메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 63-76

From cellular cultures to cellular spheroids: Is impedance spectroscopy a viable tool for monitoring multicellular spheroid (MCS) drug models?

Author keywords

3 D cellular models; bioimpedance; electrical impedance spectroscopy (EIS); label free cell based biosensors; tumor spheroids

Indexed keywords

CELL CULTURE; DIAGNOSIS; DRUG INTERACTIONS; ELECTRIC IMPEDANCE; ELECTRIC IMPEDANCE MEASUREMENT; MONOLAYERS; SPECTROSCOPY;

EID: 84875874021     PISSN: 19373333     EISSN: None     Source Type: Journal    
DOI: 10.1109/RBME.2012.2222023     Document Type: Article
Times cited : (25)

References (135)
  • 1
    • 23244464088 scopus 로고    scopus 로고
    • An overview of the drug development process
    • May-Jun.
    • R. Tonkens, "An overview of the drug development process," Physi cian Exec., vol. 31, pp. 48-52, May-Jun. 2005.
    • (2005) Physi Cian Exec. , vol.31 , pp. 48-52
    • Tonkens, R.1
  • 2
    • 0042330313 scopus 로고    scopus 로고
    • ADME-Tox in drug discovery: Integration of experimental and computational technologies
    • DOI 10.1016/S1359-6446(03)02828-9, PII S1359644603028289
    • H. Yu and A. Adedoyin, "ADME-Tox in drug discovery: Integration of experimental and computational technologies," Drug Discovery Today, vol. 8, pp. 852-861, 2003. (Pubitemid 37083343)
    • (2003) Drug Discovery Today , vol.8 , Issue.18 , pp. 852-861
    • Yu, H.1    Adedoyin, A.2
  • 3
    • 16544380146 scopus 로고    scopus 로고
    • The use of 3-D cultures for high-throughput screening: The multicellular spheroid model
    • Jun.
    • L. A. Kunz-Schughart, J. P. Freyer, F. Hofstaedter, and R. Ebner, "The use of 3-D cultures for high-throughput screening: The multicellular spheroid model," J. Biomolec. Screening, vol. 9, pp. 273-285, Jun. 2004.
    • (2004) J. Biomolec. Screening , vol.9 , pp. 273-285
    • Kunz-Schughart, L.A.1    Freyer, J.P.2    Hofstaedter, F.3    Ebner, R.4
  • 5
    • 0028816212 scopus 로고
    • Long-term maintenance of liver-specific functions in three-dimensional culture of adult rat hepatocytes with a porous gelatin sponge support
    • K. Lin, S. Maeda, and T. Saito, "Long-term maintenance of liver-specific functions in three-dimensional culture of adult rat hepatocytes with a porous gelatin sponge support," Biotechnol. Appl. Biochem., vol. 21, pp. 19-27, 1995.
    • (1995) Biotechnol. Appl. Biochem. , vol.21 , pp. 19-27
    • Lin, K.1    Maeda, S.2    Saito, T.3
  • 7
    • 0036591838 scopus 로고    scopus 로고
    • Engineering cellular microenvironments to improve cell-based drug testing
    • DOI 10.1016/S1359-6446(02)02273-0, PII S1359644602022730
    • K. Bhadriraju and C. S. Chen, "Engineering cellular microenvironments to improve cell-based drug testing," Drug Discovery Today, vol. 7, pp. 612-620, 2002. (Pubitemid 34606016)
    • (2002) Drug Discovery Today , vol.7 , Issue.11 , pp. 612-620
    • Bhadriraju, K.1    Chen, C.S.2
  • 8
    • 68549104172 scopus 로고    scopus 로고
    • Three-dimensional tissue models for drug discovery and toxicology
    • F. Pampaloni, E. H. K. Stelzer, and A. Masotti, "Three-dimensional tissue models for drug discovery and toxicology," Recent Patents Biotechnol., vol. 3, pp. 103-117, 2009.
    • (2009) Recent Patents Biotechnol. , vol.3 , pp. 103-117
    • Pampaloni, F.1    Stelzer, E.H.K.2    Masotti, A.3
  • 10
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • DOI 10.1038/nrm2236, PII NRM2236
    • F. Pampaloni, E. G. Reynaud, and E. H. K. Stelzer, "The third dimension bridges the gap between cell culture and live tissue," Nat. Rev. Mol. Cell. Biol., vol. 8, pp. 839-845, 2007. (Pubitemid 47462131)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 11
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor mi croregions: The multicell spheroid model
    • R. M. Sutherland, "Cell and environment interactions in tumor mi croregions: The multicell spheroid model," Sci., vol. 240, pp. 177-184, 1988.
    • (1988) Sci. , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan and R. Weinberg, "The hallmarks of cancer," Cell, vol. 100, pp. 57-70, 2000. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 79952264003 scopus 로고    scopus 로고
    • Multicellular spheroids as an in vitro model in experimental oncology: Applications in translational medicine
    • D. Khaitan and B. S. Dwarakanath, "Multicellular spheroids as an in vitro model in experimental oncology: Applications in translational medicine," Expert Opin. Drug Discovery, vol. 1, pp. 663-675, 2006.
    • (2006) Expert Opin. Drug Discovery , vol.1 , pp. 663-675
    • Khaitan, D.1    Dwarakanath, B.S.2
  • 15
    • 34547578768 scopus 로고    scopus 로고
    • Label-free impedance biosensors: Opportunities and challenges
    • J. S. Daniels and N. Pourmand, "Label-free impedance biosensors: Opportunities and challenges," Electroanal., vol. 19, pp. 1239-1257, 2007.
    • (2007) Electroanal. , vol.19 , pp. 1239-1257
    • Daniels, J.S.1    Pourmand, N.2
  • 16
    • 34447498398 scopus 로고    scopus 로고
    • A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: Applications of acoustic physics to the analysis of biomolecular interactions
    • DOI 10.1002/jmr.826
    • M. A. Cooper and V. T. Singleton, "A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: Applications of acoustic physics to the analysis of biomolecular interactions," J. Molec. Recognit., vol. 20, pp. 154-184, 2007. (Pubitemid 47075114)
    • (2007) Journal of Molecular Recognition , vol.20 , Issue.3 , pp. 154-184
    • Cooper, M.A.1    Singleton, V.T.2
  • 17
    • 40449105434 scopus 로고    scopus 로고
    • Label-free protein recognition two-dimensional array using nanomechanical sensors
    • DOI 10.1021/nl072740c
    • M. Yue, J. C. Stachowiak, H. Lin, R. Datar, R. Cote, and A. Majumdar, "Label-free protein recognition two-dimensional array using nanome-chanical sensors," Nano Lett., vol. 8, pp. 520-524, 2008. (Pubitemid 351346011)
    • (2008) Nano Letters , vol.8 , Issue.2 , pp. 520-524
    • Yue, M.1    Stachowiak, J.C.2    Lin, H.3    Datar, R.4    Cote, R.5    Majumdar, A.6
  • 18
    • 70349771023 scopus 로고    scopus 로고
    • Microand nanocantilever devices and systems for biomolecule detection
    • K. S. Hwang, S. M. Lee, S. K. Kim, J. H. Lee, and T. S. Kim, "Microand nanocantilever devices and systems for biomolecule detection," Annu. Rev. Anal. Chem., vol. 2, pp. 77-98, 2009.
