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Volumn 7, Issue 19, 2009, Pages 3947-3957

New organofluorine building blocks: Inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic α,α-difluoroketone hydrates

(7) Fäh, Christoph a Hardegger, Leo A a Baitsch, Lukas a Schweizer, W Bernd a Meyer, Solange b Bur, Daniel b Diederich, François a

a ETH ZURICH (Switzerland)

b ACTELION PHARMACEUTICALS LTD (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEASE; BINDING AFFINITIES; BIOLOGICAL ACTIVITIES; BUILDING BLOCKES; CONCENTRATION OF; CYCLOHEXANONES; DIFLUORINATED; DRUG-RESISTANT STRAINS; ENZYME ACTIVE SITES; H-BONDING NETWORKS; INITIAL VELOCITIES; NEW THERAPEUTIC AGENT; ORGANOFLUORINE; PEPTIDOMIMETICS; PLASMEPSIN II; PLASMEPSINS; PLASMODIUM PARASITES; PROTONATED; X RAY CRYSTAL STRUCTURES;

AMMONIUM COMPOUNDS; BINDING ENERGY; CRYSTAL STRUCTURE; EQUILIBRIUM CONSTANTS; HYDRATES;

HYDRATION;

ANTIMALARIAL AGENT; ASPARTIC PROTEINASE; FLUORINE; KETONE; PLASMEPSIN; PROTEINASE INHIBITOR; WATER;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; MALARIA; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTIMALARIALS; ASPARTIC ACID ENDOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; FLUORINE; HUMANS; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; WATER;

PLASMODIUM PARASITES;

EID: 70349293737 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b908489d Document Type: Article

Times cited : (43)

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