Nervous system regulation of the cancer genome

Brain, Behavior, and Immunity

Volumn 30, Issue SUPPL., 2013, Pages

  Cole, Steven W ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; Gene expression; Genomics; Stress; Transcriptome; Tumor microenvironment

Indexed keywords

CD68 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GELATINASE B; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2 RECEPTOR ALPHA; VASCULOTROPIN RECEPTOR 1;

ADRENERGIC SYSTEM; CANCER CELL; CANCER CHEMOTHERAPY; CANCER EPIDEMIOLOGY; CANCER GENETICS; CANCER PATIENT; CELL SURVIVAL; CLINICAL RESEARCH; DEPRESSION; DNA REPAIR; ENVIRONMENTAL FACTOR; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN GENOME; LIFESTYLE MODIFICATION; METASTASIS; NEUROENDOCRINE SYSTEM; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; SOCIAL ASPECT; SOCIAL SUPPORT; STROMA CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; NERVOUS SYSTEM; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 84875372318     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.11.008     Document Type: Review

References (124)

1. Amit I., Garber M., Chevrier N., Leite A.P., Donner Y., Eisenhaure T., Guttman M., Grenier J.K., Li W., Zuk O., Schubert L.A., Birditt B., Shay T., Goren A., Zhang X., Smith Z., Deering R., McDonald R.C., Cabili M., Bernstein B.E., Rinn J.L., Meissner A., Root D.E., Hacohen N., Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 2009, 326:257-263.
2. Antoni M.H., Lutgendorf S.K., Cole S.W., Dhabhar F.S., Sephton S.E., McDonald P.G., Stefanek M., Sood A.K. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat. Rev. Cancer 2006, 6:240-248.
3. Antoni M.H., Lutgendorf S.K., Blomberg B., Stagl J., Carver C.S., Lechner S., Diaz A., Arevalo J.M.G., Cole S.W. Transcriptional modulation of human leukocytes by cognitive-behavioral stress management in women undergoing treatment for breast cancer. Biol. Psychiatry 2012, 71:366-372.
4. Armaiz-Pena G.N., Cole S.W., Lutgendorf S.K., Sood A.K. Neuroendocrine influences on cancer progression. Brain Behav. Immun. 2012, (Epub ahead of print).
5. Bangalore S., Kumar S., Kjeldsen S.E., Makani H., Grossman E., Wetterslev J., Gupta A.K., Sever P.S., Gluud C., Messerli F.H. Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. Lancet Oncol. 2011, 12:65-82.
6. Barron T.I., Connolly R.M., Sharp L., Bennett K., Visvanathan K. Beta blockers and breast cancer mortality: a population-based study. J. Clin. Oncol. 2011, 29:2635-2644.
7. Bierhaus A., Wolf J., Andrassy M., Rohleder N., Humpert P.M., Petrov D., Ferstl R., von Eynatten M., Wendt T., Rudofsky G., Joswig M., Morcos M., Schwaninger M., McEwen B., Kirschbaum C., Nawroth P.P. A mechanism converting psychosocial stress into mononuclear cell activation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:1920-1925.
8. Black D.S., Cole S.W., Irwin M.R., Breen E., St.Cyr N.M., Nazarian N., Khalsa D.S., Lavretsky H. Yogic meditation reverses NF-kappaB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial. Psychoneuroendocrinology 2012.
9. Bower J.E., Ganz P.A., Irwin M.R., Arevalo J.M., Cole S.W. Fatigue and gene expression in human leukocytes: increased NF-kappaB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain Behav. Immun. 2011, 25:147-150.
10. Cacioppo J.T., Kiecolt-Glaser J.K., Malarkey W.B., Laskowski B.F., Rozlog L.A., Poehlmann K.M., Burleson M.H., Glaser R. Autonomic and glucocorticoid associations with the steady-state expression of latent Epstein-Barr virus. Horm. Behav. 2002, 42:32-41.
11. Cakir Y., Plummer H.K., Tithof P.K., Schuller H.M. Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. Int. J. Oncol. 2002, 21:153-157.
12. Campbell J.P., Karolak M.R., Ma Y., Perrien D.S., Masood-Campbell S.K., Penner N.L., Munoz S.A., Zijlstra A., Yang X., Sterling J.A., Elefteriou F. Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol. 2012, 10:e1001363.
13. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068. Cancer Genome Atlas Research Network.
14. Cao L., Liu X., Lin E.J., Wang C., Choi E.Y., Riban V., Lin B., During M.J. Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell 2010, 142:52-64.
15. Capitanio J.P., Mendoza S.P., Lerche N.W., Mason W.A. Social stress results in altered glucocorticoid regulation and shorter survival in simian acquired immune deficiency syndrome. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:4714-4719.
16. Caspi A., Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 2006, 7:583-590.
17. Chakroborty D., Sarkar C., Basu B., Dasgupta P.S., Basu S. Catecholamines regulate tumor angiogenesis. Cancer Res. 2009, 69:3727-3730.
18. Chang M., Brown H., Collado-Hidalgo A., Arevalo J., Galic Z., Symensma T., Tanaka L., Deng H., Zack J., Sun R., Cole S. Beta-adrenoreceptors reactivate KSHV lytic replication via PKA-dependent control of viral RTA. J. Virol 2005.
19. Chen E., Miller G.E., Walker H.A., Arevalo J.M., Sung C.Y., Cole S.W. Genome-wide transcriptional profiling linked to social class in asthma. Thorax 2009, 64:38-43. (Epub 2008 Nov 2010).
20. Chen E., Miller G.E., Kobor M.S., Cole S.W. Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Mol. Psychiatry 2011, 16:729-737.
