Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 1, 2006, Pages

  Murakami, Shinsuke ^a,b   Nagaya, Noritoshi ^a   Itoh, Takefumi ^b   Kataoka, Masaharu ^a   Iwase, Takashi ^a   Horio, Takeshi ^a   Miyahara, Yoshinori ^a   Sakai, Yoshiki ^c   Kangawa, Kenji ^a   Kimura, Hiroshi ^b  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Fibroblast; Neutrophil; Survival

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; BLEOMYCIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HYDROXYPROLINE; PROSTACYCLIN; THROMBOXANE SYNTHASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; PYRIDINE DERIVATIVE; THROMBOXANE A2; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; LUNG; METABOLISM; PATHOLOGY; PNEUMONIA; SURVIVAL;

ANIMALS; BLEOMYCIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; EPOPROSTENOL; FEMALE; INTERCELLULAR ADHESION MOLECULE-1; LUNG; MICE; MICE, INBRED C57BL; PNEUMONIA; PULMONARY FIBROSIS; PYRIDINES; SURVIVAL ANALYSIS; THROMBOXANE A2; THROMBOXANE-A SYNTHASE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33644750037     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00042.2005     Document Type: Article

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