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Volumn 16, Issue 4, 2013, Pages 449-455

Low hippocampal PI(4,5)P 2 contributes to reduced cognition in old mice as a result of loss of MARCKS

Author keywords

[No Author keywords available]

Indexed keywords

MARCKS PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C GAMMA;

EID: 84875660704     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3342     Document Type: Article
Times cited : (54)

References (57)
  • 1
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • DOI 10.1126/science.278.5337.412
    • Morrison, J.H. & Hof, P.R. Life and death of neurons in the aging brain. Science 278, 412-419 (1997). (Pubitemid 27454417)
    • (1997) Science , vol.278 , Issue.5337 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 2
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain: Morphomolecular senescence of cortical circuits
    • DOI 10.1016/j.tins.2004.07.013, PII S0166223604002413
    • Hof, P.R. & Morrison, J.H. The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci. 27, 607-613 (2004). (Pubitemid 39221397)
    • (2004) Trends in Neurosciences , vol.27 , Issue.10 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 3
    • 84858702953 scopus 로고    scopus 로고
    • The ageing cortical synapse: Hallmarks and implications for cognitive decline
    • Morrison, J.H. & Baxter, M.G. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 13, 240-250 (2012).
    • (2012) Nat. Rev. Neurosci , vol.13 , pp. 240-250
    • Morrison, J.H.1    Baxter, M.G.2
  • 4
    • 33745514065 scopus 로고    scopus 로고
    • Cholesterol synthesis rate in human hippocampus declines with aging
    • DOI 10.1016/j.neulet.2006.04.034, PII S0304394006003892
    • Thelen, K.M., Falkai, P., Bayer, T.A. & Lutjohann, D. Cholesterol synthesis rate in human hippocampus declines with aging. Neurosci. Lett. 403, 15-19 (2006). (Pubitemid 43963235)
    • (2006) Neuroscience Letters , vol.403 , Issue.1-2 , pp. 15-19
    • Thelen, K.M.1    Falkai, P.2    Bayer, T.A.3    Lutjohann, D.4
  • 5
    • 0028099263 scopus 로고
    • Membrane lipids of adult human brain: Lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years
    • Svennerholm, L., Bostrom, K., Jungbjer, B. & Olsson, L. Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years. J. Neurochem. 63, 1802-1811 (1994). (Pubitemid 24326224)
    • (1994) Journal of Neurochemistry , vol.63 , Issue.5 , pp. 1802-1811
    • Svennerholm, L.1    Bostrom, K.2    Jungbjer, B.3    Olsson, L.4
  • 6
    • 0030868794 scopus 로고    scopus 로고
    • Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes
    • DOI 10.1007/s004010050717
    • Svennerholm, L., Bostrom, K. & Jungbjer, B. Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol. 94, 345-352 (1997). (Pubitemid 27450114)
    • (1997) Acta Neuropathologica , vol.94 , Issue.4 , pp. 345-352
    • Svennerholm, L.1    Bostrom, K.2    Jungbjer, B.3
  • 7
    • 79953150945 scopus 로고    scopus 로고
    • Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis
    • Trovó, L., Van Veldhoven, P.P., Martin, M.G. & Dotti, C.G. Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis. J. Cell Sci. 124, 1308-1315 (2011).
    • (2011) J. Cell Sci , vol.124 , pp. 1308-1315
    • Trovó, L.1    Van Veldhoven, P.P.2    Martin, M.G.3    Dotti, C.G.4
  • 9
    • 80053131218 scopus 로고    scopus 로고
    • + channel Kir2.2
    • Hansen, S.B., Tao, X. & MacKinnon, R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature 477, 495-498 (2011).
    • (2011) Nature , vol.477 , pp. 495-498
    • Hansen, S.B.1    Tao, X.2    MacKinnon, R.3
  • 10
    • 84875677339 scopus 로고    scopus 로고
    • Role of phosphoinositides at the neuronal synapse
    • Frere, S.G., Chang-Ileto, B. & Di Paolo, G. Role of phosphoinositides at the neuronal synapse. Subcell. Biochem. 59, 131-175 (2012).
