Changes in the adult vertebrate auditory sensory epithelium after trauma

Hearing Research

Volumn 297, Issue , 2013, Pages 91-98

  Oesterle, Elizabeth C ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUDITORY SENSORY EPITHELIUM; CELL FUNCTION; CELL REGENERATION; CELL SURVIVAL; CELLULAR PARAMETERS; CORTI ORGAN; EAR INJURY; HAIR CELL REGENERATION; HAIR CELL REPLACEMENT; INNER EAR; NERVE CELL DEGENERATION; NEUROEPITHELIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGENERATIVE ABILITY; REVIEW; SCAR FORMATION; SUPPORT CELL; VERTEBRATE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; EAR, INNER; EPITHELIUM; HAIR CELLS, AUDITORY; HEARING; HEARING LOSS, NOISE-INDUCED; HUMANS; MEMBRANE POTENTIALS; NERVE REGENERATION; ORGAN OF CORTI; REGENERATION; SPIRAL GANGLION; STEM CELL TRANSPLANTATION; VERTEBRATES; WOUNDS AND INJURIES;

EID: 84875378626     PISSN: 03785955     EISSN: 18785891     Source Type: Journal    
DOI: 10.1016/j.heares.2012.11.010     Document Type: Review

References (138)

1. Abrashkin K.A., Izumikawa M., Miyazawa T., Wang C.H., Crumling M.A., Swiderski D.L., Beyer L.A., Gong T.W., Raphael Y. The fate of outer hair cells after acoustic or ototoxic insults. Hear. Res. 2006, 218(1-2):20-29.
2. Ades H.W., Engström H. Anatomy of the inner ear. Handbook of Sensory Physiology 1974, vol. V/I.:125-158. Springer-Verlag, New York.
3. Adler H.J., Raphael Y. New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear. Neurosci. Lett. 1996, 205:17-20.
4. Baird R.A., Steyger P.S., Schuff N.R. Mitotic and nonmitotic hair cell regeneration in the bullfrog vestibular otolith organs. Ann. N.Y. Acad. Sci. 1996, 19(781):59-70.
5. Baird R.A., Burton M.D., Lysakowski A., Fashena D.S., Naeger R.A. Hair cell recovery in mitotically blocked cultures of the bullfrog saccule. Proc. Natl. Acad. Sci. U.S.A 2000, 97(22):11722-11729.
6. Ben-Yosef T., Belyantseva I.A., Saunders T.L., Hughes E.D., Kawamoto K., Van Itallie C.M., Beyer L.A., Halsey K., Gardner D.J., Wilcox E.R., Rasmussen J., Anderson J.M., Dolan D.F., Forge A., Raphael Y., Camper S.A., Friedman T.B. Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum. Mol. Genet. 2003, 12:2049-2061.
7. Bermingham-McDonogh O., Reh T.A. Regulated reprogramming in the regeneration of sensory receptor cells. Neuron 2011, 71(3):389-405.
8. Bhatt K.A., Liberman M.C., Nadol J.B. Morphometric analysis of age-related changes in the human basilar membrane. Ann. Otol. Rhinol. Laryngol. 2001, 110(12):1147-1153.
9. Bird J.E., Daudet N., Warchol M.E., Gale J.E. Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear. J. Neurosci. 2010, 30(37):12545-12556.
10. Boettger T., Hubner C.A., Maier H., Rust M.B., Beck F.X., et al. Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature 2002, 416:874-878.
11. Bohne B.A., Rabbitt K.D. Holes in the reticular lamina after noise exposure: implication for continuing damage in the organ of Corti. Hear. Res. 1983, 11:41-53.
12. Bredberg G. Cellular pattern and nerve supply of the human organ of Corti. Acta Otolaryngol. Suppl. 1968, 236:1.
13. Brigande J.V., Heller S. Quo vadis, hair cell regeneration?. Nat. Neurosci. 2009, 12(6):679-685.
14. Brignull H.R., Raible D.W., Stone J.S. Feathers and fins: non-mammalian models for hair cell regeneration. Brain Res. 2009, 1277:12-23.
15. Burns J.C., Christophel J.J., Collado M.S., Magnus C., Carfrae M., Corwin J.T. Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds. J. Comp. Neurol. 2008, 511(3):396-414.
16. Cafaro J., Lee G.S., Stone J.S. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Dev. Dyn. 2007, 236:156-170.
17. Cheng A.G., Cunningham L.L., Rubel E.W. Mechanisms of hair cell death and protection. Curr. Opin. Otolaryngol. Head Neck Surg. 2005, 13:343-348.
