메뉴 건너뛰기




Volumn , Issue , 2009, Pages 335-348

In Vitro and In Vivo Models for Nanotoxicity Testing

Author keywords

Energy dispersive X ray analysis (EDXA); Engineered nanoparticles (NP) and nanodevices and fate of materials; in vitro and in vivo exposure settings; in vitro and in vivo models for nanotoxicity testing; Intratracheally instilled single walled carbon nanotubes (SWCNTs) and pulmonary toxicity; Nanoparticle deposition in lungs; Nanoparticles and inhalation exposure; OECD (Organization for Economic Co operation and Development) guidelines; Oral exposure gastrointestinal tract; Size dependent and chemical specific toxicity

Indexed keywords


EID: 84875618250     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747803.ch17     Document Type: Chapter
Times cited : (4)

References (60)
  • 1
    • 0033660576 scopus 로고    scopus 로고
    • Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100)
    • Allen DG, Riviere JE, Monteiro-Riviere NA (2000) Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100). J Biochem Mol Toxicol 14, 231-237.
    • (2000) J Biochem Mol Toxicol , vol.14 , pp. 231-237
    • Allen, D.G.1    Riviere, J.E.2    Monteiro-Riviere, N.A.3
  • 2
    • 33748762270 scopus 로고    scopus 로고
    • Respiratory peripheral chemosensory irritation, acute and repeated exposure toxicity studies with aerosols of triethylene glycol
    • Ballantyne B, Snelling WM, Norris JC (2006) Respiratory peripheral chemosensory irritation, acute and repeated exposure toxicity studies with aerosols of triethylene glycol. J Appl Toxicol 26, 387-396.
    • (2006) J Appl Toxicol , vol.26 , pp. 387-396
    • Ballantyne, B.1    Snelling, W.M.2    Norris, J.C.3
  • 3
    • 6344229772 scopus 로고    scopus 로고
    • Toxicological hazards of inhaled nanoparticles -potential implications for drug delivery
    • Borm PJ, Kreyling W (2004) Toxicological hazards of inhaled nanoparticles -potential implications for drug delivery. J Nanosci Nanotechnol 4, 521-531.
    • (2004) J Nanosci Nanotechnol , vol.4 , pp. 521-531
    • Borm, P.J.1    Kreyling, W.2
  • 5
    • 55949113520 scopus 로고    scopus 로고
    • Unique cellular interaction of silver nanoparticles: Size dependent generation of reactive oxygen species
    • Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess K, Schlager JJ (2008) Unique cellular interaction of silver nanoparticles: Size dependent generation of reactive oxygen species. J Phys Chem 112, 13608-13619.
    • (2008) J Phys Chem , vol.112 , pp. 13608-13619
    • Carlson, C.1    Hussain, S.M.2    Schrand, A.M.3    Braydich-Stolle, L.K.4    Hess, K.5    Schlager, J.J.6
  • 6
    • 0344530200 scopus 로고    scopus 로고
    • Sodium chloride modified silica nanoparticles as a non-viral vector with a high efficiency of DNA transfer into cells
    • Chen Y, Xue Z, Zheng D, Xia K, Zhao Y, Liu T, Long Z, Xia J (2003) Sodium chloride modified silica nanoparticles as a non-viral vector with a high efficiency of DNA transfer into cells. Curr Gene Ther 3, 273-279.
    • (2003) Curr Gene Ther , vol.3 , pp. 273-279
    • Chen, Y.1    Xue, Z.2    Zheng, D.3    Xia, K.4    Zhao, Y.5    Liu, T.6    Long, Z.7    Xia, J.8
  • 7
    • 67650951077 scopus 로고    scopus 로고
    • In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblast
    • spec. issue
    • Dechsakulthorn F, Hayes A, Bakand S, Joeng L, Winder C (2007) In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblast. AATEX 14 (spec. issue), 397-400.
    • (2007) AATEX , vol.14 , pp. 397-400
    • Dechsakulthorn, F.1    Hayes, A.2    Bakand, S.3    Joeng, L.4    Winder, C.5
  • 8
    • 20744454954 scopus 로고    scopus 로고
    • Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium
    • des Rieux A, Ragnarsson EG, Gullberg E, Preat V, Schneider YJ, Artursson P (2005) Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium. Eur J Pharm Sci 25, 455-465.
    • (2005) Eur J Pharm Sci , vol.25 , pp. 455-465
