-
1
-
-
2342609768
-
State-specific projections through 2025 of Alzheimer disease prevalence
-
L.E. Hebert, P.A. Scherr, J.L. Bienias, D.A. Bennett, and D.A. Evans State-specific projections through 2025 of Alzheimer disease prevalence Neurology 62 2004 1645
-
(2004)
Neurology
, vol.62
, pp. 1645
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
2
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
3
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, and P. Seubert Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
4
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
C. Janus, J. Pearson, J. McLaurin, P.M. Mathews, Y. Jiang, S.D. Schmidt, M.A. Chishti, P. Horne, D. Heslin, J. French, H.T. Mount, R.A. Nixon, M. Mercken, C. Bergeron, P.E. Fraser, P. St George-Hyslop, and D. Westaway A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 408 2000 979 982
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
Chishti, M.A.7
Horne, P.8
Heslin, D.9
French, J.10
Mount, H.T.11
Nixon, R.A.12
Mercken, M.13
Bergeron, C.14
Fraser, P.E.15
St George-Hyslop, P.16
Westaway, D.17
-
5
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
D. Morgan, D.M. Diamond, P.E. Gottschall, K.E. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. DiCarlo, D. Wilcock, K. Connor, J. Hatcher, C. Hope, M. Gordon, and G.W. Arendash A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature 408 2000 982 985
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
Dicarlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
6
-
-
0034192158
-
Beta-secretase revealed: Starting gate for race to novel therapies for Alzheimer's disease
-
D.M. Skovronsky, and V.M. Lee Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease Trends Pharmacol. Sci. 21 2000 161 163
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 161-163
-
-
Skovronsky, D.M.1
Lee, V.M.2
-
7
-
-
0027195933
-
Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
J.T. Jarrett, and P.T. Lansbury Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73 1993 1055 1058
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury Jr., P.T.2
-
8
-
-
0032855484
-
Kinetic analysis of amyloid fibril formation
-
H. Naiki, and F. Gejyo Kinetic analysis of amyloid fibril formation Methods Enzymol. 309 1999 305 318
-
(1999)
Methods Enzymol.
, vol.309
, pp. 305-318
-
-
Naiki, H.1
Gejyo, F.2
-
9
-
-
0032559003
-
Apolipoprotein e and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro
-
H. Naiki, K. Hasegawa, I. Yamaguchi, H. Nakamura, F. Gejyo, and K. Nakakuki Apolipoprotein E and antioxidants have different mechanisms of inhibiting Alzheimer's beta-amyloid fibril formation in vitro Biochemistry 37 1998 17882 17889
-
(1998)
Biochemistry
, vol.37
, pp. 17882-17889
-
-
Naiki, H.1
Hasegawa, K.2
Yamaguchi, I.3
Nakamura, H.4
Gejyo, F.5
Nakakuki, K.6
-
10
-
-
0036313066
-
Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro
-
K. Ono, K. Hasegawa, Y. Yoshiike, A. Takashima, M. Yamada, and H. Naiki Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro J. Neurochem. 81 2002 434 440
-
(2002)
J. Neurochem.
, vol.81
, pp. 434-440
-
-
Ono, K.1
Hasegawa, K.2
Yoshiike, Y.3
Takashima, A.4
Yamada, M.5
Naiki, H.6
-
11
-
-
0033765735
-
Oxidative injury in diseases of the central nervous system: Focus on Alzheimer's disease
-
D. Pratico, and N. Delanty Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease Am. J. Med. 109 2000 577 585
-
(2000)
Am. J. Med.
, vol.109
, pp. 577-585
-
-
Pratico, D.1
Delanty, N.2
-
12
-
-
0031741578
-
The free radical antioxidant vitamin e protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: Relevance to the free radical hypothesis of Alzheimer's disease
-
R. Subramaniam, T. Koppal, M. Green, S. Yatin, B. Jordan, J. Drake, and D.A. Butterfield The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease Neurochem. Res. 23 1998 1403 1410
-
(1998)
Neurochem. Res.
, vol.23
, pp. 1403-1410
-
-
Subramaniam, R.1
Koppal, T.2
Green, M.3
Yatin, S.4
Jordan, B.5
Drake, J.6
Butterfield, D.A.7
-
13
-
-
0027959041
-
Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation
-
Y. Goodman, M.R. Steiner, S.M. Steiner, and M.P. Mattson Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation Brain Res. 654 1994 171 176
-
(1994)
Brain Res.
, vol.654
, pp. 171-176
-
-
Goodman, Y.1
Steiner, M.R.2
Steiner, S.M.3
Mattson, M.P.4
-
14
-
-
0030756236
-
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
-
T. Kihara, S. Shimohama, H. Sawada, J. Kimura, T. Kume, H. Kochiyama, T. Maeda, and A. Akaike Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity Ann. Neurol. 42 1997 159 163
-
(1997)
Ann. Neurol.
