Recombinant human Bone Morphogenetic Protein-2 promotes wound healing in rat periodontal fenestration defects

Journal of Dental Research

Volumn 76, Issue 8, 1997, Pages 1460-1470

  King, G N ^a   King, N ^a   Cruchley, A T ^a   Wozney, J M ^b   Hughes, F J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Bone morphogenetic protein; Growth factors; Periodontal regeneration; Wound healing

Indexed keywords

BMP2 PROTEIN, HUMAN; BMP2 PROTEIN, RAT; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BONE REGENERATION; CEMENTUM; DRUG EFFECT; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NONPARAMETRIC TEST; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; PERIODONTAL DISEASE; PERIODONTIUM; PHYSIOLOGY; RAT; REGENERATION; WISTAR RAT; WOUND HEALING;

ALVEOLAR BONE LOSS; ANALYSIS OF VARIANCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; COLLAGEN; DENTAL CEMENTUM; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; OSTEOBLASTS; OSTEOCYTES; PERIODONTAL ATTACHMENT LOSS; PERIODONTIUM; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REGENERATION; STATISTICS, NONPARAMETRIC; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 0031202094     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/00220345970760080801     Document Type: Article

References (39)

1. Asahina I, Sampath TK, Nishimura I, Hauschka PV (1993). Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 123:921-933.
2. Beertsen W, Everts V (1990). Formation of acellular root cementum in relation to dental and non-dental hard tissues in the rat. J Dent Res 69:1669-1673.
3. Blömlöf J, Jansson L, Blömlöf L, Lindskog S (1995). Long-time etching at low pH jeopardizes periodontal healing. J Clin Periodontol 22:459-463.
4. Blömlöf J, Jansson L, Blömlöf L, Lindskog S (1996). Root surface etching at neutral pH promotes periodontal healing. J Clin Periodontol 23:50-55.
5. Bradbury P, Gordon KC (1990). Connective tissues and stains. In: Theory and practice of histological techniques. Bancroft JD, Stevens A, editors. Edinburgh: Churchill Livingstone, p. 132.
6. Caton J, Mota L, Landini L, Laskaris B (1994). Non-human primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontol 65:1143-1150.
7. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, et al. (1990). Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA 87:9843-9847.
8. Chen TL, Bates RL, Dudley A, Hammonds RG Jr, Amento EP (1991). Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: comparison with TGF-beta 1. J Bone Min Res 6:1387-1393.
9. [3H]-mannose utilization during cementoblast differentiation, formation of cellular cementum and development of periodontal ligament principal fibers. Anal Rec 223:209-222.
10. Elsdale T, Bard J (1972). Collagen substrata for studies on cell behavior. J Cell Biol 54 626-637.
11. Fernyhough W, Page RC (1983). Attachment, growth and synthesis by human gingival fibroblasts on demineralized or fibronectin-treated normal and diseased tooth roots. J Periodontol 54:133-140.
12. Garrett SJ, Crigger M, Egelberg J (1978). Effects of citric acid on diseased root surfaces. J Periodontol 13:155-163.
13. Hanes PJ, Polson AM (1989). Cell and fiber attachment to demineralized cementum from normal root surfaces. J Periodontol 60:188-198.
14. Hanes PJ, Polson AM, Ladenheim S (1985). Cell and fiber attachment to demineralized dentin from normal root surfaces. J Periodontol 56:752-765.
15. Hughes FJ, Collyer J, Stanfield M, Goodman SA (1995). The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro. Endocrinol 136:2671-2677.
16. Katagiri T, Yamaguchi A, Ikeda T, Yoshiki S, Wozney JM, Rosen V, et al. (1990). The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun 172:295-299.
17. Macneil RL, Sheng N, Strayhorn C, Fisher LW, Somerman MJ (1994). Bone sialoprotein is localized to the root surface during cementogenesis. J Bone Min Res 9:1597-1606.
18. Melcher AH, Cheong T, Cox J, Nemeth E, Shiga A (1986). Synthesis of cementum-like tissue in vitro by cells cultured from bone: a light and electron microscopic study. J Periodont Res 21: 592-612.
19. Polson AM, Hanes PJ (1987). Cell and fiber attachment to demineralized dentin. A comparison between normal and periodontitis-affected root surfaces. J Clin Periodontol 14:357-365.
20. Polson AM, Frederick GT, Ladenheim S, Hanes PJ (1983). The production of a root surface smear layer by instrumentation and its removal by citric acid. J Periodontol 55:443-446.
21. Ripamonti U, Heliotis M, van den Heever B, Reddi AH (1994). Bone morphogenetic proteins induce periodontal regeneration in baboons (Papio ursinus). J Periodont Res 29:439-445.
22. Rutherford RB, Ryan ME, Kennedy JE, Tucker MM, Charette MF (1993a). Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys. J Periodontol 20:537-544.
23. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M (1993b). Induction of reparative dentin formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 38:571-576.
24. Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, et al. (1992). Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267:20352-20362.
25. Selvig KA (1994). Discussion: Animal models in reconstructive therapy. J Periodontol 65:1169-1172.
26. Selvig KA, Wikesjö UME, Bogle GC, Finkelman RD (1994). Impaired early bone formation in periodontal fenestration defects in dogs following application of insulin-like growth factor II, basic fibroblast growth factor beta-1. J Clin Periodontol 21:380-385.
27. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjö UM (1995). Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 66:131-138.
28. Tenorio D, Cruchley A, Hughes FJ (1993a). Immunocytochemical investigation of the rat cementoblast phenotype. J Periodont Res 28:411-419.
29. Tenorio D, Goodman SA, Hughes FJ (1993b). Bone morphogenetic protein 2 (BMP-2) expression in the developing rat tooth germ (abstract). J Dent Res 72:713.
30. Tenorio D, Cruchley A, Hughes F (1995). The investigation of the expression of PTH receptors in rat cementoblasts. Arch Oral Biol 41:299-305.
31. Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V (1992). Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinol 130:1318-1324.
32. Urist MR (1965). Bone formation by autoinduction. Science 150:893-899.
33. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, et al. (1990). Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 87:2220-2224.
34. Wang EA, Israel DI, Kelly S, Luxenberg DP (1993). Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9:57-71.
35. Wesselink PR, Beertsen W (1994). Repair processes in the periodontium following dentoalveolar ankylosis: the effect of masticatory function. J Clin Periodontol 21:472-478.
36. Wetterwald A, Hofstetter W, Cecchini MG, Lanske B, Wagner C, Fleisch H (1996). Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 18:125-132.
37. Wozney JM (1993). Bone morphogenetic proteins and their gene expression. In: Cellular and molecular biology of bone. Noda M, editor. San Diego, CA: Academic Press Inc., pp. 131-167.
38. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. (1988). Novel regulators of bone formation: molecular clones and activities. Science 242:1528-1534.
39. Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, et al. (1991). Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113: 681-687.