    • (2012) Subcell. Biochem , vol.59 , pp. 131-175
    • Frere, S.G.1    Chang-Ileto, B.2    Di Paolo, G.3
  • 11
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • DOI 10.1038/nature05185, PII NATURE05185
    • Di Paolo, G. & De Camilli, P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657 (2006). (Pubitemid 44564702)
    • (2006) Nature , vol.443 , Issue.7112 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 12
    • 0036877968 scopus 로고    scopus 로고
    • Calcium stores and synaptic plasticity
    • DOI 10.1016/S0143416002001999
    • Fitzjohn, S.M. & Collingridge, G.L. Calcium stores and synaptic plasticity. Cell Calcium 32, 405-411 (2002). (Pubitemid 36175760)
    • (2002) Cell Calcium , vol.32 , Issue.5-6 , pp. 405-411
    • Fitzjohn, S.M.1    Collingridge, G.L.2
  • 14
    • 84859433559 scopus 로고    scopus 로고
    • Cholesterol loss during glutamate-mediated excitotoxicity
    • Sodero, A.O. et al. Cholesterol loss during glutamate-mediated excitotoxicity. EMBO J. 31, 1764-1773 (2012).
    • (2012) EMBO J , vol.31 , pp. 1764-1773
    • Sodero, A.O.1
  • 15
    • 0032523168 scopus 로고    scopus 로고
    • Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age- and stress-induced impairments in long-term potentiation
    • Murray, C.A. & Lynch, M.A. Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age-and stress-induced impairments in long-term potentiation. J. Neurosci. 18, 2974-2981 (1998). (Pubitemid 28163227)
    • (1998) Journal of Neuroscience , vol.18 , Issue.8 , pp. 2974-2981
    • Murray, C.A.1    Lynch, M.A.2
  • 16
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C
    • DOI 10.1146/annurev.biochem.70.1.281
    • Rhee, S.G. Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70, 281-312 (2001). (Pubitemid 32662212)
    • (2001) Annual Review of Biochemistry , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 17
    • 0032551746 scopus 로고    scopus 로고
    • Fodrin inhibits phospholipases A2, C, and D by decreasing polyphosphoinositide cell content
    • DOI 10.1006/bbrc.1998.8942
    • Lukowski, S., Mira, J.P., Zachowski, A. & Geny, B. Fodrin inhibits phospholipases A2, C and D by decreasing polyphosphoinositide cell content. Biochem. Biophys. Res. Commun. 248, 278-284 (1998). (Pubitemid 28386413)
    • (1998) Biochemical and Biophysical Research Communications , vol.248 , Issue.2 , pp. 278-284
    • Lukowski, S.1    Mira, J.-P.2    Zachowski, A.3    Geny, B.4
  • 19
    • 0027965240 scopus 로고
    • Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D
    • Liscovitch, M., Chalifa, V., Pertile, P., Chen, C.S. & Cantley, L.C. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J. Biol. Chem. 269, 21403-21406 (1994). (Pubitemid 24274764)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.34 , pp. 21403-21406
    • Liscovitch, M.1    Chalifa, V.2    Pertile, P.3    Chen, C.-S.4    Cantley, L.C.5
  • 20
    • 0032575524 scopus 로고    scopus 로고
    • Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
    • DOI 10.1074/jbc.273.35.22298
    • Pike, L.J. & Miller, J.M. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273, 22298-22304 (1998). (Pubitemid 28399788)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.35 , pp. 22298-22304
    • Pike, L.J.1    Miller, J.M.2
  • 21
    • 28444477387 scopus 로고    scopus 로고
    • Plasma membrane phosphoinositide organization by protein electrostatics
    • DOI 10.1038/nature04398
    • McLaughlin, S. & Murray, D. Plasma membrane phosphoinositide organization by protein electrostatics. Nature 438, 605-611 (2005). (Pubitemid 41740564)
    • (2005) Nature , vol.438 , Issue.7068 , pp. 605-611
    • McLaughlin, S.1    Murray, D.2
  • 22
    • 32944459983 scopus 로고    scopus 로고
    • Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain
    • DOI 10.1016/j.ymthe.2005.11.015, PII S1525001605017090
    • Cearley, C.N. & Wolfe, J.H. Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9 and Rh10 in the mouse brain. Mol. Ther. 13, 528-537 (2006). (Pubitemid 43257620)
