Vitamin B12 in neurology and ageing; Clinical and genetic aspects

Biochimie

Volumn 95, Issue 5, 2013, Pages 1066-1076

  McCaddon, Andrew ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Ageing; Genetics; Homocysteine; Methylmalonic acid; Neurology; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID; TRANSCOBALAMIN;

AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANEMIA; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DEGENERATIVE DISEASE; DEMENTIA; DIAGNOSTIC TEST; EPILEPSY; GENETICS; HUMAN; MULTIINFARCT DEMENTIA; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROLOGY; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; REVIEW; VITAMIN METABOLISM; BLOOD; METABOLISM;

AGING; HUMANS; METHYLMALONIC ACID; NEUROLOGY; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84875830259     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.11.017     Document Type: Review

References (151)

1. D.L. Evans, G.A. Edelsohn, and R.N. Golden Organic psychosis without anemia or spinal cord symptoms in patients with vitamin B12 deficiency Am. J. Psychiatry 140 1983 218 221
2. E.B. Healton, D.G. Savage, J.C. Brust, T.J. Garrett, and J. Lindenbaum Neurologic aspects of cobalamin deficiency Medicine (Baltimore) 70 1991 229 245
3. M. Hector, and J.R. Burton What are the psychiatric manifestations of vitamin B12 deficiency? J. Am. Geriatr. Soc. 36 1988 1105 1112
4. D.G. Savage, and J. Lindenbaum Neurological complications of acquired cobalamin deficiency: clinical aspects Baillieres Clin. Haematol. 8 1995 657 678
5. J.D. Russell, F.E. Batten, and J. Collier Subacute combined degeneration of the cord Brain 23 1900 39 62
6. D.G. Weir, and J.M. Scott Brain function in the elderly: role of vitamin B12 and folate Br. Med. Bull. 55 1999 669 682
7. R.D. Adams, and C.S. Kubik Subacute degeneration of the brain in pernicious anaemia N. Engl. J. Med. 231 1944 1 9
8. A. Ferraro, S. Arieti, and W.H. English Cerebral changes in the course of pernicious anaemia and their relationship to psychiatric symptoms J. Neuropathol. Exp. Neurol. 1945 217 239
9. W.S. Beck Cobalamin and the nervous system N. Engl. J. Med. 318 1988 1752 1754
10. R. Carmel Pernicious anemia. The expected findings of very low serum cobalamin levels, anemia, and macrocytosis are often lacking Arch. Intern. Med. 148 1988 1712 1714
11. R. Carmel Subtle and atypical cobalamin deficiency states Am. J. Hematol. 34 1990 108 114
12. R. Carmel Current concepts in cobalamin deficiency Annu. Rev. Med. 51 2000 357 375
13. V. Herbert The 1986 Herman award lecture. Nutrition science as a continually unfolding story: the folate and vitamin B-12 paradigm Am. J. Clin. Nutr. 46 1987 387 402
14. B. Regland, L. Abrahamsson, C.G. Gottfries, and E. Magnus Vitamin B12 analogues, homocysteine, methylmalonic acid, and transcobalamins in the study of vitamin B12 deficiency in primary degenerative dementia Dementia 1 1990 272 277
15. J.W. Miller, M.G. Garrod, A.L. Rockwood, M.M. Kushnir, L.H. Allen, M.N. Haan, and R. Green Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency Clin. Chem. 52 2006 278 285
16. A.M. Hvas, and E. Nexo Holotranscobalamin-a first choice assay for diagnosing early vitamin B deficiency? J. Intern. Med. 257 2005 289 298
17. K. Nilsson, L. Gustafson, R. Faldt, A. Anderson, I. Vaara, R. Nilsson, B. Alm, and B. Hultberg Plasma methylmalonic acid in relation to serum cobalamin and plasma homocysteine in a psychogeriatric population and the effect of cobalamin treatment Int. J. Geriatr. Psychiatry 12 1997 67 72
