Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells

Scandinavian Journal of Immunology

Volumn 77, Issue 4, 2013, Pages 246-254

  Volchenkov, R ^a   Karlsen, M ^a   Jonsson, R ^a   Appel, S ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CALCITRIOL; DELTA15 PROSTAGLANDIN J2; DEXAMETHASONE; INTERLEUKIN 10; PROSTAGLANDIN J2; TRANSCRIPTION FACTOR FOXP3; TROGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL CULTURE; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY B CELL; REGULATORY T LYMPHOCYTE; SUPERNATANT; T LYMPHOCYTE; TOLEROGENIC DENDRITIC CELL;

B-LYMPHOCYTES, REGULATORY; CALCITRIOL; DENDRITIC CELLS; DEXAMETHASONE; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; INFLAMMATION; INTERLEUKIN-10; MACROPHAGES; PHENOTYPE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84875622341     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12039     Document Type: Article

References (40)

1. Cooper GS, Bynum ML, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun 2009;33:197-207.
2. Stoop JN, Robinson JH, Hilkens CM. Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models? Ann Rheum Dis 2011;70:1526-33.
3. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
4. Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000;191:411-6.
5. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003;21:685-711.
6. Torres-Aguilar H, Blank M, Jara LJ, Shoenfeld Y. Tolerogenic dendritic cells in autoimmune diseases: crucial players in induction and prevention of autoimmunity. Autoimmun Rev 2010;10:8-17.
7. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007;7:610-21.
8. Shevach EM. Regulatory T cells in autoimmmunity*. Annu Rev Immunol 2000;18:423-49.
9. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-42.
10. + regulatory T cells. J Immunol 2004;172:5986-93.
11. + T regulatory cells in humans. Hum Immunol 2005;66:13-20.
12. Gavin MA, Torgerson TR, Houston E et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci USA 2006;103:6659-64.
13. Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care 2011;34:2026-32.
14. Carter NA, Rosser EC, Mauri C. Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther 2012;14:R32.
15. Henry E, Desmet CJ, Garze V et al. Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma. J Immunol 2008;181:7230-42.
16. Martin E, Capini C, Duggan E et al. Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB. Arthritis Rheum 2007;56:2255-66.
17. Szeles L, Keresztes G, Torocsik D et al. 1, 25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol 2009;182:2074-83.
18. Appel S, Brossart P. Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. Endocr Metab Immune Disord Drug Targets 2007;7:93-7.
19. Boks MA, Kager-Groenland JR, Haasjes MS, Zwaginga JJ, van Ham SM, ten Brinke A. IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction-a comparative study of human clinical-applicable DC. Clin Immunol 2012;142:332-42.
20. Naranjo-Gomez M, Raich-Regue D, Onate C et al. Comparative study of clinical grade human tolerogenic dendritic cells. J Transl Med 2011;9:89.
21. Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, Hilkens CM. Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. Arthritis Rheum 2010;62:3656-65.
22. Karlsen M, Hovden AO, Vogelsang P, Tysnes BB, Appel S. Bromelain treatment leads to maturation of monocyte-derived dendritic cells but cannot replace PGE2 in a cocktail of IL-1beta, IL-6, TNF-alpha and PGE2. Scand J Immunol 2011;74:135-43.
23. Pordes AG, Baumgartner CK, Allacher P et al. T cell-independent restimulation of FVIII-specific murine memory B cells is facilitated by dendritic cells together with toll-like receptor 7 agonist. Blood 2011;118:3154-62.
24. Matasic R, Dietz AB, Vuk-Pavlovic S. Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J Leukoc Biol 1999;66:909-14.
25. Anderson AE, Swan DJ, Sayers BL et al. LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells. J Leukoc Biol 2009;85:243-50.
26. Collins AV, Brodie DW, Gilbert RJ et al. The interaction properties of costimulatory molecules revisited. Immunity 2002;17:201-10.
27. Sumpter TL, Thomson AW. The Status of PD-L1 (B7-H1) on tolerogenic APCs. Eur J Immunol 2011;41:286-90.
28. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
29. + regulatory T cells. Nat Immunol 2003;4:330-6.
30. + T cells. Eur J Immunol 2007;37:129-38.
31. Kmieciak M, Gowda M, Graham L et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med 2009;7:89.
32. van der Aar AM, Sibiryak DS, Bakdash G et al. Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J Allergy Clin Immunol 2011;127:1532-40 e7.
33. Guilliams M, Henri S, Tamoutounour S et al. From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets. Eur J Immunol 2010;40:2089-94.
34. Eynon EE, Parker DC. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J Exp Med 1992;175:131-8.
35. + phenotype controls T cell-dependent inflammatory responses. Immunity 2008;28:639-50.
36. Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003;197:489-501.
37. Evans JG, Chavez-Rueda KA, Eddaoudi A et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol 2007;178:7868-78.
38. Iwata Y, Matsushita T, Horikawa M et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117:530-41.
39. Blair PA, Norena LY, Flores-Borja F et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010;32:129-40.
40. Giannoukakis N, Trucco M. A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 2012;19:279-87.