    • (2009) Annu. Rev. Anal. Chem. , vol.2 , pp. 77-98
    • Hwang, K.S.1    Lee, S.M.2    Kim, S.K.3    Lee, J.H.4    Kim, T.S.5
  • 21
    • 85167482596 scopus 로고    scopus 로고
    • Design of integrated microfluidic device for sorting magnetic beads in biological assays
    • DOI 10.1109/20.951254, PII S0018946401063841
    • M. Tondra, M. Granger, R. Fuerst, M. Porter, C. Nordman, J. Taylor, and S. Akou, "Design of integrated microfluidic device for sorting magnetic beads in biological assays," IEEE Trans. Magn., vol. 37, no. 4, pt. 1, pp. 2621-2623, Apr. 2001. (Pubitemid 32969384)
    • (2001) IEEE Transactions on Magnetics , vol.37 , Issue.I4 , pp. 2621-2623
    • Tondra, M.1    Granger, M.2    Fuerst, R.3    Porter, M.4    Nordman, C.5    Taylor, J.6    Akou, S.7
  • 22
    • 84856390811 scopus 로고    scopus 로고
    • Using label-free screening technology to improve efficiency in drug discovery
    • Aug.
    • R. Halai and M. A. Cooper, "Using label-free screening technology to improve efficiency in drug discovery," Expert Opin. Drug Discovery, vol. 7, pp. 123-131, Aug. 2012.
    • (2012) Expert Opin. Drug Discovery , vol.7 , pp. 123-131
    • Halai, R.1    Cooper, M.A.2
  • 23
    • 60349111587 scopus 로고    scopus 로고
    • Mammalian cell-based biosensors for pathogens and toxins
    • P. Banerjee and A. K. Bhunia, "Mammalian cell-based biosensors for pathogens and toxins," Trends Biotechnol., vol. 27, pp. 179-188, 2009.
    • (2009) Trends Biotechnol. , vol.27 , pp. 179-188
    • Banerjee, P.1    Bhunia, A.K.2
  • 24
    • 22144482062 scopus 로고    scopus 로고
    • Quartz crystal microbalance biosensor study of endothelial cells and their extracellular matrix following cell removal: Evidence for transient cellular stress and viscoelastic changes during detachment and the elastic behavior of the pure matrix
    • DOI 10.1016/j.ab.2005.05.013, PII S000326970500374X
    • K. A. Marx, T. Zhou, A. Montrone, D. McIntosh, and S. J. Braunhut, "Quartz crystal microbalance biosensor study of endothelial cells and their extracellular matrix following cell removal: Evidence for transient cellular stress and viscoelastic changes during detachment and the elastic behavior of the pure matrix," Anal. Biochem., vol. 343, pp. 23-34, 2005. (Pubitemid 40978606)
    • (2005) Analytical Biochemistry , vol.343 , Issue.1 , pp. 23-34
    • Marx, K.A.1    Zhou, T.2    Montrone, A.3    McIntosh, D.4    Braunhut, S.J.5
  • 25
    • 42949124474 scopus 로고    scopus 로고
    • The application of cell-based label-free technology in drug discovery
    • DOI 10.1002/biot.200800020
    • Xi, N. Yu, X. Wang, X. Xu, and Y. Abassi, "The application of cell-based label-free technology in drug discovery," Biotechnol. J., vol. 3, pp. 484-495, 2008. (Pubitemid 351618734)
    • (2008) Biotechnology Journal , vol.3 , Issue.4 , pp. 484-495
    • Xi, B.1    Yu, N.2    Wang, X.3    Xu, X.4    Abassi, Y.A.5
  • 26
    • 54949092509 scopus 로고    scopus 로고
    • Design, fabrication, and impedance characterization of a capacitance-based salinity sensor for marine applications
    • R. A. Rahman, S. Bhat, and S. Bhansali, "Design, fabrication, and impedance characterization of a capacitance-based salinity sensor for marine applications," J. Electrochem. Soc., vol. 155, pp. J355-J360, 2008.
    • (2008) J. Electrochem. Soc. , vol.155
    • Rahman, R.A.1    Bhat, S.2    Bhansali, S.3
  • 27
    • 0028530404 scopus 로고
    • Impedance spectroscopy on dielectric gas sensors
    • H. E. Endres, S. Drost, and F. Hutter, "Impedance spectroscopy on dielectric gas sensors," Sens. Actuators B, Chem., vol. 22, pp. 7-11, 1994.
    • (1994) Sens. Actuators B, Chem. , vol.22 , pp. 7-11
    • Endres, H.E.1    Drost, S.2    Hutter, F.3
  • 28
    • 33846323280 scopus 로고    scopus 로고
    • Quantification of the heterogeneity in breast cancer cell lines using whole-cell impedance spectroscopy
    • DOI 10.1158/1078-0432.CCR-06-1346
    • Han, L. Yang, and A. B. Frazier, "Quantification of the heterogeneity in breast cancer cell lines using whole-cell impedance spectroscopy," Clin. Cancer Res., vol. 13, pp. 139-143, Jan. 2007. (Pubitemid 46121862)
    • (2007) Clinical Cancer Research , vol.13 , Issue.1 , pp. 139-143
    • Han, A.1    Yang, L.2    Frazier, A.B.3
  • 29
    • 77957292591 scopus 로고    scopus 로고
    • Electrochemical impedance spec-troscopy
    • B.-Y. Chang and S.-M. Park, "Electrochemical impedance spec-troscopy," Annu. Rev. Anal. Chem., vol. 3, pp. 207-229, 2010.
    • (2010) Annu. Rev. Anal. Chem. , vol.3 , pp. 207-229
    • Chang, B.-Y.1    Park, S.-M.2
  • 30
    • 30744454018 scopus 로고    scopus 로고
    • Reflections on the history of electrochemical impedance spectroscopy
    • DOI 10.1016/j.electacta.2005.02.107, PII S0013468605007991, Electrochemical Impedance Spectroscopy Selection of Papers from the 6th International Symposium (EIS 2004)
    • D. Macdonald, "Reflections on the history of electrochemical impedance spectroscopy," Electrochim. Acta, vol. 51, pp. 1376-1388, 2006. (Pubitemid 43098814)
    • (2006) Electrochimica Acta , vol.51 , Issue.8-9 , pp. 1376-1388
    • MacDonald, D.D.1
  • 31
    • 0348222765 scopus 로고    scopus 로고
    • Low-frequency electrochemical impedance for measuring corrosion of epoxy-coated reinforcing steel in concrete
    • Aug.
    • Sagues and A. M. Zayed, "Low-frequency electrochemical impedance for measuring corrosion of epoxy-coated reinforcing steel in concrete," Corrosion, vol. 47, pp. 852-859, Aug. 2012.
    • (2012) Corrosion , vol.47 , pp. 852-859
    • Sagues1    Zayed, A.M.2
  • 32
    • 65449131969 scopus 로고    scopus 로고
    • Three-electrode cell set-up electrical equivalent circuit applied to impedance analysis of thin polyaniline film modified electrodes
    • V. Horvat-Radošević and K. Kvastek, "Three-electrode cell set-up electrical equivalent circuit applied to impedance analysis of thin polyaniline film modified electrodes," J. Electroanal. Chem., vol. 631, pp. 10-21, 2009.
    • (2009) J. Electroanal. Chem. , vol.631 , pp. 10-21
    • Horvat-Radošević, V.1    Kvastek, K.2
  • 34
    • 58149234842 scopus 로고    scopus 로고
    • Impedance studies of bio-behavior and chemosensitivity of cancer cells by micro-electrode arrays
    • Q. Liu, J. Yu, L. Xiao, J. C. O. Tang, Y. Zhang, P. Wang, and M. Yang, "Impedance studies of bio-behavior and chemosensitivity of cancer cells by micro-electrode arrays," Biosens. Bioelectron., vol. 24, pp. 1305-1310, 2009.