18. A. Vogiatzoglou, A. Oulhaj, A.D. Smith, E. Nurk, C.A. Drevon, P.M. Ueland, S.E. Vollset, G.S. Tell, and H. Refsum Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status Clin. Chem. 55 2009 2198 2206
19. S.A. David, and H. Refsum Do we need to reconsider the desirable blood level of vitamin B12? J. Intern. Med. 271 2012 179 182
20. S.N. Fedosov Metabolic signs of vitamin B(12) deficiency in humans: computational model and its implications for diagnostics Metabolism 59 2010 1124 1138
21. D.L. Lildballe, S. Fedosov, P. Sherliker, H. Hin, R. Clarke, and E. Nexo Association of cognitive impairment with combinations of vitamin B(1)(2)-related parameters Clin. Chem. 57 2011 1436 1443
22. L.C. Pennypacker, R.H. Allen, J.P. Kelly, L.M. Matthews, J. Grigsby, K. Kaye, J. Lindenbaum, and S.P. Stabler High prevalence of cobalamin deficiency in elderly outpatients J. Am. Geriatr. Soc. 40 1992 1197 1204
23. W.G. Thompson, and M.L. Freedman Vitamin B12 and geriatrics: unanswered questions Acta Haematol. 82 1989 169 174
24. Y. Yao, S.L. Yao, S.S. Yao, G. Yao, and W. Lou Prevalence of vitamin B12 deficiency among geriatric outpatients J. Fam. Pract. 35 1992 524 528
25. H.W. Baik, and R.M. Russell Vitamin B12 deficiency in the elderly Annu. Rev. Nutr. 19 1999 357 377
26. H. Nilsson-Ehle, R. Jagenburg, S. Landahl, S. Lindstedt, A. Svanborg, and J. Westin Serum cobalamins in the elderly: a longitudinal study of a representative population sample from age 70 to 81 Eur. J. Haematol. 47 1991 10 16
27. J. Lindenbaum, I.H. Rosenberg, P.W. Wilson, S.P. Stabler, and R.H. Allen Prevalence of cobalamin deficiency in the Framingham elderly population Am. J. Clin. Nutr. 60 1994 2 11
28. R.H. Allen, J. Lindenbaum, and S.P. Stabler High prevalence of cobalamin deficiency in the elderly Trans. Am. Clin. Climatol. Assoc. 107 1995 37 45
29. K. Bjorkegren, and K. Svardsudd Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes-a population-based study J. Intern. Med. 249 2001 423 432
30. R. Clarke, J. Grimley Evans, J. Schneede, E. Nexo, C. Bates, A. Fletcher, A. Prentice, C. Johnston, P.M. Ueland, H. Refsum, P. Sherliker, J. Birks, G. Whitlock, E. Breeze, and J.M. Scott Vitamin B12 and folate deficiency in later life Age Ageing 33 2004 34 41
31. C.J. Bates, J. Schneede, G. Mishra, A. Prentice, and M.A. Mansoor Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over Eur. J. Clin. Nutr. 57 2003 349 357
32. C. McCracken, P. Hudson, R. Ellis, and A. McCaddon Methylmalonic acid and cognitive function in the medical research council cognitive function and ageing study Am. J. Clin. Nutr. 84 2006 1406 1411
33. C.C. Tangney, Y. Tang, D.A. Evans, and M.C. Morris Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline Neurology 72 2009 361 367
34. L. Elsborg, V. Lund, and P. Bastrup-Madsen Serum vitamin B12 levels in the aged Acta Med. Scand. 200 1976 309 314
35. J.M. Howard, C. Azen, D.W. Jacobsen, R. Green, and R. Carmel Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels Eur. J. Clin. Nutr. 52 1998 582 587
36. K.L. Tucker, S. Rich, I. Rosenberg, P. Jacques, G. Dallal, P.W. Wilson, and J. Selhub Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study Am. J. Clin. Nutr. 71 2000 514 522
37. H. Nilsson-Ehle Age-related changes in cobalamin (vitamin B12) handling. Implications for therapy Drugs Aging 12 1998 277 292