    • (2006) Molecular Therapy , vol.13 , Issue.3 , pp. 528-537
    • Cearley, C.N.1    Wolfe, J.H.2
  • 23
    • 34249051111 scopus 로고    scopus 로고
    • Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    • DOI 10.1111/j.1474-9726.2007.00283.x
    • Foster, T.C. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell 6, 319-325 (2007). (Pubitemid 46785137)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 319-325
    • Foster, T.C.1
  • 24
    • 33947493213 scopus 로고    scopus 로고
    • Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: Minding the store
    • DOI 10.1111/j.1474-9726.2007.00295.x
    • Thibault, O., Gant, J.C. & Landfield, P.W. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell 6, 307-317 (2007). (Pubitemid 46785136)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 307-317
    • Thibault, O.1    Gant, J.C.2    Landfield, P.W.3
  • 25
    • 34249075140 scopus 로고    scopus 로고
    • Alterations in intrinsic neuronal excitability during normal aging
    • DOI 10.1111/j.1474-9726.2007.00297.x
    • Disterhoft, J.F. & Oh, M.M. Alterations in intrinsic neuronal excitability during normal aging. Aging Cell 6, 327-336 (2007). (Pubitemid 46785138)
    • (2007) Aging Cell , vol.6 , Issue.3 , pp. 327-336
    • Disterhoft, J.F.1    Oh, M.M.2
  • 27
    • 33645455342 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling
    • Gärtner, A. et al. Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J. Neurosci. 26, 3496-3504 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 3496-3504
    • Gärtner, A.1
  • 28
    • 34047178403 scopus 로고    scopus 로고
    • Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression
    • DOI 10.1523/JNEUROSCI.4340-06.2007
    • Horne, E.A. & Dell'Acqua, M.L. Phospholipase C is required for changes in postsynaptic structure and function associated with NMDA receptor-dependent long-term depression. J. Neurosci. 27, 3523-3534 (2007). (Pubitemid 46515123)
    • (2007) Journal of Neuroscience , vol.27 , Issue.13 , pp. 3523-3534
    • Horne, E.A.1    Dell'Acqua, M.L.2
  • 29
    • 33745145504 scopus 로고    scopus 로고
    • Myristoylated alanine rich C kinase substrate (MARCKS) hetetozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation
    • DOI 10.1002/hipo.20177
    • Hussain, R.J. et al. Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation. Hippocampus 16, 495-503 (2006). (Pubitemid 44712074)
    • (2006) Hippocampus , vol.16 , Issue.5 , pp. 495-503
    • Hussain, R.J.1    Stumpo, D.J.2    Balckshear, P.J.3    Lenox, R.H.4    Abel, T.5    McNamara, R.K.6
  • 30
    • 0032564337 scopus 로고    scopus 로고
    • Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background
    • McNamara, R.K. et al. Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background. Proc. Natl. Acad. Sci. USA 95, 14517-14522 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14517-14522
    • McNamara, R.K.1
  • 31
    • 0031406039 scopus 로고    scopus 로고
    • The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus
    • DOI 10.1016/S0028-3908(97)00181-0, PII S0028390897001810
    • Palmer, M.J., Irving, A.J., Seabrook, G.R., Jane, D.E. & Collingridge, G.L. The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36, 1517-1532 (1997). (Pubitemid 28085911)
    • (1997) Neuropharmacology , vol.36 , Issue.11-12 , pp. 1517-1532
    • Palmer, M.J.1    Irving, A.J.2    Seabrook, G.R.3    Jane, D.E.4    Collingridge, G.L.5
  • 32
    • 48249142346 scopus 로고    scopus 로고
    • Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro
    • Martin, M.G. et al. Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol. Biol. Cell 19, 2101-2112 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 2101-2112
    • Martin, M.G.1
  • 34
    • 67650345368 scopus 로고    scopus 로고
    • MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains
    • Yamaguchi, H. et al. MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains. J. Cell. Physiol. 220, 748-755 (2009).
