Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus

Osteoarthritis and Cartilage

Volumn 21, Issue 5, 2013, Pages 700-709

  Nishida, T ^a   Kubota, S ^a   Aoyama, E ^b   Takigawa, M ^a,b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chondrocyte hypertrophy like changes; Chondrocytes; Glycolytic metabolism; Intracellular ATP production; Osteoarthritis (OA); Sodium fluoride

Indexed keywords

COLLAGEN TYPE 10; FLUORIDE SODIUM; GELATINASE B; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN;

ALP GENE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CHONDROCYTE HYPERTROPHY; CHONDROPATHY; COL10A1 GENE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; MATRIX METALLOPROTEINASE 13 GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VEGF GENE; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; BONE MORPHOGENETIC PROTEINS; CELL DEATH; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; GLYCOLYSIS; HUMANS; HYPERTROPHY; NF-KAPPA B; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SODIUM FLUORIDE; SODIUM LACTATE;

EID: 84875900557     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.01.013     Document Type: Article

References (32)

1. Goldring M.B., Goldring S.R. Osteoarthritis. J Cell Physiol 2007, 213:626-634.
2. van der Kraan P.M., van den Berg W.B. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?. Osteoarthritis Cartilage 2012, 20:223-232.
3. McDaniel G., Renner J.B., Sloane R., Kraus V.B. Association of knee and ankle osteoarthritis with physical performance. Osteoarthritis Cartilage 2011, 19:634-638.
4. Little C.B., Zaki S. What constitutes an " animal model of osteoarthritis" - the need for consensus?. Osteoarthritis Cartilage 2012, 20:261-267.
5. Guzman R.E., Evans M.G., Bove S., Morenko B., Kilgore K. Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol 2003, 31:619-624.
6. Ditzel H.J. The K/BxN mouse: a model of human inflammatory arthritis. Trends Mol Med 2004, 10:40-45.
7. Matsumoto I., Staub A., Benoist C., Mathis D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 1999, 286:1732-1735.
8. Mobasheri A., Vannucci S.J., Bondy C.A., Carter S.D., Innes J.F., Arteaga M.F., et al. Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol Histopathol 2002, 17:1239-1267.
9. Yoon B.S., Lyons K.M. Multiple functions of BMPs in chondrogenesis. J Cell Biochem 2004, 93:93-103.
10. Doi H., Nishida K., Yorimitsu M., Komiyama T., Kadota Y., Tetsunaga T., et al. Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes. Acta Med Okayama 2008, 62:119-126.
11. Takigawa M., Tajima K., Pan H.-O., Enomoto M., Kinoshita A., Suzuki F., et al. Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes. Cancer Res 1989, 49:3996-4002.
12. Takigawa M., Pan H.-O., Kinoshita A., Tajima K., Takano Y. Establishment from a human chondrosarcoma of a new immortal cell line with high tumorigenicity in vivo, which is able to form proteoglycan-rich cartilage-like nodules and to respond to insulin in vitro. Int J Cancer 1991, 48:717-725.
13. Iwamoto-Enomoto M., Takigawa M. Regulation of tumor-derived and immortalized chondrocytes. Biological Regulation of the Chondrocytes 1992, 321-338. CRC Press, Boca Raton. M. Adolphe (Ed.).
14. Mukhopadhyay K., Lefebvre V., Zhou G., Garofalo S., Kimura J.H., de Crombrugghe B. Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-α1 (II) collagen gene. J Biol Chem 1995, 270:27711-27719.
15. Nishida T., Kubota S., Aoyama E., Janune D., Maeda A., Takigawa M. Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes. Endocrinology 2011, 152:4232-4241.
16. Nishida T., Kondo S., Maeda A., Kubota S., Lyons K.M., Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1α expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 2009, 44:24-31.
17. Nishida T., Kubota S., Kojima S., Kuboki T., Nakao K., Kushibiki T., et al. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res 2004, 19:1308-1319.
18. Burkhardt D., Hwa S.-Y., Ghosh P. A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis. Osteoarthritis Cartilage 2001, 9:238-247.
19. Kubota S., Hattori T., Shimo T., Nakanishi T., Takigawa M. Novel intracellular effects of human connective tissue growth factor expressed in cos-7 cells. FEBS Lett 2000, 474:58-62.
20. Yoshimura K., Miyamoto Y., Yasuhara R., Maruyama T., Akiyama T., Yamada A., et al. Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1β via late phase activation of nuclear factor κB and expression of phagocyte-type NADPH oxidase. J Biol Chem 2011, 286:14744-14752.
21. Shimizu H., Yokoyama S., Asahara H. Growth and differentiation of the developing limb bud from the perspective of chondrogenesis. Dev Growth Differ 2007, 49:449-454.
22. Harbrow D.J., Robinson M.G., Monsour P.A. The effect of chronic fluoride administration on rat condylar cartilage. Aust Dent J 1992, 37:55-62.
23. Meredith D., Bell P., McClure B., Wilkins R. Functional and molecular characterization of lactic acid transport in bovine articular chondrocytes. Cell Physiol Biochem 2002, 12:227-234.
24. Heywood H.K., Lee D.A. Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol 2010, 222:248-253.
25. Halestrap A.P., Price N.T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999, 343:281-299.
26. Hinoi E., Takarada T., Tsuchihashi Y., Fujimori S., Moriguchi N., Wang L., et al. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol 2006, 70:925-935.
27. Samuvel D.J., Sundararaj K.P., Nareika A., Lopes-Virella M.F., Huang Y. Lactate boosts TLR4 signaling and NF-κB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation. J Immunol 2009, 182:2476-2484.
28. Rattigan Y.I., Patel B.B., Ackerstaff E., Sukenick G., Koutcher J.A., Glod J.W., et al. Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. Exp Cell Res 2012, 318:326-335.
29. Maeda A., Nishida T., Aoyama E., Kubota S., Lyons K.M., Kuboki T., et al. CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem 2009, 145:207-216.
30. Yoon B.S., Ovchinnikov D.A., Yoshii I., Mishina Y., Behringer R.R., Lyons K.M. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci USA 2005, 102:5062-5067.
31. Buckwalter J.A., Mankin H.J., Grodzinsky A.J. Articular cartilage and osteoarthritis. Instr Course Lect 2005, 54:465-480.
32. Fukui N., Miyamoto Y., Nakajima M., Ikeda Y., Hikita A., Furukawa H., et al. Zonal gene expression of chondrocytes in osteoarthritic cartilage. Arthritis Rheum 2008, 58:3843-3853.