The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia

Journal of Microencapsulation

Volumn 29, Issue 3, 2012, Pages 211-218

  Hazekawa, Mai ^a   Sakai, Yoshiki ^b   Yoshida, Miyako ^a   Haraguchi, Tamami ^a   Uchida, Takahiro ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

CA1; Hippocampus; Neuroprotect; Particle size; Passive avoidance; Slow release

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; MICROSPHERE; POLYGLACTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PASSIVE AVOIDANCE; RAT; SINGLE DRUG DOSE; STEADY STATE; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION;

ANIMALS; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; EPOPROSTENOL; HIPPOCAMPUS; LACTIC ACID; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; PYRIDINES; RATS; RATS, WISTAR; TIME FACTORS; TREATMENT OUTCOME;

EID: 84859599445     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652048.2011.622054     Document Type: Article

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