Sequestration of DROSHA and DGCR8 by expanded CGG RNA Repeats Alters microRNA processing in fragile X-associated tremor/ataxia syndrome

Cell Reports

Volumn 3, Issue 3, 2013, Pages 869-880

  Sellier, Chantal ^a,b   Freyermuth, Fernande ^a   Tabet, Ricardos ^a   Tran, Tuan ^c   He, Fang ^d   Ruffenach, Frank ^a   Alunni, Violaine ^a   Moine, Herve ^a   Thibault, Christelle ^a   Page, Adeline ^a   Tassone, Flora ^e   Willemsen, Rob ^g   Disney, Matthew D ^c   Hagerman, Paul J ^e,f   Todd, Peter K ^d   Charlet Berguerand, Nicolas ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b sous section pédiatrie   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DGCR8 PROTEIN; DROSHA PROTEIN; MICRORNA; RIBONUCLEASE III; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL VIABILITY; CGG REPEAT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITE; DNA STRUCTURE; EMBRYO; FRAGILE X ASSOCIATED TREMOR ATAXIA SYNDROME; HUMAN; HUMAN TISSUE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA PROCESSING;

ANIMALS; ATAXIA; BRAIN; CELL DEATH; FRAGILE X SYNDROME; HUMANS; MICE; MICE, INBRED C57BL; MICRORNAS; NEURONS; PROTEIN BINDING; PROTEINS; RIBONUCLEASE III; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANSCRIPTION, GENETIC; TREMOR; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84875804170     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.02.004     Document Type: Article

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