Decrease in abundance of apurinic/apyrimidinic endonuclease causes failure of base excision repair in culture-adapted human embryonic stem cells

Stem Cells

Volumn 31, Issue 4, 2013, Pages 693-702

  Krutá, Miriama ^a,b   Bálek, Lukáš ^a   Hejnová, Renata ^a   DobšáKová, Zuzana ^a,c   Eiselleová, Livia ^a   Matulka, Kamil ^a   Bárta, Tomáš ^a   Fojtík, Petr ^a   Fajkus, Jiří ^a,c   Hampl, Aleš ^a,b   Dvořák, Petr ^a,b   Rotrekl, Vladimír ^a,b  

^a MASARYK UNIVERSITY   (Czech Republic)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Apurinic apyrimidinic endonuclease 1; Base excision repair; Culture adaptation; Genome instability; Human embryonic stem cells

Indexed keywords

DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE 1; HISTONE H2AX; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TELOMERASE; UNCLASSIFIED DRUG;

ADAPTATION; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EMBRYONIC STEM CELL; ENZYME ACTIVITY; EXCISION REPAIR; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TELOMERE;

CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; EMBRYONIC STEM CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; KARYOTYPING;

EID: 84875799162     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1312     Document Type: Article

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