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Volumn 64, Issue 5, 2010, Pages 503-509

Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics

Author keywords

Hispanic elderly; Homocysteine; Polymorphism; Transcobalamin; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; CYTIDINE; GUANOSINE; HOMOCYSTEINE; METHYLMALONIC ACID; TRANSCOBALAMIN; VITAMIN B COMPLEX;

EID: 77952092523     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2010.20     Document Type: Article
Times cited : (21)

References (49)
  • 1
    • 0036045429 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the transcobalamin gene: Relationship with transcobalamin concentrations and risk for neural tube defects
    • Afman LA, Lievers KJA, van der Put NMJ, Trijbels FJM, Blom HJ (2002). Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet 10, 433-438.
    • (2002) Eur. J. Hum Genet. , vol.10 , pp. 433-438
    • Afman, L.A.1    Lievers, K.J.A.2    Van Der Put, N.3    Trijbels, F.J.M.4    Blom, H.J.5
  • 2
    • 33847176545 scopus 로고    scopus 로고
    • Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children
    • Alessio AC, Hoehr NF, Siqueira LH, Bydlowski SP, Annichino-Bizzacchi JM (2007). Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children. Thromb Res 119, 571-577.
    • (2007) Thromb Res. , vol.119 , pp. 571-577
    • Alessio, A.C.1    Hoehr, N.F.2    Siqueira, L.H.3    Bydlowski, S.P.4    Annichino-Bizzacchi, J.M.5
  • 3
    • 33947096863 scopus 로고    scopus 로고
    • Pyrosequencing assay for genotyping of the transcobalamin II 776C>G polymorphism
    • Bottiger AK, Nilsson TK (2007). Pyrosequencing assay for genotyping of the transcobalamin II 776C>G polymorphism. Scand J Clin Lab Invest 67, 247-251.
    • (2007) Scand J. Clin. Lab. Invest. , vol.67 , pp. 247-251
    • Bottiger, A.K.1    Nilsson, T.K.2
  • 4
    • 0346023028 scopus 로고    scopus 로고
    • Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism
    • Bowen RAR, Wong BYL, Cole DEC (2004). Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism. Clin Biochem 37, 128-133.
    • (2004) Clin. Biochem. , vol.37 , pp. 128-133
    • Bowen, R.A.R.1    Wong, B.Y.L.2    Cole, D.E.C.3
  • 5
    • 46749120334 scopus 로고    scopus 로고
    • Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects
    • Brouns R, Ursem N, Lindemans J, Hop W, Pluijm S, Steegers e et al. (2008). Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects. Prenat Diagn 28, 485-493.
    • (2008) Prenat Diagn. , vol.28 , pp. 485-493
    • Brouns, R.1    Ursem, N.2    Lindemans, J.3    Hop, W.4    Pluijm, S.5    Steegers, E.6
  • 8
    • 34848881628 scopus 로고    scopus 로고
    • Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    • Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J (2007). Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 28, 856-865.
    • (2007) Hum Mutat , vol.28 , pp. 856-865
    • Fredriksen, A.1    Meyer, K.2    Ueland, P.M.3    Vollset, S.E.4    Grotmol, T.5    Schneede, J.6
  • 9
    • 47649133075 scopus 로고    scopus 로고
    • Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms
    • Garrod MG, Green R, Allen LH, Mungas DM, Jagust WJ, Haan MN et al. (2008). Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms. Clin Chem 54, 1210-1217.
    • (2008) Clin. Chem. , vol.54 , pp. 1210-1217
    • Garrod, M.G.1    Green, R.2    Allen, L.H.3    Mungas, D.M.4    Jagust, W.J.5    Haan, M.N.6
  • 10
    • 0030900736 scopus 로고    scopus 로고
    • Novel reductant for determination of total plasma homocysteine
    • Gilfix BM, Blank DW, Rosenblatt DS (1997). Novel reductant for determination of total plasma homocysteine. Clin Chem 43, 687-688.