38. S.D. Krasinski, R.M. Russell, I.M. Samloff, R.A. Jacob, G.E. Dallal, R.B. McGandy, and S.C. Hartz Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators J. Am. Geriatr. Soc. 34 1986 800 806
39. A.W. McEvoy, J.D. Fenwick, K. Boddy, and O.F. James Vitamin B12 absorption from the gut does not decline with age in normal elderly humans Age Ageing 11 1982 180 183
40. J.D. Scarlett, H. Read, and K. O'Dea Protein-bound cobalamin absorption declines in the elderly Am. J. Hematol. 39 1992 79 83
41. E. Joosten, W. Pelemans, P. Devos, E. Lesaffre, W. Goossens, A. Criel, and R. Verhaeghe Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin Eur. J. Haematol. 51 1993 25 30
42. D.Z. van Asselt, W.J. van den Broek, C.B. Lamers, F.H. Corstens, and W.H. Hoefnagels Free and protein-bound cobalamin absorption in healthy middle-aged and older subjects J. Am. Geriatr. Soc. 44 1996 949 953
43. D.Z. van Asselt, L.C. De Groot, W.A. van Staveren, H.J. Blom, R.A. Wevers, I. Biemond, and W.H. Hoefnagels Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects Am. J. Clin. Nutr. 68 1998 328 334
44. M. Wolters, A. Strohle, and A. Hahn Cobalamin: a critical vitamin in the elderly Prev. Med. 39 2004 1256 1266
45. E. Andres, E. Noel, and B. Goichot Metformin-associated vitamin B12 deficiency Arch. Intern. Med. 162 2002 2251 2252
46. D.L. Marcus, N. Shadick, J. Crantz, M. Gray, F. Hernandez, and M.L. Freedman Low serum B12 levels in a hematologically normal elderly subpopulation J. Am. Geriatr. Soc. 35 1987 635 638
47. J. Metz, A.H. Bell, L. Flicker, T. Bottiglieri, J. Ibrahim, E. Seal, D. Schultz, H. Savoia, and K.M. McGrath The significance of subnormal serum vitamin B12 concentration in older people: a case control study J. Am. Geriatr. Soc. 44 1996 1355 1361
48. P. Gimsing, and E. Nexo Cobalamin-binding capacity of haptocorrin and transcobalamin: age-correlated reference intervals and values from patients Clin. Chem. 35 1989 1447 1451
49. T. Addison Anemia: disease of the suprarenal capsules Lond Med. Gaz. 43 1849 517
50. J. Holmes Cerebral manifestations of vitamin B12 deficiency BMJ 2 1956 1394
51. H. Droller, and J. Dossett Vitamin B12 levels in senile dementia and confusional states Geriatrics 1959 367 373
52. E.J. Byrne Reversible dementia Int. J. Geriatr. Psychiatry 2 1987 73 81
53. M. Inada, M. Toyoshima, and M. Kameyama Cobalamin contents of the brains in some clinical and pathologic states Int. J. Vitam. Nutr. Res. 52 1982 423 429
54. J. Lindenbaum, E.B. Healton, D.G. Savage, J.C. Brust, T.J. Garrett, E.R. Podell, P.D. Marcell, S.P. Stabler, and R.H. Allen Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis N. Engl. J. Med. 318 1988 1720 1728
55. I.R. Bell, J.S. Edman, D.W. Marby, A. Satlin, T. Dreier, B. Liptzin, and J.O. Cole Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population Biol. Psychiatry 27 1990 125 137
56. H.F.K. Chiu Vitamin B12 deficiency and dementia Int. J. Geriatr. Psychiatry 11 1996 851 858
57. D.C. Martin, J. Francis, J. Protetch, and F.J. Huff Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study J. Am. Geriatr. Soc. 40 1992 168 172
58. R. Carmel, P.S. Gott, C.H. Waters, K. Cairo, R. Green, W. Bondareff, C.M. DeGiorgio, J.L. Cummings, D.W. Jacobsen, and G. Buckwalter The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities Eur. J. Haematol. 54 1995 245 253