    • Des Rieux, A.1    Ragnarsson, E.G.2    Gullberg, E.3    Preat, V.4    Schneider, Y.J.5    Artursson, P.6
  • 9
    • 33947265152 scopus 로고    scopus 로고
    • An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells
    • des Rieux A, Fievez V, Theate I, Mast J, Preat V, Schneider YJ (2007) An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. Eur J Pharm Sci 30, 380-391.
    • (2007) Eur J Pharm Sci , vol.30 , pp. 380-391
    • Des Rieux, A.1    Fievez, V.2    Theate, I.3    Mast, J.4    Preat, V.5    Schneider, Y.J.6
  • 11
    • 0034107229 scopus 로고    scopus 로고
    • Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations
    • Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB (2000) Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 55, 24-35.
    • (2000) Toxicol Sci , vol.55 , pp. 24-35
    • Driscoll, K.E.1    Costa, D.L.2    Hatch, G.3    Henderson, R.4    Oberdorster, G.5    Salem, H.6    Schlesinger, R.B.7
  • 13
    • 0035478442 scopus 로고    scopus 로고
    • Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas
    • Florence AT, Hussain N (2001) Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev 50 (Suppl. 1), S69-S89.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.SUPPL. 1
    • Florence, A.T.1    Hussain, N.2
  • 16
    • 33751171961 scopus 로고    scopus 로고
    • Identification of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches
    • Gullberg E, Keita AV, Salim SY, Andersson M, Caldwell KD, Soderholm JD, Artursson P (2006) Identification of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches. J Pharmacol Exp Ther 319, 632-639.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 632-639
    • Gullberg, E.1    Keita, A.V.2    Salim, S.Y.3    Andersson, M.4    Caldwell, K.D.5    Soderholm, J.D.6    Artursson, P.7
  • 17
    • 23944463473 scopus 로고    scopus 로고
    • Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    • Gurr JR, Wang AS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213, 66-73.
    • (2005) Toxicology , vol.213 , pp. 66-73
    • Gurr, J.R.1    Wang, A.S.2    Chen, C.H.3    Jan, K.Y.4
  • 18
    • 32044451341 scopus 로고    scopus 로고
    • A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors
    • Hardman R (2006) A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors. Environ Health Perspect 114, 165-172.
    • (2006) Environ Health Perspect , vol.114 , pp. 165-172
    • Hardman, R.1
  • 20
    • 0028235218 scopus 로고
    • Comparative, quantitative study of lymphoid and nonlymphoid uptake of 60 nm polystyrene particles
    • Hillery AM, Jani PU, Florence AT (1994) Comparative, quantitative study of lymphoid and nonlymphoid uptake of 60 nm polystyrene particles. J Drug Target 2, 151-156.
    • (1994) J Drug Target , vol.2 , pp. 151-156
    • Hillery, A.M.1    Jani, P.U.2    Florence, A.T.3
  • 21
    • 0035206137 scopus 로고    scopus 로고
    • Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    • Hillyer JF, Albrecht RM (2001) Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90, 1927-1936.
    • (2001) J Pharm Sci , vol.90 , pp. 1927-1936
    • Hillyer, J.F.1    Albrecht, R.M.2
  • 23
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
    • Hussain N, Jaitley V, Florence AT (2001) Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv Drug Deliv Rev 50, 107-142.
    • (2001) Adv Drug Deliv Rev , vol.50 , pp. 107-142
    • Hussain, N.1    Jaitley, V.2    Florence, A.T.3
  • 24
    • 0024953407 scopus 로고
    • The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
    • Jani P, Halbert GW, Langridge J, Florence AT (1989) The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J Pharm Pharmacol 41, 809-812.
    • (1989) J Pharm Pharmacol , vol.41 , pp. 809-812
    • Jani, P.1    Halbert, G.W.2    Langridge, J.3    Florence, A.T.4
  • 28
    • 1542726626 scopus 로고    scopus 로고
    • Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    • Lam CW, James JT, McCluskey R, Hunter RL (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77, 126-134.
    • (2004) Toxicol Sci , vol.77 , pp. 126-134
