Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors of β-secretase (BACE1)

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 8, 2013, Pages 2396-2412

  Edraki, Najmeh ^a,b   Firuzi, Omidreza ^b   Foroumadi, Alireza ^a,c   Miri, Ramin ^b   Madadkar Sobhani, Armin ^d   Khoshneviszadeh, Mehdi ^a,b   Shafiee, Abbas ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF TEHRAN   (Iran)

Author keywords

Alzheimer disease; BACE1 inhibitor; Phenylimino 2H chromen 3 carboxamide

Indexed keywords

4 BROMOPHENYL PIPERAZINE DERIVATIVE; AMYLOID BETA PROTEIN; BETA SECRETASE INHIBITOR; MOLECULAR SCAFFOLD; N [2 (4 BENZYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 (4 BENZYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 2 CYANOACETAMIDE; N [2 (4 BENZYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; N [2 (4 BENZYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 2 IMINO 8 METHOXY 2H CHROMENE 3 CARBOXAMIDE; N [2 (4 BENZYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 8 METHOXY 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 (4 TERT BUTOXYCARBONYL PIPERAZIN 1 YL) 5 BROMOPHENYL] 2 IMINO 2H CHROMENE 3 CARBOXAMIDE; N [2 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL) 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (2 METHOXYBENZOYL)PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (3 CHLOROBENZOYL)PIPERAZIN 1 YL] 5-BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (3 CYANOBENZYL)PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (3 NITROBENZOYL)PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (4 METHOXYBENZOYL)PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 (4 METHOXYBENZYL)PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [2 [4 [2 (1H INDOL 2 YL)ETHYL]PIPERAZIN 1 YL] 5 BROMOPHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 (PIPERAZIN 1 YL)PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (2 PHTHALIMIDOETHYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (3 CYANOPROPYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (3 PHTHALIMIDOPROPYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (4 PHTHALIMIDOBUTYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (FURAN 2 CARBONYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; N [5 BROMO 2 [4 (THIOPHEN 2 CARBONYL)PIPERAZIN 1 YL]PHENYL] 2 (PHENYLIMINO) 2H CHROMENE 3 CARBOXAMIDE; PHENYLALANINE; PHENYLIMINO 2H CHROMEN 3 CARBOXAMIDE DERIVATIVE; PHENYLIMINO GROUP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BENZOPYRANS; CELL LINE, TUMOR; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; NEUROBLASTOMA;

EID: 84875755407     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.064     Document Type: Article

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