59. S. Teunisse, A.E. Bollen, W.A. van Gool, and G.J. Walstra Dementia and subnormal levels of vitamin B12: effects of replacement therapy on dementia J. Neurol. 243 1996 522 529
60. R. Eastley, G.K. Wilcock, and R.S. Bucks Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function Int. J. Geriatr. Psychiatry 15 2000 226 233
61. A.J. Larner, and J.S. Rakshi Vitamin B12 deficiency and dementia Eur. J. Neurol. 8 2001 730 731
62. C.J.M. Van Tiggelen Alzheimer's disease/alcohol dementia: association with zinc deficiency and cerebral vitamin B12 deficiency J. Orthomole. Psychiatry 13 1983 97 104
63. M.G. Cole, and J.F. Prchal Low serum vitamin B12 in Alzheimer-type dementia Age Ageing 13 1984 101 105
64. D.S. Karnaze, and R. Carmel Low serum cobalamin levels in primary degenerative dementia. Do some patients harbor atypical cobalamin deficiency states? Arch. Intern. Med. 147 1987 429 431
65. B. Regland, C.G. Gottfries, L. Oreland, and L. Svennerholm Low B12 levels related to high activity of platelet MAO in patients with dementia disorders. A retrospective study Acta Psychiatr. Scand. 78 1988 451 457
66. M.J. Renvall, A.A. Spindler, J.W. Ramsdell, and M. Paskvan Nutritional status of free-living Alzheimer's patients Am. J. Med. Sci. 298 1989 20 27
67. T. Ikeda, Y. Furukawa, S. Mashimoto, K. Takahashi, and M. Yamada Vitamin B12 levels in serum and cerebrospinal fluid of people with Alzheimer's disease Acta Psychiatr. Scand. 82 1990 327 329
68. T.Q. Nijst, R.A. Wevers, H.C. Schoonderwaldt, O.R. Hommes, and A.F. de Haan Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia J. Neurol. Neurosurg. Psychiatry 53 1990 951 954
69. T. Bottiglieri, P. Godfrey, T. Flynn, M.W. Carney, B.K. Toone, and E.H. Reynolds Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine J. Neurol. Neurosurg. Psychiatry 53 1990 1096 1098
70. K. Eto, T. Asada, K. Arima, T. Makifuchi, and H. Kimura Brain hydrogen sulfide is severely decreased in Alzheimer's disease Biochem. Biophys. Res. Commun. 293 2002 1485 1488
71. S.P. Stabler, J. Lindenbaum, and R.H. Allen Vitamin B-12 deficiency in the elderly: current dilemmas Am. J. Clin. Nutr. 66 1997 741 749
72. A. McCaddon, and C.L. Kelly Familial Alzheimer's disease and vitamin B12 deficiency Age Ageing 23 1994 334 337
73. A. McCaddon, and C.L. Kelly Alzheimer's disease: a 'cobalaminergic' hypothesis Med. Hypotheses 37 1992 161 165
74. B. Regland, and C.G. Gottfries Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in Down's syndrome, AIDS and Alzheimer's disease? Med. Hypotheses 38 1992 11 19
75. I.H. Rosenberg, and J. Miller Nutritional factors in physical and cognitive functions of elderly people Am. J. Clin. Nutr. 55 1992 1237s 1243s
76. E. Joosten, E. Lesaffre, R. Riezler, V. Ghekiere, L. Dereymaeker, W. Pelemans, and E. Dejaeger Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J. Gerontol. A Biol. Sci. Med. Sci. 52 1997 M76 M79
77. A. McCaddon, G. Davies, P. Hudson, S. Tandy, and H. Cattell Total serum homocysteine in senile dementia of Alzheimer type Int. J. Geriatr. Psychiatry 13 1998 235 239
78. R. Clarke, A.D. Smith, K.A. Jobst, H. Refsum, L. Sutton, and P.M. Ueland Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease Arch. Neurol. 55 1998 1449 1455
79. M. Lehmann, C.G. Gottfries, and B. Regland Identification of cognitive impairment in the elderly: homocysteine is an early marker Dement. Geriatr. Cogn. Disord. 10 1999 12 20
80. F. Leblhuber, J. Walli, E. Artner-Dworzak, K. Vrecko, B. Widner, G. Reibnegger, and D. Fuchs Hyperhomocysteinemia in dementia J. Neural Transm. 107 2000 1469 1474