    • (2009) Biosens. Bioelectron. , vol.24 , pp. 1305-1310
    • Liu, Q.1    Yu, J.2    Xiao, L.3    Tang, J.C.O.4    Zhang, Y.5    Wang, P.6    Yang, M.7
  • 35
    • 0027233863 scopus 로고
    • Monitoring motion of confluent cells in tissue culture
    • DOI 10.1006/excr.1993.1014
    • C.-M. Lo, C. R. Keese, and I. Giaever, "Monitoring motion of confluent cells in tissue culture," Exper. Cell Res., vol. 204, pp. 102-109, 1993. (Pubitemid 23203091)
    • (1993) Experimental Cell Research , vol.204 , Issue.1 , pp. 102-109
    • Lo, C.-M.1    Keese, C.R.2    Giaever, I.3
  • 36
    • 45749136837 scopus 로고    scopus 로고
    • Cell culture monitoring by impedance mapping using a multielectrode scanning impedance spectroscopy system (CellMap)
    • R. Rahman, J. Register, G. Vuppala, and S. Bhansali, "Cell culture monitoring by impedance mapping using a multielectrode scanning impedance spectroscopy system (CellMap)," Physiolog. Meas., vol. 29, pp. S227-39, 2008.
    • (2008) Physiolog. Meas. , vol.29
    • Rahman, R.1    Register, J.2    Vuppala, G.3    Bhansali, S.4
  • 37
    • 44649091608 scopus 로고    scopus 로고
    • Fundamentals of impedance spectroscopy
    • Hoboken, NJ: Wiley
    • J. R. Macdonald and W. B. Johnson, "Fundamentals of impedance spectroscopy," in Impedance Spectroscopy. Hoboken, NJ: Wiley, 2005, pp. 1-26.
    • (2005) Impedance Spectroscopy , pp. 1-26
    • MacDonald, J.R.1    Johnson, W.B.2
  • 39
    • 0015324923 scopus 로고
    • The interpretation of current-voltage relations recorded from a spherical cell with a single mi-croelectrode
    • Engel, V. Barcilon, and R. S. Eisenberg, "The interpretation of current-voltage relations recorded from a spherical cell with a single mi-croelectrode," Biophys. J., vol. 12, pp. 384-403, 1972.
    • (1972) Biophys. J. , vol.12 , pp. 384-403
    • Barcilon, E.V.1    Eisenberg, R.S.2
  • 41
    • 0029977149 scopus 로고    scopus 로고
    • Dielectric spectroscopy of single human erythrocytes at physiological ionic strength: Dispersion of the cytoplasm
    • J. Gimsa, T. Müller, T. Schnelle, and G. Fuhr, "Dielectric spectroscopy of single human erythrocytes at physiological ionic strength: Dispersion of the cytoplasm," Biophys. J., vol. 71, pp. 495-506, 1996. (Pubitemid 26227335)
    • (1996) Biophysical Journal , vol.71 , Issue.1 , pp. 495-506
    • Gimsa, J.1    Muller, T.2    Schnelle, T.3    Fuhr, G.4
  • 43
    • 0037983669 scopus 로고    scopus 로고
    • Instantaneous, quantitative single-cell viability assessment by electrical evaluation of cell membrane integrity with microfabricated devices
    • Y. Huang, N. S. Sekhon, J. Borninski, N. Chen, and B. Rubinsky, "Instantaneous, quantitative single-cell viability assessment by electrical evaluation of cell membrane integrity with microfabricated devices," Sens. Actuators A, Phys., vol. 105, pp. 31-39, 2003.
    • (2003) Sens. Actuators A, Phys. , vol.105 , pp. 31-39
    • Huang, Y.1    Sekhon, N.S.2    Borninski, J.3    Chen, N.4    Rubinsky, B.5
  • 44
    • 33947707296 scopus 로고    scopus 로고
    • Single cell dielectric spectroscopy
    • M. Hywel et al., "Single cell dielectric spectroscopy," J. Phys. D: Appl. Phys., vol. 40, p. 61, 2007.
    • (2007) J. Phys. D: Appl. Phys. , vol.40 , pp. 61
    • Hywel, M.1
  • 45
    • 79960449663 scopus 로고    scopus 로고
    • Impedance-controlled cell entrapment using microhole-array chips allows the isolation and identification of single, highly productive cells
    • C. M. Kurz, A. Maurer, K. Thees, S. Schillberg, T. Velten, and H. Thielecke, "Impedance-controlled cell entrapment using microhole-array chips allows the isolation and identification of single, highly productive cells," Sens. Actuators B, Chem., vol. 158, pp. 345-352, 2011.
    • (2011) Sens. Actuators B, Chem. , vol.158 , pp. 345-352
    • Kurz, C.M.1    Maurer, A.2    Thees, K.3    Schillberg, S.4    Velten, T.5    Thielecke, H.6
  • 47
    • 0036642720 scopus 로고    scopus 로고
    • Characterization of biological cells by dielectric spectroscopy
    • DOI 10.1016/S0022-3093(02)01110-9, PII S0022309302011109
    • K. Asami, "Characterization of biological cells by dielectric spec-troscopy," J. Non-Cryst. Solids, vol. 305, pp. 268-277, 2002. (Pubitemid 34552132)
    • (2002) Journal of Non-Crystalline Solids , vol.305 , Issue.1-3 , pp. 268-277
    • Asami, K.1
  • 48
    • 0346996456 scopus 로고    scopus 로고
    • Bioelectrical impedance assay to monitor changes in cell shape during apoptosis
    • DOI 10.1016/S0956-5663(03)00269-0
    • S. Arndt, J. Seebach, K. Psathaki, H.-J. Galla, and J. Wegener, "Bio-electrical impedance assay to monitor changes in cell shape during apoptosis," Biosens. Bioelectron., vol. 19, pp. 583-594, 2004. (Pubitemid 37542351)
    • (2004) Biosensors and Bioelectronics , vol.19 , Issue.6 , pp. 583-594
    • Arndt, S.1    Seebach, J.2    Psathaki, K.3    Galla, H.-J.4    Wegener, J.5
  • 51
    • 60349112311 scopus 로고    scopus 로고
    • Design rule for optimization of microelectrodes used in electric cell-substrate impedance sensing (ECIS)
    • D. T. Price, A. R. Rahman, and S. Bhansali, "Design rule for optimization of microelectrodes used in electric cell-substrate impedance sensing (ECIS)," Biosens. Bioelectron., vol. 24, pp. 2071-2076, 2009.
    • (2009) Biosens. Bioelectron. , vol.24 , pp. 2071-2076
    • Price, D.T.1    Rahman, A.R.2    Bhansali, S.3
  • 52
    • 63849107132 scopus 로고    scopus 로고
    • A detailed model for high-frequency impedance characterization of ovarian cancer epithelial cell layer using ECIS electrodes
    • Feb.
    • A. R. Rahman, C. M. Lo, and S. Bhansali, "A detailed model for high-frequency impedance characterization of ovarian cancer epithelial cell layer using ECIS electrodes," IEEE Trans. Biomed. Eng., vol. 56, no. 2, pp. 485-492, Feb. 2009.
