Zuker, C. S. (2000) A Drosophila mechanosensory transduction channel. Science 287, 2229-2234
8. Kang, L., Gao, J., Schafer, W. R., Xie, Z., and Xu, X. Z. (2010) C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel. Neuron 67, 381-391
9. Lingueglia, E. (2007) Acid-sensing ion channels in sensory perception. J. Biol. Chem. 282, 17325-17329
10. Price, M. P., McIlwrath, S. L., Xie, J., Cheng, C., Qiao, J., Tarr, D. E., Sluka, K. A., Brennan, T. J., Lewin, G. R., and Welsh, M. J. (2001) The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32, 1071-1083
11. Bianchi, L., and Driscoll, M. (2002) Protons at the gate. DEG/ENaC ion channels help us feel and remember. Neuron 34, 337-340
12. Borzan, J., Zhao, C., Meyer, R. A., and Raja, S. N. (2010) A role for acidsensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli. Anesthesiology 113, 647-654
13. Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W., and Abboud, F. M. (2009) The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64, 885-897
14. Darboux, I., Lingueglia, E., Pauron, D., Barbry, P., and Lazdunski, M. (1998)Anew member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system. Biochem. Biophys. Res. Commun. 246, 210-216
15. Benson, C. J., Xie, J., Wemmie, J. A., Price, M. P., Henss, J. M., Welsh, M. J., and Snyder, P. M. (2002) Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc. Natl. Acad. Sci. U.S.A. 99, 2338-2343
16. Ainsley, J. A., Pettus, J. M., Bosenko, D., Gerstein, C. E., Zinkevich, N., Anderson, M. G., Adams, C. M., Welsh, M. J., and Johnson, W. A. (2003) Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr. Biol. 13, 1557-1563
17. Adams, C. M., Anderson, M. G., Motto, D. G., Price, M. P., Johnson, W. A., and Welsh, M. J. (1998) Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J. Cell Biol. 140, 143-152
18. Zhong, L., Hwang, R. Y., and Tracey, W. D. (2010) Pickpocket is a DEG/ ENaC protein required for mechanical nociception in Drosophila larvae. Curr. Biol. 20, 429-434
19. Song, W., Onishi, M., Jan, L. Y., and Jan, Y. N. (2007) Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc. Natl. Acad. Sci. U.S.A. 104, 5199-5204
20. Hwang, R. Y., Zhong, L., Xu, Y., Johnson, T., Zhang, F., Deisseroth, K., and Tracey, W. D. (2007) Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr. Biol. 17, 2105-2116
21. Golic, K. G., and Golic, M. M. (1996) Engineering the Drosophila genome. Chromosome rearrangements by design. Genetics 144, 1693-1711
22. Ryder, E., Blows, F., Ashburner, M., Bautista-Llacer, R., Coulson, D., Drummond, J., Webster, J., Gubb, D., Gunton, N., Johnson, G., O'Kane, C. J., Huen, D., Sharma, P., Asztalos, Z., Baisch, H., Schulze, J., Kube, M., Kittlaus, K., Reuter, G., Maroy, P., Szidonya, J., Rasmuson-Lestander, A., Ekström, K., Dickson, B., Hugentobler, C., Stocker, H., Hafen, E., Lepesant, J. A., Pflugfelder, G., Heisenberg, M., Mechler, B., Serras, F., Corominas, M., Schneuwly, S., Preat, T., Roote, J., and Russell, S. (2004) The DrosDel collection. A set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics 167, 797-813
23. Gloor, G. B., Preston, C. R., Johnson-Schlitz, D. M., Nassif, N. A., Phillis, R. W., Benz, W. K., Robertson, H. M., and Engels, W. R. (1993) Type I repressors of P element mobility. Genetics 135, 81-95
24. Soll, D. R. (1995) The use of computers in understanding how animal cells crawl. Int. Rev. Cytol. 163, 43-104
25. Sicaeros, B., and O'Dowd, D. K. (2007) Preparation of neuronal cultures from midgastrula stage Drosophila embryos. J. Vis. Exp. 2007, 226
26. Hong, K., and Driscoll, M. (1994) A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature 367, 470-473
27. Driscoll, M., and Chalfie, M. (1991) The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature 349, 588-593
28. Chalfie, M., and Wolinsky, E. (1990) The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature 345, 410-416
29. Huang, M., and Chalfie, M. (1994) Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature 367, 467-470
30. Ainsley, J. A., Kim, M. J., Wegman, L. J., Pettus, J. M., and Johnson, W. A. (2008) Sensory mechanisms controlling the timing of larval developmental and behavioral transitions require the Drosophila DEG/ENaC subunit, Pickpocket1. Dev. Biol. 322, 46-55
31. Mano, I., and Driscoll, M. (1999) DEG/ENaC channels. A touchy superfamily that watches its salt. BioEssays 21, 568-578
32. Jasti, J., Furukawa, H., Gonzales, E. B., and Gouaux, E. (2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449, 316-323
33. Gonzales, E. B., Kawate, T., and Gouaux, E. (2009) Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature 460, 599-604
34. Cheng, L. E., Song, W., Looger, L. L., Jan, L. Y., and Jan, Y. N. (2010) The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron 67, 373-380
35. Li, W., Feng, Z., Sternberg, P. W., and Xu, X. Z. (2006) A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue. Nature 440, 684-687