18. Coco A., Epp S.B., Fallon J.B., Xu J., Millard R.E., Shepherd R.K. Does cochlear implantation and electrical stimulation affect residual hair cells and spiral ganglion neurons?. Hear. Res. 2007, 225(1-2):60-70.
19. Collado M.S., Burns J.C., Hu Z., Corwin J.T. Recent advances in hair cell regeneration research. Curr. Opin. Otolaryngol. Head Neck Surg. 2008, 16(5):465-471.
20. Corwin J.T., Cotanche D.A. Regeneration of sensory hair cells after acoustic trauma. Science 1988, 240(4860):1772-1774.
21. Cotanche D.A. Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Hear. Res. 1987, 30:181-196.
22. Cotanche D.A., Kaiser C.L. Hair cell fate decisions in cochlear development and regeneration. Hear. Res. 2010, 266(1-2):18-25.
23. Cotanche D.A., Messana E.P., Ofsie M.S. Migration of hyaline cells into the chick basilar papilla during severe noise damage. Hear. Res. 1995, 91(1-2):148-159.
24. Dai C.F., Mangiardi D., Cotanche D.A., Steyger P.S. Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo. Hear. Res. 2006, 213(1-2):64-78.
25. Dallos P., Harris D. Properties of auditory nerve responses in absence of outer hair cells. J. Neurophysiol. 1978, 41(2):365-383.
26. de Felipe M.M., Feijoo Redondo A.F., García-Sancho J., Schimmang T., Alonso M.B. Cell- and gene-therapy approaches to inner ear repair. Histol. Histopathol 2011, 26(7):923-940.
27. de Groot J.C., Meeuwsen F., Ruizendaal W.E., Veldman J.E. Ultrastructural localization of gentamicin in the cochlea. Hear. Res. 1990, 50(1-2):35-42.
28. Duncan L.J., Mangiardi D.A., Matsui J.I., Anderson J.K., McLaughlin-Williamson K., Cotanche D.A. Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms. J. Comp. Neurol. 2006, 499:691-701.
29. Edge A., Chen Z.-Y. Hair cell regeneration. Curr. Opin. Neurobiol. 2008, 18:377-382.
30. Forge A. Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment. Hear. Res. 1985, 19(2):171-182.
31. Forge A., Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hear. Res. 2000, 139(1-2):97-115.
32. Forge A., Li L., Nevill G. Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs. J. Comp. Neurol. 1998, 397(1):69-88.
33. Forge A., Souter M., Denman-Johnson K. Structural development of sensory cells in the ear. Semin. Cell. Dev. Biol. 1997, 8:225-237.
34. Gale J.E., Meyers J.R., Periasamy A., Corwin J.T. Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule. J. Neurobiol. 2002, 50(2):81-92.
35. Girod D.A., Duckert L.G., Rubel E.W. Possible precursors of regenerated hair cells in the avian cochlea following acoustic trauma. Hear. Res. 1989, 42(2-3):175-194.
36. Gleich O., Manley G.A. The hearing organ of birds and crocodilia. Comparative Hearing: Birds and Reptiles 2000, 70-138. Springer Verlag, New York. R.J. Dooling, R.R. Fay, A.N. Popper (Eds.).
37. Groves A.K. The challenge of hair cell regeneration. Exp. Biol. Med. (Maywood) 2010, 235(4):434-446.
38. Hawkins J.E., Johnsson L.G., Stebbins W.C., Moody D.B., Coombs S.L. Hearing loss and cochlear pathology in monkeys after noise exposure. Acta Otolaryngol. 1976, 81(3-4):337-343.
39. Hinojosa R., Nelson E.G., Lerner S.A., Redleaf M.I., Schramm D.R. Aminoglycoside ototoxicity: a human temporal bone study. Laryngoscope 2001, 111(10):1797-1805.
40. Hirose K., Discolo C.M., Keasler J.R., Ransohoff R. Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma. J. Comp. Neurol. 2005, 489(2):180-194.
41. Hirose K., Westrum L.E., Cunningham D.E., Rubel E.W. Electron microscopy of degenerative changes in the chick basilar papilla after gentamicin exposure. J. Comp. Neurol. 2004, 470(2):164-180.
42. Hoa M., Linthicum F.H., Merchant S., Segil N. Supporting cell survival in temporal bones of patients with known hearing loss. Assoc. Res. Otolaryngol. 2010, Abstract 33.
