Efficient one-pot synthesis of the GABAB positive allosteric modulator (R,S)-5,7-Di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2- one

Synthetic Communications

Volumn 38, Issue 20, 2008, Pages 3398-3405

  Alker, Andre M ^a   Grillet, François ^a   Malherbe, Pari ^a   Norcross, Roger D ^a   Thomas, Andrew W ^a   Masciadri, Raffaello ^a,b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b NONE   (Switzerland)

Author keywords

(R,S) 5,7 Di tert butyl 3 hydroxy 3 trifluoromethyl 3H benzofuran 2 one; GABAB positive allosteric modulator; Gallium(III) chloride; One pot synthesis

Indexed keywords

2 (3,5 DI TERT BUTYL 2 HYDROXYPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY PROPIONIC ACID; 4 AMINOBUTYRIC ACID; 5 (3,5 DI TERT BUTYL 2 HYDROXYPHENYL) 3 ( 1 NAPTHALEN 1 YLETHYL) 5 TRIFLUOROMETHYLOXAZOLIDINE 2,4 DIONE; 5,7 DI TERT BUTYL 3 HYDROXY 3 TRIFLUOROMETHYL 3H BENZOFURAN 2 ONE; BENZOFURAN DERIVATIVE; GALLIUM CHLORIDE; LACTONE; LEWIS ACID; LITHIUM SALT; PHENOL DERIVATIVE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ONE POT SYNTHESIS; QUANTUM YIELD; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

EID: 53149100874     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910801979403     Document Type: Article

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