Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 214-221

  Gomes, Tatiana F ^a   Pompeu, Thais E T ^b   Rodrigues, Daniel A ^a   Noël, François ^b   Menegatti, Ricardo ^a   Andrade, Carolina H ^a   Sabino, José R ^a   Gil, Eric S ^a   Dalla Costa, Teresa ^c   Betti, Andresa H ^c   Antonio, Camila B ^c   Rates, Stela M K ^c   Fraga, Carlos A M ^b   Barreiro, Eliezer J ^b   De Oliveira, Valéria ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Biotransformation; Filamentous fungi; LASSBio 579; Pharmacological evaluation; Schizophrenia

Indexed keywords

1 [1 (4 CHLOROPHENYL) 1H 4PYRAZOLYLMETHYL] HENYLHEXAHYDROPIPERAZINE; CLOZAPINE; CYTOCHROME P450 1A2; DOPAMINE 4 RECEPTOR; LASSBIO 579; OLANZAPINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPSYCHOTIC ACTIVITY; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; CUNNINGHAMELLA ECHINULATA; DRUG ACTIVITY; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSFORMATION; FUNGAL STRAIN; HYDROXYLATION; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; NONHUMAN; POTENTIOMETRY; PREDICTION; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LEAD; MALE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875974181     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.011     Document Type: Article

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