    • (1997) Clin. Chem. , vol.43 , pp. 687-688
    • Gilfix, B.M.1    Blank, D.W.2    Rosenblatt, D.S.3
  • 11
    • 27744463119 scopus 로고    scopus 로고
    • Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population
    • Green R, Miller JW (2005). Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population. Clin Chem Lab Med 43, 1048-1051.
    • (2005) Clin. Chem. Lab. Med. , vol.43 , pp. 1048-1051
    • Green, R.1    Miller, J.W.2
  • 12
    • 70350236688 scopus 로고    scopus 로고
    • Vitamin B12
    • Zempleni J, Rucker RB, McCormick DB, Suttie JW (eds) , 4th edn Taylor and Francis: Boca Raton, FL
    • Green R, Miller JW (2007). Vitamin B12. In: Zempleni J, Rucker RB, McCormick DB, Suttie JW (eds). Handbook of Vitamins, 4th edn Taylor and Francis: Boca Raton, FL. pp 413-457.
    • (2007) Handbook of Vitamins , pp. 413-457
    • Green, R.1    Miller, J.W.2
  • 13
    • 34250715385 scopus 로고    scopus 로고
    • Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2)
    • Gueant J-L, Chabi NW, Gueant-Rodriguez R-M, Mutchinick OM, Debard R, Payet C et al. (2007). Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2). J Med Genet 44, 363-367.
    • (2007) J. Med. Genet. , vol.44 , pp. 363-367
    • J-L, G.1    Chabi, N.W.2    R-M, G.-R.3    Mutchinick, O.M.4    Debard, R.5    Payet, C.6
  • 14
    • 0037865225 scopus 로고    scopus 로고
    • Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans
    • Gueant-Rodriguez RM, Rendeli C, Namour B, Venuti L, Romano A, Anello G et al. (2003). Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans. Neurosci Lett 344, 189-192.
    • (2003) Neurosci. Lett. , vol.344 , pp. 189-192
    • Gueant-Rodriguez, R.M.1    Rendeli, C.2    Namour, B.3    Venuti, L.4    Romano, A.5    Anello, G.6
  • 15
    • 0037318833 scopus 로고    scopus 로고
    • Prevalence of dementia in older Latinos: The influence of type 2 diabetes mellitus, stroke and genetic factors
    • Haan MN, Mungas DM, Gonzalez HM, Ortiz TA, Acharya A, Jagust WJ (2003). Prevalence of dementia in older Latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors. J Am Geriatr Soc 51, 169-177.
    • (2003) J. Am. Geriatr. Soc. , vol.51 , pp. 169-177
    • Haan, M.N.1    Mungas, D.M.2    Gonzalez, H.M.3    Ortiz, T.A.4    Acharya, A.5    Jagust, W.J.6
  • 16
    • 0344256728 scopus 로고    scopus 로고
    • Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    • Herrmann W, Obeid R, Schorr H, Geisel J (2003). Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk. Clin Chem Lab Med 41, 1478-1488.
    • (2003) Clin. Chem. Lab. Med. , vol.41 , pp. 1478-1488
    • Herrmann, W.1    Obeid, R.2    Schorr, H.3    Geisel, J.4
  • 17
    • 0033551352 scopus 로고    scopus 로고
    • The effect of folic acid fortification on plasma folate and total homocysteine concentrations
    • Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH (1999). The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 340, 1449-1454.
    • (1999) N Engl. J. Med. , vol.340 , pp. 1449-1454
    • Jacques, P.F.1    Selhub, J.2    Bostom, A.G.3    Wilson, P.W.4    Rosenberg, I.H.5
  • 19
    • 0034781986 scopus 로고    scopus 로고
    • Analysis of dicarboxylic acids by tandem mass spectrometry: High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine
    • Kushnir MM, Komaromy-Hiller G, Shushan B, Urry FM, Roberts WL (2001). Analysis of dicarboxylic acids by tandem mass spectrometry: high-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. Clin Chem 47, 1993-2002.