    • Lam, C.W.1    James, J.T.2    McCluskey, R.3    Hunter, R.L.4
  • 29
    • 34648836736 scopus 로고    scopus 로고
    • Comparative study on the acute pulmonary toxicity induced by 3 and 20nm TiO2 primary particles in mice
    • Li J, Li Q, Xu J, Li J, Cai X, Liu R, Li Y, Ma J, Li W (2007) Comparative study on the acute pulmonary toxicity induced by 3 and 20nm TiO2 primary particles in mice. Environ Toxicol Pharmacol 24, 239-244.
    • (2007) Environ Toxicol Pharmacol , vol.24 , pp. 239-244
    • Li, J.1    Li, Q.2    Xu, J.3    Li, J.4    Cai, X.5    Liu, R.6    Li, Y.7    Ma, J.8    Li, W.9
  • 30
    • 33845218637 scopus 로고    scopus 로고
    • In vitro toxicity of silica nanoparticles in human lung cancer cells
    • Lin W, Huang YW, Zhou XD, Ma Y (2006) In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 217, 252-259.
    • (2006) Toxicol Appl Pharmacol , vol.217 , pp. 252-259
    • Lin, W.1    Huang, Y.W.2    Zhou, X.D.3    Ma, Y.4
  • 31
    • 33745481652 scopus 로고    scopus 로고
    • Surfactant effects on carbon nanotube interactions with human keratinocytes
    • Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ (2005a) Surfactant effects on carbon nanotube interactions with human keratinocytes. Nanomedicine 1, 293-299.
    • (2005) Nanomedicine , vol.1 , pp. 293-299
    • Monteiro-Riviere, N.A.1    Inman, A.O.2    Wang, Y.Y.3    Nemanich, R.J.4
  • 33
    • 38149135806 scopus 로고    scopus 로고
    • Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    • Murdock RC, Braydich-Stolle L, Schrand AM, Schlager JJ, Hussain SM (2008) Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicol Sci 101, 239-253.
    • (2008) Toxicol Sci , vol.101 , pp. 239-253
    • Murdock, R.C.1    Braydich-Stolle, L.2    Schrand, A.M.3    Schlager, J.J.4    Hussain, S.M.5
  • 34
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311, 622-627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 35
    • 0034369123 scopus 로고    scopus 로고
    • Toxicology of ultrafine particles: in vivo studies
    • Oberdörster G (2000) Toxicology of ultrafine particles: in vivo studies. Phil Trans R Soc A 358, 2719-2740.
    • (2000) Phil Trans R Soc A , vol.358 , pp. 2719-2740
    • Oberdörster, G.1
  • 36
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    • Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113, 823-839.
    • (2005) Environ Health Perspect , vol.113 , pp. 823-839
    • Oberdörster, G.1    Oberdörster, E.2    Oberdörster, J.3
  • 37
    • 17344388294 scopus 로고    scopus 로고
    • Intratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response
    • Osier M, Baggs RB, Oberdörster G (1997) Intratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response. Environ Health Perspect 105 (Suppl. 5), 1265-1271.
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 5 , pp. 1265-1271
    • Osier, M.1    Baggs, R.B.2    Oberdörster, G.3
  • 40
    • 0035734318 scopus 로고    scopus 로고
    • The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
    • Pflucker F, Wendel V, Hohenberg H, Gartner E, Will T, Pfeiffer S, Wepf R, Gers-Barlag H (2001) The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacol Appl Skin Physiol 14 (Suppl. 1), 92-97.
    • (2001) Skin Pharmacol Appl Skin Physiol , vol.14 , Issue.SUPPL. 1 , pp. 92-97
    • Pflucker, F.1    Wendel, V.2    Hohenberg, H.3    Gartner, E.4    Will, T.5    Pfeiffer, S.6    Wepf, R.7    Gers-Barlag, H.8
  • 41
    • 2442498325 scopus 로고    scopus 로고
    • Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types
    • Renwick LC, Brown D, Clouter A, Donaldson K (2004) Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 61, 442-447.
    • (2004) Occup Environ Med , vol.61 , pp. 442-447
    • Renwick, L.C.1    Brown, D.2    Clouter, A.3    Donaldson, K.4
  • 42
    • 33645800783 scopus 로고    scopus 로고
    • Penetration of intact skin by quantum dots with diverse physicochemical properties
    • Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA (2006) Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol Sci 91, 159-165.
    • (2006) Toxicol Sci , vol.91 , pp. 159-165
    • Ryman-Rasmussen, J.P.1    Riviere, J.E.2    Monteiro-Riviere, N.A.3
  • 43
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • Sayes CM, Reed KL, Warheit DB (2007) Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 97, 163-180.
    • (2007) Toxicol Sci , vol.97 , pp. 163-180
    • Sayes, C.M.1    Reed, K.L.2    Warheit, D.B.3
  • 44
    • 28844492553 scopus 로고    scopus 로고
    • Nanotechnology. Calls rise for more research on toxicology of nanomaterials
    • Service RF (2005) Nanotechnology. Calls rise for more research on toxicology of nanomaterials. Science 310, 1609.
    • (2005) Science , vol.310 , pp. 1609
    • Service, R.F.1
  • 46
    • 32744466260 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic effects of single wall carbon nanotube exposure on human keratinocytes and bronchial epithelial cells
    • 227th ACS NationalMeeting, March 28-April 1, 2004, Anaheim, CA
    • Shvedova AA, Kisin E, Keshava N, Murray AR, Gorelik AO, Arepalli S, Gandelsman VZ, Castranova V (2004a) Cytotoxic and genotoxic effects of single wall carbon nanotube exposure on human keratinocytes and bronchial epithelial cells. 227th ACS NationalMeeting, March 28-April 1, 2004, Anaheim, CA.
    • (2004)
    • Shvedova, A.A.1    Kisin, E.2    Keshava, N.3    Murray, A.R.4    Gorelik, A.O.5    Arepalli, S.6    Gandelsman, V.Z.7    Castranova, V.8
  • 47
    • 22144458072 scopus 로고    scopus 로고
    • Exposure of human bronchial cells to carbon nanotubes caused oxidative stress and cytotoxicity
    • Proceedings of the Meeting of the SFRR Europe, June 26-29, 2003
    • Shvedova A, Kisin E, Murray A, Schwegler-Berry D, Gandelsman V, Baron P, Maynard A, Gunter M, Castranova V (2004b) Exposure of human bronchial cells to carbon nanotubes caused oxidative stress and cytotoxicity. Proceedings of the Meeting of the SFRR Europe, June 26-29, 2003.
    • (2004)
    • Shvedova, A.1    Kisin, E.2    Murray, A.3    Schwegler-Berry, D.4    Gandelsman, V.5    Baron, P.6    Maynard, A.7    Gunter, M.8    Castranova, V.9
  • 52
    • 27944471462 scopus 로고    scopus 로고
    • In vitro cytotoxicity of nanoparticles in mammalian germ-line stem cell
    • Vinardell MP (2005) In vitro cytotoxicity of nanoparticles in mammalian germ-line stem cell. Toxicol Sci 88, 285-286.
    • (2005) Toxicol Sci , vol.88 , pp. 285-286
    • Vinardell, M.P.1
  • 56
    • 33645823891 scopus 로고    scopus 로고
    • Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area
    • Warheit DB, Webb TR, Sayes CM, Colvin VL, Reed KL (2006) Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci 91, 227-236.
    • (2006) Toxicol Sci , vol.91 , pp. 227-236
    • Warheit, D.B.1    Webb, T.R.2    Sayes, C.M.3    Colvin, V.L.4    Reed, K.L.5
  • 57
    • 33845613217 scopus 로고    scopus 로고
    • Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics
    • Warheit DB, Webb TR, Colvin VL, Reed KL, Sayes CM (2007a) Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci 95, 270-280.
    • (2007) Toxicol Sci , vol.95 , pp. 270-280
    • Warheit, D.B.1    Webb, T.R.2    Colvin, V.L.3    Reed, K.L.4    Sayes, C.M.5
  • 58
    • 33846110902 scopus 로고    scopus 로고
    • Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties
    • Warheit DB, Webb TR, Reed KL, Frerichs S, Sayes CM (2007b) Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties. Toxicology 230, 90-104.
    • (2007) Toxicology , vol.230 , pp. 90-104
    • Warheit, D.B.1    Webb, T.R.2    Reed, K.L.3    Frerichs, S.4    Sayes, C.M.5
  • 60
    • 24044447605 scopus 로고    scopus 로고
    • The chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption
    • Zhou Y, Yokel RA (2005) The chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption. Toxicol Sci 87, 15-26.
    • (2005) Toxicol Sci , vol.87 , pp. 15-26
    • Zhou, Y.1    Yokel, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.