메뉴 건너뛰기




Volumn 145, Issue 2, 2009, Pages 207-216

CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes

Author keywords

BMP signalling; BMP 2; CCN family 2 connective tissue growth factor (CCN2 CTGF); Chondrocytes; Endochondral ossification

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEOGLYCAN;

EID: 59449095447     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn159     Document Type: Article
Times cited : (89)

References (34)
  • 1
    • 0038688357 scopus 로고    scopus 로고
    • The genetic basis for skeletal diseases
    • Zelzer, E. and Olsen, B.R. (2003) The genetic basis for skeletal diseases. Nature 423, 343-348
    • (2003) Nature , vol.423 , pp. 343-348
    • Zelzer, E.1    Olsen, B.R.2
  • 2
    • 34547414492 scopus 로고    scopus 로고
    • Growth and differentiation of the developing limb bud from the perspective of chondrogenesis
    • Shimizu, H., Yokoyama, S., and Asahara, H. (2007) Growth and differentiation of the developing limb bud from the perspective of chondrogenesis. Develop. Growth Differ. 49, 449-454
    • (2007) Develop. Growth Differ , vol.49 , pp. 449-454
    • Shimizu, H.1    Yokoyama, S.2    Asahara, H.3
  • 3
    • 0023948230 scopus 로고
    • Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes
    • Redini, F., Galera, P., Mauviel, A., Loyau, G., and Pujol, J.P. (1988) Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes. FEBS Lett. 234, 172-176
    • (1988) FEBS Lett , vol.234 , pp. 172-176
    • Redini, F.1    Galera, P.2    Mauviel, A.3    Loyau, G.4    Pujol, J.P.5
  • 4
    • 59449103550 scopus 로고    scopus 로고
    • Trippel, S.B. (1992) Role of insulin-like growth factors in the regulation of chondrocytes in Biological Regulation of the Chondrocytes (Adolphe, M., ed.) pp. 161-190, CRC Press, Boca Raton, FL
    • Trippel, S.B. (1992) Role of insulin-like growth factors in the regulation of chondrocytes in Biological Regulation of the Chondrocytes (Adolphe, M., ed.) pp. 161-190, CRC Press, Boca Raton, FL
  • 5
    • 13444296903 scopus 로고    scopus 로고
    • Multiple functions of BMPs in chondrogenesis
    • Yoon, B.S. and Lyons, K.M. (2004) Multiple functions of BMPs in chondrogenesis. J. Cell. Biochem. 93, 93-103
    • (2004) J. Cell. Biochem , vol.93 , pp. 93-103
    • Yoon, B.S.1    Lyons, K.M.2
  • 6
    • 33846626061 scopus 로고    scopus 로고
    • Role of CCN2/CTGF/ Hcs24 in bone growth
    • Kubota, S. and Takigawa, M. (2007) Role of CCN2/CTGF/ Hcs24 in bone growth. Int. Rev. Cytol. 257, 1-41
    • (2007) Int. Rev. Cytol , vol.257 , pp. 1-41
    • Kubota, S.1    Takigawa, M.2
  • 7
    • 0034464865 scopus 로고    scopus 로고
    • Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture
    • Nakanishi, T., Nishida, T., Shimo, T., Kobayashi, K., Kubo, T., Tamatani, T., Tezuka, K., and Takigawa, M. (2000) Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology 141, 264-273
    • (2000) Endocrinology , vol.141 , pp. 264-273
    • Nakanishi, T.1    Nishida, T.2    Shimo, T.3    Kobayashi, K.4    Kubo, T.5    Tamatani, T.6    Tezuka, K.7    Takigawa, M.8
  • 8
    • 9144268023 scopus 로고    scopus 로고
    • Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor)
    • Nishida, T., Kubota, S., Kojima, S., Kuboki, T., Nakao, K., Kushibiki, T., Tabata, Y., and Takigawa, M. (2004) Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). J. Bone Miner. Res. 19, 1308-1319
    • (2004) J. Bone Miner. Res , vol.19 , pp. 1308-1319
    • Nishida, T.1    Kubota, S.2    Kojima, S.3    Kuboki, T.4    Nakao, K.5    Kushibiki, T.6    Tabata, Y.7    Takigawa, M.8
  • 10
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
    • Abreu, J.G., Ketpura, N.I., Reversade, B., and de Robertis, E.M. (2002) Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat. Cell Biol. 4, 599-604