43. Hordichok A.J., Steyger P.S. Closure of supporting cell scar formations requires dynamic actin mechanisms. Hear. Res. 2007, 232(1-2):1-19.
44. Hudspeth A.J. The cellular basis of hearing: the biophysics of hair cells. Science 1985, 230(4727):745-752.
45. Hume C.R., Bratt D.L., Oesterle E.C. Expression of LHX3 and SOX2 during mouse inner ear development. Gene Expr. Patterns 2007, 7:798-807.
46. Husbands J.M., Steinberg S.A., Kurian R., Saunders J.C. Tip-link integrity on chick tall hair cell stereocilia following intense sound exposure. Hear. Res. 1999, 135(1-2):135-145.
47. Imamura S., Adams J.C. Distribution of gentamicin in the guinea pig inner ear after local or systemic application. J. Assoc. Res. Otolaryngol. 2003, 4(2):176-195.
48. Izumikawa M., Batts S.A., Miyazawa T., Swiderski D.L., Raphael Y. Response of the flat cochlear epithelium to forced expression of Atoh1. Hear. Res. 2008, 240(1-2):52-56.
49. Izumikawa M., Minoda R., Kawamoto K., Abrashkin K.A., Swiderski D.L., et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat. Med. 2005, 11:271-276.
50. Janas J.D., Cotanche D.A., Rubel E.W. Avian cochlear hair cell regeneration: stereological analyses of damage and recovery from a single high dose of gentamicin. Hear. Res. 1995, 92(1-2):17-29.
51. Jia S., Yang S., Guo W., He D.Z. Fate of mammalian cochlear hair cells and stereocilia after loss of the stereocilia. J. Neurosci. 2009, 29(48):15277-15285.
52. Jin Z.H., Kikuchi T., Tanaka K., Kobayashi T. Expression of glutamate transporter GLAST in the developing mouse cochlea. Tohoku J. Exp. Med. 2003, 200:137-144.
53. Johnsson L.G., Hawkins J.E., Kingsley T.C., Black F.O., Matz G.J. Aminoglycoside-induced cochlear pathology in man. Acta Otolaryngol. Suppl. 1981, 383:1-19.
54. Jopling C., Boue S., Izpisua Belmonte J.C. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat. Rev. Mol. Cell. Biol. 2011, 12(2):79-89.
55. Kim Y.H., Raphael Y. Cell division and maintenance of epithelial integrity in the deafened auditory epithelium. Cell Cycle 2007, 6(5):612-619.
56. Kopke R.D., Liu W., Gabaizadeh R., Jacono A., Feghali J., Spray D., et al. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am. J. Otol. 1997, 18:559-571.
57. Köppl C. Birds-same thing, but different? Convergent evolution in the avian and mammalian auditory systems provides informative comparative models. Hear. Res. 2011, 273(1-2):65-71.
58. Kujawa S.G., Liberman M.C. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J. Neurosci. 2009, 29(45):14077-14085.
59. Ladrech S., Guitton M., Saido T., Lenoir M. Calpain activity in the amikacin-damaged rat cochlea. J. Comp. Neurol. 2004, 477(2):149-160.
60. Laine H., Sulg M., Kirjavainen A., Pirvola U. Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors. Dev. Biol. 2010, 337(1):134-146.
61. Leonova E.V., Raphael Y. Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti. Hear. Res. 1997, 113(1-2):14-28.
62. Li H., Roblin G., Liu H., Heller S. Generation of hair cells by stepwise differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A 2003, 100:13495-13500.
63. Liberman M.C., Mulroy M.J. Acute and chronic effects of acoustic trauma: cochlear pathology and auditory nerve pathophysiology. New Perspectives on Noise-induced Hearing Loss 1982, 105-136. Raven, New York. R.P. Hamernik, D. Henderson, R. Salvi (Eds.).
64. Liu W., Staecker H., Stupak H., Malgrange B., Lefebvre P., Van De Water T.R. Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 1998, 9:2609-2614.
65. Liu Z., Dearman J.A., Cox B.C., Walters B.J., Zhang L., Ayrault O., Zindy F., Gan L., Roussel M.F., Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression. J. Neurosci. 2012, 32(19):6600-6610.
66. Liu Z., Walters B.J., Owen T., Brimble M.A., Steigelman K.A., Zhang L., Mellado Lagarde M.M., Valentine M.B., Yu Y., Cox B.C., Zuo J. Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J. Neurosci. 2012, 32(31):10530-10540.