81. M. Budge, C. Johnston, E. Hogervorst, C. de Jager, E. Milwain, S.D. Iversen, L. Barnetson, E. King, and A.D. Smith Plasma total homocysteine and cognitive performance in a volunteer elderly population Ann. N. Y. Acad. Sci. 903 2000 407 410
82. N.D. Prins, T. Den Heijer, A. Hofman, P.J. Koudstaal, J. Jolles, R. Clarke, and M.M. Breteler Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study Neurology 59 2002 1375 1380
83. E. Hogervorst, H.M. Ribeiro, A. Molyneux, M. Budge, and A.D. Smith Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease Arch. Neurol. 59 2002 787 793
84. P.S. Sachdev Homocysteine and brain atrophy Prog. Neuropsychopharmacol. Biol. Psychiatry 2005
85. T. Den Heijer, S.E. Vermeer, R. Clarke, M. Oudkerk, P.J. Koudstaal, A. Hofman, and M.M. Breteler Homocysteine and brain atrophy on MRI of non-demented elderly Brain 126 2003 170 175
86. A. McCaddon, P. Hudson, G. Davies, A. Hughes, J.H. Williams, and C. Wilkinson Homocysteine and cognitive decline in healthy elderly Dement. Geriatr. Cogn. Disord. 12 2001 309 313
87. A. Oulhaj, H. Refsum, H. Beaumont, J. Williams, E. King, R. Jacoby, and A.D. Smith Homocysteine as a predictor of cognitive decline in Alzheimer's disease Int. J. Geriatr. Psychiatry 25 2010 82 90
88. S. Seshadri, A. Beiser, J. Selhub, P.F. Jacques, I.H. Rosenberg, R.B. D'Agostino, P.W. Wilson, and P.A. Wolf Plasma homocysteine as a risk factor for dementia and Alzheimer's disease N. Engl. J. Med. 346 2002 476 483
89. G. Ravaglia, P. Forti, F. Maioli, M. Martelli, L. Servadei, N. Brunetti, E. Porcellini, and F. Licastro Homocysteine and folate as risk factors for dementia and Alzheimer disease Am. J. Clin. Nutr. 82 2005 636 643
90. D.E. Zylberstein, L. Lissner, C. Bjorkelund, K. Mehlig, D.S. Thelle, D. Gustafson, S. Ostling, M. Waern, X. Guo, and I. Skoog Midlife homocysteine and late-life dementia in women. A prospective population study Neurobiol. Aging 32 2011 380 386
91. A.D. Smith The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr. Bull. 29 2008 S143 S172
92. O. Stanger, B. Fowler, K. Piertzik, M. Huemer, E. Haschke-Becher, A. Semmler, S. Lorenzl, and M. Linnebank Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations Expert. Rev. Neurother. 9 2009 1393 1412
93. J. Selhub, A. Troen, and I.H. Rosenberg B vitamins and the aging brain Nutr. Rev. 68 Suppl. 2 2010 S112 S118
94. C.S. Johnston, and J.A. Thomas Holotranscobalamin II levels in plasma are related to dementia in older people J. Am. Geriatr. Soc. 45 1997 779 780
95. H. Refsum, and A.D. Smith Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin J. Neurol. Neurosurg. Psychiatry 74 2003 959 961
96. B. Hooshmand, A. Solomon, I. Kareholt, J. Leiviska, M. Rusanen, S. Ahtiluoto, B. Winblad, T. Laatikainen, H. Soininen, and M. Kivipelto Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study Neurology 75 2010 1408 1414
97. B. Hooshmand, A. Solomon, I. Kareholt, M. Rusanen, T. Hanninen, J. Leiviska, B. Winblad, T. Laatikainen, H. Soininen, and M. Kivipelto Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study J. Intern. Med. 271 2012 204 212
98. H. Kubova, J. Folbergrova, and P. Mares Seizures induced by homocysteine in rats during ontogenesis Epilepsia 36 1995 750 756
99. M. Schwaninger, P. Ringleb, R. Winter, B. Kohl, W. Fiehn, P.A. Rieser, and I. Walter-Sack Elevated plasma concentrations of homocysteine in antiepileptic drug treatment Epilepsia 40 1999 345 350
