CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor

Journal of Immunology

Volumn 164, Issue 10, 2000, Pages 5055-5061

  Cho, Chul Soo ^a,b   Cho, Mi La ^a,b   Min, So Youn ^b   Kim, Wan Uk ^a,b   Min, Do June ^a,b   Lee, Shin Seok ^a   Park, Sung Hwan ^a,b   Choe, Jongseon ^c   Kim, Ho Youn ^a,b,d  

^a Division of Rheumatology   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Kangwon National University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; DEXAMETHASONE; INDOMETACIN; MESSENGER RNA; MONOCLONAL ANTIBODY; PYRROLIDINE DITHIOCARBAMATE; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT TUMOR NECROSIS FACTOR; VASCULOTROPIN;

ARTHRITIS; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; L CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE ACTIVATION;

EID: 0034657793     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.10.5055     Document Type: Article

References (49)

1. Koch. A 1998. Angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. 41:951.
2. Walsh, D. A. 1999. Angiogenesis and arthritis. Rheumatology 38:103.
3. Klagsbrun, M., and P. A. D'Amore. 1991. Regulators of angiogenesis. Annu. Rev. Physiol. 53:217.
4. Dvorak, H. F., L. F. Brown, M. Detmar, and A. M. Dvorak. 1995. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am. J. Pathol. 146:1029.
5. Conn, G., D. D. Soderman, M. Schaeffer, M. Wile, V. B. Hatcher, and K. A. Thomas. 1990. Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line. Proc. Natl. Acad. Sci. USA 87:1323.
6. Ferrara, N., K. Carver-Moore, H. Chen, M. Dowd, L. Lu, K. S. O'Shea, L. Powell-Braxton, K. J. Hillan, and M. W. Moore. 1996. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439.
7. Detmar, M., K. T. Yeo, J. A. Nagi, L. Van de Water, L. F. Brown, B. Berse, B. M. Elicker, S. Ledbetter, and H. F. Dvorak. 1995. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J. Invest. Dermatol. 105:44.
8. Senger, D. R., S. J. Galli, A. M. Dvorak, C. A. Peruzzi, V. S. Harvey, and H. F. Dvorak. 1983. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983.
9. Fava, R. A., N. J. Olsen, G. Spencer-Green, K. T. Yeo, T. K. Yeo, B. Berse, R. W. Jackman, D. R. Senger, H. F. Dvorak, and L. F. Brown. 1994. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J. Exp. Med. 180:341.
10. Koch, A. E., L. A. Harlow, G. K. Haines, E. P. Amento, E. N. Unemori. W. L. Wong, R. M. Pope, and N. Ferrara. 1994. Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol. 152:4149.
11. Nagashima, M., S. Yoshino, T. Ishiwata, and G. Asano. 1995. Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J. Rheumatol. 22:1624.
12. Jackson, J. R., J. A. L. Minton, M. L. Ho, N. Wei, and J. D. Winkler. 1997. Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1β. J. Rheumatol. 24:1253.
13. Berse, B., J. A. Hunt, R. J. Diegel, P. Morganelli, K. T. Yeo, F. Brown, and R. A. Fava. 1999. Hypoxia augments cytokine (transforming growth factor-β (TGF-β) and IL-1)-induced vascular endothelial growth factor secretion by human synovial fibroblasts. Clin. Exp. Immunol. 115:176.
14. Ikeda, E., M. G. Achen, G. Breier, and W. Risau. 1995. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem. 270:19761.
15. Ben-Av, P., L. J. Crofford, R. L. Wilder, and T. Hla. 1995. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett. 372:83.
16. Cohen, T., D. Nahari, L. W. Cerem, G. Neufeld, and B. Z. Levi. 1996. Interleukin-6 induces the expression of vascular endothelial growth-factor. J. Biol. Chem. 271:736.
17. Pertovaara, L., A. Kaipainen, T. Mustonen, A. Orpana, N. Ferrara, O. Saksela, and K. Alitalo. 1994. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J. Biol. Chem. 269:6271.
18. Grewal, I. S., and R. A. Flavell. 1998. The CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
19. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J. P. Galizzi, C. van Kooten, Y. J. Liu. F. Roussel, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
20. Malik, N., B. W. Greenfield, A. F. Wahl, and P. A. Kiener. 1996. Activation of human monocytes through CD40 induces matrix metalloproteinase. J. Immunol. 156:3952.
21. Yellin, M. J., S. Winikoff, S. M. Fortune, D. Baum, M. K. Crow, S. Lederman, and L. Chess. 1994. Ligation of CD40 on fibroblasts induces CD54(ICAM-1) and CD106(VCAM-1) upregulation. IL-6 production and proliferation J. Leukocyte Biol. 58:209.
22. Kiener, P. A., P. Moran-Davis, B. M. Rankin, A. F. Wahl, A. Aruffo, and D. Hollenbauch. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917.