    • (2009) IEEE Trans. Biomed. Eng. , vol.56 , Issue.2 , pp. 485-492
    • Rahman, A.R.1    Lo, C.M.2    Bhansali, S.3
  • 53
    • 85172051961 scopus 로고    scopus 로고
    • Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip
    • S. Haas, H.-G.Jahnke, M.Glass, R.Azendorf, S. Schmidt, and A. A. Ro-bitzki, "Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip," Lab on a Chip, vol. 10.
    • Lab on A Chip , vol.10
    • Haas, S.1    Jahnke, H.-G.2    Glass, M.3    Azendorf, R.4    Schmidt, S.5    Ro-Bitzki, A.A.6
  • 54
    • 77953912427 scopus 로고    scopus 로고
    • Detection of the osteogenic differentiation of mesenchymal stem cells in 2-D and 3-D cultures by electrochemical impedance spectroscopy
    • C. Hildebrandt, H. Büth, S. Cho, Impidjati, and H. Thielecke, "Detection of the osteogenic differentiation of mesenchymal stem cells in 2-D and 3-D cultures by electrochemical impedance spectroscopy," J. Biotechnol., vol. 148, pp. 83-90, 2010.
    • (2010) J. Biotechnol. , vol.148 , pp. 83-90
    • Hildebrandt, C.1    Büth, H.2    Cho Impidjati, S.3    Thielecke, H.4
  • 55
    • 0036795547 scopus 로고    scopus 로고
    • Real-time impedance assay to follow the invasive activities of metastatic cells in culture
    • C. R. Keese, K. Bhawe, J. Wegener, and I. Giaever, "Real-time impedance assay to follow the invasive activities of metastatic cells in culture," BioTechniques, vol. 33, pp. 842-850, 2002. (Pubitemid 35168069)
    • (2002) BioTechniques , vol.33 , Issue.4 , pp. 842-850
    • Keese, C.R.1    Bhawe, K.2    Wegener, J.3    Giaever, I.4
  • 56
    • 0028446185 scopus 로고
    • A biosensor that monitors cell morphology with electrical fields
    • Jun.-Jul.
    • C. R. Keese and I. Giaever, "A biosensor that monitors cell morphology with electrical fields," IEEE Eng. Med. Biol. Mag., vol. 13, no. 3, pp. 402-408, Jun.-Jul. 1994.
    • (1994) IEEE Eng. Med. Biol. Mag. , vol.13 , Issue.3 , pp. 402-408
    • Keese, C.R.1    Giaever, I.2
  • 57
    • 0035870187 scopus 로고    scopus 로고
    • Monitoring motility, spreading, and mortality of adherent insect cells using an impedance sensor
    • DOI 10.1021/ac0011585
    • J. H. T. Luong, M. Habibi-Rezaei, J. Meghrous, C. Xiao, K. B. Male, and A. Kamen, "Monitoring motility, spreading, and mortality of adherent insect cells using an impedance sensor," Anal. Chem., vol. 73, pp. 1844-1848, 2001. (Pubitemid 32862451)
    • (2001) Analytical Chemistry , vol.73 , Issue.8 , pp. 1844-1848
    • Luong, J.H.T.1    Habibi-Rezaei, M.2    Meghrous, J.3    Xiao, C.4    Male, K.B.5    Kamen, A.6
  • 58
    • 80052672446 scopus 로고    scopus 로고
    • Real-time monitoring of neural differentiation of human mesenchymal stem cells by electric cell-substrate impedance sensing
    • doi:10.1155/2011/485173
    • H. E. Park, D. Kim, H. S. Koh, S. Cho, J.-S. Sung, and J. Y. Kim, "Real-time monitoring of neural differentiation of human mesenchymal stem cells by electric cell-substrate impedance sensing," J. Biomed. Biotechnol., vol. 2011, 2011, 485173, doi:10.1155/2011/485173.
    • (2011) J. Biomed. Biotechnol. , vol.2011 , pp. 485173
    • Park, H.E.1    Kim, D.2    Koh, H.S.3    Cho, S.4    Sung, J.-S.5    Kim, J.Y.6
  • 61
    • 26944481910 scopus 로고    scopus 로고
    • A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer therapy: 3-Dimensional in vitro tumor spheroids as a screening model
    • DOI 10.1177/1087057105277841
    • P. Bartholomä, Impidjati, A. Reininger-Mack, Z. Zhang, H. Thielecke, and A. Robitzki, "A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer therapy: 3-dimensional in vitro tumor spheroids as a screening model," J. Biomolec. Screen., vol. 10, pp. 705-714, Oct. 2005. (Pubitemid 41476805)
    • (2005) Journal of Biomolecular Screening , vol.10 , Issue.7 , pp. 705-714
    • Bartholoma, P.1    Empidjati2    Reininger-Mack, A.3    Zhang, Z.4    Thielecke, H.5    Robitzki, A.6
  • 64
    • 12844281818 scopus 로고    scopus 로고
    • Development of a Novel Microcapillary Array: Characterization of in Vitro 3-D Tissue Models by Bioimpedance Spectroscopy
    • A. Robitzki, H. Thielecke, and A. Reininger-Mack, "Development of a Novel Microcapillary Array: Characterization of in Vitro 3-D Tissue Models by Bioimpedance Spectroscopy," in Proc. IEEE-EMBS Special Topic Conf., 2002, pp. 52-53.
    • (2002) Proc. IEEE-EMBS Special Topic Conf. , pp. 52-53
    • Robitzki, A.1    Thielecke, H.2    Reininger-Mack, A.3
  • 65
    • 0035094284 scopus 로고    scopus 로고
    • Biohybrid microarrays-Im-pedimetric biosensors with 3-D in vitro tissues for toxicological and biomedical screening
    • H. Thielecke, A. Mack, and A. Robitzki, "Biohybrid microarrays-Im-pedimetric biosensors with 3-D in vitro tissues for toxicological and biomedical screening," J. Anal. Chem., vol. 369, pp. 23-29, 2001.
    • (2001) J. Anal. Chem. , vol.369 , pp. 23-29
    • Thielecke, H.1    MacK, A.2    Robitzki, A.3
  • 66
    • 34347353063 scopus 로고    scopus 로고
    • Circulating tumor cells (CTC) detection: Clinical impact and future directions
    • DOI 10.1016/j.canlet.2006.12.014, PII S0304383506006860
    • P. Paterlini-Brechot and N. L. Benali, "Circulating tumor cells (CTC) detection: Clinical impact and future directions," Cancer Lett., vol. 253, pp. 180-204, 2007. (Pubitemid 47017533)
    • (2007) Cancer Letters , vol.253 , Issue.2 , pp. 180-204
    • Paterlini-Brechot, P.1    Benali, N.L.2
  • 68
    • 77954260151 scopus 로고    scopus 로고
    • Single-cell microfluidic impedance cytometry: A review
    • T. Sun and H. Morgan, "Single-cell microfluidic impedance cytometry: A review," Microfluidics and Nanofluidics, vol. 8, pp. 423-443, 2010.
    • (2010) Microfluidics and Nanofluidics , vol.8 , pp. 423-443
    • Sun, T.1    Morgan, H.2
  • 69
    • 36448977298 scopus 로고    scopus 로고
    • Broadband single cell impedance spectroscopy using maximum length sequences: Theoretical analysis and practical considerations
    • S. Tao, G. Shady, B. Catia, G. G. Nicolas, and M. Hywel, "Broadband single cell impedance spectroscopy using maximum length sequences: Theoretical analysis and practical considerations," Meas. Sci. Technol., vol. 18, p. 2859, 2007.