    • (2001) Clin. Chem. , vol.47 , pp. 1993-2002
    • Kushnir, M.M.1    Komaromy-Hiller, G.2    Shushan, B.3    Urry, F.M.4    Roberts, W.L.5
  • 20
    • 0028143693 scopus 로고
    • Polymorphism of human transcobalamin II: Substitution of proline and/or glutamine residues by arginine
    • Li N, Sood GK, Seetharam S, Seetharam B (1994). Polymorphism of human transcobalamin II: substitution of proline and/or glutamine residues by arginine. Biochim Biophys Acta 1219, 515-520.
    • (1994) Biochim Biophys. Acta , vol.1219 , pp. 515-520
    • Li, N.1    Sood, G.K.2    Seetharam, S.3    Seetharam, B.4
  • 21
    • 0036721305 scopus 로고    scopus 로고
    • Polymorphisms in the transcobalamin gene: Association with plasma homocysteine in healthy individuals and vascular disease patients
    • Lievers KJA, Afman LA, Kluijtmans LAJ, Boers GH, Verhoef P, den Heijer M et al. (2002). Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem 48, 1383-1389.
    • (2002) Clin. Chem. , vol.48 , pp. 1383-1389
    • Lievers, K.J.A.1    Afman, L.A.2    Kluijtmans, L.A.J.3    Boers, G.H.4    Verhoef, P.5    Heijer, M.D.6
  • 22
    • 0032925193 scopus 로고    scopus 로고
    • Holotranscobalamin-a sensitive marker of cobalamin malabsorption
    • Lindgren A, Kilander A, Bagge E, Nexø e (1999). Holotranscobalamin-a sensitive marker of cobalamin malabsorption. Eur J Clin Invest 29, 321-329.
    • (1999) Eur. J. Clin. Invest. , vol.29 , pp. 321-329
    • Lindgren, A.1    Kilander, A.2    Bagge, E.3    Nexø, E.4
  • 23
    • 33746620531 scopus 로고    scopus 로고
    • Study of four genes belonging to the folate pathway: Transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate
    • Martinelli M, Scapoli L, Palmieri A, Pezzetti F, Baciliero U, Padula e et al. (2006). Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. Hum Mutat 27, 294.
    • (2006) Hum Mutat , vol.27 , pp. 294
    • Martinelli, M.1    Scapoli, L.2    Palmieri, A.3    Pezzetti, F.4    Baciliero, U.5    Padula, E.6
  • 24
  • 26
    • 31844440194 scopus 로고    scopus 로고
    • Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency
    • Miller JW, Garrod MG, Rockwood AL, Kushnir MM, Allen LH, Haan MN et al. (2006). Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency. Clin Chem 52, 278-285.
    • (2006) Clin. Chem. , vol.52 , pp. 278-285
    • Miller, J.W.1    Garrod, M.G.2    Rockwood, A.L.3    Kushnir, M.M.4    Allen, L.H.5    Haan, M.N.6
  • 27
    • 0037100425 scopus 로고    scopus 로고
    • Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults
    • Miller JW, Ramos MI, Garrod MG, Flynn MA, Green R (2002). Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults. Blood 100, 718-720.
    • (2002) Blood , vol.100 , pp. 718-720
    • Miller, J.W.1    Ramos, M.I.2    Garrod, M.G.3    Flynn, M.A.4    Green, R.5
  • 28
    • 77952094214 scopus 로고    scopus 로고
    • (published erratum appears in Blood
    • (published erratum appears in Blood 100:3483).
    • , vol.100 , pp. 3483
  • 29
    • 0009803853 scopus 로고    scopus 로고
    • Transcobalamin polymorphism, homocysteine, and aging
    • Namour F, Gueant J-L (2001). Transcobalamin polymorphism, homocysteine, and aging. Blood 98, 3499.
