Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus

American Journal of Gastroenterology

Volumn 103, Issue 6, 2008, Pages 1510-1516

  Capello, Astrid ^a   Moons, Leon M G ^a   Van De Winkel, Anouk ^a   Siersema, Peter D ^a   Van Dekken, Herman ^a   Kuipers, Ernst J ^a   Kusters, Johannes G ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Central Laboratory for Bacteriology and Serology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR; GUGGULSTERONE;

ARTICLE; BARRETT ESOPHAGUS; BILE ACID METABOLISM; CANCER CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE CONTROL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SQUAMOUS EPITHELIUM;

ADULT; AGED; BARRETT ESOPHAGUS; BILE ACIDS AND SALTS; CARRIER PROTEINS; CASE-CONTROL STUDIES; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CHEMOKINES; DNA-BINDING PROTEINS; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 44949083340     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2008.01908.x     Document Type: Article

References (26)

1. Souza RF, Morales CP, Spechler SJ. Review article: A conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus. Aliment Pharmacol Ther 2001 15 : 1087 100.
2. Fullard M, Kang JY, Neild P, et al. Systematic review: Does gastro-oesophageal reflux disease progress? Aliment Pharmacol Ther 2006 24 : 33 45.
3. Eksteen B, Miles A, Curbishley SM, et al. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. J Immunol 2006 177 : 593 603.
4. Muhlbauer M, Allard B, Bosserhoff AK, et al. Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells. Am J Physiol 2004 286 : G1000 8.
5. Bax DA. Barrett's esophagus: A molecular characterization. Rotterdam: Optima Grafische Communicatie, 2005.
6. Parks DJ, Blanchard SG, Bledsoe RK, et al. Bile acids: Natural ligands for an orphan nuclear receptor. Science 1999 284 : 1365 8.
7. Makishima M, Okamoto AY, Repa JJ, et al. Identification of a nuclear receptor for bile acids. Science 1999 284 : 1362 5.
8. Wang H, Chen J, Hollister K, et al. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999 3 : 543 53.
9. De Gottardi A, Dumonceau JM, Bruttin F, et al. Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. Mol Cancer 2006 5 : 48.
10. Schote AB, Turner JD, Schiltz J, et al. Nuclear receptors in human immune cells: Expression and correlations. Mol Immunol 2007 44 : 1436 45.
11. Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000 6 : 517 26.
12. Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004 25 : 677 86.
13. Moons LM, Siersema PD, Groothuismink ZMA, et al. Bile acids induce a shift towards a Th2 cytokine profile in Barrett's esophagus. Gastroenterology 2006 130 : A405.
14. Urizar NL, Liverman AB, Dodds DT, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 2002 296 : 1703 6.
15. Wu J, Xia C, Meier J, et al. The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol 2002 16 : 1590 7.
16. Cui J, Huang L, Zhao A, et al. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem 2003 278 : 10214 20.
17. Haggitt RC. Pathology of Barrett's esophagus. J Gastrointest Surg 2000 4 : 117 8.
18. Bax DA, Haringsma J, Einerhand AW, et al. MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio. J Clin Pathol 2004 57 : 1267 72.
19. Nishihira T, Hashimoto Y, Katayama M, et al. Molecular and cellular features of esophageal cancer cells. J Cancer Res Clin Oncol 1993 119 : 441 9.
20. Gotley DC, Morgan AP, Ball D, et al. Composition of gastro-oesophageal refluxate. Gut 1991 32 : 1093 9.
21. Jenkins GJ, Harries K, Doak SH, et al. The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis 2004 25 : 317 23.
22. Kauer WK, Peters JH, DeMeester TR, et al. Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 1997 122 : 874 81.
23. Kalaany NY, Mangelsdorf DJ. LXRS and FXR: The yin and yang of cholesterol and fat metabolism. Ann Rev Physiol 2006 68 : 159 91.
24. Salminen JT, Tuominen JA, Ramo OJ, et al. Oesophageal acid exposure: Higher in Barrett's oesophagus than in reflux oesophagitis. Ann Med 1999 31 : 46 50.
25. Xu X, LoCicero J 3rd., Macri E, et al. Barrett's esophagus and associated adenocarcinoma in a mouse surgical model. J Surg Res 2000 88 : 120 4.
26. Sinal CJ, Tohkin M, Miyata M, et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000 102 : 731 44.