    • (2007) Meas. Sci. Technol. , vol.18 , pp. 2859
    • Tao, S.1    Shady, G.2    Catia, B.3    Nicolas, G.G.4    Hywel, M.5
  • 70
    • 59649100860 scopus 로고    scopus 로고
    • Digital signal processing methods for impedance microfluidic cytometry
    • T. Sun, C. van Berkel, N. Green, and H. Morgan, "Digital signal processing methods for impedance microfluidic cytometry," Microfluidics and Nanofluidics, vol. 6, pp. 179-187, 2009.
    • (2009) Microfluidics and Nanofluidics , vol.6 , pp. 179-187
    • Sun, T.1    Van Berkel, C.2    Green, N.3    Morgan, H.4
  • 71
    • 77956871537 scopus 로고    scopus 로고
    • A novel impedance-based cellular assay for the detection of anti-calcium channel autoantibodies in type 1 diabetes
    • M. W. Jackson and T. P. Gordon, "A novel impedance-based cellular assay for the detection of anti-calcium channel autoantibodies in type 1 diabetes," J. Immunolog. Meth., vol. 361, pp. 31-36, 2010.
    • (2010) J. Immunolog. Meth. , vol.361 , pp. 31-36
    • Jackson, M.W.1    Gordon, T.P.2
  • 72
    • 0030578217 scopus 로고    scopus 로고
    • Impedance analysis of epithelial and endothelial cell monolayers cultured on gold surfaces
    • DOI 10.1016/0165-022X(96)00005-X
    • J. Wegener, M. Sieber, and H.-J. Galla, "Impedance analysis of epithelial and endothelial cell monolayers cultured on gold surfaces," J. Biochem. Biophys. Meth., vol. 32, pp. 151-170, 1996. (Pubitemid 26238459)
    • (1996) Journal of Biochemical and Biophysical Methods , vol.32 , Issue.3 , pp. 151-170
    • Wegener, J.1    Sieber, M.2    Galla, H.-J.3
  • 73
    • 0024364509 scopus 로고
    • Tumour spheroid technology in cancer therapy research
    • DOI 10.1016/0277-5379(89)90404-5
    • J. Carlsson and T. Nederman, "Tumour spheroid technology in cancer therapy research," Eur. J. Cancer Clin. Oncol., vol. 25, pp. 1127-33, 1989. (Pubitemid 19209604)
    • (1989) European Journal of Cancer and Clinical Oncology , vol.25 , Issue.8 , pp. 1127-1133
    • Carlsson, J.1    Nederman, T.2
  • 74
    • 34547931078 scopus 로고    scopus 로고
    • Modeling Tissue Morphogenesis and Cancer in 3D
    • DOI 10.1016/j.cell.2007.08.006, PII S0092867407010288
    • K. M. Yamada and E. Cukierman, "Modeling tissue morphogenesis and cancer in 3-D," Cell, vol. 130, pp. 601-610, 2007. (Pubitemid 47268064)
    • (2007) Cell , vol.130 , Issue.4 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 75
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3-D tissue physiology in vitro
    • L. G. Griffith and M. A. Swartz, "Capturing complex 3-D tissue physiology in vitro," Nat. Rev. Mol. Cell Biol., vol. 7, pp. 211-224, 2006.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 76
    • 2542489289 scopus 로고    scopus 로고
    • Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions
    • DOI 10.1002/bit.20086
    • R. Glicklis, J. C. Merchuk, and S. Cohen, "Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocel-lular functions," Biotechnol. Bioeng., vol. 86, pp. 672-680, 2004. (Pubitemid 38685208)
    • (2004) Biotechnology and Bioengineering , vol.86 , Issue.6 , pp. 672-680
    • Glicklis, R.1    Merchuk, J.C.2    Cohen, S.3
  • 77
    • 0018286639 scopus 로고    scopus 로고
    • Oxygen diffusion distance and development of necrosis in multicell spheroids
    • Mar.
    • A. J. Franko and R. M. Sutherland, "Oxygen diffusion distance and development of necrosis in multicell spheroids," Radiation Res., vol. 79, pp. 439-453, Mar. 2012.
    • (2012) Radiation Res. , vol.79 , pp. 439-453
    • Franko, A.J.1    Sutherland, R.M.2
  • 78
    • 0029922596 scopus 로고    scopus 로고
    • Multicellular membranes as an in vitro model for extravascular diffusion in tumours
    • D. S. Cowan, K. O. Hicks, and W. R. Wilson, "Multicellular membranes as an in vitro model for extravascular diffusion in tumours," Brit. J. Cancer. Suppl., vol. 27, pp. S28-31, 1996.
    • (1996) Brit. J. Cancer. Suppl. , vol.27
    • Cowan, D.S.1    Hicks, K.O.2    Wilson, W.R.3
  • 79
    • 78650062139 scopus 로고    scopus 로고
    • A review of three-dimensional in vitro tissue models for drug discovery and transport studies
    • N. T. Elliott and F. Yuan, "A review of three-dimensional in vitro tissue models for drug discovery and transport studies," J. Pharm. Sci., vol. 100, pp. 59-74, 2011.
    • (2011) J. Pharm. Sci. , vol.100 , pp. 59-74
    • Elliott, N.T.1    Yuan, F.2
  • 80
    • 84857165754 scopus 로고    scopus 로고
    • Study of growth kinetics of Pd metal catalyzed silica nanowires for biosensor applications
    • E. Huey, S. K. Arya, S. Krishnan, D. K. Sood, A. Dey, E. Murphy-Perez, and S. Bhansali, "Study of growth kinetics of Pd metal catalyzed silica nanowires for biosensor applications," Procedia Eng., vol. 25, pp. 1577-1580.
    • Procedia Eng. , vol.25 , pp. 1577-1580
    • Huey, E.1    Arya, S.K.2    Krishnan, S.3    Sood, D.K.4    Dey, A.5    Murphy-Perez, E.6    Bhansali, S.7
  • 81
    • 78650599095 scopus 로고    scopus 로고
    • Quantitative impedance analysis of nanowires and cancer cells
    • F. Alexander, Jr, E. Huey, D. T. Price, and S. Bhansali, "Quantitative impedance analysis of nanowires and cancer cells," Procedia Eng., vol. 5, pp. 842-845.
    • Procedia Eng. , vol.5 , pp. 842-845
    • Alexander, F.1    Huey, Jr.E.2    Price, D.T.3    Bhansali, S.4
  • 82
    • 85172049252 scopus 로고    scopus 로고
    • Optimized growth and integration of silica nanowires into interdigitated micro-electrode structures for biosensing
    • E. Huey, S. Krishnan, S. K. Arya, A. Dey, and S. Bhansali, "Optimized growth and integration of silica nanowires into interdigitated micro-electrode structures for biosensing," Sens. Actuators B, Chem.
    • Sens. Actuators B, Chem
    • Huey, E.1    Krishnan, S.2    Arya, S.K.3    Dey, A.4    Bhansali, S.5
  • 83
    • 2242495402 scopus 로고    scopus 로고
    • In vivo imaging of quantum dots encapsulated in phospholipid micelles
    • DOI 10.1126/science.1077194
    • B. Dubertret, P. Skourides, D. J. Norris, V. Noireaux, A. H. Brivanlou, and A. Libchaber, "In vivo imaging of quantum dots encapsulated in phospholipid micelles," Sci., vol. 298, pp. 1759-1762, Nov. 2002. (Pubitemid 35404113)
    • (2002) Science , vol.298 , Issue.5599 , pp. 1759-1762
    • Dubertret, B.1    Skourides, P.2    Norris, D.J.3    Noireaux, V.4    Brivanlou, A.H.5    Libchaber, A.6
  • 86
    • 36849009670 scopus 로고    scopus 로고
    • Experimental anti-tumor therapy in 3-D: Spheroids - Old hat or new challenge?
