Bone morphogenetic proteins: Periodontal regeneration

North American Journal of Medical Sciences

Volumn 5, Issue 3, 2013, Pages 161-168

  Rao, Subramaniam M ^a   Ugale, Gauri M ^a   Warad, Shivaraj B ^a  

^a Department of Prosthodontics   (India)

Author keywords

Bone; Bone morphogenetic proteins; Gene therapy; Osteogenic protein; Periodontal regeneration

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 6; CARRIER PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOGENIC PROTEIN 1; RECOMBINANT HUMAN GROWTH DIFFERENTIATION FACTOR 5; RECOMBINANT PROTEIN; STAT PROTEIN; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANKYLOSIS; CELL DIFFERENTIATION; FOOD AND DRUG ADMINISTRATION; GENE DELIVERY SYSTEM; GENE THERAPY; GENE TRANSFER; HUMAN; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTICS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TISSUE REGENERATION; WOUND HEALING;

EID: 84875387728     PISSN: 22501541     EISSN: 19472714     Source Type: Journal    
DOI: 10.4103/1947-2714.109175     Document Type: Review

References (67)

1. American Academy of Periodontology. Glossary of periodontal terms. 3rd ed. Chicago (IL): American Academy of Periodontology; 1992.
2. Melcher AH. On the repair potential of the periodontal tissues. J Periodontol 1976;47:256-60.
3. Jaebum L, Andreas S, Cristiano S, Wikesjo ME. Periodontal Regeneration: Focus on Growth and Differentiation Factors. Dent Clin N Am 2010;54:93-111.
4. Bartold PM, McCulloch AG, Narayanan AS, Pitarus. Tissue engineering: A new paradigm for periodontal regeneration based on molecular cell biology. Periodontology 2000 2000;24:253-69.
5. Ripamonti U, Reddi AH. Tissue engineering, morphogenesis and regeneration of the periodontal tissues by bone morphogenetic proteins. Crit Rev Oral Biol Med 1997;8:154-63.
6. Ripamonti U, Reddi AH. Periodontal regeneration: Potential role of bone morphogenetic proteins. J Periodont Res 1994; 29:225-35.
7. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893-9.
8. Urist MR, Strates. Bone Morphogenetic proteins. J Dent Res 1971;50:S1392-406.
9. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, et al. Identification of transforming growth factor-B family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 1990;87:9843-7.
10. Huang YH, Polimeni G, Qahash M, Wikesjo ME. Bone morphogenetic proteins and osseointegration: Current knowledge-future possibilities. Periodontology 2000 2008;47:206-23.
11. Sykaras N, Opperman L. Bone Morphogenetic proteins (BMPs): How do they function and what can they offer the clinician? J Oral Sci 2003;45:57-73.
12. Urist MR. Substratum for bone morphogenesis. Symp Soc Dev Biol 1970;4:125-63.
13. Wikesjo UM, Huang YH, Polimeni G, Qahash M. Bone morphogenetic proteins: A realistic alternative to bone grafting for alveolar reconstruction. Oral Maxillofacial Surg Clin N Am 2007;19:535-51.
14. Sakou T. Bone morphogenetic proteins: From basic studies to clinical approaches. Bone 1998;22:591-603.
15. Schaub RG, Wozney J. Novel agents that promote bone regeneration. Curr Opin Biotechnol 1991;2:868-71.
16. Schmitt JM, Hwang K, Winn SR, Hollinger JO. Bone morphogenetic proteins: An update on basic biology and clinical relevance. J Orthop Res 1999;17:269-78.
17. Vukicevic S, Paralkar VM, Cunningham NS, Gutkind JS, Reddi AH. Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. Dev Biol 1990;140:209-14.
18. Lyons KM, Pelton RW, Hogan BL. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor---like genes co-ordinately regulate aspects of embryonic development. Genes Dev 1989;3:1657-68.
19. Lyons KM, Pelton RW, Hogan BL. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 1990;109:833-44.
20. Jones CM, Lyons KM, Hogan BL. Involvement of bone morphogenetic protein-4(BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development 1991;111:531-42.
