Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells

Oncology Reports

Volumn 20, Issue 6, 2008, Pages 1321-1327

  Kim, Eun Soo ^a   Hong, Sung Yi ^b   Lee, Hye Kyung ^b   Kim, Seung Won ^b   An, Min Jin ^a   Kim, Tae Il ^a   Lee, Kyoung Ryul ^b   Kim, Won Ho ^a   Cheon, Jea Hee ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Seoul Medical Science Institute   (South Korea)

Author keywords

Angiogenesis; Colorectal cancer; Guggulsterone; Hypoxia inducible factor 1 ; Signal transducer and activator of transcription 3; Vascular endothelial growth factor

Indexed keywords

GELATINASE A; GELATINASE B; GUGGULSTERONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; STAT3 PROTEIN; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; PREGNA 4,17 DIENE 3,16 DIONE; PREGNA-4,17-DIENE-3,16-DIONE; PREGNANE DERIVATIVE; STAT3 PROTEIN, HUMAN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; BIOLOGICAL MODEL; CELL MOTION; COLON TUMOR; GENE EXPRESSION REGULATION; METABOLISM; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); PROMOTER REGION; TUMOR CELL LINE; VASCULAR ENDOTHELIUM;

ANGIOGENESIS INHIBITORS; CELL LINE, TUMOR; CELL MOVEMENT; COLONIC NEOPLASMS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PREGNENEDIONES; PROMOTER REGIONS, GENETIC; STAT3 TRANSCRIPTION FACTOR; TETRAZOLIUM SALTS; THIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 59249093262     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000147     Document Type: Article

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