Nanotopography-mediated Reverse Uptake for siRNA Delivery into Neural Stem Cells to Enhance Neuronal Differentiation

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Solanki, Aniruddh ^a   Shah, Shreyas ^a   Yin, Perry T ^b   Lee, Ki Bum ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; SILICON DIOXIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX9;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; GENE SILENCING; GENETICS; METABOLISM; METHODOLOGY; NEURAL STEM CELL; RAT; RNA INTERFERENCE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; GENE KNOCKDOWN TECHNIQUES; NANOPARTICLES; NEURAL STEM CELLS; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SILICON DIOXIDE; SOX9 TRANSCRIPTION FACTOR;

EID: 84875765221     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01553     Document Type: Article

References (51)

1. Ferreira, L., Karp, J. M., Nobre, L. & Langer, R. New opportunities: The use of Nanotechnologies to manipulate and track stem cells. Cell Stem Cell 3, 136-146 (2008).
2. Kumar, S., Chanda, D. & Ponnazhagan, S. Therapeutic potential of genetically modified mesenchymal stem cells. Gene Ther. 15, 711-715 (2008). (Pubitemid 351627354)
3. Green, J. J. et al. Nanoparticles for Gene Transfer to Human Embryonic Stem Cell Colonies. Nano Letters 8, 3126-3130 (2008).
4. Yang, F. et al. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc. Natl. Acad. Sci. USA 107, 3317-3322 (2010).
5. Zoldan, J. et al. Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture. Biomaterials 32, 7793-7800 (2011).
6. Ding, L. & Buchholz, F. RNAi in embryonic stem cells. Stem Cell Rev. 2, 11-18 (2006). (Pubitemid 44195973)
7. Heidersbach, A., Gaspar-Maia, A.,McManus, M. T. & Ramalho-Santos, M. RNA interference in embryonic stem cells and the prospects for future therapies. Gene Ther. 13, 478-486 (2006).
8. Yau, W. W. Y., Rujitanaroj, P. O., Lam, L. & Chew, S. Y. Directing stem cell fate by controlled RNA interference. Biomaterials 33, 2608-2628 (2012).
9. Geng, T., Zhan, Y. H.,Wang, J. & Lu, C. Transfection of cells using flow-through electroporation based on constant voltage. Nature Protoc. 6, 1192-1208 (2011).
10. Kim, J. E., Shin, J. Y. & Cho,M.H.Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects. Arch. Toxicol. 86, 685-700 (2012).
11. van Gaal, E. V. B. et al. How to screen non-viral gene delivery systems in vitro? J. Control. Release 154, 218-232 (2011).
12. Merdan, T., Kopecek, J. & Kissel, T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliver. Rev. 54, 715-758 (2002). (Pubitemid 35247524)
13. Rosner, M. et al. Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nature Protoc. 5, 1081-1095 (2010).
14. McMahon, K. M. et al. Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery. Nano Lett. 11, 1208-1214 (2011).
15. Tseng, S. J. & Tang, S. C. Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing. Bioconjugate Chem. 18, 1383-1390 (2007).
16. Omidi, Y., Barar, J. & Akhtar, S. Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr Drug Deliv 2, 429-41 (2005). (Pubitemid 41277775)
17. Akhtar, S. & Benter, I. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv Drug Deliv Rev 59, 164-82 (2007). (Pubitemid 46773052)
18. Omidi, Y. et al. Microarray analysis of the toxicogenomics and the genotoxic potential of a cationic lipid-based gene delivery nanosystem in human alveolar epithelial a549 cells. Toxicol Mech Methods 18, 369-78 (2008). (Pubitemid 351892732)
19. Zhao, F. et al. Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials. Small 7, 1322-1337 (2011).
20. Braydich-Stolle, L., Hussain, S., Schlager, J. J. & Hofmann, M. C. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol. Sci. 88, 412-419 (2005). (Pubitemid 41672149)
21. Soenen, S. J. H. & De Cuyper, M. Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects. Nanomedicine 5, 1261-1275 (2010).
22. Solanki, A., Kim, J. D. & Lee, K. B. Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging. Nanomedicine 3, 567-578 (2008).
23. Yoo, J. W., Irvine, D. J., Discher, D. E.&Mitragotri, S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nature Rev. Drug Discov. 10, 521-535 (2011).
