Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

Chinese Journal of Cancer Research

Volumn 24, Issue 4, 2012, Pages 323-331

  Che, Li ^a   Yuan, Yan Hua ^a   Jia, Jun ^a   Ren, Jun ^a  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

GLI1; hedgehog; Hepatocellular carcinoma; patched; prognosis; smoothened; sonic hedgehog

Indexed keywords

ALPHA FETOPROTEIN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SIZE; CANCER SURVIVAL; CANCER TISSUE; CLINICAL ARTICLE; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; LIVER CELL CARCINOMA; MALE; MOLECULAR WEIGHT; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTOR VARIABLE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84875458024     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.1007/s11670-012-0271-z     Document Type: Article

References (44)

1. Sicklick JK, Li YX, Jayaraman A, et al. Dysregulation of the hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis 2006;27:748-757.
2. Patil MA, Zhang J, Ho C, et al. Hedgehog signaling in human hepatocellular carcinoma. Cancer Biol Ther 2006;5:111-117.
3. Huang S, He J, Zhang X, et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006;27:1334-1340.
4. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-331.
5. Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980;287:795-801.
6. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-1671.
7. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85:841-851.
8. Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive euroectodermal tumors of the central nervous system. Cancer Res 1998;58:1798-1803.
9. Xie J, Murone M, Luoh SM, et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391:90-92.
10. Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431:707-712.
11. Sanchez P, Clement V, Ruiz i Altaba A. Therapeutic targeting of the hedgehog- GLI pathway in prostate cancer. Cancer Res 2005;65:2990-2992.
12. Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-317.
13. Velcheti V, Govindan R. Hedgehog signaling pathway and lung cancer. J Thorac Oncol 2007;2:7-10.
14. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors. Nature 2003;425:846-851.
15. Monzo M, Moreno I, Artells R, et al. Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients. Cancer Lett 2006;233:117-123.
16. Dimmler A, Brabletz T, Hlubek F, et al. Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is upregulated in acidic conditions. Lab Invest 2003;83:1829-1837.
17. Isohata N, Aoyagi K, Mabuchi T, et al. Hedgehog and epithelial- mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int J Cancer 2009;125:1212-1221.
18. Ma X, Chen K, Huang S, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005;26:1698-705.
19. Feldmann G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007;67:2187-2196.
20. Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64:6071-6074.
21. Mukherjee S, Frolova N, Sadlonova A, et al. Hedgehog signaling and response to Cyclopamine differ in epithelialand stromal cells in benign breast and breast cancer. Cancer Biol Ther 2006;5:674-683.
22. Chen X, Horiuchi A, Kikuchi N, et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis. Cancer Science 2007;98:68-76.
23. Deutsch G, Jung J, Zhang M, et al. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001;128:871-881.
24. ten Haaf A, Bektas N, von Serenyi S, et al. Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival. BMC Cancer 2009;9:298.
25. Li YC, Deng YH, Guo ZH, et al. Prognostic value of hedgehog signal component expressions in hepatoblastoma patients. Eur J Med Res 2010;15:468-474.
26. Souzaki M, Kubo M, Kai M, et al. Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer. Cancer Sci 2011;102:373-381.
27. Saze Z, Terashima M, Kogure M, et al. Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer. Dig Surg 2012;29:115-123.
28. He HC, Chen JH, Chen XB, et al. Expression of hedgehog pathway components is associated with bladder cancer progression and clinical outcome. Pathol Oncol Res 2012;18:349-355.
29. Che L, Ren J, Yuan YH, et al. Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas. Beijing Da Xue Xue Bao (in Chinese) 2008;40:616-623.
30. Katoh Y, Katoh M. Hedgehog signaling pathway and gastrointestinalstem cell signaling network (Review). Int J Mol Med 2006;18:1019-1023.
31. Yang L, Xie G, Fan Q, et al. Activation of the hedgehogsignaling pathway in human cancer and the clinical implications. Oncogene 2010;29:469-481.
32. Hebrok M. Hedgehog signaling in pancreas development. Mech Dev 2003;120:45-57.
33. Watkins DN, Peacock CD. Hedgehog signalling in foregut malignancy. Biochem Pharmacol 2004;68:1055-1060.
34. Fattovich G, Giustina G, Degos F, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997;112:463-472.
35. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003;362:1907-1917.
36. Shackel NA, McGuinness PH, Abbott CA, et al. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut 2001;49:565-576.
37. Shackel NA, McGuinness PH, Abbott CA, et al. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Am J Pathol 2002;160:641-654.
38. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000;127:2763-2772.
39. Jung Y, McCall SJ, Li YX, et al. Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. Hepatology 2007;45:1091-1096.
40. Keeler RF, Binns W. Teratogeneic compaunds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Tetratology 1968;1:5-10.
41. Incardona JP, Gaffield W, Kapur RP, et al. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 1998;125:3553-3562.
42. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science 2002;297:1559-1561.
43. Chen JK, Taipale J, Cooper MK, et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002;16:2743-2748.
44. Katano M. Hedgehog signaling pathway as a therapeutic target in breast cancer. Cancer Lett 2005;227:99-104.