Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts

Cancer

Volumn 119, Issue 7, 2013, Pages 1321-1329

  Guan, Baoxiang ^a   Li, Hao ^a,b   Yang, Zhengduo ^a,b   Hoque, Ashraful ^a   Xu, Xiaochun ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

bile acids; cyclooxygenase 2; esophageal cancer; farnesoid X activated receptor; guggulsterone; retinoic acid receptor

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLOOXYGENASE 2; FARNESOID X RECEPTOR; GUGGULSTERONE; KI 67 ANTIGEN; RETINOIC ACID RECEPTOR BETA; SHORT HAIRPIN RNA;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRADING; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS RESECTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR XENOGRAFT;

ADENOCARCINOMA; AGED; ANIMALS; BILE ACIDS AND SALTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 2; ESOPHAGEAL NEOPLASMS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MICE; MICE, NUDE; PREGNENEDIONES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 84875382618     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27910     Document Type: Article

References (40)

1. Blot W,. Esophageal cancer trends and risk factors. Semin Oncol. 1994; 21: 403-410.
2. Spechler SJ,. Barrett's esophagus: a molecular perspective. Curr Gastroenterol Rep. 2005; 7: 177-181.
3. Chen X, Yang CS,. Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention. Carcinogenesis. 2001; 22: 1119-1129.
4. Barak N, Ehrenpreis ED, Harrison JR, Sitrin MD,. Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. Obes Rev. 2002; 3: 9-15.
5. Makishima M, Okamoto AY, Repa JJ, et al. Identification of a nuclear receptor for bile acids. Science. 1999; 284: 1362-1625.
6. Parks DJ, Blanchard SG, Bledsoe RK, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999; 284: 1365-1368.
7. Xu X-C, Liu X, Tahara E, Lippman SM, Lotan R,. Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines. Cancer Res. 1999; 59: 2477-2483.
8. Smith KJ, O'Brien SM, Smithers BM, et al. Interactions among smoking, obesity, and symptoms of acid reflux in Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 2005; 14: 2481-2486.
9. Lindblad M, Rodriguez LA, Lagergren J,. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control. 2005; 16: 285-294.
10. Xu X-C,. Risk factors and altered gene expression in esophageal cancer. In:, Verma M, ed. Cancer Epidemiology. New York: Humana Press; 2009: 335-360.
11. Jaiswal K, Lopez-Guzman C, Souza RF, Spechler SJ, Sarosi GA Jr,. Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line. Am J Physiol Gastrointest Liver Physiol. 2006; 290: G335-G342.
12. Looby E, Abdel-Latif MM, Athie-Morales V, Duggan S, Long A, Kelleher D,. Deoxycholate induces COX-2 expression via Erk1/2, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells [serial online]. BMC Cancer. 2009; 9: 190.
13. Bernstein H, Bernstein C, Payne CM, Dvorak K,. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterol. 2009; 15: 3329-3340.
14. Wu J, Gong J, Geng J, Song Y,. Deoxycholic acid induces the overexpression of intestinal mucin, MUC2, via NF-kB signaling pathway in human esophageal adenocarcinoma cells [serial online]. BMC Cancer. 2008; 8: 333.
15. Li M, Song S, Lippman SM, et al. Induction of retinoic acid receptor-β suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene. 2002; 21: 411-418.
16. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ,. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001; 294: 1866-1870.
17. Houle B, Leduc F, Bradley WE,. Implication of RARB in epidermoid (squamous) lung cancer. Genes Chromosomes Cancer. 1991; 3: 358-366.
18. Ren M, Pozzi S, Bistulfi G, et al. Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance. Mol Cell Biol. 2005; 25: 10591-10603.
19. 2 associated with suppression of cyclooxygenase-2. Cancer Prevent Res. 2009; 2: 274-280.
20. 2 expression. Oncogene. 2005; 24: 8268-8276.
21. Chambon P,. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996; 10: 940-954.
22. 2 on tumor cell growth and gene expression through binding to and inhibiting RhoA. Cancer Res. 2006; 66: 7111-7118.
23. Huang J, Liang ZD, Wu TT, et al. Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. Cancer Res. 2007; 67: 1589-1593.
24. Song S, Xu X-C,. Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells. Biochem Biophys Res Commun. 2001; 281: 872-877.
25. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B,. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009; 89: 147-191.
26. Wang YD, Yang F, Chen WD, et al. Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol. 2008; 22: 1622-1632.
27. Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A,. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res. 2008; 68: 9589-9594.
28. Swales KE, Korbonits M, Carpenter R, Walsh DT, Warner TD, Bishop-Bailey D,. The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression. Cancer Res. 2006; 66: 10120-10126.
29. Journe F, Durbecq V, Chaboteaux C, et al. Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients. Breast Cancer Res Treat. 2009; 115: 523-535.
30. De Gottardi A, Dumonceau JM, Bruttin F, et al. Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro [serial online]. Mol Cancer. 2006; 5: 48.
31. Das A, Yaqoob U, Mehta D, Shah VH,. FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9. Arterioscler Thromb Vasc Biol. 2009; 29: 562-570.
32. Capello A, Moons LM, Van de Winkel A, et al. Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus. Am J Gastroenterol. 2008; 103: 1510-1516.
33. Lee JY, Lee KT, Lee JK, et al. Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. Br J Cancer. 2011; 104: 1027-1037.
34. Shishodia S, Sethi G, Ahn KS, Aggarwal BB,. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem Pharmacol. 2007; 74: 118-130.
35. Urizar NL, Moore DD,. GUGULIPID: a natural cholesterol lowering agent. Annu Rev Nutr. 2003; 23: 303-313.
36. Kim ES, Hon SY, Lee HK, et al. Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. Oncol Rep. 2008; 20: 1321-1327.
37. Urizar NL, Liverman AB, Dodds DT, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002; 296: 1703-1706.
38. Cui J, Huang L, Zhao A, Lew JL, Sahoo S, Meinke PT,. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem. 2003; 278: 10214-10220.
39. Jaiswal K, Tello V, Lopez-Guzman C, et al. Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line. Surgery. 2004; 136: 160-168.
40. Jenkins GJ, Harries K, Doak SH, et al. The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis. 2004; 25: 317-323.