Human monocyte-derived macrophages spontaneously differentiated in vitro show distinct phenotypes

Journal of Cellular Physiology

Volumn 228, Issue 7, 2013, Pages 1464-1472

  Eligini, Sonia ^a   Crisci, Mauro ^a   Bono, Elisa ^a   Songia, Paola ^a   Tremoli, Elena ^a,b   Colombo, Gualtiero I ^a   Colli, Susanna ^b  

^a CENTRO CARDIOLOGICO MONZINO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD163 ANTIGEN; CHEMOKINE; CHEMOKINE CCL18; EOTAXIN 2; INTERLEUKIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL ISOLATION; CYTOCHEMISTRY; CYTOSKELETON; ENDOCYTOSIS; EOSINOPHIL; FLOW CYTOMETRY; FLUORESCENCE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LASER MICROSCOPY; LEUKEMIA CELL LINE; LIPID COMPOSITION; LYMPHOCYTE ACTIVATION; MACROPHAGE; MONOCYTE DERIVED MACROPHAGE; MORPHOTYPE; PHENOTYPE; PINOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY BURST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SPINDLE CELL;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOPTOSIS; CELL DIFFERENTIATION; CELL SHAPE; CHEMOKINES; CYTOKINES; CYTOSKELETON; ENDOCYTOSIS; HUMANS; INTERLEUKIN-10; JURKAT CELLS; LIPID METABOLISM; MACROPHAGES; PHENOTYPE; RECEPTORS, CELL SURFACE; RESPIRATORY BURST; TRANSCRIPTOME;

EID: 84875509475     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24301     Document Type: Article

References (61)