    • DOI 10.1080/09553000701727531, PII 787786632
    • J. Friedrich, R. Ebner, and L. A. Kunz-Schughart, "Experimental antitumor therapy in 3-D: Spheroids-old hat or new challenge?," Int. J. Radiat. Biol., vol. 83, pp. 849-871, 2007. (Pubitemid 350219104)
    • (2007) International Journal of Radiation Biology , vol.83 , Issue.11-12 , pp. 849-871
    • Friedrich, J.1    Ebner, R.2    Kunz-Schughart, L.A.3
  • 87
    • 33646368912 scopus 로고    scopus 로고
    • Dynamic analysis of hepatoma spheroid formation: Roles of E-cadherin and β1-integrin
    • DOI 10.1007/s00441-005-0148-2
    • R.-Z. Lin, L.-F. Chou, C.-C. Chien, and H.-Y. Chang, "Dynamic analysis of hepatoma spheroid formation: Roles of E-cadherin and-in-tegrin," Cell Tissue Res., vol. 324, pp. 411-422, 2006. (Pubitemid 43673483)
    • (2006) Cell and Tissue Research , vol.324 , Issue.3 , pp. 411-422
    • Lin, R.-Z.1    Chou, L.-F.2    Chien, C.-C.M.3    Chang, H.-Y.4
  • 88
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • R.-Z. Lin and H.-Y. Chang, "Recent advances in three-dimensional multicellular spheroid culture for biomedical research," Biotechnol. J., vol. 3, pp. 1172-1184, 2008.
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.-Z.1    Chang, H.-Y.2
  • 90
    • 0034807979 scopus 로고    scopus 로고
    • Optimized suspension culture: The rotating-wall vessel
    • Jul.
    • T. G. Hammond and J. M. Hammond, "Optimized suspension culture: The rotating-wall vessel," Amer. J. Physiol.-Renal Physiol., vol. 281, pp. F12-F25, Jul. 2001.
    • (2001) Amer. J. Physiol.-Renal Physiol. , vol.281
    • Hammond, T.G.1    Hammond, J.M.2
  • 92
    • 0035118470 scopus 로고    scopus 로고
    • The role of actin filaments and microtubules in hepatocyte spheroid self-assembly
    • DOI 10.1002/1097-0169(200103)48:3<175::AID-CM1007>3.0.CO;2-2
    • E. S. Tzanakakis, L. K. Hansen, and W.-S. Hu, "The role of actin filaments and microtubules in hepatocyte spheroid self-assembly," Cell Motility Cytoskeleton, vol. 48, pp. 175-189, 2001. (Pubitemid 32181928)
    • (2001) Cell Motility and the Cytoskeleton , vol.48 , Issue.3 , pp. 175-189
    • Tzanakakis, E.S.1    Hansen, L.K.2    Hu, W.-S.3
  • 94
    • 0036636095 scopus 로고    scopus 로고
    • Building epithelial architecture: Insights from three-dimensional culture models
    • DOI 10.1038/nrm859
    • L. E. O'Brien, M. M. P. Zegers, and K. E. Mostov, "Building epithelial architecture: Insights from three-dimensional culture models," Nat. Rev. Mol. Cell. Biol., vol. 3, pp. 531-537, 2002. (Pubitemid 34733434)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.7 , pp. 531-537
    • O'Brien, L.E.1    Zegers, M.M.P.2    Mostov, K.E.3
  • 95
    • 35048832907 scopus 로고    scopus 로고
    • Tissue engineering with electric fields: Immobilization of mammalian cells in multilayer aggregates using dielectrophoresis
    • DOI 10.1002/bit.21416
    • A. Sebastian, A.-M. Buckle, and G. H. Markx, "Tissue engineering with electric fields: Immobilization of mammalian cells in multilayer aggregates using dielectrophoresis," Biotechnol. Bioeng., vol. 98, pp. 694-700, 2007. (Pubitemid 47556136)
    • (2007) Biotechnology and Bioengineering , vol.98 , Issue.3 , pp. 694-700
    • Sebastian, A.1    Buckle, A.-M.2    Markx, G.H.3
  • 96
    • 45349084219 scopus 로고    scopus 로고
    • Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates
    • M. D. Ungrin, C. Joshi, A. Nica, C. l. Bauwens, and P. W. Zandstra, "Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates," PLoS ONE, vol. 3, p. e1565, 2008.
    • (2008) PLoS ONE , vol.3
    • Ungrin, M.D.1    Joshi, C.2    Nica, A.3    Bauwens, C.L.4    Zandstra, P.W.5
  • 97
    • 58449109224 scopus 로고    scopus 로고
    • Simple poly(dimethylsiloxane) surface modification to control cell adhesion
    • M.-H. Wu, "Simple poly(dimethylsiloxane) surface modification to control cell adhesion," Surface Interface Anal., vol. 41, pp. 11-16, 2009.
    • (2009) Surface Interface Anal. , vol.41 , pp. 11-16
    • Wu, M.-H.1
  • 98
    • 60549103259 scopus 로고    scopus 로고
    • Spheroid-based drug screen: Considerations and practical approach
    • J. Friedrich, C. Seidel, R. Ebner, and L. A. Kunz-Schughart, "Spheroid-based drug screen: Considerations and practical approach," Nat. Protocols, vol. 4, pp. 309-324, 2009.
    • (2009) Nat. Protocols , vol.4 , pp. 309-324
    • Friedrich, J.1    Seidel, C.2    Ebner, R.3    Kunz-Schughart, L.A.4
  • 99
    • 0025147270 scopus 로고
    • Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro
    • M. Lund-Johansen, R. Bjerkvig, P. A. Humphrey, S. H. Bigner, D. D. Bigner, and O.-D. Laerum, "Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro," Cancer Res., vol. 50, pp. 6039-6044, Sep. 1990. (Pubitemid 20331419)
    • (1990) Cancer Research , vol.50 , Issue.18 , pp. 6039-6044
    • Lund-Johansen, M.1    Bjerkvig, R.2    Humphrey, P.A.3    Bigner, S.H.4    Bigner, D.D.5    Laerum, O.-D.6
  • 101
    • 85172050417 scopus 로고    scopus 로고
    • Drug delivery to the bone-implant interface: Functional hydroxyapatite surfaces and particles Chapter 7: Confocal microscopy for monitoring uptake and distribution of nanoparti-cles in a three-dimensional cell culture model
    • Germany: Univ. Regensburg vol. Doctorate Bavaria
    • A. Schuessele, W. Eder, L. A. Kunz-Schughart, T. Blunk, J. Tessmar, and A. Goepferich, "Drug delivery to the bone-implant interface: Functional hydroxyapatite surfaces and particles Chapter 7: Confocal microscopy for monitoring uptake and distribution of nanoparti-cles in a three-dimensional cell culture model," in Chemistry and Pharmacy. Regensburg, Germany: Univ. Regensburg, 2006, vol. Doctorate Bavaria.
    • (2006) Chemistry and Pharmacy. Regensburg
    • Schuessele, A.1    Eder, W.2    Kunz-Schughart, L.A.3    Blunk, T.4    Tessmar, J.5    Goepferich, A.6
  • 102
    • 0025689830 scopus 로고
    • Proton NMR microscopy of multicellular tumor spheroid morphology
    • Dec.