, vol.42
, pp. 159-163
-
-
Kihara, T.1
Shimohama, S.2
Sawada, H.3
Kimura, J.4
Kume, T.5
Kochiyama, H.6
Maeda, T.7
Akaike, A.8
-
15
-
-
4544227975
-
Vitamin a exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro
-
K. Ono, Y. Yoshiike, A. Takashima, K. Hasegawa, H. Naiki, and M. Yamada Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro Exp. Neurol. 189 2004 380 392
-
(2004)
Exp. Neurol.
, vol.189
, pp. 380-392
-
-
Ono, K.1
Yoshiike, Y.2
Takashima, A.3
Hasegawa, K.4
Naiki, H.5
Yamada, M.6
-
17
-
-
0032239976
-
Lipoic acid as an antioxidant. the role of dihydrolipoamide dehydrogenase
-
M.S. Patel, and Y.S. Hong Lipoic acid as an antioxidant. The role of dihydrolipoamide dehydrogenase Methods Mol. Biol. 108 1998 337 346
-
(1998)
Methods Mol. Biol.
, vol.108
, pp. 337-346
-
-
Patel, M.S.1
Hong, Y.S.2
-
18
-
-
0035955513
-
Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway
-
L. Zhang, G.Q. Xing, J.L. Barker, Y. Chang, D. Maric, W. Ma, B.S. Li, and D.R. Rubinow Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway Neurosci. Lett. 312 2001 125 128
-
(2001)
Neurosci. Lett.
, vol.312
, pp. 125-128
-
-
Zhang, L.1
Xing, G.Q.2
Barker, J.L.3
Chang, Y.4
Maric, D.5
Ma, W.6
Li, B.S.7
Rubinow, D.R.8
-
19
-
-
0037305211
-
Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y
-
J. Gasic-Milenkovic, C. Loske, and G. Munch Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y J. Alzheimers Dis. 5 2003 25 30
-
(2003)
J. Alzheimers Dis.
, vol.5
, pp. 25-30
-
-
Gasic-Milenkovic, J.1
Loske, C.2
Munch, G.3
-
20
-
-
0035851024
-
Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism
-
W. Deuther-Conrad, C. Loske, R. Schinzel, R. Dringen, P. Riederer, and G. Munch Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism Neurosci. Lett. 312 2001 29 32
-
(2001)
Neurosci. Lett.
, vol.312
, pp. 29-32
-
-
Deuther-Conrad, W.1
Loske, C.2
Schinzel, R.3
Dringen, R.4
Riederer, P.5
Munch, G.6
-
21
-
-
0037342554
-
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
-
S.A. Farr, H.F. Poon, D. Dogrukol-Ak, J. Drake, W.A. Banks, E. Eyerman, D.A. Butterfield, and J.E. Morley The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice J. Neurochem. 84 2003 1173 1183
-
(2003)
J. Neurochem.
, vol.84
, pp. 1173-1183
-
-
Farr, S.A.1
Poon, H.F.2
Dogrukol-Ak, D.3
Drake, J.4
Banks, W.A.5
Eyerman, E.6
Butterfield, D.A.7
Morley, J.E.8
-
22
-
-
0034986275
-
Alpha-lipoic acid as a new treatment option for Alzheimer type dementia
-
K. Hager, A. Marahrens, M. Kenklies, P. Riederer, and G. Munch Alpha-lipoic acid as a new treatment option for Alzheimer type dementia Arch. Gerontol. Geriatr. 32 2001 275 282
-
(2001)
Arch. Gerontol. Geriatr.
, vol.32
, pp. 275-282
-
-
Hager, K.1
Marahrens, A.2
Kenklies, M.3
Riederer, P.4
Munch, G.5
-
23
-
-
0033598697
-
Interaction between a beta(1-42) and a beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro
-
K. Hasegawa, I. Yamaguchi, S. Omata, F. Gejyo, and H. Naiki Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro Biochemistry 38 1999 15514 15521
-
(1999)
Biochemistry
, vol.38
, pp. 15514-15521
-
-
Hasegawa, K.1
Yamaguchi, I.2
Omata, S.3
Gejyo, F.4
Naiki, H.5
-
24
-
-
0036838889
-
Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro
-
K. Ono, K. Hasegawa, M. Yamada, and H. Naiki Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro Biol. Psychiatry 52 2002 880 886
-
(2002)
Biol. Psychiatry
, vol.52
, pp. 880-886
-
-
Ono, K.1
Hasegawa, K.2
Yamada, M.3
Naiki, H.4
-
25
-
-
0030030956
-
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro
-
H. Naiki, and K. Nakakuki First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro Lab. Invest. 74 1996 374 383
-
(1996)
Lab. Invest.
, vol.74
, pp. 374-383
-
-
Naiki, H.1
Nakakuki, K.2
-
26
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
27
-
-
0029863551
-
Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger
-
T. Tomiyama, A. Shoji, K. Kataoka, Y. Suwa, S. Asano, H. Kaneko, and N. Endo Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger J. Biol. Chem. 271 1996 6839 6844
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6839-6844
-
-
Tomiyama, T.1
Shoji, A.2
Kataoka, K.3
Suwa, Y.4
Asano, S.5
Kaneko, H.6
Endo, N.7
-
28
-
-
0035808264
-
Anti-amyloidogenic activity of tetracyclines: Studies in vitro
-
G. Forloni, L. Colombo, L. Girola, F. Tagliavini, and M. Salmona Anti-amyloidogenic activity of tetracyclines: studies in vitro FEBS Lett. 487 2001 404 407
-
(2001)
FEBS Lett.
