Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 1, 2000, Pages 134-138

  Golin, John ^a   Barkatt, Alisa ^a   Cronin, Susan ^a,b   Eng, George ^c   May, Leopold ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

^b IMMACULATA UNIVERSITY   (United States)

^c UNIVERSITY OF THE DISTRICT OF COLUMBIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; CHLORAMPHENICOL DERIVATIVE; CLOTRIMAZOLE; CYCLOHEXIMIDE; GENE PRODUCT; HYDROCARBON; LINCOMYCIN; ORGANOTIN COMPOUND; TRIBUTYLTIN; TRIETHYLTIN; TRIMETHYLTIN; TRIPENTYLTIN; TRIPHENYLTIN CHLORIDE; TRIPROPYLTIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; FUNGUS GROWTH; HYDROPHOBICITY; MOLECULAR SIZE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

EID: 0033988629     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.1.134-138.2000     Document Type: Article

References (18)

1. Balzi, E., M. Wang, S. Leterme, L. Van Dyck, and A. Coffeau. 1994. PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcriptional regulator PDR1. J. Biol. Chem. 269:2206-2214.
2. Cain, K., and D. E. Griffiths. 1977. Studies of energy-linked reaction: localization of the site of action of trialkyltin in yeast mitochondria. Biochem. J. 162:575-580.
3. Egner, R., F. Rosenthal, A. Kralli, D. Sanglard, and K. Kuchler. 1998. Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. Mol. Biol. Cell 9:523-543.
4. Fleckenstein, A., J. Shallom, and J. Golin. 1999. A PDR5-independent pathway of multi-drug resistance regulated by the SIN4 gene product. Yeast 15:133-137.
5. Gottesmann, M., and I. Pastan. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427.
6. Gros, P., R. Dhir, J. Croop, and F. Talbot. 1991. A single amino acid substitution strongly modulates the activity and substrate specificity of mouse mdr1 and mdr3 drug efflux pumps. Proc. Natl. Acad. Sci. USA 88:7289-7293.
7. Jiang, Y. W., and D. J. Stillman. 1995. Regulation of HIS4 expression by the Saccharomyces cerevisiae SIN4 transcriptional regulator. Genetics 140:103-114.
8. Kolaczkowski, M., M. Vanderest, A. Eybularz-Kolaczkowski, J. Soumillion, W. Konings, and A. Goffeau. 1996. Anticancer drugs, ionophoric peptides and steroids as substrates of the yeast multidrug transporter Pdr5p. J. Biol. Chem. 271:31543-31548.
9. Kraus, C. A., and C. C. Callis. 1923. Studies relating to the metallo-organic compounds. I. Introduction. II. The equivalent conductance of trimethylstannyl chloride in ethyl alcohol. J. Am. Chem. Soc. 45:2624-2632.
10. OCT from structures. Chem. Rev. 93:1281-1306.
11. Leonard, P. J., P. K. Rathod, and J. Golin. 1994. Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux. Antimicrob. Agents Chemother. 38:2492-2494.
12. Loo, A. J., and D. M. Clark. 1993. Functional consequences of proline mutations in the predicted transmembrane domains of P-glycoprotein. J. Biol. Chem. 268:3143-3149.
13. Luedke, E., E. Lucero, and G. Eng. 1991. Molecular volume as a predictor of organotin biotoxicity. Main Group Met. Chem. 14:59-66.
14. Meyers, S., W. Schauer, E. Balzi, M. Wagner, A. Goffeau, and J. Golin. 1992. Interaction of the yeast pleiotropic drug resistance genes - PDR1 and PDR5. Curr. Genet. 21:431-436.
15. Nogac, I., K. Kohno, J. Kikuchi, J. Kawano, and M. Akuyama. 1989. Analysis of structural features of dihydropyridine analogs needed to reverse MDR and inhibit photo affinity labeling of P-glycoprotein. Biol. Pharm. 38:519-517.
16. Servos, J., E. Hasse, and M. Brendel. 1993. Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Mol. Gen. Genet. 236:214-218.
17. Wulf, R. G., and K. H. Byington. 1975. On the structure-activity relationships and mechanism of organotin induced nonenergy dependent swelling of liver mitochondria. Arch. Biochem. Biophys. 167:176-185.
18. Zamora, J., H. L. Pearce, and W. T. Beck. 1988. Physical-chemical properties shared by compounds that modulate MDR in human leukemic cells. Mol. Pharmacol. 33:454-462.