Expression of hedgehog pathway components is associated with bladder cancer progression and clinical outcome

Pathology and Oncology Research

Volumn 18, Issue 2, 2012, Pages 349-355

  He, Hui Chan ^a   Chen, Jia Hong ^a   Chen, Xi Bin ^a   Qin, Guo Qiang ^d   Cai, Chao ^a   Liang, Yu Xiang ^a   Han, Zhao Dong ^a   Dai, Qi Shan ^a   Chen, Yan Ru ^a   Zeng, Guo Hua ^b   Zhu, Jian Guo ^c,d   Jiang, Fu Neng ^a   Zhong, Wei De ^a,b,d  

^a GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c GUIZHOU PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Bladder cancer; Gli1; Hedgehog signaling pathway; Patched; Prognosis; Sonic hedgehog

Indexed keywords

PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECURRENCE FREE SURVIVAL;

ADOLESCENT; ADULT; AGED; CARCINOMA, TRANSITIONAL CELL; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HEDGEHOG PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER; URINARY BLADDER NEOPLASMS; YOUNG ADULT;

EID: 84863490288     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9451-2     Document Type: Article

References (26)

1. Kramer MW, Escudero DO, Lokeshwar SD et al (2011) Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis. Cancer 117:1197-209
2. Lei Y, Yan S, Ming-De L et al (2011) Prognostic significance of Aurora-A expression in human bladder cancer. Acta Histochem 113:514-518
3. Canesin G, Gonzalez-Peramato P, Palou J et al (2010) Galectin-3 expression is associated with bladder cancer progression and clinical outcome. Tumour Biol 31:277-285
4. Pasca di Magliano M, Hebrok M (2003) Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3:903-911
5. Kameda C, Tanaka H, Yamasaki A (2009) The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptornegative breast cancer. Anticancer Res 29:871-879
6. Lauth M, Toftgrd R (2007) The Hedgehog pathway as a drug target in cancer therapy. urr Opin Investig. Drugs 8:457-461
7. Laurendeau I, Ferrer M, Garrido D (2010) Gene expression profiling of the Hedgehog signaling pathway in human meningiomas. Mol Med 16:262-270
8. Walter K, Omura N, Hong SM (2010) Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin Cancer Res 16:1781-1789
9. Berman DM, Karhadkar SS, Maitra A (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425:846-851
10. Ma X, Chen K, Huang S (2005) Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26:1698-705
11. Thayer SP, di Magliano MP, Heiser PW (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856
12. Yanai K, Nagai S, Wada J (2007) Hedgehog signaling pathway is a possible therapeutic target for gastric cancer. J Surg Oncol 95:55-62
13. Chen G, Goto Y, Sakamoto R et al (2011) GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor. Biochem Biophys Res Commun 404:809-815
14. Kelleher FC. Hedgehog signalling and therapeutics in pancreatic cancer. Carcinogenesis. 2010 In press
15. Chen M, Hildebrandt MA, Clague J et al (2010) Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscleinvasive bladder cancer. Cancer Prev Res (Phila) 3:1235-1245
16. Greene FL, Balch CM, Fleming ID et al (2002) AJCC cancer staging manual, 6th edn. AJCC Springer-Verlag, New York, pp 335-340
17. Oue T, Yoneda A, Uehara S et al (2010) Increased expression of the hedgehog signaling pathway in pediatric solid malignancies. J Pediatr Surg 45:387-392
18. Brown RS, Wahl RL (1993) Overexpression of Glut-1 glucose transporter in human breast cancer: an immunohistochemical study. Cancer 72:2979-2985
19. Ju B, Spitsbergen J, Eden CJ et al (2009) Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Mol Cancer 8:40
20. Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15:3059-3087
21. Merchant JL, Saqui-Salces M, El-Zaatari M (2010) Hedgehog signaling in gastric physiology and cancer. Prog Mol Biol Transl Sci 96:133-156
22. Morton JP, Mongeau ME, Klimstra DS (2007) Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 104:5103-5108
23. Berman DM, Karhadkar SS, Maitra A (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors. Nature 425:846-851
24. Rush SZ, Abel TW, Valadez JG et al (2010) Activation of the Hedgehog pathway in pilocytic astrocytomas. Neuro Oncol 12:790-798
25. Liao X, Siu MK, Au CW et al (2009) A berrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 30:131-140
26. Yang Y, Tian X, Xie X et al (2010) Expression and regulation of hedgehog signaling pathway in pancreatic cancer. Langenbecks Arch Surg 395:515-525