21. Wall NA, Blessing M, Wright CV, Hogan BL. Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J Cell Biol 1993;120:493-502.
22. Massgue J, Weis-Garcia F. Serine/threonine kinase receptors: Mediators of transforming growth factor beta family signals. Cancer Surv 1996;27:41-64.
23. Attisano L, Wrana JL, Lopez-Casillas F, Massgue J. TGF-beta receptors and actions. Biochim Biophys Acta 1994;1222:71-80.
24. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase Cell 1992;68:775-85.
25. Yamashita H, Ten Dijke P, Heldin CH, Miyazono K. Bone morphgenetic protein receptors. Bone 1996;19:569-74.
26. Massgue J. TGF-beta signal transduction. Ann Rev Biochem 1998;106:753-91.
27. Von Bubnoff A, Cho KW. Intracellular BMP signalling regulation in vertebrates: Pathway or network? Dev Biol 2001;239:1-14.
28. Kawai S, Sugiura T. Characterization of human bone morphgenetic protein (BMP)-4 and-7 gene promoters: Activation of BMP promoters by Gli, a Sonic hedgehog mediator. Bone 2001;29:54-61.
29. Brunet LJ, McMahon JA, McMahon AP, Harland RM. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 1998;280:1455-7.
30. Carrinton JL, Reddi AH. Parallels between development of embryonic and matrix induced endochondral bone. Bioessays 1991;13:403-8.
31. Hall BK. Cellular interactions during cartilage and bone development. J Craniofac Genet Dev Biol 1991;11:238-50.
32. Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev 1994;4:737-44.
33. Wozney JM. The bone morphogenetic family and osteogenesis. Mol Reprood Dev 1992;32:160-7.
34. Boyan BD, Caplan AL, Heckman JD, Lennon DP, Ehler W, Schwartz Z. Osteochondral progenitor cells in acute and chronic canine nonunions. J Orthop Res 1999;17:246-55.
35. Israel DI, Nove J, Kerns KM, Moutsatsos IK, Kaufman RJ. Expression and characterization of Bone morphogenetic protein-2 in Chinese hamster ovary cells. Growth Factors 1992;7:139-50.
36. Zhao M, Wang H, Zhou T. Expression of recombinant mature peptide of human bone morphogenetic protein-2 in Escherichia coli and its activity in bone formation. Chin Biochem J 1994;10:319-24.
37. Kimelman N, Pelled G, Helm GA, Huard J, Schwarz EM, Gazit D. Review: Gene and stem cell-based therapeutics for bone regeneration and repair. Tissue Eng 2007;13:1135-50.
38. Mont MA, Ragland PS, Biggins B, Friedlaender G, Patel T, Cook S, et al. Use of bone morphogenetic proteins for musculoskeletal applications. An overview. J Bone Joint Surg 2004;86:41-55.
39. Haider ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: current challenges in BMP delivery. Biotechnol Lett 2009;31:1817-24.
40. Holinger JO, Schmitt JM, Buck DC, Shannon R, Joh SP, Zegzula HD, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res 1998;43:356-64.
41. Huang YH, Polimeni G, Qahash M, Wikesjo UM. Bone morphogenetic proteins and osseointegration: current knowledge-future possibilities. Periodontol 2000 2008;47:206-23.
42. Uludag H, Augusta D, Palmer R, Timony G, Wozney J. Characterization of rhBMP-2 pharmakokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 1999;46:193-202.
43. Murata M, Inoue M Arisue M, Kuboki Y, Nagai N. Carrier-dependency of cellular differentiation induced by bone morphogenetic protein in ectopic sites. Int J Oral Maxillofac Surg 1998;27:391-6.
44. Li RH, Wozney JM. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol 2001;19:255-65.
45. Yamano S, Haku K, Ishioka M, Lin TY, Hanatani S. The potential of tissue engineering and regeneration for craniofacial bone. Dentistry 2012;2:136.
46. Sampath TK, Reddi AH. Homology of bone-inductive proteins from human, monkey, bovine and rat extra cellular matrix. Proc Natl Acad Sci USA 1983;80:6591-5.