    • (2001) Blood , vol.98 , pp. 3499
    • Namour, F.1    J-L, G.2
  • 30
    • 0032578853 scopus 로고    scopus 로고
    • Isoelectric phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism
    • Namour F, Guy M, Aimone-Gastin I, de Nonancourt M, Mrabet N, Gueant J-L (1998). Isoelectric phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism. Biochem Biophys Res Comm 251, 769-774.
    • (1998) Biochem. Biophys. Res. Comm , vol.251 , pp. 769-774
    • Namour, F.1    Guy, M.2    Aimone-Gastin, I.3    De Nonancourt, M.4    Mrabet, N.5    J-L, G.6
  • 31
    • 0035865701 scopus 로고    scopus 로고
    • Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: Relation to transcobalamin and homocysteine concentration in blood
    • Namour F, Olivier J, Abdelmouttaleb I, Adjalla C, Debard R, Salvat C et al. (2001). Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Blood 97, 1092-1098.
    • (2001) Blood , vol.97 , pp. 1092-1098
    • Namour, F.1    Olivier, J.2    Abdelmouttaleb, I.3    Adjalla, C.4    Debard, R.5    Salvat, C.6
  • 32
    • 18644368562 scopus 로고    scopus 로고
    • Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study
    • Nexo E, Hvas AM, Bleie O, Refsum H, Fedosov SN, Vollset SE et al. (2002). Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study. Clin Chem 48, 1768-1771.
    • (2002) Clin. Chem. , vol.48 , pp. 1768-1771
    • Nexo, E.1    Hvas, A.M.2    Bleie, O.3    Refsum, H.4    Fedosov, S.N.5    Vollset, S.E.6
  • 33
    • 24344491209 scopus 로고    scopus 로고
    • A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss
    • Parle-McDermott A, Pangilinan F, Mills JL, Signore CC, Molloy AM, Cotter A et al. (2005). A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss. Mol Hum Reprod 11, 477-480.
    • (2005) Mol. Hum Reprod. , vol.11 , pp. 477-480
    • Parle-McDermott, A.1    Pangilinan, F.2    Mills, J.L.3    Signore, C.C.4    Molloy, A.M.5    Cotter, A.6
  • 34
    • 33751092579 scopus 로고    scopus 로고
    • A transcobalamin gene polymorphism and the risk of venous thrombosis. The BRATROS (Brazilian thrombosis study)
    • Pereira AC, Lourenco DM, Maffei FH, Morelli VM, Rollo HA, Zago MA et al. (2007). A transcobalamin gene polymorphism and the risk of venous thrombosis. The BRATROS (Brazilian Thrombosis Study). Thromb Res 119, 183-188.
    • (2007) Thromb Res. , vol.119 , pp. 183-188
    • Pereira, A.C.1    Lourenco, D.M.2    Maffei, F.H.3    Morelli, V.M.4    Rollo, H.A.5    Zago, M.A.6
  • 35
    • 0142154026 scopus 로고    scopus 로고
    • 776C>G polymorphism of the transcobalamin II gene as a risk factor for spina bifida
    • Pietrzyk JJ, Bik-Multanowski M (2003). 776C>G polymorphism of the transcobalamin II gene as a risk factor for spina bifida. Mol Gen Metab 80, 364.
    • (2003) Mol. Gen. Metab. , vol.80 , pp. 364
    • Pietrzyk, J.J.1    Bik-Multanowski, M.2
  • 36
    • 59449100953 scopus 로고    scopus 로고
    • The protein and the gene encoding the receptor for the cellular uptake of transcobalamin bound cobalamin
    • Quadros EV, Nakayama Y, Sequeira JM (2009). The protein and the gene encoding the receptor for the cellular uptake of transcobalamin bound cobalamin. Blood 113, 186-192.