    • (2002) Nat. Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    de Robertis, E.M.4
  • 12
    • 0024893773 scopus 로고
    • Bone morphogenetic proteins
    • Wozney, J.M. (1989) Bone morphogenetic proteins. Prog. Growth Factor Res. 1, 267-280
    • (1989) Prog. Growth Factor Res , vol.1 , pp. 267-280
    • Wozney, J.M.1
  • 13
    • 0345363018 scopus 로고    scopus 로고
    • Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line
    • Valcourt, U., Ronzière, M.-C., Winkler, P., Rosen, V., Herbage, D., and Mallein-Gerin, F. (1999) Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line. Exp. Cell Res. 251, 264-274
    • (1999) Exp. Cell Res , vol.251 , pp. 264-274
    • Valcourt, U.1    Ronzière, M.-C.2    Winkler, P.3    Rosen, V.4    Herbage, D.5    Mallein-Gerin, F.6
  • 14
    • 0031843385 scopus 로고    scopus 로고
    • Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5
    • Shukunami, C., Ohta, Y., Sakuda, M., and Hiraki, Y. (1998) Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5. Exp. Cell Res. 241, 1-11
    • (1998) Exp. Cell Res , vol.241 , pp. 1-11
    • Shukunami, C.1    Ohta, Y.2    Sakuda, M.3    Hiraki, Y.4
  • 16
    • 0035504887 scopus 로고    scopus 로고
    • Intracellular BMP signaling regulation in vertebrates: Pathway or network?
    • von Bubnoff, A. and Cho, K.W. (2001) Intracellular BMP signaling regulation in vertebrates: pathway or network? Dev. Biol. 239, 1-14
    • (2001) Dev. Biol , vol.239 , pp. 1-14
    • von Bubnoff, A.1    Cho, K.W.2
  • 18
    • 33845971522 scopus 로고    scopus 로고
    • Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis
    • Bandyopadhyay, A., Tsuji, K., Cox, K., Harfe, B.D, Rosen, V., and Tabin, C.J. (2006) Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. 2, 2116-2130
    • (2006) PLoS Genet , vol.2 , pp. 2116-2130
    • Bandyopadhyay, A.1    Tsuji, K.2    Cox, K.3    Harfe, B.D.4    Rosen, V.5    Tabin, C.J.6
  • 22
    • 52449129589 scopus 로고    scopus 로고
    • CCN2 (connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes
    • Nishida, T., Kawaki, H., Baxter, R.M., Deyoung, R.A., Takigawa, M., and Lyons, K.M. (2007) CCN2 (connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J. Cell Commun. Signal. 1, 45-58
    • (2007) J. Cell Commun. Signal , vol.1 , pp. 45-58
    • Nishida, T.1    Kawaki, H.2    Baxter, R.M.3    Deyoung, R.A.4    Takigawa, M.5    Lyons, K.M.6
  • 23
    • 0038798680 scopus 로고    scopus 로고
    • CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes
    • Nishida, T., Kubota, S., Fukunaga, T., Kondo, S., Yosimichi, G., Nakanishi, T., Takano-Yamamoto, T., and Takigawa, M. (2003) CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J. Cell. Physiol. 196, 265-275
    • (2003) J. Cell. Physiol , vol.196 , pp. 265-275
    • Nishida, T.1    Kubota, S.2    Fukunaga, T.3    Kondo, S.4    Yosimichi, G.5    Nakanishi, T.6    Takano-Yamamoto, T.7    Takigawa, M.8
  • 24
    • 21044456200 scopus 로고    scopus 로고
    • Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development
    • Yamaai, T., Nakanishi, T., Asano, M., Nawachi, K., Yosimichi, G., Ohyama, K., Komori, T., Sugimoto, T., and Takigawa, M. (2005) Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development. J. Bone Miner. Metab. 23, 280-288
    • (2005) J. Bone Miner. Metab , vol.23 , pp. 280-288
    • Yamaai, T.1    Nakanishi, T.2    Asano, M.3    Nawachi, K.4    Yosimichi, G.5    Ohyama, K.6    Komori, T.7    Sugimoto, T.8    Takigawa, M.9
  • 25
    • 0036260532 scopus 로고    scopus 로고
    • CTGF/ Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes
    • Nishida, T., Kubota, S., Nakanishi, T., Kuboki, T., Yosimichi, G., Kondo, S., and Takigawa, M. (2002) CTGF/ Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes. J. Cell. Physiol. 192, 55-63