100. P. Allain, A. Le Bouil, E. Cordillet, L. Le Quay, H. Bagheri, and J.L. Montastruc Sulfate and cysteine levels in the plasma of patients with Parkinson's disease Neurotoxicology 16 1995 527 529
101. W. Kuhn, R. Roebroek, H. Blom, D. van Oppenraaij, H. Przuntek, A. Kretschmer, T. Buttner, D. Woitalla, and T. Muller Elevated plasma levels of homocysteine in Parkinson's disease Eur. Neurol. 40 1998 225 227
102. C. Toth, K. Breithaupt, S. Ge, Y. Duan, J.M. Terris, A. Thiessen, S. Wiebe, D.W. Zochodne, and O. Suchowersky Levodopa, methylmalonic acid, and neuropathy in idiopathic Parkinson disease Ann. Neurol. 68 2010 28 36
103. J. Levin, K. Botzel, A. Giese, M. Vogeser, and S. Lorenzl Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis Dement. Geriatr. Cogn. Disord. 29 2010 553 559
104. T. Muller, B. Werne, B. Fowler, and W. Kuhn Nigral endothelial dysfunction, homocysteine, and Parkinson's disease Lancet 354 1999 126 127
105. T. Muller, D. Woitalla, B. Hauptmann, B. Fowler, and W. Kuhn Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease Neurosci. Lett. 308 2001 54 56
106. F. Blandini, R. Fancellu, E. Martignoni, A. Mangiagalli, C. Pacchetti, A. Samuele, and G. Nappi Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease Clin. Chem. 47 2001 1102 1104
107. J.W. Miller, J. Selhub, M.R. Nadeau, C.A. Thomas, R.G. Feldman, and P.A. Wolf Effect of l-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status Neurology 60 2003 1125 1129
108. P.E. O'Suilleabhain, V. Sung, C. Hernandez, L. Lacritz, R.B. Dewey Jr., T. Bottiglieri, and R. Diaz-Arrastia Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations Arch. Neurol. 61 2004 865 868
109. P. Lamberti, S. Zoccolella, E. Armenise, S.V. Lamberti, A. Fraddosio, M. de Mari, G. Iliceto, and P. Livrea Hyperhomocysteinemia in l-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration Eur. J. Neurol. 12 2005 365 368
110. S. Zoccolella, S.V. Lamberti, G. Iliceto, A. Santamato, P. Lamberti, and G. Logroscino Hyperhomocysteinemia in l-dopa treated patients with Parkinson's disease: potential implications in cognitive dysfunction and dementia? Curr. Med. Chem. 17 2010 3253 3261
111. E.H. Reynolds Multiple sclerosis and vitamin B12 metabolism J. Neuroimmunol. 40 1992 225 230
112. E.H. Reynolds, T. Bottiglieri, M. Laundy, R.F. Crellin, and S.G. Kirker Vitamin B12 metabolism in multiple sclerosis Arch. Neurol. 49 1992 649 652
113. C.E. Teunissen, M.P. Van Boxtel, J. Jolles, J. De Vente, F. Vreeling, F. Verhey, C.H. Polman, C.D. Dijkstra, and H.J. Blom Homocysteine in relation to cognitive performance in pathological and non-pathological conditions Clin. Chem. Lab Med. 43 2005 1089 1095
114. G.S. Ramsaransing, M.R. Fokkema, A. Teelken, A.V. Arutjunyan, M. Koch, and J. De Keyser Plasma homocysteine levels in multiple sclerosis J. Neurol. Neurosurg. Psychiatry 77 2006 189 192
115. C. Russo, F. Morabito, F. Luise, A. Piromalli, L. Battaglia, A. Vinci, L. Trapani, V.,M. de, V.,P. Morabito, F. Condino, A. Quattrone, and U. Aguglia Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis J. Neurol. 255 2008 64 69
116. D.E. Goodkin, D.W. Jacobsen, N. Galvez, M. Daughtry, M. Secic, and R. Green Serum cobalamin deficiency is uncommon in multiple sclerosis Arch. Neurol. 51 1994 1110 1114
