Adherent monomer-misfolded SOD1

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Watanabe, Yasuhiro ^a   Morita, Eri ^a   Fukada, Yasuyo ^a   Doi, Koji ^a   Yasui, Kenichi ^a   Kitayama, Michio ^a   Nakano, Toshiya ^a   Nakashima, Kenji ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ENOLASE; ALPHA TUBULIN; BETA ACTIN; BETA TUBULIN; CLATHRIN HEAVY CHAIN; COFILIN 1; COPPER ZINC SUPEROXIDE DISMUTASE; GENE PRODUCT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; MICROTUBULE ASSOCIATED PROTEIN 2; MYELIN BASIC PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SYNTAXIN; MUTANT PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; FAMILIAL DISEASE; GENE MUTATION; GLYCOGENOLYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MOUSE; MUTANT; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; TRANSGENE; WILD TYPE; ANIMAL; C57BL MOUSE; CEREBELLUM; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; METABOLISM; PATHOLOGY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; SPINAL CORD; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CEREBELLUM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOMICS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 55849103203     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003497     Document Type: Article

References (28)

1. Cleveland DW, Rothstein JD (2001) From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2: 806-819.
2. Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 7: 710-723.
3. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362: 59-62.
4. Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, et al. (2006) Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312: 1389-1392.
5. Takahashi K, Nakamura H, Okada E (1972) Hereditary amyotrophic lateral sclerosis. Histochemical and electron microscopic study of hyaline inclusions in motor neurons. Arch Neurol 27: 292-299.
6. Nakashima K, Watanabe Y, Kuno N, Nanba E, Takahashi K (1995) Abnormality of Cu/Zn superoxide dismutase (SOD1) activity in Japanese familial amyotrophic lateral sclerosis with two base pair deletion in the SOD1 gene. Neurology 45: 1019-1020.
7. Watanabe Y, Kato S, Adachi Y, Nakashima K (2000) Frameshift, nonsense and non amino acid altering mutations in SOD1 in familial ALS: report of a Japanese pedigree and literature review. Amyotroph Lateral Scler Other Motor Neuron Disord 1: 251-258.
8. Watanabe Y, Kono Y, Nanba E, Ohama E, Nakashima K (1997) Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis. FEBS Lett 400: 108-112.
9. Watanabe Y, Kuno N, Kono Y, Nanba E, Ohama E, et al. (1997) Absence of the mutant SOD1 in familial amyotrophic lateral sclerosis (FALS) with two base pair deletion in the SOD1 gene. Acta Neurol Scand 95: 167-172.
10. Watanabe Y, Yasui K, Nakano T, Doi K, Fukada Y, et al. (2005) Mouse motor neuron disease caused by truncated SOD1 with or without C-terminal modification. Brain Res Mol Brain Res 135: 12-20.
11. Rakhit R, Crow JP, Lepock JR, Kondejewski LH, Cashman NR, et al. (2004) Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. J Biol Chem 279: 15499-15504.
12. Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, et al. (2007) An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat Med 13: 754-759.
13. Ross CA, Poirier MA (2004) Protein aggregation and neurodegenerative disease. Nat Med 10: S10-17.
14. Palmieri F (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 447: 689-709.
15. Daugaard M, Rohde M, Jaattela M (2007) The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Lett 581: 3702-3710.
16. Martin LJ, Liu Z, Chen K, Price AC, Pan Y, et al. (2007) Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol 500: 20-46.
17. Ellis DZ, Rabe J, Sweadner KJ (2003) Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 23: 43-51.
18. Ames Ar (2000) CNS energy metabolism as related to function. Brain Res Brain Res Rev 34: 42-68.
19. Aperia A (2007) New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target. J Intern Med 261: 44-52.
20. Golden WC, Brambrink AM, Traystman RJ, Shaffner DH, Martin LJ (2003) Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets. Neurochem Res 28: 1883-1889.
21. Browne SE, Yang L, DiMauro JP, Fuller SW, Licata SC, et al. (2006) Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis 22: 599-610.
22. Albin RL, Greenamyre JT (1992) Alternative excitotoxic hypotheses. Neurology 42: 733-738.
23. Mattiazzi M, D'Aurelio M, Gajewski CD, Martushova K, Kiaei M, et al. (2002) Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem 277: 29626-29633.
24. Okado-Matsumoto A, Fridovich I (2002) Amyotrophic lateral sclerosis: a proposed mechanism. Proc Natl Acad Sci U S A 99: 9010-9014.
25. Massignan T, Casoni F, Basso M, Stefanazzi P, Biasini E, et al. (2007) Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse. Biochem Biophys Res Commun 353: 719-725.
26. Lukas TJ, Luo WW, Mao H, Cole N, Siddique T (2006) Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis. Mol Cell Proteomics 5: 1233-1244.
27. Casoni F, Basso M, Massignan T, Gianazza E, Cheroni C, et al. (2005) Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis. J Biol Chem 280: 16295-16304.
28. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, et al. (2005) A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol 58: 277-289.