Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes

Journal of Cellular Physiology

Volumn 222, Issue 1, 2010, Pages 248-253

  Heywood, Hannah K ^a   Lee, David A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANOSINE; BIOLOGICAL MARKER; DNA; GUANOSINE; OLIGOMYCIN; OXYGEN; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANALYTICAL PARAMETERS; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL EXPANSION; CELL ISOLATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; ENERGY METABOLISM; IN VITRO STUDY; MONOLAYER CULTURE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALS; BIOSENSING TECHNIQUES; CATTLE; CELL ADHESION; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; CHONDROCYTES; GLYCOLYSIS; LACTIC ACID; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PHENOTYPE;

EID: 73949112802     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21946     Document Type: Article

References (33)

1. Archer CW, Rooney P, Wolpert L. 1982. Cell shape and cartilage differentiation of early chick limb bud cells in culture. Cell Differ 11:245-251.
2. Benya PD, Shaffer JD. 1982. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215-224.
3. Boveris A, Chance B. 1973. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134:707-716.
4. Brand MD, Harper ME, Taylor HC. 1993. Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes. Biochem J 291:739-748.
5. Brittberg M. 1999. Autologous chondrocyte transplantation. Clin Orthop Relat Res 367:S147-S155.
6. Brittberg M. 2008. Autologous chondrocyte implantation - Technique and long-term follow-up. Injury 39:S40-S49.
7. Bywaters EGL. 1937. The metabolism of joint tissues. J Pathol Bacteriol 44:247-268.
8. DiMauro S, Schon EA. 2003. Mitochondrial respiratory-chain diseases. N Engl J Med 348:2656-2668.
9. Domm C, Schunke M, Christesen K, Kurz B. 2002. Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage 10:13-22.
10. Grimshaw MJ, Mason RM. 2000. Bovine articular chondrocyte function in vitro depends upon oxygen tension. Osteoarthritis Cartilage 8:386-392.
11. Halliwell B. 1993. Oxidative DNA damage. DNA and free radicals. West Sussex: Ellis Horwood Ltd.
12. Heywood HK, Lee DA. 2008. Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun 373:224-229.
13. Heywood HK, Sembi PK, Lee DA, Bader DL. 2004. Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng 10:1467-1479.
14. Heywood HK, Bader DL, Lee DA. 2006. Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. J Cell Physiol 206:402-410.
15. Jekabsons M, Nicholls D. 2004. In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate. J Biol Chem 279:32980-33000.
16. Johnson K, Jung A, Murphy A, Andreyev A, Dykens J, Terkeltaub R. 2000. Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum 43:1560-1570.
17. Johnson K, Svensson CI, Etten DV, Ghosh SS, Murphy AN, Powell HC, Terkeltaub R. 2004. Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum 50:1216-1225.
18. Jones DG, Peterson L. 2007. Autologous chondrocyte implantation. Instr Course Lect 56:429-445.
19. Kellner K, Liebsch G, Klimant I, Wolfbeis OS, Blunk T, Schulz MB, Gopferich A. 2002. Determination of oxygen gradients in engineered tissue using a fluorescent sensor. Biotechnol Bioeng 80:73-83.
20. Krebs HA. 1972. The Pasteur effect and the relations between respiration and fermentation. Essays Biochem 8:1-34.
21. Lund-Olesen K. 1970. Oxygen tension in synovial fluids. Arthritis Rheum 13:769-776.
22. Mignotte F, Champagne AM, Froger-Gaillard B, Benel L, Gueride M, Adolphe M, Mounolou JC. 1991. Mitochondrial biogenesis in rabbit articular chondrocytes transferred to culture. Biol Cell 71:67-72.
23. Moussavi-Harami F, Duwayri Y, Martin JA, Buckwalter JA. 2004. Oxygen effects on senescence in chondrocytes and mesenchymal stem cells: Consequences for tissue engineering. Iowa Orthop J 24:15-20.
24. Newman P, Watt FM. 1988. Influence of cytochalasin D-induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes. Exp Cell Res 178:199-210.
25. Nicholls D, Ferguson S. 2002. Bioenergetics 3. London, UK: Academic Press.
26. Otte P. 1991. Basic cell metabolism of articular cartilage. Manometric studies. Z Rheumatol 50:304-312.
27. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5:741-747.
28. Peterson L, Minas T, Brittberg M, Lindahl A. 2003. Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: Results at two to ten years. J Bone Joint Surg Am 85-A:17-24.
29. Rosenthal OAM, Wagoner BG. 1941. Studies in the metabolism of articular cartilage. I. Respiration and glycolysis of cartilage in relation to its age. J Cell Physiol 17:221-233.
30. Sengers BG, Heywood HK, Lee DA, Oomens CW, Bader DL. 2005. Nutrient utilization by bovine articular chondrocytes: A combined experimental and theoretical approach. J Biomech Eng 127:758-766.
31. Silver AA. 1975. Measurement of pH and ionic composition of pericellular sites. Phil Trans Roy Soc London 271:261-272.
32. Tomita M, Sato EF, Nishikawa M, Yamano Y, Inoue M. 2001. Nitric oxide regulates mitochondrial respiration and functions of articular chondrocytes. Arthritis Rheum 44:96-104.
33. Yudoh K, Nguyen T, Nakamura H, Hongo-Masuko K, Kato T, Nishioka K. 2005. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: Oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther 7:R380-R391.