67. Makary C.A., Shin J., Kujawa S.G., Liberman M.C., Merchant S.N. Age-related primary cochlear neuronal degeneration in human temporal bones. J. Assoc. Res. Otolaryngol. 2011, 12(6):711-717.
68. Manley G.A. Lizard auditory papillae: an evolutionary kaleidoscope. Hear. Res. 2011, 273(1-2):59-64.
69. Matsui J.I., Ogilvie J.M., Warchol M.E. Inhibition of caspases prevents ototoxic and ongoing hair cell death. J. Neurosci. 2002, 22(4):1218-1227.
70. McCullar J.S., Ty S., Campbell S., Oesterle E.C. Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 2010, 30(2):478-490.
71. McDowell B., Davies S., Forge A. The effect of gentamicin-induced hair cell loss on the tight junctions of the reticular lamina. Hear. Res. 1989, 40(3):221-232.
72. Nadol J.B., Ketten D.R., Burgess B.J. Otopathology in a case of multichannel cochlear implantation. Laryngoscope 1994, 104(3 Pt 1):299-303.
73. Nakano Y., Kim S.H., Kim H.M., Sanneman J.D., Zhang Y., Smith R.J., Marcus D.C., Wangemann P., Nessler R.A., Banfi B. A claudin-9-based ion permeability barrier is essential for hearing. PLoS Genet. 2009, 5:e1000610.
74. Oesterle E.C., Stone J.S. Hair cell regeneration: mechanisms guiding cell proliferation and differentiation. Hair Cell Regeneration, Repair, and Protection 2008, 141-197. Springer-Verlag, New York. R.J. Salvi, A.N. Popper, R.R. Fay (Eds.).
75. Oesterle E., Campbell S. Supporting cell characteristics in long-deafened aged mouse ears. J. Assoc. Res. Otolaryngol. 2009, 10(4):525-544.
76. Oesterle E., Campbell S., Taylor R., Forge A., Hume C.R. Sox2 and Jagged1 expression in adult mouse inner ear sensory epithelia. J. Assoc. Res. Otolaryngol. 2008, 9(1):65-89.
77. Kip1 is required to maintain proliferative quiescence in the adult cochlea and pituitary. Cell Cycle 2011, 10(8):1-12.
78. Oshima K., Grimm C.M., Corrales C.E., Senn P., Martinez Monedero R., Géléoc G.S., Edge A., Holt J.R., Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J. Assoc. Res. Otolaryngol. 2007, 8(1):18-31.
79. Oshima K., Shin K., Diensthuber M., Peng A.W., Ricci A.J., Heller S. Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell. 2010, 141(4):704-716.
80. Oshima K., Suchert S., Blevins N.H., Heller S. Curing hearing loss: patient expectations, health care practitioners, and basic science. J. Commun. Dis. 2010, 43:311-318.
81. Raphael Y., Altschuler R.A. Scar formation after drug-induced cochlear insult. Hear. Res. 1991, 51(2):173-183.
82. Raphael Y., Altschuler R.A. Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration. Cell. Motil. Cytoskeleton 1991, 18(3):215-227.
83. Raphael Y., Altschuler R.A. Structure and innervation of the cochlea. Brain Res. Bull. 2003, 60:397-422.
84. Raphael Y., Kim Y.H., Osumi Y., Izumikawa M. Non-sensory cells in the deafened organ of Corti: approaches for repair. Int. J. Dev. Biol. 2007, 51(6-7):649-654.
85. Riazuddin S., Ahmed Z.M., Fanning A.S., Lagziel A., Kitajiri S., Ramzan K., Khan S.N., Chattaraj P., Friedman P.L., Anderson J.M., Belyantseva I.A., Forge A., Friedman T.B. Tricellulin is a tight-junction protein necessary for hearing. Am. J. Hum. Genet. 2006, 79:1040-1051.
86. Roberson D.W., Kreig C.S., Rubel E.W. Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium. Aud. Neurosci. 1996, 195-205.
87. Roberson D.W., Rubel E.W. Cell division in the gerbil cochlea after acoustic trauma. Am. J. Otol 1994, 15:28-34.
88. Roberson D.W., Alosi J.A., Cotanche D.A. Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium. J. Neurosci. Res. 2004, 78:461-471.
89. Robertson D. Functional significance of dendritic swelling after loud sounds in the guinea pig cochlea. Hear. Res. 1983, 9(3):263-278.
90. Ronaghi M., Nasr M., Heller S. Concise review: Inner ear stem cells-an oxymoron, but why?. Stem Cells 2012, 30(1):69-74.