    • (2002) J. Cell. Physiol , vol.192 , pp. 55-63
    • Nishida, T.1    Kubota, S.2    Nakanishi, T.3    Kuboki, T.4    Yosimichi, G.5    Kondo, S.6    Takigawa, M.7
  • 26
    • 50249133597 scopus 로고    scopus 로고
    • TGF-β1 and WISP-1/CCN4 can regulate each other's activity to cooperatively control osteoblast function
    • Inkson, C.A., Ono, M., Kuznetsov, S.A., Fisher, L.W., Gehron Robey, P., and Young, M.F. (2008) TGF-β1 and WISP-1/CCN4 can regulate each other's activity to cooperatively control osteoblast function. J. Cell. Biochem. 104, 1865-1878
    • (2008) J. Cell. Biochem , vol.104 , pp. 1865-1878
    • Inkson, C.A.1    Ono, M.2    Kuznetsov, S.A.3    Fisher, L.W.4    Gehron Robey, P.5    Young, M.F.6
  • 27
    • 1942488254 scopus 로고    scopus 로고
    • Module-specific antibodies against human connective tissue growth factor: Utility for structural and functional analysis of the factor as related to chondrocytes
    • Minato, M., Kubota, S., Kawaki, H., Nishida, T., Miyauchi, A., Hanagata, H., Nakanishi, T., Takano-Yamamoto, T., and Takigawa, M. (2004) Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes. J. Biochem. 135, 347-354
    • (2004) J. Biochem , vol.135 , pp. 347-354
    • Minato, M.1    Kubota, S.2    Kawaki, H.3    Nishida, T.4    Miyauchi, A.5    Hanagata, H.6    Nakanishi, T.7    Takano-Yamamoto, T.8    Takigawa, M.9
  • 28
    • 0030754093 scopus 로고    scopus 로고
    • Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor
    • Brigstock, D.R., Steffen, C.L., Kim, G.Y., Vegunta, R.K., Diehl, J.R., and Harding, P.A. (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J. Biol. Chem. 272, 20275-20282
    • (1997) J. Biol. Chem , vol.272 , pp. 20275-20282
    • Brigstock, D.R.1    Steffen, C.L.2    Kim, G.Y.3    Vegunta, R.K.4    Diehl, J.R.5    Harding, P.A.6
  • 29
    • 32344444422 scopus 로고    scopus 로고
    • CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin a5b1
    • Hoshijima, M., Hattori, T., Inoue, M., Araki, D., Hanagata, H., Miyauchi, A., and Takigawa, M. (2006) CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin a5b1. FEBS Lett. 580, 1376-1382
    • (2006) FEBS Lett , vol.580 , pp. 1376-1382
    • Hoshijima, M.1    Hattori, T.2    Inoue, M.3    Araki, D.4    Hanagata, H.5    Miyauchi, A.6    Takigawa, M.7
  • 30
    • 21344475120 scopus 로고    scopus 로고
    • The role of bone morphogenetic proteins in endochondral bone formation
    • Tsumaki, N. and Yoshikawa, H. (2005) The role of bone morphogenetic proteins in endochondral bone formation. Cytokine Growth Factor Rev. 16, 279-285
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 279-285
    • Tsumaki, N.1    Yoshikawa, H.2
  • 31
    • 0242334002 scopus 로고    scopus 로고
    • MAP kinases in chondrocyte differentiation
    • Stanton, L.-A., Underhill, T. M., and Beier, F. (2003) MAP kinases in chondrocyte differentiation. Dev. Biol. 263, 165-175
    • (2003) Dev. Biol , vol.263 , pp. 165-175
    • Stanton, L.-A.1    Underhill, T.M.2    Beier, F.3
  • 32
    • 0035574614 scopus 로고    scopus 로고
    • Regulatory mechanisms in the pathways of cartilage and bone formation
    • de Crombrugghe, B., Lefebvre, V., and Nakashima, K. (2001) Regulatory mechanisms in the pathways of cartilage and bone formation. Curr. Opin. Cell Biol. 13, 721-727
    • (2001) Curr. Opin. Cell Biol , vol.13 , pp. 721-727
    • de Crombrugghe, B.1    Lefebvre, V.2    Nakashima, K.3
  • 33
    • 0036399170 scopus 로고    scopus 로고
    • Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators
    • Balemans, W. and Vau Hul, W. (2002) Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev. Biol. 250, 231-250
    • (2002) Dev. Biol , vol.250 , pp. 231-250
    • Balemans, W.1    Vau Hul, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.