Hypoxia-inducible factor-1α suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion

Oncology Research

Volumn 20, Issue 5-6, 2013, Pages 213-220

  Xu, Zongquan ^a   Chen, Xiaoping ^b   Peng, Cheng ^a   Liu, Enyu ^a   Li, Yunguang ^a   Li, Changhai ^b   Niu, Jun ^a  

^a SHANDONG UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

HepG2 cell apoptosis; Hypoxia inducible factor 1 (HIF 1 ); Omi HtrA2

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROTEIN BCL 2; SERINE PROTEINASE; SERINE PROTEINASE OMI;

APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN HEPG2; HUMAN; HUMAN CELL; HYPOXIA; LIVER CELL CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

EID: 84875606817     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504013X13589503482815     Document Type: Article

References (26)

1. Wang, G. L.; Jiang, B. H.; Rue, E. A.; Semenza, G. L. Hypoxia-inducible factor 1 is basic-helix -loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92: 5510-5514; 1995.
2. Ema, M.; Taya, S.; Yokotani, N.; Sogawa, K.; Matsuda, Y.; Fujii-Kuriyama, Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1a regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. USA 94: 4273-4278; 1997.
3. Tian, H.; McKnight, S. L.; Russell, D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11: 72-82; 1997.
4. Salceda, S.; Caro, J. Hypoxia-inducible factor 1a (HIF-1a) protein is rapidly degraded by the ubiquitin-protea-some system under normoxic conditions its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272: 22642-22647; 1997.
5. Huang, L. E.; Gu, J.; Schau, M.; Bunn, H. F. Regulation of hypoxia-inducible factor 1a is mediated by an O2-dependent degradation domain via the ubiquitin-protea-some pathway. Proc. Natl. Acad. Sci. USA 95: 7987-7992; 1998.
6. Kallio, P. J.; Wilson, W. J.; O'Brien, S.; Makino, Y.; Poellinger, L. Regulation of the hypoxia-inducible transcription factor 1a by the ubiquitin-proteasome pathway. J. Biol. Chem. 274: 6519-6525; 1999.
7. Semenza, G. L. HIF-1: Using two hands to flip the angio-genic switch. Cancer Metastasis Rev. 19: 59-65; 2000.
8. Grosfeld, A.; Andre, J.; Hauguel-De Mouzon, S.; Berra, E.; Pouyssegur, J.; Guerre-Millo, M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J. Biol. Chem. 277: 42953-42957; 2002.
9. Wenger, R. H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J. 16: 1151-1162; 2002.
10. Bracken, C. P.; Whitelaw, M. L.; Peet, D. J. The hypoxia-inducible factors: Key transcriptional regulators of hyp-oxic responses. Cell. Mol. Life Sci. 60: 1376-1393; 2003.
11. Suzuki, Y.; Imai, Y.; Nakayama, H.; Takahashi, K.; Takio, K.; Takahashi, R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8: 613-621; 2001.
12. Hegde, R.; Srinivasula, S. M.; Zhang, Z. J.; Wassell, R.; Mukattash, R.; Cilenti, L.; et al. Identification of Omi/ HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277: 432-438; 2002.
13. Martins, L. M.; Ingram, Iaccarino, I.; Tenev, T.; GsGchmeissner, S.; Totty, N. F.; Lemoine, N. R.; et al. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif. J. Biol. Chem. 277: 439-444; 2002.
14. Verhagen, A. M.; Silke, J.; Ekert, P. G.; Pakusch, M.; Kaufmann, H.; Connolly, L. M.; et al. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277: 445-454; 2002.
15. Faccio, L.; Fusco, C.; Viel, A.; Zervos, A. S. Tissue specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif. Genomics 68: 343-347; 2000.
16. Li, W.; Srinivasula, S. M.; Chai, J.; Li, P.; Wu, J.; Zhang, J.; et al. Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat. Struct. Biol. 9: 436-441; 2002.
17. Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ. 11: 208-216; 2004.
18. Xu, Z.; Chen, X.; Niu, J.; Liu, E.; Li, C.; Peng, C. The prognostic significance of Omi/HtrA2 expression and correlation between Omi/HtrA2 and HIF-1a in primary hepa-tocelluar carcinoma cells. Chin. J. Surg. 1: 49-52; 2012.
19. Gossen, M.; Freundlieb, S.; Bender, G.; Muller, G.; Hillen, W.; Bujard, H. Transcriptional activation by tetracyclines in mammalian cells. Science 268: 1766-1769; 1995.
20. Gossen, M.; Bujard, H. Tight control of gene expression in mammalian cells by tetracycline responsive promoters. Proc. Natl. Acad. Sci. USA 89: 5547-5551; 1992.
21. Zhang, Q.; Zhang, Z. F.; Rao, J. Y.; Sato, J. D.; Brown, J.; Messadi, D. V.; Le, A. D. Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int. J. Cancer 111: 849-857; 2004.
22. Greijer, A. E.; Van der Wall, E. The role of hypoxia inducible factor-1 (HIF-1) in hypoxia induced apoptosis. J. Clin. Pathol. 57: 1009-1014; 2004.
23. Gillet, R.; Grimber, G.; Cavard, C.; Bennoun, M.; Mignon, A.; Briand, P.; Joulin, V. Effect of Bcl-2 expression on hepatic preneoplasia in mice. Cancer Letts. 177: 1891; 2002.
24. Gray, C. W.; Ward, R. V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; et al. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur. J. Biochem. 267: 5699-5710; 2000.
25. Liu, Z.; Sun, C.; Olejniczak, E. T.; Meadows, R. P.; Betz, S. F.; Oost, T.; et al. Structural basis for binding of Smac/ DIABLO to the XIAP BIR3 domain. Nature 408: 1004-1008; 2000.
26. Wu, G.; Chai, J.; Suber, T. L.; Wu, J. W.; Du, C.; Wang, X.; et al. Structural basis of IAP recognition by Smac/ DIABLO. Nature 408: 1008-1012; 2000.