Functional impact of a single mutation within the transmembrane domain of the multidrug ABC transporter Pdr5

Biochemistry

Volumn 52, Issue 13, 2013, Pages 2184-2195

  Kueppers, Petra ^a   Gupta, Rakeshkumar P ^a   Stindt, Jan ^a,b   Smits, Sander H J ^a   Schmitt, Lutz ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-ASE ACTIVITY; COMPETITIVE INHIBITION; KINETIC AND THERMODYNAMIC PARAMETERS; NUCLEOTIDE-BINDING DOMAIN; SUBSTRATE SPECIFICITY; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES; WILD-TYPE PROTEINS;

ACTIVATION ANALYSIS; BIOCHEMISTRY; ENZYME ACTIVITY;

BIOLOGICAL MEMBRANES;

ABC TRANSPORTER; ABC TRANSPORTER PDR5; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME ACTIVITY; GENE MUTATION; HYDROLYSIS; MOLECULAR INTERACTION; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; THERMODYNAMICS; YEAST CELL;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; FLUORESCENT DYES; HYDROLYSIS; IMMUNOSUPPRESSIVE AGENTS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RHODAMINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; TACROLIMUS;

FUNGI; SACCHAROMYCETALES;

EID: 84875796676     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3015778     Document Type: Article

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