91. Ryals B.M., Rubel E.W. Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science 1988, 240(4860):1774-1776.
92. Saha S., Slepecky N.B. Age-related changes in microtubules in the guinea pig organ of Corti. Tubulin isoform shifts with increasing age suggest changes in micromechanical properties of the sensory epithelium. Cell. Tissue Res. 2000, 300(1):29-46.
93. Schuknecht H. Lesions of the organ of Corti. Trans. Am. Acad. Ophthalmol. Otolaryngol. 1953, 57:366-383.
94. Shibata S.B., Budenz C.L., Bowling S.A., Pfingst B.E., Raphael Y. Nerve maintenance and regeneration in the damaged cochlea. Hear. Res. 2011, 281(1-2):56-64.
95. Shibata S.B., Raphael Y. Future approaches for inner ear protection and repair. J. Commun. Disord. 2010, 43(4):295-310.
96. Slattery E.L., Warchol M.E. Cisplatin ototoxicity blocks sensory regeneration in the avian inner ear. J. Neurosci. 2010, 30(9):3473-3481.
97. Slepecky N.B. The structure of the mammalian cochlea. The Cochlea 1996, 44-129. Springer-Verlag, New York. P. Dallos, A.N. Popper, R.R. Fay (Eds.).
98. Smith C.A. Progress in Sensory Physiology 2, Recent Advances in Structural Correlates of Auditory Receptors 1981, Springer-Verlag, New York. Autrum, Ottoson, Schmidt (Eds.).
99. Smith C.A., Takasaka T. Auditory receptor organs of reptiles, birds, and mammals. Contrib. Sens. Physiol. 1971, 5:129-178.
100. Sobkowicz H.M., August B.K., Slapnick S.M. Epithelial repair following mechanical injury of the developing organ of Corti in culture: an electron microscopic and autoradiographic study. Exp. Neurol. 1992, 115(1):44-49.
101. Sobkowicz H.M., August B.K., Slapnick S.M. Post-traumatic survival and recovery of the auditory sensory cells in culture. Acta Otolaryngol. 1996, 116(2):257-262.
102. Sobkowicz H.M., August B.K., Slapnick S.M. Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture. Int. J. Dev. Neurosci. 2002, 20(7):537-554.
103. Souter M., Nevill G., Forge A. Postnatal maturation of the organ of Corti in gerbils: morphology and physiological responses. J. Comp. Neurol. 1997, 386:635-651.
104. Spicer S.S., Schulte B.A. Differences along the place-frequency map in the structure of supporting cells in the gerbil cochlea. Hear. Res. 1994, 79:161-177.
105. Spoendlin H. Degeneration behaviour of the cochlear nerve. Arch. Klin. Exp. Ohren. Nasen. Kehlkopfheilkd. 1971, 200(4):275-291.
106. Spoendlin H.H. The innervation of the cochlear receptor. Proceeding of a Symposium on Basic Mechanisms in Hearing 1973, 185-234. Academic Press, New York.
107. Spoendlin H.H., Gacek R.R. Electron microscopic study of the efferent and afferent innervation of the organ of Corti in the cat. Ann. Otol. Rhinol. Laryngol. 1963, 72:660-686.
108. Stankovic K., Rio C., Xia A., Sugawara M., Adams J.C., Liberman M.C., Corfas G. Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J. Neurosci. 2004, 24(40):8651-8661.
109. Stone J.S., Cotanche D.A. Hair cell regeneration in the avian auditory epithelium. Int. J. Dev. Biol. 2007, 51:633-647.
110. Stone J.S., Choi Y.S., Woolley S.M., Yamashita H., Rubel E.W. Progenitor cell cycling during hair cell regeneration in the vestibular and auditory epithelia of the chick. J. Neurocytol. 1999, 28:863-876.
111. Sugahara K., Cunningham L.L., Rubel E.W. Protection of adult vestibular hair cells against aminoglycoside toxicity by inhibition in the JNK signaling pathway. Hear. Res. 2006, 221:128-135.
112. Sugawara M., Corfas G., Liberman M.C. Influence of supporting cells on neuronal degeneration after hair cell loss. J. Assoc. Res. Otolaryngol. 2005, 6(2):136-147.
113. Sugawara M., Murtie J.C., Stankovic K.M., Liberman M.C., Corfas G. Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear. J. Comp. Neurol. 2007, 501(1):30-37.
