The significance of subnormal serum vitamin B12 concentration in older people: A case control study

Journal of the American Geriatrics Society

Volumn 44, Issue 11, 1996, Pages 1355-1361

  Metz, J ^a   Bell, A H ^a   Flicker, L ^b   Bottiglieri, T ^c   Ibrahim, J ^b   Seal, E ^b   Schultz, D ^a   Savoia, H ^a   McGrath, K M ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b NorthWest Hospital   (Australia)

^c BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYANOCOBALAMIN; FOLIC ACID; GASTRIN; HOMOCYSTEINE; INTRINSIC FACTOR; PARIETAL CELL ANTIBODY; TRANSCOBALAMIN II;

AGED; ARTICLE; AUSTRALIA; CLINICAL PROTOCOL; COGNITION; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; NEUROLOGIC DISEASE; NEUROPSYCHOLOGICAL TEST; NEUTROPHIL; VITAMIN BLOOD LEVEL;

EID: 0029905218     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1996.tb01407.x     Document Type: Article

References (20)

1. Lindenbaum J, Savage DG, Stabler SP et al. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107.
2. 12 levels. J Am Geriatr Soc 1991;39:A47.
3. Pennypacker LC, Allen RH, Kelly JP et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992;40:1197-1204.
4. Joosten E, Pelemans W, Devos P et al. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin. Eur J Haematol 1993;51:25-30.
5. 6 occur commonly in the elderly. Am J Clin Nutr 1993;58:468-476.
6. Lindenbaum J, Rosenberg IH, Wilson PWF, et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60:2-11.
7. 12 levels in a hematologically normal elderly subpopulation. J Am Geriatr Soc 1987;35: 635-638.
8. Healton EH, Savage DG, Brust JCM et al. Neurologic aspects of cobalamin deficiency. Medicine 1991;70:229-245.
9. Herzlich B, Herbert V. Depletion of serum holotranscobalamin II. Lab Invest 1986;58:332-337.
10. Vu T, Amin J, Ramos M et al. New assay for the rapid determination of plasma holotranscobalamin II levels: Preliminary evaluation in cancer patients. Am J Hematol 1993;42:202-211.
11. Ubbink JB, Vermaak WJ, Bissbort S. Rapid high performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 1991;565:441-446.
12. Wilcken DEL, Gupta VJ, Betts AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci 1981;61:743-749.
13. 12 or folate deficiency. Eur J Haematol 1994;52:227-232.
14. 12-deficient humans. Br J Haematol 1968;14:575-592.
15. Kang SS, Wong PWK, Malinow MR. Hyperhomocyst(e)inanemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 1992;12:279-298.
16. 12 and folate levels in the elderly. J Am Geriatr Soc. 1991;39:1155-1159.
17. Lindenbaum J, Savage DG, Stabler SP et al. Neuropsychiatric disorders in cobalamin deficiency. In: Bhatt HR, James VHT, Besser GM, Bottazzo GF, Keen H, eds. Advances in Thomas Addison's Diseases. Bristol, UK: Journal of Endocrinology, Ltd.
18. Metz J. Cobalamin deficiency and the pathogenesis of nervous system disease. Annu Rev Nutr 1992;12:59-79.
19. Bottiglieri T, Hyland K, Reynolds EH The clinical potential of ademetionine (S-adenosylmethione) in neurological disorders. Drugs 1994;48:137-152.
20. Green R, Kinsella LJ. Current concepts in the diagnosis of cobalamin deficiency Neurology 1995;45:1435-1440.