47. Ripamonti U, Ma S, Cunningham N, Yeates L, Reddi AH. Initiation of bone regeneration in adult baboons by osteogenin, a bone morphogenetic protein. Matrix 1992;12:369-80.
48. Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic proteins induce periodontal regenerationin the baboon (Papio Ursinus). J Periodont Res 1994;29:439-45.
49. Bowers G, Felton F, Middleton C, Glynn D, Sharp S, Mellonig J, et al. Histologic comparision of regeneration in human intrabony defects when osteogenin is combined with demineralised freeze dried bone allograft and with purified bovine collagen. J Periodontol 1991;62:690-702.
50. Sigurdsson TJ, Nygaard L, Tatakis DN, Fu E, Turek TJ, Jin L, et al. Periodontal repair in dogs. Evaluation of rhBMP/2 carriers. Int J Periodont Restor Dent 1996;16:524-37.
51. Wikesjö UM, Guglielmoni P, Promsudthi A, Cho KS, Trombelli L, Selvig KA, et al. Peridontal repair in dogs: Effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 1999;26:392-400.
52. Ishikawa I, Kinoshita A, Oda S, Roongruangphol T. Regenerative therapy in periodontal disease: Histological observations after implantation of rhBMP-2 in surgically created periodontal defects in adult dogs. Dent Jpn 1994;31:141-6.
53. King GN, King N, Churchley AT, Wozney JM, Hughes FJ. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 1997;76:1460-70.
54. Giannobile WV, Ryan S, Shih MS, Su DL, Kaplan PL, Chan TC. Recombinant osteogenic protein-1(OP-1) stimulates periodontal wound healing in class III furcation defects. J Periodontal 1998;69:129-37
55. King GN, Cochran DL. Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: A critical review. J Periodontol 2002;73:925-36.
56. Huang KK, Shen C, Chiang CY, Hsieh YD, Fu E. Effects of bone morphogenetic proteins-6 on periodontal wound healing in a fenestration defect of rats. J Periodont Res 2005;40:1-10.
57. Ripamonti U, Heliotis M, Rueger DC, Sampath TK. Induction of cementogenesis by recombinant human osteogenic protein-1 (hOP-1/BMP-7) in the baboon (Papio ursinus). Arch Oral Biol 1996;41:121-6.
58. Ripamonti U, Crooks J, Teare J, Petit JC, Rugger DC. Periodontal tissue regeneration by recombinant human osteogenic protein-1 in periodontally-induced furcation defects in primate Papio ursinus. S Afr J Sci 2002;98:361-8.
59. Wikesjö UM, Sorensen RG, Kinoshita A, Jian Li X, Wozney JM. Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment. J Clin Periodontal 2004;31:662-70.
60. Kim CS, Choi SH, Chai JK, Cho KS, Moon IS, Wikesjö UM, et al. Periodontal repair in surgically created intrabony defects in dogs: Influence of the number of bone walls on healing response. J Periodontol 2004;75:229-35.
61. Stavropoulos A, Windisch P, Gera I, Capsius B, Sculean A, Wikesjo UM. A phase IIa randomized controlled clinical and histological pilot study evaluating rhGDF-5/b-TCP for periodontal regeneration. J Clin Periodontol 2011;38:1044-54.
62. Oortgiesen DA, Walboomers XF, Brockners AL, Meijer GJ, Jansen JA. Periodontal regeneration using injectable bone cement combined with BMP-2 or FGF-2. J Tissue Eng Regen Med 2012 May 2. [Epub ahead of print].
63. Ditto AJ, Shah PN, Yun YH. Non-viral gene delivery using nanoparticles. Expert Opin Drug Deliv 2009;6:1149-60.
64. Rios HF, Lin Z, Oh B, Park CH, Giannobile WV. Cell-and gene-based therapeutic strategies for periodontal regenerative medicine. J Periodontol 2011;82:1223-37.
65. Jin QM, Anusaksathien O, Webb SA, Rutherford RB, Giannobile WV. Gene therapy of bone morphogenetic protein for periodontal tissue engineering. J Periodontol 2003;74:202-13.
66. Lin Z, Rios HF, Park CH, Taut AD, Jin Q, Sugai JV, et al. LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells. Gene Ther 2012;20:1-6.
67. Miron RJ, Zhang YF. Osteoinduction: A review of old concepts with new standards. J Dent Res 2012;91:736-44.