23. Caux, C., C. Massacrier, B. Banbervliet, B. Dubois, I. Van Kooten, C. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263.
24. Sekine, C., H. Yagita, N. Miyasaka, and K. Okumura. 1998. Expression and function of CD40 in rheumatoid arthritis synovium. J. Rheumatol. 25:1048.
25. Garrone, P., E. M. Neidhardt, E. Garcia, L Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265.
26. Hodgkin, P. D., L. C. Yamasshita, R. L. Coffman, and M. R. Kehry. 1990, Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J. Immunol. 145:2025.
27. Ferrara, N., J. Winer, T. Burton, A. Rowland, M. Siegel, H. S. Phillips, T. Terrell, G. A. Keller, and Q. D. Levinson. 1992. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J. Clin. Invest. 91:160.
28. MacDonald, K. P., Y. Nishioka, P. E. Lipsky, and R. Thomas. 1997. Functional CD40 ligand is expressed by T cells in rheumatoid arthritis. J. Clin. Invest. 100: 2404.
29. Schonbeck, U., F. Mach, J. Y. Bonnefoy, H. Loppnow, H. D. Flad, and P. Libby. 1997. Ligation of CD40 activates interleukin 1β-converting enzyme (caspase-1) activity in vascular smooth and endothelial cells and promotes elaboration of active interleukin 1beta. J. Biol. Chem. 272:19569.
30. 2 production in human lung fibroblasts. J. Immunol. 160:1053.
31. Lalmanach-Girard, A. C., T. C. Chiles, D. C. Parker, and T. L. Rothstein. 1993. T cell-dependent induction of NF-κB in B cells. J. Exp. Med. 177:1215.
32. Berberich, I., G. L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates NF-κB. J. Immunol. 153:4357.
33. Brostjan, C., J. Anrather, V. Csizmadia, G. Natarajan, and H. Winkler. 1997. Glucocorticoids inhibit E-selectin expression by targeting NF-κB and not ATF/ C-Jun. J. Immunol. 158:3836.
34. Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283.
35. Yuan, F., Y. Chen, M. Dellian, N Safabakhsh, N. Ferrara, and R. K. Jain. 1996. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by anti-vascular endothelial growth factor vascular permeability factor antibody. Proc. Nalt. Acad. Sci. USA 93:14765.
36. Dune, F. H., R. A. Fava, T M. Foy, A. Aruffo, J. A. Ledbetter, and R. J. Noelle. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 261:1328.
37. Stout, R. D., J. Suttles, J. Xu, I. S. Grewal, and R. A. Flavell. 1996. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 156:8.
38. Peacock, D. J., M. L. Banquerigo, and E. Brahn. 1992. Angiogenesis inhibition suppresses collagen arthritis. J. Exp. Med. 175:1135.
39. Storgard, C. M., D. G. Slupack, A Jonczyk, S. L. Goodman, R. I. Fox, and D. A. Cheresh. 1999. Decreased angiogenesis and arthritic disease in rabbits treated with an αv/β3 antagonist. J. Clin. Invest. 103:47.
40. Harigai, M., M. Hara, S. Nakazawa, C. Fukasawa, S. Ohta, T. Sugiura, K. Inoue, and S. Kashiwazaki. 1999. Ligation of CD40 induced tumor necrosis factor-α in rheumatoid arthritis: a novel mechanism of activation of synoviocytes. J Rheumatol. 26:1035.
41. Paleolog, E. M., S. Young, A. C. Stark, R. V. Mcclosky, M. F. Feldmann, and R. N. Maini. 1998. Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor α and interleukin-1 in rheumatoid arthritis. Arthritis Rheum. 41:1258.
42. Dechanet, J., C. Grosset, J.-L. Taupin, P. Merville, J. Banchereau, J. Ripoche, and J.-F. Moreau. 1997. CD40 ligand stimulate proinflammatory cytokine production by human endothelial cells. J. Immunol. 159:5640.
43. Ren, C. L., T. Mono, S. M. Fu, and R. S. Geha. 1994. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med. 179:673.
44. Paris, M., F. Gaskin, J. T. Parsons, and S. M. Fu. 1994. CD40 signalling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein. J. Exp. Med. 179:1923.
45. Francis, D. A., J. G. Karras, X. Ke, R. Sen, and T. L. Rothstein. 1995. Induction of the transcription factors NF-κB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol. 7:151.
46. Huo, L., and T. L. Rothstein. 1995. Receptor-specific induction of individual AP-1 components in B lymphocytes. J. Immunol. 154:3300.
47. Paliogianni, F., A. Raptis, S. S. Ahuja, S. M. Najjar, and D. T. Boumpas. 1993. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J. Clin. Invest. 91:1481.
48. Schreck, R., B. Meier, D. N. Mannel, W. Droge, and P. A. Baeuerle. 1992. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J Exp. Med. 175:1181.
49. Hankel, T., T. Machleidt, I. Alkalay, M. Kronke, Y. Ben Neriah, and P. A. Baeuerle. 1993. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365:182.