, vol.487
, pp. 404-407
-
-
Forloni, G.1
Colombo, L.2
Girola, L.3
Tagliavini, F.4
Salmona, M.5
-
29
-
-
0028913416
-
Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: Implications for Alzheimer's disease
-
R. Kisilevsky, L.J. Lemieux, P.E. Fraser, X. Kong, P.G. Hultin, and W.A. Szarek Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease Nat. Med. 1 1995 143 148
-
(1995)
Nat. Med.
, vol.1
, pp. 143-148
-
-
Kisilevsky, R.1
Lemieux, L.J.2
Fraser, P.E.3
Kong, X.4
Hultin, P.G.5
Szarek, W.A.6
-
30
-
-
0030600371
-
Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation
-
C. Soto, M.S. Kindy, M. Baumann, and B. Frangione Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation Biochem. Biophys. Res. Commun. 226 1996 672 680
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.226
, pp. 672-680
-
-
Soto, C.1
Kindy, M.S.2
Baumann, M.3
Frangione, B.4
-
31
-
-
0035251678
-
Nicotine and amyloid formation
-
H. Zeng, Y. Zhang, L.-J. Peng, H. Shao, N.K. Menon, J. Yang, A.R. Salomon, R.P. Freidland, and M.G. Zagorski Nicotine and amyloid formation Biol. Psychiatry 49 2001 248 257
-
(2001)
Biol. Psychiatry
, vol.49
, pp. 248-257
-
-
Zeng, H.1
Zhang, Y.2
Peng, L.-J.3
Shao, H.4
Menon, N.K.5
Yang, J.6
Salomon, A.R.7
Freidland, R.P.8
Zagorski, M.G.9
-
32
-
-
0022520147
-
Effect of antibiotics on the generation of reactive oxygen species
-
Y. Miyachi, A. Yoshioka, S. Imamura, and Y. Niwa Effect of antibiotics on the generation of reactive oxygen species J. Invest. Dermatol. 86 1986 449 453
-
(1986)
J. Invest. Dermatol.
, vol.86
, pp. 449-453
-
-
Miyachi, Y.1
Yoshioka, A.2
Imamura, S.3
Niwa, Y.4
-
33
-
-
0032994040
-
In vitro and in vivo studies investigating possible antioxidant actions of nicotine: Relevance to Parkinson's and Alzheimer's diseases
-
W. Linert, M.H. Bridge, M. Huber, K.B. Bjugstad, S. Grossman, and G.W. Arendash In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson's and Alzheimer's diseases Biochim. Biophys. Acta 1454 1999 143 152
-
(1999)
Biochim. Biophys. Acta
, vol.1454
, pp. 143-152
-
-
Linert, W.1
Bridge, M.H.2
Huber, M.3
Bjugstad, K.B.4
Grossman, S.5
Arendash, G.W.6
-
34
-
-
0027437311
-
Antioxidant activity of all-trans-retinol in homogeneous solution and in phosphatidylcholine liposomes
-
L. Tesoriere, M. Ciaccio, A. Bongiorno, A. Riccio, A.M. Pintaudi, and M.A. Livrea Antioxidant activity of all-trans-retinol in homogeneous solution and in phosphatidylcholine liposomes Arch. Biochem. Biophys. 307 1993 217 223
-
(1993)
Arch. Biochem. Biophys.
, vol.307
, pp. 217-223
-
-
Tesoriere, L.1
Ciaccio, M.2
Bongiorno, A.3
Riccio, A.4
Pintaudi, A.M.5
Livrea, M.A.6
-
35
-
-
0029909010
-
Neuroprotection by the metabolic antioxidant alpha-lipoic acid
-
L. Packer, H.J. Tritschler, and K. Wessel Neuroprotection by the metabolic antioxidant alpha-lipoic acid Free Radic. Biol. Med. 22 1997 359 378
-
(1997)
Free Radic. Biol. Med.
, vol.22
, pp. 359-378
-
-
Packer, L.1
Tritschler, H.J.2
Wessel, K.3
-
36
-
-
0035783744
-
Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia
-
A. Wong, S. Dukic-Stefanovic, J. Gasic-Milenkovic, R. Schinzel, H. Wiesinger, P. Riederer, and G. Munch Anti-inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia Eur. J. Neurosci. 14 2001 1961 1967
-
(2001)
Eur. J. Neurosci.
, vol.14
, pp. 1961-1967
-
-
Wong, A.1
Dukic-Stefanovic, S.2
Gasic-Milenkovic, J.3
Schinzel, R.4
Wiesinger, H.5
Riederer, P.6
Munch, G.7
|