Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes

Endocrinology

Volumn 152, Issue 11, 2011, Pages 4232-4241

  Nishida, Takashi ^a   Kubota, Satoshi ^a   Aoyama, Eriko ^b   Janune, Danilo ^a   Maeda, Azusa ^a   Takigawa, Masaharu ^a,b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RAT; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HUMANS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; PROTEIN BINDING;

EID: 80054894825     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-0234     Document Type: Article

References (37)

1. Itoh N, Ornitz DM 2004 Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563-569 (Pubitemid 39314564)
2. Lefebvre V, Smits P 2005 Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res C Embryo Today 75:200-212 (Pubitemid 41456322)
3. Ornitz DM 2005 FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev 16:205-213 (Pubitemid 40616117)
4. Ellman MB, An HS, Muddasani P, Im HJ 2008 Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene 420:82-89
5. Weksler NB, Lunstrum GP, Reid ES, Horton WA 1999 Differential effects of fibroblast growth factor (FGF) 9 and FGF2 on proliferation, differentiation and terminal differentiation of chondrocytic cells in vitro. Biochem J 342:677-682 (Pubitemid 29452653)
6. Krejci P, Prochazkova J, Smutny J, Chlebova K, Lin P, Aklian A, Bryja V, Kozubik A, Wilcox WR 2010 FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene- induced premature senescence. Bone 47:102-110
7. Kubota S, Takigawa M 2007 Role of CCN2/CTGF/Hcs24 in bone growth. Int Rev Cytol 257:1-41 (Pubitemid 46186474)
8. Redini F, Galera P, Mauviel A, Loyau G, Pujol JP 1988 Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEBS Lett 234: 172-176
9. Trippel ST 1992 Role of insulin-like growth factors in the regulation of chondrocytes. In: Adolphe M, ed. Biological regulation of the chondrocytes. Boca Raton, FL: CRC Press; 161-190
10. Yoon BS, LyonsKM2004 Multiple functions of BMPs in chondrogenesis. J Cell Biochem 93:93-103
11. Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, Bouillon R, Carmeliet G 2004 Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest 113:188-199
12. Abreu JG, Ketpura NI, Reversade B, De Robertis EM 2002 Connective- tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat Cell Biol 4:599-604
13. Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M 2009 CCN family2/ connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem 145:207-216
14. Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y 2002 Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem 277:36288-36295
15. Nakanishi T, Nishida T, Shimo T, Kobayashi K,KuboT, Tamatani T, Tezuka K, Takigawa M 2000 Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 141:264-273 (Pubitemid 32260367)
16. Yosimichi G, Kubota S, Nishida T, Kondo S, Yanagita T, Nakao K, Takano-Yamamoto T, Takigawa M 2006 Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes. Bone 38:853-863 (Pubitemid 44498592)
17. Nishida T, Kubota S, Nakanishi T, Kuboki T, Yosimichi G, Kondo S, Takigawa M 2002 CTGF/Hcs24, a hypertrophic chondrocytespecific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes. J Cell Physiol 192:55-63 (Pubitemid 34587387)
18. Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M 2004 Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J Bone Miner Res 19:1308-1319 (Pubitemid 41094373)
19. Minato M, Kubota S, Kawaki H, Nishida T, Miyauchi A, Hanagata H, Nakanishi T, Takano-Yamamoto T, Takigawa M 2004 Module- specific antibodies against human connective tissue growth factor: Utility for structural and functional analysis of the factor as related to chondrocytes. J Biochem 135:347-354 (Pubitemid 38506760)
20. Nishida T, Nakanishi T, Shimo T, Asano M, Hattori T, Tamatani T, Tezuka K, Takigawa M 1998 Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8). Biochem Biophys Res Commun 247:905-909 (Pubitemid 28418489)
21. Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M 2009 N-terminal domains ofCCNfamily2/ connective tissue growth factor bind to aggrecan. Biochem J 420:413-420
22. Takigawa M, Tajima K, Pan HO, Enomoto M, Kinoshita A, Suzuki F, Takano Y, Mori Y 1989 Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes. Cancer Res 49: 3996-4002 (Pubitemid 19197434)
23. Takigawa M, Pan HO, Kinoshita A, Tajima K, Takano Y 1991 Establishment from a human chondrosarcoma of a new immortal cell line with high tumorigenicity in vivo, which is able to form proteoglycan-rich cartilage-like nodules and to respond to insulin in vitro. Int J Cancer 48:717-725
24. Iwamoto-Enomoto M, Takigawa M 1992 Regulation of tumor-derived and immortalized chondrocytes. In: Adolphe M, ed. Biological regulation of the chondrocytes. Boca Raton, FL: CRC Press; 321-338
25. Tamura T, Nakanishi T, Kimura Y, Hattori T, Sasaki K, Norimatsu H, Takahashi K, Takigawa M 1996 Nitric oxide mediates interleukin- 1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis. Endocrinology 137:3729-3737 (Pubitemid 26284639)
26. Eguchi T, Kubota S, Kondo S, Shimo T, Hattori T, Nakanishi T, Kuboki T, Yatani H, Takigawa M 2001 Regulatory mechanism of humanconnective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8. J Biochem 130:79-87 (Pubitemid 32674568)
27. Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M 2009 CCN family2/ connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1α expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone 44:24-31
28. Nishida T, Maeda A, Kubota S, Takigawa M 2008 Role of mechanical- stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. Biorheology 45:289-299
29. Karlsson R, Katsamba PS, Nordin H, Pol E, Myszka DG 2006 Analyzing a kinetic titration series using affinity biosensors. Anal Biochem 349:136-147 (Pubitemid 43129567)
30. Krejci P, Masri B, Fontaine V, Mekikian PB, Weis M, Prats H, Wilcox WR 2005 Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis. J Cell Sci 118:5089-5100 (Pubitemid 41672439)
31. Kolesnikova TV, Lau LF 1998 Human Cyr61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene 16:747-754 (Pubitemid 28076085)
32. Nishida T, Kubota S, Fukunaga T, Kondo S, Yosimichi G, Nakanishi T, Takano-Yamamoto T, Takigawa M 2003 CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol 196:265-275 (Pubitemid 36775873)
33. Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J 2007 Fibroblast growth factor expression in the postnatal growth plate. Bone 40:577-586 (Pubitemid 46187233)
34. Tam EM, Morrison CJ, Wu YI, Stack MS, Overall CM 2004 Membrane protease proteomics: isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc Natl Acad Sci USA 101:6917-6922 (Pubitemid 38596418)
35. Haeusler G, Walter I, Helmreich M, Egerbacher M 2005 Localization of matrix metalloproteinases, (MMPs), their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation. Calcif Tissue Int 76:326-335 (Pubitemid 41557278)
36. Nishida T, Nakanishi T, Asano M, Shimo T, Takigawa M 2000 Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro. J Cell Physiol 184:197-206 (Pubitemid 30432311)
37. Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M 2011 CCN family2/ connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res 26:351-363