117. C.E. Teunissen, J. Killestein, J.J. Kragt, C.H. Polman, C.D. Dijkstra, and H.J. Blom Serum homocysteine levels in relation to clinical progression in multiple sclerosis J. Neurol. Neurosurg. Psychiatry 79 2008 1349 1353
118. N. Triantafyllou, M.E. Evangelopoulos, V.K. Kimiskidis, E. Kararizou, F. Boufidou, K.N. Fountoulakis, M. Siamouli, C. Nikolaou, C. Sfagos, N. Vlaikidis, and D. Vassilopoulos Increased plasma homocysteine levels in patients with multiple sclerosis and depression Ann. Gen. Psychiatry 7 2008 17
119. S. Zoccolella, I.L. Simone, P. Lamberti, V. Samarelli, R. Tortelli, L. Serlenga, and G. Logroscino Elevated plasma homocysteine levels in patients with amyotrophic lateral sclerosis Neurology 70 2008 222 225
120. R.J. Bateman, C. Xiong, T.L. Benzinger, A.M. Fagan, A. Goate, N.C. Fox, D.S. Marcus, N.J. Cairns, X. Xie, T.M. Blazey, D.M. Holtzman, A. Santacruz, V. Buckles, A. Oliver, K. Moulder, P.S. Aisen, B. Ghetti, W.E. Klunk, E. McDade, R.N. Martins, C.L. Masters, R. Mayeux, J.M. Ringman, M.N. Rossor, P.R. Schofield, R.A. Sperling, S. Salloway, and J.C. Morris Clinical and biomarker changes in dominantly inherited Alzheimer's disease N. Engl. J. Med. 2012
121. S.M. Lucas, N.J. Rothwell, and R.M. Gibson The role of inflammation in CNS injury and disease Br. J. Pharmacol. 147 Suppl. 1 2006 S232 S240
122. R.V. Banerjee, and R.G. Matthews Cobalamin-dependent methionine synthase FASEB J. 4 1990 1450 1459
123. C.L. Elmore, and R.G. Matthews The many flavors of hyperhomocyst(e) inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism Antioxid. Redox Signal. 9 2007 1911 1921
124. A. McCaddon, B. Regland, P. Hudson, and G. Davies Functional vitamin B(12) deficiency and Alzheimer disease Neurology 58 2002 1395 1399
125. A. McCaddon, and P. Hudson Alzheimer's disease, oxidative stress and B-vitamin depletion Future Neurol. 2 2007 537 547
126. P. McGing, B. Reed, D.G. Weir, and J.M. Scott The effect of vitamin B12 inhibition in vivo: impaired folate polyglutamate biosynthesis indicating that 5-methyltetrahydropteroylglutamate is not its usual substrate Biochem. Biophys. Res. Commun. 82 1978 540 546
127. D. Fuchs, M. Jaeger, B. Widner, B. Wirleitner, E. Artner-Dworzak, and F. Leblhuber Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake? Clin. Chem. Lab Med. 39 2001 691 694
128. A. McCaddon, S. Tandy, P. Hudson, R. Gray, G. Davies, D. Hill, and J. Duguid Absence of macrocytic anaemia in Alzheimer's disease Clin. Lab. Haematol. 26 2004 259 263
129. G. Scalabrino, D. Veber, and E. Mutti Experimental and clinical evidence of the role of cytokines and growth factors in the pathogenesis of acquired cobalamin-deficient leukoneuropathy Brain Res. Rev. 2008
130. J.W. Miller Vitamin B12 deficiency, tumor necrosis factor-alpha, and epidermal growth factor: a novel function for vitamin B12? Nutr. Rev. 60 2002 142 144
131. R. Obeid, M. Kasoha, J.P. Knapp, P. Kostopoulos, G. Becker, K. Fassbender, and W. Herrmann Folate and methylation status in relation to phosphorylated tau protein(181P) and {beta}-amyloid(1-42) in cerebrospinal fluid Clin. Chem. 53 2007 1129 1136
132. A. McCaddon, and P.R. Hudson Methylation and phosphorylation: a tangled relationship? Clin. Chem. 53 2007 999 1000
133. A. Fuso, and S. Scarpa One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiol. Aging 2011
134. E. Sontag, V. Nunbhakdi-Craig, J.M. Sontag, R. Diaz-Arrastia, E. Ogris, S. Dayal, S.R. Lentz, E. Arning, and T. Bottiglieri Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation J. Neurosci. 27 2007 2751 2759