    • L. O. Sillerud, J. P. Freyer, M. Neeman, and M. A. Mattingly, "Proton NMR microscopy of multicellular tumor spheroid morphology," Magn. Reson. Med., vol. 16, pp. 380-9, Dec. 1990.
    • (1990) Magn. Reson. Med. , vol.16 , pp. 380-389
    • Sillerud, L.O.1    Freyer, J.P.2    Neeman, M.3    Mattingly, M.A.4
  • 103
    • 78149256887 scopus 로고    scopus 로고
    • Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: Monitoring by magnetic resonance imaging and optical imaging
    • Aug
    • K. Kruttwig, C. Brueggemann, E. Kaijzel, S. Vorhagen, T. Hilger, C. Lowik, and M. Hoehn, "Development of a three-dimensional in vitro model for longitudinal observation of cell behavior: Monitoring by magnetic resonance imaging and optical imaging," Mol. Imag. Biol., vol. 12, pp. 367-76, Aug.
    • Mol. Imag. Biol. , vol.12 , pp. 367-376
    • Kruttwig, K.1    Brueggemann, C.2    Kaijzel, E.3    Vorhagen, S.4    Hilger, T.5    Lowik, C.6    Hoehn, M.7
  • 106
    • 33845380520 scopus 로고    scopus 로고
    • Bipolar resistivity profiling of 3D tissue culture
    • DOI 10.1016/j.bios.2006.02.016, PII S0956566306000881
    • P. Linderholm, J. Vannod, Y. Barrandon, and P. Renaud, "Bipolar resistivity profiling of 3-D tissue culture," Biosens. Bioelectron., vol. 22, pp. 789-796, 2007. (Pubitemid 44894856)
    • (2007) Biosensors and Bioelectronics , vol.22 , Issue.6 , pp. 789-796
    • Linderholm, P.1    Vannod, J.2    Barrandon, Y.3    Renaud, P.4
  • 107
    • 79960454962 scopus 로고    scopus 로고
    • A novel organotypic tauopathy model on a new mi-crocavity chip for bioelectronic label-free and real time monitoring
    • D. Krinke, H.-G. Jahnke, T. G. A. Mack, A. Hirche, F. Striggow, and A. A. Robitzki, "A novel organotypic tauopathy model on a new mi-crocavity chip for bioelectronic label-free and real time monitoring," Biosens. Bioelectron., vol. 26, pp. 162-168, 2010.
    • (2010) Biosens. Bioelectron. , vol.26 , pp. 162-168
    • Krinke, D.1    Jahnke, H.-G.2    MacK, T.G.A.3    Hirche, A.4    Striggow, F.5    Robitzki, A.A.6
  • 108
    • 11144317934 scopus 로고    scopus 로고
    • Evaluation of impedance spectroscopy for the characterization of small biological samples in tissue-based test systems
    • Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
    • H. Thielecke, J. Fleckenstein, P. Bartholoma, and C. Rube, "Evaluation of impedance spectroscopy for the characterization of small biological samples in tissue-based test systems," in Proc. 26th Annu. Int. Conf. IEEE Eng. Med. Biol. Conf., 2004, pp. 2070-2073. (Pubitemid 40035824)
    • (2004) Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings , vol.III26 , pp. 2070-2073
    • Thielecke, H.1    Fleckenstein, J.2    Bartholoma, P.3    Rube, C.4
  • 109
    • 0035014916 scopus 로고    scopus 로고
    • A multicellular spheroid-based sensor for anti-cancer therapeutics
    • DOI 10.1016/S0956-5663(01)00140-3, PII S0956566301001403
    • H. Thielecke, A. Mack, and A. Robitzki, "A multicellular spheroid-based sensor for anti-cancer therapeutics," Biosens. Bioelectron., vol. 16, pp. 261-269, 2001. (Pubitemid 32522785)
    • (2001) Biosensors and Bioelectronics , vol.16 , Issue.4-5 , pp. 261-269
    • Thielecke, H.1    Mack, A.2    Robitzki, A.3
  • 110
    • 54949152106 scopus 로고
    • Electrical properties of tissue and cell suspensions
    • H. Schwan, "Electrical properties of tissue and cell suspensions," Adv. Biol. Med. Phys., vol. 5, pp. 147-209, 1957.
    • (1957) Adv. Biol. Med. Phys. , vol.5 , pp. 147-209
    • Schwan, H.1
  • 111
    • 0009613165 scopus 로고
    • Electrical characteristics of tissues
    • H. P. Schwan, "Electrical characteristics of tissues," Biophysik, vol. 1, pp. 198-208, 1963.
    • (1963) Biophysik , vol.1 , pp. 198-208
    • Schwan, H.P.1
  • 113
    • 67650496659 scopus 로고    scopus 로고
    • Three-dimensional micro-electrode array for recording dissociated neuronal cultures
    • K. Musick, D. Khatami, and B. C. Wheeler, "Three-dimensional micro-electrode array for recording dissociated neuronal cultures," Lab on a Chip, vol. 9, pp. 2036-2042, 2009.
    • (2009) Lab on A Chip , vol.9 , pp. 2036-2042
    • Musick, K.1    Khatami, D.2    Wheeler, B.C.3
  • 114
    • 78649748444 scopus 로고    scopus 로고
    • Studies on neuronal differentiation and signalling processes with a novel impedimetric biosensor
    • T. Valero, G. Moschopoulou, S. Kintzios, P. Hauptmann, M. Naumann, and T. Jacobs, "Studies on neuronal differentiation and signalling processes with a novel impedimetric biosensor," Biosens. Bioelectron., vol. 26, pp. 1407-1413, 2010.
    • (2010) Biosens. Bioelectron. , vol.26 , pp. 1407-1413
    • Valero, T.1    Moschopoulou, G.2    Kintzios, S.3    Hauptmann, P.4    Naumann, M.5    Jacobs, T.6
  • 116
    • 0034606915 scopus 로고    scopus 로고
    • Hepatocyte behavior within three-dimensional porous alginate scaffolds
    • DOI 10.1002/(SICI)1097-0290(20000205)67:3<344::AID-BIT11>3.0.CO;2-2
    • R. Glicklis, L. Shapiro, R. Agbaria, J. C. Merchuk, and S. Cohen, "Hep-atocyte behavior within three-dimensional porous alginate scaffolds," Biotechnol. Bioeng., vol. 67, pp. 344-353, 2000. (Pubitemid 30051332)
    • (2000) Biotechnology and Bioengineering , vol.67 , Issue.3 , pp. 344-353
    • Glicklis, R.1    Shapiro, L.2    Agbaria, R.3    Merchuk, J.C.4    Cohen, S.5
  • 117
    • 0016489816 scopus 로고
    • Differentiation of clonal lines of tera-tocarcinoma cells: Formation of embryoid bodies in vitro
    • Apr.
    • G. R. Martin and M. J. Evans, "Differentiation of clonal lines of tera-tocarcinoma cells: Formation of embryoid bodies in vitro," Proc. Nat. Acad. Sciences, vol. 72, pp. 1441-1445, Apr. 1975.
    • (1975) Proc. Nat. Acad. Sciences , vol.72 , pp. 1441-1445
    • Martin, G.R.1    Evans, M.J.2
  • 118
    • 77953757244 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3-D co-culture device
    • T. Liu, B. Lin, and J. Qin, "Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3-D co-culture device," Lab on a Chip, vol. 10, pp. 1671-1677.