    • (2009) J. Cell. Physiol , vol.220 , pp. 748-755
    • Yamaguchi, H.1
  • 35
    • 78751545856 scopus 로고    scopus 로고
    • The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells
    • Kalwa, H. & Michel, T. The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J. Biol. Chem. 286, 2320-2330 (2011).
    • (2011) J. Biol. Chem , vol.286 , pp. 2320-2330
    • Kalwa, H.1    Michel, T.2
  • 38
    • 56249139742 scopus 로고    scopus 로고
    • Regulation of postsynaptic AMPA responses by synaptojanin 1
    • Gong, L.W. & De Camilli, P. Regulation of postsynaptic AMPA responses by synaptojanin 1. Proc. Natl. Acad. Sci. USA 105, 17561-17566 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17561-17566
    • Gong, L.W.1    De Camilli, P.2
  • 39
    • 18344387548 scopus 로고    scopus 로고
    • EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
    • DOI 10.1038/ncb1252
    • Irie, F., Okuno, M., Pasquale, E.B. & Yamaguchi, Y. EphrinB-EphB signaling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat. Cell Biol. 7, 501-509 (2005). (Pubitemid 40637410)
    • (2005) Nature Cell Biology , vol.7 , Issue.5 , pp. 501-509
    • Irie, F.1    Okuno, M.2    Pasquale, E.B.3    Yamaguchi, Y.4
  • 40
    • 84862224363 scopus 로고    scopus 로고
    • Coupling exo-and endocytosis: An essential role for PIP(2) at the synapse
    • Koch, M. & Holt, M. Coupling exo-and endocytosis: an essential role for PIP(2) at the synapse. Biochim. Biophys. Acta 1821, 1114-1132 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1821 , pp. 1114-1132
    • Koch, M.1    Holt, M.2
  • 41
    • 84862778677 scopus 로고    scopus 로고
    • Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs
    • Kim, J.Y. et al. Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs. EMBO J. 31, 2144-2155 (2012).
    • (2012) EMBO J , vol.31 , pp. 2144-2155
    • Kim, J.Y.1
  • 43
    • 70449130430 scopus 로고    scopus 로고
    • A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells
    • Rivera, G.M., Vasilescu, D., Papayannopoulos, V., Lim, W.A. & Mayer, B.J. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol. Cell 36, 525-535 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 525-535
    • Rivera, G.M.1    Vasilescu, D.2    Papayannopoulos, V.3    Lim, W.A.4    Mayer, B.J.5
  • 44
    • 58149300222 scopus 로고    scopus 로고
    • Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching
    • Li, H., Chen, G., Zhou, B. & Duan, S. Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5- diphosphate signaling is critical for dendrite branching. Mol. Biol. Cell 19, 4804-4813 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4804-4813
    • Li, H.1    Chen, G.2    Zhou, B.3    Duan, S.4
  • 45
    • 0034717707 scopus 로고    scopus 로고
    • GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism
    • Laux, T. et al. GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149, 1455-1472 (2000).
