Effect of antioxidants on the stability of ONO-1301, a novel long-acting prostacyclin agonist, loaded in PLGA microspheres

Journal of Microencapsulation

Volumn 30, Issue 3, 2013, Pages 245-256

  Uchida, Takahiro ^a   Hazekawa, Mai ^a   Morisaki, Tomomi ^a   Yoshida, Miyako ^a   Sakai, Yoshiki ^b  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Microspheres; Oxidation; PLGA; Stabilisation; Stability

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; ALPHA TOCOPHEROL; BUTYLCRESOL; MICROSPHERE; POLYGLACTIN;

ACIDITY; ANGIOGENESIS; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PHYSICAL CHEMISTRY; RAT; ROOM TEMPERATURE;

ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, LIQUID; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; PROSTAGLANDINS I; PYRIDINES;

EID: 84875831045     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2012.720721     Document Type: Article

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