    • (2009) Blood , vol.113 , pp. 186-192
    • Quadros, E.V.1    Nakayama, Y.2    Sequeira, J.M.3
  • 37
    • 29744454316 scopus 로고    scopus 로고
    • Holotranscobalamin and total transcobalamin in human plasma: Determination, determinants, and reference values in healthy adults
    • Refsum H, Johnston C, Guttormsen AB, Nexo e (2006). Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults. Clin Chem 52, 129-137.
    • (2006) Clin. Chem. , vol.52 , pp. 129-137
    • Refsum, H.1    Johnston, C.2    Guttormsen, A.B.3    Nexo, E.4
  • 39
    • 48249126469 scopus 로고    scopus 로고
    • Public health significance of elevated homocysteine
    • Selhub J (2008). Public health significance of elevated homocysteine. Food Nutr Bull 29 (Suppl 2), S116-S125.
    • (2008) Food Nutr Bull. , vol.29 , Issue.2 SUPPL.
    • Selhub, J.1
  • 42
    • 41949107137 scopus 로고    scopus 로고
    • Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: A Dutch case-control study
    • Verkleij-Hagoort AC, van Driel LM, Lindemans J, Isaacs A, Steegers EA, Helbing WA et al. (2008). Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study. Mol Genet Metab 94, 112-119.
    • (2008) Mol. Genet. Metab. , vol.94 , pp. 112-119
    • Verkleij-Hagoort, A.C.1    Van Driel, L.M.2    Lindemans, J.3    Isaacs, A.4    Steegers, E.A.5    Helbing, W.A.6
  • 44
    • 0345601187 scopus 로고    scopus 로고
    • Analysis of the transcobalamin II 776C>G (259P>R) single nucleotide polymorphism by denaturing HPLC in healthy elderly: Associations with cobalamin, homocysteine and holo-transcobalamin II
    • Wans S, Schuttler K, Jakubiczka S, Muller A, Luley C, Dierkes J (2003). Analysis of the transcobalamin II 776C>G (259P>R) single nucleotide polymorphism by denaturing HPLC in healthy elderly: associations with cobalamin, homocysteine and holo-transcobalamin II. Clin Chem Lab Med 41, 1532-1536.
    • (2003) Clin. Chem. Lab. Med. , vol.41 , pp. 1532-1536
    • Wans, S.1    Schuttler, K.2    Jakubiczka, S.3    Muller, A.4    Luley, C.5    Dierkes, J.6
  • 47
    • 0036878158 scopus 로고    scopus 로고
    • No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease
    • Zetterberg H, Coppola A, D'Angelo A, Palmer M, Rymo L, Blennow K (2002a). No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. Thromb Res 108, 127-131.
    • (2002) Thromb Res. , vol.108 , pp. 127-131
    • Zetterberg, H.1    Coppola, A.2    D'Angelo, A.3    Palmer, M.4    Rymo, L.5    Blennow, K.6
  • 48
    • 0038610892 scopus 로고    scopus 로고
    • The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer disease
    • Zetterberg H, Nexo E, Regland B, Minthon L, Boson R, Palmér M et al. (2003). The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer disease. Clin Chem 49, 1195-1198.
    • (2003) Clin. Chem. , vol.49 , pp. 1195-1198
    • Zetterberg, H.1    Nexo, E.2    Regland, B.3    Minthon, L.4    Boson, R.5    Palmér, M.6
  • 49
    • 1842855010 scopus 로고    scopus 로고
    • The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion
    • Zetterberg H, Regland B, Palmer M, Rymo L, Zafiropoulos A, Arvanitis DA et al. (2002b). The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion. Hum Reprod 17, 3033-3036.
    • (2002) Hum Reprod , vol.17 , pp. 3033-3036
    • Zetterberg, H.1    Regland, B.2    Palmer, M.3    Rymo, L.4    Zafiropoulos, A.5    Arvanitis, D.A.6


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