135. M. Hooper Pernicious Anaemia: The Forgotten Disease The Causes and Consequences of Vitamin B12 Deficiency 2012 Hammersmith Health Books London
136. M.S. Lewis, L.S. Miller, M.A. Johnson, E.B. Dolce, R.H. Allen, and S.P. Stabler Elevated methylmalonic acid is related to cognitive impairment in older adults enrolled in an elderly nutrition program J. Nutr. Elder. 24 2005 47 65
137. E.V. Quadros Advances in the understanding of cobalamin assimilation and metabolism Br. J. Haematol. 148 2010 195 204
138. S.P. Daiger, M.L. Labowe, M. Parsons, L. Wang, and L.L. Cavalli-Sforza Detection of genetic variation with radioactive ligands. III. Genetic polymorphism of transcobalamin II in human plasma Am. J. Hum. Genet. 30 1978 202 214
139. L.L. Cavalli-Sforza, S.P. Daiger, and D.P. Rummel Detection of genetic variation with radioactive ligands. I. Electrophoretic screening of plasma proteins with a selected panel of compounds Am. J. Hum. Genet. 29 1977 581 592
140. M. Frater-Schroder, H.J. Porck, A.W. Eriksson, S.P. Daiger, and L.L. Cavalli-Sforza Standardization of nomenclature for transcobalamin II variants Hum. Genet. 61 1982 165 166
141. F. Namour, M. Guy, I. Aimone-Gastin, M. de Nonancourt, N. Mrabet, and J.L. Gueant Isoelectrofocusing phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism Biochem. Biophys. Res. Commun. 251 1998 769 774
142. F. Namour, J. Olivier, I. Abdelmouttaleb, C. Adjalla, R. Debard, C. Salvat, and J. Gueant Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood Blood 97 2001 1092 1098
143. A. McCaddon, K. Blennow, P. Hudson, B. Regland, and D. Hill Transcobalamin polymorphism and homocysteine Blood 98 2001 3497 3499
144. J.L. Gueant, N.W. Chabi, R.M. Gueant-Rodriguez, O.M. Mutchinick, R. Debard, C. Payet, X. Lu, C. Villaume, J.P. Bronowicki, E.V. Quadros, A. Sanni, E. Amouzou, B. Xia, M. Chen, G. Anello, P. Bosco, C. Romano, H.R. Arrieta, B.E. Sanchez, A. Romano, B. Herbeth, W. Anwar, and F. Namour Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2) J. Med. Genet. 44 2007 363 367
145. M.G. Garrod, L.H. Allen, M.N. Haan, R. Green, and J.W. Miller Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics Eur. J. Clin. Nutr. 64 2010 503 509
146. J.W. Miller, M.I. Ramos, M.G. Garrod, M.A. Flynn, and R. Green Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults Blood 100 2002 718 720
147. A.M. Matteini, J.D. Walston, K. Bandeen-Roche, D.E. Arking, R.H. Allen, L.P. Fried, A. Chakravarti, S.P. Stabler, and M.D. Fallin Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty J. Nutr. Health Aging 14 2010 73 77
148. E.V. Quadros, Y. Nakayama, and J.M. Sequeira The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin Blood 113 2009 186 192
149. W. Jiang, J.M. Sequeira, Y. Nakayama, S.C. Lai, and E.V. Quadros Characterization of the promoter region of TCblR/CD320 gene, the receptor for cellular uptake of transcobalamin-bound cobalamin Gene 466 2010 49 55
150. F. Pangilinan, A. Mitchell, J. VanderMeer, A.M. Molloy, J. Troendle, M. Conley, P.N. Kirke, M. Sutton, J.M. Sequeira, E.V. Quadros, J.M. Scott, J.L. Mills, and L.C. Brody Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects J. Med. Genet. 47 2010 677 685
151. J.L. Mills, T.C. Carter, D.M. Kay, M.L. Browne, L.C. Brody, A. Liu, P.A. Romitti, M. Caggana, and C.M. Druschel Folate and vitamin B12-related genes and risk for omphalocele Hum. Genet. 131 2012 739 746