24. Bettinger, C. J., Langer, R. & Borenstein, J. T. Engineering substrate topography at the micro-and nanoscale to control cell function. Angew Chem Int Ed Engl 48, 5406-15 (2009).
25. Yim, E. K., Darling, E. M., Kulangara, K., Guilak, F. & Leong, K. W. Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials 31, 1299-306 (2010).
26. Adler, A. F. & Leong, K.W. Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery. Nano Today 5, 553-569 (2010).
27. Teo, B. K. et al. The effect of micro and nanotopography on endocytosis in drug and gene delivery systems. Biomaterials 32, 9866-75 (2011).
28. Saha, K. et al. Substrate modulus directs neural stem cell behavior. Biophys J 95, 4426-38 (2008).
29. Jung, J. et al. Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery. Angewandte Chemie International Edition 49, 103-107 (2010).
30. Moe, A. A. et al. Microarray with micro-and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells. Small 8, 3050-61 (2012).
31. Dhara, S. K., Majumder, A., Dodla, M. C. & Stice, S. L. Nonviral gene delivery in neural progenitors derived from human pluripotent stem cells. Methods Mol Biol 767, 343-54 (2011).
32. Myung, S. et al. Graphene-Encapsulated Nanoparticle-Based Biosensor for the Selective Detection of Cancer Biomarkers. Adv. Mater. 23, 2221-1 (2011).
33. Dhaliwal, A., Lam, J., Maldonado, M., Lin, C. & Segura, T. Extracellular matrix modulates non-viral gene transfer to mouse mesenchymal stem cells. Soft Matter 8, 1451-1459 (2012).
34. Khormaee, S., Ali, O. A., Chodosh, J. & Mooney, D. J. Optimizing siRNA efficacy through alteration in the target cell-adhesion substrate interaction. J Biomed Mater Res A 100, 2637-43 (2012).
35. Reddi, A. H. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotech. 16, 247-252 (1998).
36. Kalluri, R. Basement membranes: Structure, assembly and role in tumour angiogenesis. Nature Rev. Cancer 3, 422-433 (2003). (Pubitemid 37328846)
37. Bengali, Z., Rea, J. C. & Shea, L. D. Gene expression and internalization following vector adsorption to immobilized proteins: dependence on protein identity and density. J Gene Med 9, 668-78 (2007). (Pubitemid 47288825)
38. Kong, H. J., Hsiong, S. & Mooney, D. J. Nanoscale cell adhesion ligand presentation regulates nonviral gene delivery and expression. Nano Lett 7, 161-6 (2007). (Pubitemid 46225846)
39. Pelkmans, L., Burli, T., Zerial, M. & Helenius, A. Caveolin-stabilized membrane domains asmultifunctional transport and sorting devices in endocytic membrane traffic. Cell 118, 767-780 (2004). (Pubitemid 39221735)
40. Stolt, C. C. et al. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Gene. Dev. 17, 1677-1689 (2003). (Pubitemid 36828793)
41. Cheng, L. C., Pastrana, E., Tavazoie, M. & Doetsch, F. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature Neurosci. 12, 399-408 (2009).
42. Makeyev, E. V., Zhang, J. W., Carrasco, M. A. & Maniatis, T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative Pre-mRNA splicing. Mol. Cell 27, 435-448 (2007). (Pubitemid 47126944)
43. Sato, T., Ishii, T. & Okahata, Y. In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency. Biomaterials 22, 2075-2080 (2001). (Pubitemid 32738750)
44. Segura, T., Volk, M. J. & Shea, L. D. Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification. J Control Release 93, 69-84 (2003). (Pubitemid 37346269)
45. Bengali, Z. et al. Gene delivery through cell culture substrate adsorbed DNA complexes. Biotechnol Bioeng 90, 290-302 (2005). (Pubitemid 40779206)
46. Mehrotra, S., Lee, I.&Chan, C. Multilayer mediated forward and patterned siRNA transfection using linear-PEI at extended N/P ratios. Acta Biomater 5, 1474-88 (2009).
47. Oyane, A., Tsurushima, H. & Ito, A. Highly efficient gene transfer system using a laminin-DNA-apatite composite layer. J Gene Med 12, 194-206 (2010).
48. Kam, K. R. et al.Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography. Nano Lett 13, 164-71 (2013).
49. Park, S., Kim, Y. S., Kim, W. B. & Jon, S. Carbon nanosyringe array as a platform for intracellular delivery. Nano Lett 9, 1325-9 (2009).
50. Shalek, A. K. et al.Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia. Nano Letters 12, 6498-6504 (2012).
51. Shalek, A. K. et al. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci USA 107, 1870-5 (2010).