Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2456-2465

  Han, Changho ^a   Salyer, Amy E ^a   Kim, Eun Hoo ^a   Jiang, Xinyi ^a   Jarrard, Rachel E ^a   Powers, Matthew S ^b   Kirchhoff, Aaron M ^b   Salvador, Tolani K ^c   Chester, Julia A ^b   Hockerman, Gregory H ^a   Colby, David A ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPYL PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ALCOHOL; BACLOFEN; FLUORINE; HYDROGEN; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ALDOL REACTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; STARTLE REFLEX; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY; X RAY;

ANIMALS; BEHAVIOR, ANIMAL; FEMALE; GABA-B RECEPTOR AGONISTS; HALOGENATION; KETONES; MALE; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, GABA-B;

EID: 84875703174     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301805e     Document Type: Article

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