Voltage-dependent gating underlies loss of ENaC function in pseudohypoaldosteronism type 1

Biophysical Journal

Volumn 100, Issue 8, 2011, Pages 1930-1939

  Kucher, Volodymyr ^a   Boiko, Nina ^a   Pochynyuk, Oleh ^b   Stockand, James D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959748112     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.02.046     Document Type: Article

References (27)

1. Canessa, C. M., J. D. Horisberger, and B. C. Rossier. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 361:467-470. (Pubitemid 23050138)
2. + channel is made of three homologous subunits. Nature. 367:463-467. (Pubitemid 24046048)
3. + channel. J. Biol. Chem. 270:27411-27414.
4. Kellenberger, S., and L. Schild. 2002. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. 82:735-767. (Pubitemid 34743337)
5. Garty, H., and L. G. Palmer. 1997. Epithelial sodium channels: function, structure, and regulation. Physiol. Rev. 77:359-396. (Pubitemid 27184343)
6. Benos, D. J., and B. A. Stanton. 1999. Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. J. Physiol. 520:631-644. (Pubitemid 29533023)
7. + channel subunit stoichiometry. Biophys. J. 88:3966-3975. (Pubitemid 40991109)
8. Jasti, J., H. Furukawa, E. Gouaux. 2007. Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature. 449:316-323. (Pubitemid 47443482)
9. Gonzales, E. B., T. Kawate, and E. Gouaux. 2009. Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature. 460:599-604.
10. Lifton, R. P. 1995. Genetic determinants of human hypertension. Proc. Natl. Acad. Sci. USA. 92:8545-8551.
11. Gründer, S., D. Firsov, B. C. Rossier. 1997. A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J. 16:899-907. (Pubitemid 27113169)
12. Chang, S. S., S. Grunder, R. P. Lifton. 1996. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat. Genet. 12:248-253. (Pubitemid 26080082)
13. Hummler, E., P. Barker, B. C. Rossier. 1997. A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc. Natl. Acad. Sci. USA. 94:11710-11715. (Pubitemid 27451063)
14. Tavernarakis, N., J. K. Everett, M. Driscoll. 2001. Structural and functional features of the intracellular amino terminus of DEG/ENaC ion channels. Curr. Biol. 11:R205-R208. (Pubitemid 32241505)
15. + channel α subunit involved in gating. Pflugers Arch. 438:709-715. (Pubitemid 29454988)
16. Hong, K., I. Mano, and M. Driscoll. 2000. In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit. J. Neurosci. 20:2575-2588. (Pubitemid 30220345)
17. Nishida, M., M. Cadene, R. MacKinnon. 2007. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J. 26:4005-4015. (Pubitemid 47367496)
18. Pegan, S., C. Arrabit, S. Choe. 2005. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat. Neurosci. 8:279-287. (Pubitemid 40300184)
19. + conduction pathway. J. Biol. Chem. 282:5781-5789. (Pubitemid 47093767)
20. Witter, R., F. Nozirov, R. Fu. 2008. Solid-state 19F NMR spectroscopy reveals that Trp41 participates in the gating mechanism of the M2 proton channel of influenza A virus. J. Am. Chem. Soc. 130:918-924.
21. Schnell, J. R., and J. J. Chou. 2008. Structure and mechanism of the M2 proton channel of influenza A virus. Nature. 451:591-595. (Pubitemid 351186272)
22. Takeuchi, H., A. Okada, and T. Miura. 2003. Roles of the histidine and tryptophan side chains in the M2 proton channel from influenza A virus. FEBS Lett. 552:35-38. (Pubitemid 37103006)
23. Stouffer, A. L., R. Acharya, W. F. DeGrado. 2008. Structural basis for the function and inhibition of an influenza virus proton channel. Nature. 451:596-599. (Pubitemid 351186271)
24. Tang, Y., F. Zaitseva, L. H. Pinto. 2002. The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J. Biol. Chem. 277:39880-39886. (Pubitemid 35190974)
25. Pochynyuk, O., V. Kucher, J. Stockand. 2009. Intrinsic voltage dependence of the epithelial Na+ channel is masked by a conserved transmembrane domain tryptophan. J. Biol. Chem. 284:25512-25521.
26. Pochynyuk, O., Q. Tong, J. D. Stockand. 2007. Molecular determinants of PI (4, 5) P2 and PI (3, 4, 5) P3 regulation of the epithelial Na+ channel. J. Gen. Physiol. 130:399-413. (Pubitemid 47481603)
27. + channel in a mammalian expression system. Methods Mol. Biol. 337:3-13.