    • (2000) J. Cell Biol. , vol.149 , pp. 1455-1472
    • Laux, T.1
  • 46
    • 25644436461 scopus 로고    scopus 로고
    • Essential role for the PKC target MARCKS in maintaining dendritic spine morphology
    • DOI 10.1016/j.neuron.2005.08.027, PII S0896627305007026
    • Calabrese, B. & Halpain, S. Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron 48, 77-90 (2005). (Pubitemid 41384167)
    • (2005) Neuron , vol.48 , Issue.1 , pp. 77-90
    • Calabrese, B.1    Halpain, S.2
  • 47
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta, S.R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997). (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 48
    • 0034175688 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal
    • Hetman, M., Cavanaugh, J.E., Kimelman, D. & Xia, Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J. Neurosci. 20, 2567-2574 (2000). (Pubitemid 30220344)
    • (2000) Journal of Neuroscience , vol.20 , Issue.7 , pp. 2567-2574
    • Hetman, M.1    Cavanaugh, J.E.2    Kimelman, D.3    Zhengui, X.4
  • 49
    • 0036237137 scopus 로고    scopus 로고
    • Akt phosphorylation and neuronal survival after traumatic brain injury in mice
    • DOI 10.1006/nbdi.2002.0482
    • Noshita, N., Lewen, A., Sugawara, T. & Chan, P.H. Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol. Dis. 9, 294-304 (2002). (Pubitemid 34442078)
    • (2002) Neurobiology of Disease , vol.9 , Issue.3 , pp. 294-304
    • Noshita, N.1    Lewen, A.2    Sugawara, T.3    Chan, P.H.4
  • 52
    • 51549108502 scopus 로고    scopus 로고
    • The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
    • Napoli, I. et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134, 1042-1054 (2008).
    • (2008) Cell , vol.134 , pp. 1042-1054
    • Napoli, I.1
  • 53
    • 0037442448 scopus 로고    scopus 로고
    • Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
    • DOI 10.1016/S0003-2697(02)00607-3
    • Gray, A., Olsson, H., Batty, I.H., Priganica, L. & Peter Downes, C. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. Anal. Biochem. 313, 234-245 (2003). (Pubitemid 36259947)
    • (2003) Analytical Biochemistry , vol.313 , Issue.2 , pp. 234-245
    • Gray, A.1    Olsson, H.2    Batty, I.H.3    Priganica, L.4    Downes, C.P.5
  • 54
    • 0035943628 scopus 로고    scopus 로고
    • Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components
    • Spizz, G. & Blackshear, P.J. Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components. J. Biol. Chem. 276, 32264-32273 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 32264-32273
    • Spizz, G.1    Blackshear, P.J.2
  • 55
    • 58149375379 scopus 로고    scopus 로고
    • Spred1 is required for synaptic plasticity and hippocampus-dependent learning
    • Denayer, E. et al. Spred1 is required for synaptic plasticity and hippocampus-dependent learning. J. Neurosci. 28, 14443-14449 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 14443-14449
    • Denayer, E.1
  • 56
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the Morris water maze in the study of learning and memory
    • DOI 10.1016/S0165-0173(01)00067-4, PII S0165017301000674
    • D'Hooge, R. & De Deyn, P.P. Applications of the Morris water maze in the study of learning and memory. Brain Res. Brain Res. Rev. 36, 60-90 (2001). (Pubitemid 32763130)
    • (2001) Brain Research Reviews , vol.36 , Issue.1 , pp. 60-90
    • D'Hooge, R.1    De Deyn, P.P.2
  • 57
    • 0031695813 scopus 로고    scopus 로고
    • Generalization of fear responses in C57BL/6N mice subjected to one- trial foreground contextual fear conditioning
    • DOI 10.1016/S0166-4328(98)00039-4, PII S0166432898000394
    • Radulovic, J., Kammermeier, J. & Spiess, J. Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning. Behav. Brain Res. 95, 179-189 (1998). (Pubitemid 28459047)
    • (1998) Behavioural Brain Research , vol.95 , Issue.2 , pp. 179-189
    • Radulovic, J.1    Kammermeier, J.2    Spiess, J.3


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