114. Tannenbaum J., Slepecky N.B. Localization of microtubules containing posttranslationally modified tubulin in cochlear epithelial cells during development. Cell. Motil. Cytoskeleton 1997, 38(2):146-162.
115. Taylor R.R., Jagger D.J., Forge A. Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. PLoS One 2012, 7(1):e30577.
116. Teufert K.B., Linthicum F.H., Connell S.S. The effect of organ of Corti loss on ganglion cell survival in humans. Otol. Neurotol. 2006, 27(8):1146-1151.
117. Van Dijk P., Mason M.J., Schoffelen R.L., Narins P.M., Meenderink S.W. Mechanics of the frog ear. Hear. Res. 2011, 273(1-2):46-58.
118. van Ruijven M.W., de Groot J.C., Smoorenburg G.F. Time sequence of degeneration pattern in the guinea pig cochlea during cisplatin administration. A quantitative histological study. Hear. Res. 2004, 197(1-2):44-54.
119. van Ruijven M.W., de Groot J.C., Klis S.F., Smoorenburg G.F. The cochlear targets of cisplatin: an electrophysiological and morphological time-sequence study. Hear. Res. 2005, 205(1-2):241-248.
120. von Ilberg C., Spoendlin H., Arnold W. Autoradiographical distribution of locally applied dihydrostreptomycin in the inner ear. Acta Otolaryngol. 1971, 71(2):159-165.
121. Wang Q., Steyger P.S. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J. Assoc. Res. Otolaryngol. 2009, 10(2):205-219.
122. Warchol M.E. Cellular mechanisms of aminoglycoside ototoxicity. Curr. Opin. Otolaryngol. Head Neck Surg. 2010, 18(5):454-458.
123. Warchol M.E. Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and species. Hear. Res. 2011, 273(1-2):72-79.
124. Warchol M.E., Corwin J.T. Regenerative proliferation in organ cultures of the avian cochlea: identification of the initial progenitors and determination of the latency of the proliferative response. J. Neurosci. 1996, 16(17):5466-5477.
125. Warchol M., Hirose K. Resident macrophages are not required for normal hair cell regeneration in the avian cochlea. Assoc. Res. Otolaryngol. Abstr. 2012, 35:244.
126. Webster D.B. Degeneration followed by partial regeneration of the organ of Corti in deafness (dn/dn) mice. Exp. Neurol. 1992, 115(1):27-31.
127. Wei D., Yamoah E.N. Regeneration of the mammalian inner ear sensory epithelium. Curr. Opin. Otolaryngol. Head Neck Surg. 2009, 17(5):373-380.
128. Wever E.G. The Reptile Ear 1978, Princeton Univ. Press, Princeton N.J.
129. Wever E.G. The Amphibian Ear 1985, Princeton Univ. Press, Princeton N.J.
130. White P.M., Doetzlhofer A., Lee Y.S., Groves A.K., Segil N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature 2006, 441(7096):984-987.
131. Wilcox E.R., Burton Q.L., Naz S., Riazuddin S., Smith T.N., Ploplis B., Belyantseva I., Ben-Yosef T., Liburd N.A., Morell R.J., Kachar B., Wu D.K., Griffith A.J., Friedman T.B. Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell 2001, 104:165-172.
132. Yamasoba T., Kondo K. Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo. Cell. Tissue Res. 2006, 325:23-31.
133. Yamasoba T., Schacht J., Shoji F., Miller J.M. Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo. Brain Res. 1999, 815:317-325.
134. Ylikoski J., Wersäll J., Björkroth B. Degeneration of neural elements in the cochlea of the guinea-pig after damage to the organ of corti by ototoxic antibiotics. Acta Otolaryngol. Suppl. 1974, 326:23-41.
135. Zhao Y.-D., Yamoah E.N., Gillespie P.G. Regeneration of broken tip links and restoration of mechanical transduction in hair cells. Proc. Natl. Acad. Sci. USA 1996, 94:15469-15474.
136. Zheng J.L., Keller G., Gao W.Q. Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery. J. Neurosci. 1999, 19:2161-2170.
137. Zilberstein Y., Liberman M.C., Corfas G. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J. Neurosci. 2012, 32(2):405-410.
138. Zuccotti A., Kuhn S., Johnson S.L., Franz C., Singer W., Hecker D., Geisler H.S., Köpschall I., Rohbock K., Gutsche K., Dlugaiczyk J., Schick B., Marcotti W., Rüttiger L., Schimmang T., Knipper M. Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss. J. Neurosci. 2012, 32(25):8545-8553.