1. Adamson S, Leitinger N. 2011. Phenotypic modulation of macrophages in response to plaque lipids. Curr Opin Lipidol 22: 335-342.
2. Adorni MP, Favari E, Ronda N, Granata A, Bellosta S, Arnaboldi L, Corsini A, Gatti R, Bernini F. 2011. Free cholesterol alters macrophage morphology and mobility by an ABCA1 dependent mechanism. Atherosclerosis 215: 70-76.
3. Akagawa KS. 2002. Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages. Int J Hematol 76: 27-34.
4. Ancuta P, Wang J, Gabuzda D. 2006. CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells. J Leukoc Biol 80: 1156-1164.
5. Andersen CL, Jensen JL, Orntoft TF. 2004. Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64: 5245-5250.
6. Barbieri SS, Eligini S, Brambilla M, Tremoli E, Colli S. 2003. Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation: Critical role of NADPH oxidase. Cardiovasc Res 60: 187-197.
7. Benoit M, Desnues B, Mege JL. 2008. Macrophage polarization in bacterial infections. J Immunol 181: 3733-3739.
8. Colli S, Lalli M, Rise P, Mussoni L, Eligini S, Galli C, Tremoli E. 1999. Increased thrombogenic potential of human monocyte-derived macrophages spontaneously transformed into foam cells. Thromb Haemost 81: 576-581.
9. Couper KN, Blount DG, Riley EM. 2008. IL-10: The master regulator of immunity to infection. J Immunol 180: 5771-5777.
10. Daigneault M, Preston JA, Marriott HM, Whyte MK, Dockrell DH. 2010. The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS ONE 5: e8668.
11. De Nichilo MO, Burns GF. 1993. Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages. Proc Natl Acad Sci USA 90: 2517-2521.
12. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. 1998. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 101: 890-898.
13. Fujita E, Shimizu A, Masuda Y, Kuwahara N, Arai T, Nagasaka S, Aki K, Mii A, Natori Y, Iino Y, Katayama Y, Fukuda Y. 2010. Statin attenuates experimental anti-glomerular basement membrane glomerulonephritis together with the augmentation of alternatively activated macrophages. Am J Pathol 177: 1143-1154.
14. Gordon S, Taylor PR. 2005. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964.
15. Guetta J, Strauss M, Levy NS, Fahoum L, Levy AP. 2007. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis 191: 48-53.
16. Hagg DA, Olson FJ, Kjelldahl J, Jernas M, Thelle DS, Carlsson LM, Fagerberg B, Svensson PA. 2009. Expression of chemokine (C-C motif) ligand 18 in human macrophages and atherosclerotic plaques. Atherosclerosis 204: e15-e20.
17. Heusinkveld M, de Vos van Steenwijk PJ, Goedemans R, Ramwadhdoebe TH, Gorter A, Welters MJ, van Hall T, van der Burg SH. 2011. M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol 187: 1157-1165.
18. Jaqaman K, Kuwata H, Touret N, Collins R, Trimble WS, Danuser G, Grinstein S. 2011. Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell 146: 593-606.
19. Johnson JL, Newby AC. 2009. Macrophage heterogeneity in atherosclerotic plaques. Curr Opin Lipidol 20: 370-378.
20. Kerr MC, Teasdale RD. 2009. Defining macropinocytosis. Traffic 10: 364-371.
21. Khandani A, Eng E, Jongstra-Bilen J, Schreiber AD, Douda D, Samavarchi-Tehrani P, Harrison RE. 2007. Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fcgamma receptor-mediated phagocytosis in nonelicited macrophages. J Leukoc Biol 82: 417-428.
22. Kohro T, Tanaka T, Murakami T, Wada Y, Aburatani H, Hamakubo T, Kodama T. 2004. A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. J Atheroscler Thromb 11: 88-97.
23. Kruth HS, Jones NL, Huang W, Zhao B, Ishii I, Chang J, Combs CA, Malide D, Zhang WY. 2005. Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein. J Biol Chem 280: 2352-2360.
24. Krysko DV, Denecker G, Festjens N, Gabriels S, Parthoens E, D'Herde K, Vandenabeele P. 2006. Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells. Cell Death Differ 13: 2011-2022.
25. Lagord C, Berry M, Logan A. 2002. Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord. Mol Cell Neurosci 20: 69-92.
26. Lambrecht BN. 2006. Alveolar macrophage in the driver's seat. Immunity 24: 366-368.
27. Ley K, Miller YI, Hedrick CC. 2011. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol 31: 1506-1516.
28. Lumeng CN, Bodzin JL, Saltiel AR. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184.
29. Luster AD. 2001. Antichemokine immunotherapy for allergic diseases. Curr Opin Allergy Clin Immunol 1: 561-567.
30. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. 2002. Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23: 549-555.
31. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. 2004. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25: 677-686.
32. McLaren JE, Michael DR, Ashlin TG, Ramji DP. 2011. Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy. Prog Lipid Res 50: 331-347.
33. Medeiros AI, Serezani CH, Lee SP, Peters-Golden M. 2009. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med 206: 61-68.
34. Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. 2003. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: Role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell 14: 4196-4206.
35. Mosser DM, Edwards JP. 2008. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
36. Movahedi K, Laoui D, Gysemans C, Baeten M, Stange G, Van den Bossche J, Mack M, Pipeleers D, In't Veld P, De Baetselier P, Van Ginderachter JA. 2010. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res 70: 5728-5739.
37. Murray PJ, Wynn TA. 2011. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 11: 723-737.
38. Pello OM, Silvestre C, De Pizzol M, Andres V. 2011. A glimpse on the phenomenon of macrophage polarization during atherosclerosis. Immunobiology 216: 1172-1176.
39. Peyron P, Vaubourgeix J, Poquet Y, Levillain F, Botanch C, Bardou F, Daffe M, Emile JF, Marchou B, Cardona PJ, de Chastellier C, Altare F. 2008. Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog 4: e1000204.
40. Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM, Haskard DO, Landis RC. 2004. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: Antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res 94: 119-126.
41. Reefman E, Horst G, Nijk MT, Limburg PC, Kallenberg CG, Bijl M. 2007. Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcgamma receptor-dependent mechanism. Arthritis Rheum 56: 3399-3411.
42. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J. 2006. TM4 microarray software suite. Methods Enzymol 411: 134-193.
43. Savill J, Dransfield I, Gregory C, Haslett C. 2002. A blast from the past: Clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2: 965-975.
44. Schutyser E, Richmond A, Van Damme J. 2005. Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes. J Leukoc Biol 78: 14-26.
45. Shah CA, Wang H, Bei L, Platanias LC, Eklund EA. 2011. HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells. J Biol Chem 286: 3161-3176.
46. Sierra-Filardi E, Vega MA, Sanchez-Mateos P, Corbi AL, Puig-Kroger A. 2010. Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. Immunobiology 215: 788-795.
47. Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, Hainzl A, Schatz S, Qi Y, Schlecht A, Weiss JM, Wlaschek M, Sunderkotter C, Scharffetter-Kochanek K. 2011. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 121: 985-997.
48. Sutherland MW, Learmonth BA. 1997. The tetrazolium dyes MTS and XTT provide new quantitative assays for superoxide and superoxide dismutase. Free Radic Res 27: 283-289.
49. Tabas I, Zha X, Beatini N, Myers JN, Maxfield FR. 1994. The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages. J Biol Chem 269: 22547-22556.
50. Van Gelder RN, von Zastrow ME, Yool A, Dement WC, Barchas JD, Eberwine JH. 1990. Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc Natl Acad Sci USA 87: 1663-1667.
51. van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13: 136-143.
52. Wang R, Chandawarkar RY. 2010. Phagocytosis of fungal agents and yeast via macrophage cell surface scavenger receptors. J Surg Res 164: e273-e279.
53. Westermann S, Weber K. 2003. Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 4: 938-947.
54. Wilson HM. 2010. Macrophages heterogeneity in atherosclerosis-Implications for therapy. J Cell Mol Med 14: 2055-2065.
55. Wintergerst ES, Jelk J, Asmis R. 1998. Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived macrophages. A novel cell culture system to study macrophage differentiation and heterogeneity. Histochem Cell Biol 110: 231-241.
56. Xu W, Roos A, Schlagwein N, Woltman AM, Daha MR, van Kooten C. 2006. IL-10-producing macrophages preferentially clear early apoptotic cells. Blood 107: 4930-4937.
57. Xu W, Schlagwein N, Roos A, van den Berg TK, Daha MR, van Kooten C. 2007. Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. Eur J Immunol 37: 1594-1599.
58. Xu YZ, Thuraisingam T, Morais DA, Rola-Pleszczynski M, Radzioch D. 2010. Nuclear translocation of beta-actin is involved in transcriptional regulation during macrophage differentiation of HL-60 cells. Mol Biol Cell 21: 811-820.
59. Zerbinatti CV, Gore RW. 2003. Uptake of modified low-density lipoproteins alters actin distribution and locomotor forces in macrophages. Am J Physiol Cell Physiol 284: C555-C561.
60. Zielonka J, Vasquez-Vivar J, Kalyanaraman B. 2008. Detection of 2-hydroxyethidium in cellular systems: A unique marker product of superoxide and hydroethidine. Nat Protoc 3: 8-21.
61. Zwadlo G, Brocker EB, von Bassewitz DB, Feige U, Sorg C. 1985. A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. J Immunol 134: 1487-1492.