Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells

Journal of Leukocyte Biology

Volumn 66, Issue 6, 1999, Pages 909-914

  Matasić, Richard ^a   Dietz, Allan B ^a   Vuk Pavlović, Stanimir ^a,b  

^a MAYO CLINIC CANCER CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Cell surface molecules; Cellular differentiation; Immunomodulators

Indexed keywords

CD14 ANTIGEN; CD36 ANTIGEN; CD68 ANTIGEN; CD83 ANTIGEN; CYTOKINE; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SUBPOPULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0033430255     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.6.909     Document Type: Article

References (31)

1. Auphan, N., DiDonato, J. A., Rosetti, C., Helmberg, A., Karin, M. (1995) Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270, 286-290.
2. Scheinman, R. I., Cogsweli, P. C., Lofquist, A. K., Baldwin, J. A. S. (1995) Rule of transcriptional activation of IκBa in mediation of immunosuppression by glucocorticoids. Science 270, 283-286.
3. Beg, A. A., Baltimore, D. (1996) An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784.
4. Byron, K. A., Varigos, G., Wootton, A. (1992) Hydrocortisone inhibition of human interleukin-4. Immunol. 77, 624-626.
5. Adcock, I. M., Brown, C. R., Gelder, C. M., Shirasaki, H., Peters, M. J., Barnes, P. J. (1995) Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am. J. Physiol. 268, C331-C338.
6. Paliogianni, F., Boumpas, D. T. (1995) Glucocorticoids regulate calcineurin-dependent trans-activating pathways for interleukin-2 gene transcription in human T lymphocytes. Transplant. 59, 1333-1339.
7. Yamaoka, K., Otsuka, T., Niiro, H., Arinobu, Y., Niho, Y., Hamasaki, N., Izuhara, K. (1998) Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes. J. Immunol. 160, 838-845.
8. Kitajima, T., Ariizumi, K., Bergstresser, P. R., Takashima, A. (1996) A novel mechanism of glucocorticoid-induced immune suppression: the inhibition of T cell-mediated terminal maturation of a murine dendritic cell line. J. Clin. Invest. 98, 142-147.
9. Lim, T. K., Chen, G. H., McDonald, R. A., Toews, G. B. (1996) Granulocyte-macrophage colony-stimulating factor overrides the immuno-suppressive function of corticosteroids on rat pulmonary dendritic cells. Stem Cells 14, 292-299.
10. Moser, M., De Smedt, T., Sornasse, T., Tielemans, F., Chentoufi, A. A., Muraille, E., Van Mechelen, M., Urbain, J., Leo, O. (1995) Glucocorticoids down-regulate dendritic cell function in vitro and in vivo. Eur. J. Immunol. 25, 2818-2824.
11. Holt, P. G., Thomas, J. A. (1997) Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells. Immunol. 91, 145-150.
12. Brokaw, J. J., White, G. W., Baluk, P., Anderson, G. P., Umemoto, E. Y., McDonald, D. M. (1998) Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa. Am. J. Respir. Cell Mol. Biol. 19, 598-605.
13. Nelson, D. J., McWilliam, A. S., Haining, S., Holt, P. G. (1995) Modulation of airway intraepithelial dendritic cell following exposure to steroids. Am. J. Respir. Crit. Care Med. 151, 475-481.
14. Vieira, P. L., Kalinski, P., Wierenga, E. A., Kapsenberg, M. L., de Jong, E. C. (1998) Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. J. Immunol. 161, 5245-5251.
15. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
16. Thomas, R., Quinn, C. (1996) Functional differentiation of dendritic cells in rheumatoid arthritis: Role of CD86 in the synovium. J. Immunol. 156, 3074-3086.
17. Fernandez, N. C., Lozier, A., Flament, C., Ricciardi-Castagnoli, P., Bellet, D., Suter, M., Perricaudet, M., Tursz, T., Maraskovsky, E., Zitvogel, L. (1999) Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vitro. Nature Med. 5, 405-411.
18. Jonuleit, H., Kuhn, U., Muller, G., Steinbrink, K., Paragnik, L., Schmitt, E., Knop, J., Enk, A. H. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27, 3135-3142.
19. Gardner, A. M., Xu, F. H., Fady, C., Jacoby, F. J., Duffey, D. C., Tu, Y., Lichtenstein, A. (1997) Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Rad. Biol. Med. 22, 73-83.
20. 2+ and reactive oxygen intermediates as messengers. FEBS Lett. 392, 129-136.
21. Verhoven, B., Schlegel, R. A., Williamson, P. (1995) Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J. Exp. Med. 182, 1597-1601.
22. Sharp, A. M., Walters, C. A., Wong, S. D., Caterson, I. D. (1992) RIMA and RIA compared for assessing dexamethasone suppression of corticotropin in plasma. Clin. Chem. 38, 149.
23. Oyama, T., Ran, S., Ishida, T., Nadaf, S., Kerr, L., Carbone, D. P., Gabrilovich, D. I. (1998) Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232.
24. Rescigno, M., Martino, M., Sutherland, C. L. Gold, M. R., Ricciardi-Castagnoli, R. (1998) Dendritic cell survival and maturation are regulated by different signaling pathways. J. Exp. Med. 188, 2175-2180.
25. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., Verma, I. M. (1996) Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789.
26. Wallach, D. (1997) Cell death induction by TNF: a matter of self control. Trends Biol. Sci. 22, 107-109.
27. Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., Fitzgerald, M. J., Rothstein, T. L., Sherr, D. H. (1996) Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15, 4682-4690.
28. Bellosillo, B., Pique, M., Barragan, M., Castano, E., Villamor, N., Colomer, D., Montserrat, E., Pons, G., Gil, J. (1998) Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood 92, 1406-1414.
29. Kishimotu, T., Kikutani, H., von dem Borne, A. E. G. K., Goyert, S. M., Mason, D. Y., Miyasaka, M., Moretta, L., Okumura, K., Shaw, S., Springer, T. A., Sugamura, K., Zola, H. (1997) White cell differentiation antigens. In Leukocyte Typing, Volume VI, New York: Garland.
30. Goerdt, S., Orfanos, C. E. (1999) Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10, 137-142.
31. Piemonti, L., Monti, P., Allavena, P., Sironi, M., Soldini, L., Leone, B. E., Socci, C., Di Carlo, V. (1999) Glucocorticoids affect human dendritic cell differentiation and maturation. J. Immunol. 162, 6473-6481.