Transporter targeted gatifloxacin prodrugs: Synthesis, permeability, and topical ocular delivery

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3136-3146

  Vooturi, Sunil K ^a   Kadam, Rajendra S ^a   Kompella, Uday B ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b The University of Colorado Denver   (United States)

Author keywords

amino acid transporter; drug delivery; endophthalmitis; gatifloxacin; monocarboxylic acid transporter; ocular delivery; organic cation transporter; prodrugs

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ANTIBIOTIC AGENT; ATB TRANSPORTER; CARBOXYPROPYLGATIFLOXACIN; DIMETHYLAMINOPROPYLGATIFLOXACIN; GATIFLOXACIN; MEMBRANE PROTEIN; MONOCARBOXYLATE TRANSPORTER; N METHYLTRYPTOPHAN; NICOTINIC ACID; ORGANIC CATION TRANSPORTER; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CILIARY BODY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; DIFFUSION CHAMBER; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; EYE; IN VITRO STUDY; IN VIVO STUDY; IRIS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN TARGETING; RABBIT; RETINA; SCLERA; SCLERA CHOROID RETINAL PIGMENT EPITHELIUM; TANDEM MASS SPECTROMETRY; TRANSPORT KINETICS; USSING CHAMBER; VITREOUS BODY;

ADMINISTRATION, TOPICAL; ANIMALS; BIOLOGICAL TRANSPORT; CHROMATOGRAPHY, LIQUID; DRUG DELIVERY SYSTEMS; EYE; FLUOROQUINOLONES; MONOCARBOXYLIC ACID TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; PERMEABILITY; PRODRUGS; RABBITS; SOLUBILITY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84868575032     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300245r     Document Type: Article

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