    • Lab on A Chip , vol.10 , pp. 1671-1677
    • Liu, T.1    Lin, B.2    Qin, J.3
  • 119
    • 64249112508 scopus 로고    scopus 로고
    • On-line observation of cell growth in a three-dimensional matrix on surface-modified micro-electrode arrays
    • S.-P. Lin, T. R. Kyriakides, and J.-J. J. Chen, "On-line observation of cell growth in a three-dimensional matrix on surface-modified micro-electrode arrays," Biomaterials, vol. 30, pp. 3110-3117, 2009.
    • (2009) Biomaterials , vol.30 , pp. 3110-3117
    • Lin, S.-P.1    Kyriakides, T.R.2    Chen, J.-J.J.3
  • 120
    • 79960133978 scopus 로고    scopus 로고
    • The xCELLigence system for real-time and label-free monitoring of cell viability
    • N. Ke, X. Wang, X. Xu, and Y. A. Abassi, "The xCELLigence system for real-time and label-free monitoring of cell viability," Methods Mol Biol., vol. 740, pp. 33-43, 2011.
    • (2011) Methods Mol Biol. , vol.740 , pp. 33-43
    • Ke, N.1    Wang, X.2    Xu, X.3    Abassi, Y.A.4
  • 121
    • 1542268994 scopus 로고    scopus 로고
    • Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro
    • DOI 10.1016/j.cardiores.2003.12.022, PII S0008636303007909
    • B. C. Heng, H. K. Haider, E. K.-W. Sim, T. Cao, and S. C. Ng, "Strategies for directing the differentiation of stem cells into the cardiomyo-genic lineage in vitro," Cardiovascular Res., vol. 62, pp. 34-42, Apr. 2004. (Pubitemid 38326809)
    • (2004) Cardiovascular Research , vol.62 , Issue.1 , pp. 34-42
    • Heng, B.C.1    Haider, H.Kh.2    Sim, E.K.-W.3    Cao, T.4    Ng, S.C.5
  • 122
    • 77954707949 scopus 로고    scopus 로고
    • Alternating current electric field effects on neural stem cell viability and differentiation
    • M. A. Matos and M. T. Cicerone, "Alternating current electric field effects on neural stem cell viability and differentiation," Biotechnol. Prog., vol. 26, pp. 664-670, 2010.
    • (2010) Biotechnol. Prog. , vol.26 , pp. 664-670
    • Matos, M.A.1    Cicerone, M.T.2
  • 123
    • 0033573265 scopus 로고    scopus 로고
    • Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells
    • DOI 10.1002/(SICI)1097-4644(19991215)75:4<710::AID-JCB16>3.0.CO;2-Z
    • H. Sauer, G. Rahimi, J. Hescheler, and M. Wartenberg, "Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells," J. Cellular Biochem., vol. 75, pp. 710-723, 1999. (Pubitemid 29529925)
    • (1999) Journal of Cellular Biochemistry , vol.75 , Issue.4 , pp. 710-723
    • Sauer, H.1    Rahimi, G.2    Hescheler, J.3    Wartenberg, M.4
  • 124
    • 70449528393 scopus 로고    scopus 로고
    • Electrical stimulation of human embryonic stem cells: Cardiac differentiation and the generation of reactive oxygen species
    • E. Serena, E. Figallo, N. Tandon, C. Cannizzaro, S. Gerecht, N. Elvas-sore, and G. Vunjak-Novakovic, "Electrical stimulation of human embryonic stem cells: Cardiac differentiation and the generation of reactive oxygen species," Exper. Cell Res., vol. 315, pp. 3611-3619, 2009.
    • (2009) Exper. Cell Res. , vol.315 , pp. 3611-3619
    • Serena, E.1    Figallo, E.2    Tandon, N.3    Cannizzaro, C.4    Gerecht, S.5    Elvas-Sore, N.6    Vunjak-Novakovic, G.7
  • 127
    • 2942553906 scopus 로고    scopus 로고
    • Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells
    • C. Y. C. Huang, K. L. Hagar, L. E. Frost, Y. Sun, and H. S. Cheung, "Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells," STEM CELLS, vol. 22, pp. 313-323, 2004. (Pubitemid 38736615)
    • (2004) Stem Cells , vol.22 , Issue.3 , pp. 313-323
    • Huang, C.-Y.C.1    Hagar, K.L.2    Frost, L.E.3    Sun, Y.4    Cheung, H.S.5
  • 131
    • 79955786504 scopus 로고    scopus 로고
    • Spheroid confrontation assay: A simple method to monitor the three-dimensional migration of different cell types in vitro
    • May
    • K. Hattermann, J. Held-Feindt, and R. Mentlein, "Spheroid confrontation assay: A simple method to monitor the three-dimensional migration of different cell types in vitro," Ann Anat., vol. 193, pp. 181-4, May 2011.
    • (2011) Ann Anat. , vol.193 , pp. 181-184
    • Hattermann, K.1    Held-Feindt, J.2    Mentlein, R.3
  • 132
    • 60549103259 scopus 로고    scopus 로고
    • Spheroid-based drug screen: Considerations and practical approach
    • J. Friedrich, C. Seidel, R. Ebner, and L. A. Kunz-Schughart, "Spheroid-based drug screen: Considerations and practical approach," Nat. Protoc., vol. 4, pp. 309-24, 2009.
    • (2009) Nat. Protoc. , vol.4 , pp. 309-324
    • Friedrich, J.1    Seidel, C.2    Ebner, R.3    Kunz-Schughart, L.A.4
  • 133
    • 84991885325 scopus 로고    scopus 로고
    • Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells
    • G. Cheng, J. Tse, R. K. Jain, and L. L. Munn, "Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells," PLoS ONE, vol. 4, p. e4632, 2009.
    • (2009) PLoS ONE , vol.4
    • Cheng, G.1    Tse, J.2    Jain, R.K.3    Munn, L.L.4
  • 134
    • 0031883357 scopus 로고    scopus 로고
    • Four-dimensional analysis of human brain tumor spheroid invasion into fetal rat brain aggregates using confocal scanning laser microscopy
    • DOI 10.1023/A:1005758626348
    • S. Khoshyomn, P. L. Penar, W. J. McBride, and D. J. Taatjes, "Four-dimensional analysis of human brain tumor spheroid invasion into fetal rat brain aggregates using confocal scanning laser microscopy," J. Neuro-Oncology, vol. 38, pp. 1-10, 1998. (Pubitemid 28107887)
    • (1998) Journal of Neuro-Oncology , vol.38 , Issue.1 , pp. 1-10
    • Khoshyomn, S.1    Penar, P.L.2    McBride, W.J.3    Taatjes, D.J.4
  • 135
    • 34848863744 scopus 로고    scopus 로고
    • Effect of electrode geometry on the impedance evaluation of tissue and cell culture
    • DOI 10.1016/j.snb.2007.07.038, PII S0925400507004625, Eurosensors XX The 20th European Conference on Solid-State Transducers
    • A. R. Abdur Rahman, D. T. Price, and S. Bhansali, "Effect of electrode geometry on the impedance evaluation of tissue and cell culture," Sens. Actuators B, Chem., vol. 127, pp. 89-96, 2007. (Pubitemid 47503708)
    • (2007) Sensors and Actuators, B: Chemical , vol.127 , Issue.1 , pp. 89-96
    • Abdur Rahman, A.R.1    Price, D.T.2    Bhansali, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.