21. Chida Y., Hamer M., Wardle J., Steptoe A. Do stress-related psychosocial factors contribute to cancer incidence and survival?. Nat. Clin. Pract. Oncol. 2008, 5:466-475. (Epub 2008 May 2020).
22. Cohen L., Cole S.W., Sood A.K., Prinsloo S., Kirschbaum C., Arevalo J.M., Jennings N.B., Scott S., Vence L., Wei Q., Kentor D., Radvanyi L., Tannir N., Jonasch E., Tamboli P., Pisters L. Depressive symptoms and cortisol rhythmicity predict survival in patients with renal cell carcinoma: role of inflammatory signaling. PLoS One 2012, 7:e42324.
23. Cole S.W. Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity. Brain Behav. Immun. 2008, 22:1049-1055.
24. Cole S.W. Social regulation of human gene expression. Curr. Dir. Psychol. Sci. 2009, 18:132-137.
25. Cole S.W. Elevating the perspective on human stress genomics. Psychoneuroendocrinology 2010, 35:955-962.
26. Cole S.W., Sood A.K. Molecular pathways: beta-adrenergic signaling in cancer. Clin. Cancer Res. 2012, 18:1201-1206.
27. Cole S.W., Kemeny M.E., Taylor S.E., Visscher B.R., Fahey J.L. Accelerated course of human immunodeficiency virus infection in gay men who conceal their homosexual identity. Psychosom. Med. 1996, 58:219-231.
28. Cole S.W., Kemeny M.E., Taylor S.E. Social identity and physical health: accelerated HIV progression in rejection-sensitive gay men. J. Pers. Soc. Psychol. 1997, 72:320-336.
29. Cole S.W., Yan W., Galic Z., Arevalo J., Zack J.A. Expression-based monitoring of transcription factor activity: the TELiS database. Bioinformatics 2005, 21:803-810.
30. Cole S.W., Hawkley L.C., Arevalo J.M., Sung C.Y., Rose R.M., Cacioppo J.T. Social regulation of gene expression in human leukocytes. Genome Biol. 2007, 8:1-13.
31. Cole S., Arevalo J., Takahashi R., Sloan E.K., Lutgendorf S., Sood A.K., Sheridan J.F., Seeman T. Computational identification of gene-social environment interaction at the human IL6 locus. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:5681-5686.
32. Cole S.W., Hawkley L.C., Arevalo J.M., Cacioppo J.T. Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3080-3085.
33. Cole, S.W., Conti, G., Arevalo, J.M., Ruggiero, A.M., Heckman, J.J., Suomi, S.J., 2012. Transcriptional modulation of the developing immune system by early life social adversity. Proc. Natl. Acad. Sci. U. S. A., in press. PubMed PMID: 23184974 (Epub 2012 Nov 26).
34. Collado-Hidalgo A., Sung C., Cole S. Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication. Brain Behav. Immun. 2006, 20:552-563. (Epub 2006 Feb 2028).
35. Creswell J.D., Irwin M.R., Burklund L.J., Lieberman M.D., Arevalo J.M., Ma J., Breen E.C., Cole S.W. Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial. Brain Behav. Immun. 2012, 26:1095-1101.
36. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
37. De Giorgi V., Grazzini M., Gandini S., Benemei S., Lotti T., Marchionni N., Geppetti P. Treatment with beta-blockers and reduced disease progression in patients with thick melanoma. Arch. Intern. Med. 2011, 171:779-781.
38. Dhabhar F.S., Saul A.N., Daugherty C., Holmes T.H., Bouley D.M., Oberyszyn T.M. Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma. Brain Behav. Immun. 2010, 24:127-137.
39. Drell T.L., Joseph J., Lang K., Niggemann B., Zaenker K.S., Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res. Treat. 2003, 80:63-70.
40. Fagundes C.P., Glaser R., Johnson S.L., Andridge R.R., Yang E.V., Di Gregorio M.P., Chen M., Lambert D.R., Jewell S.D., Bechtel M.A., Hearne D.W., Herron J.B., Kiecolt-Glaser J.K. Basal cell carcinoma: stressful life events and the tumor environment. Arch. Gen. Psychiatry 2012, 69:618-626.
41. Felger J.C., Cole S.W., Pace T.W., Hu F., Woolwine B.J., Doho G.H., Raison C.L., Miller A.H. Molecular signatures of peripheral blood mononuclear cells during chronic interferon-alpha treatment: relationship with depression and fatigue. Psychol. Med. 2012, 42:1591-1603.
42. Feng Z., Liu L., Zhang C., Zheng T., Wang J., Lin M., Zhao Y., Wang X., Levine A.J., Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:7013-7018.
43. Finch C.E. The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans 2007, Academic Press, Burlington, MA.
44. Frankenhaeuser M., Lundberg U., Forsman L. Dissociation between sympathetic-adrenal and pituitary-adrenal responses to an achievement situation characterized by high controllability: comparison between type A and type B males and females. Biol. Psychol. 1980, 10:79-91.
45. Glaser R., Kiecolt-Glaser J.K., Speicher C.E., Holliday J.E. Stress, loneliness, and changes in herpesvirus latency. J. Behav. Med. 1985, 8:249-260.
46. Glaser R., Kutz L.A., MacCallum R.C., Malarkey W.B. Hormonal modulation of Epstein-Barr virus replication. Neuroendocrinology 1995, 62:356-361.
47. Goldfarb Y., Levi B., Sorski L., Frenkel D., Ben-Eliyahu S. CpG-C immunotherapeutic efficacy is jeopardized by ongoing exposure to stress: potential implications for clinical use. Brain Behav. Immun. 2011, 25:67-76.
48. Grossman E., Messerli F.H., Goldbourt U. Antihypertensive therapy and the risk of malignancies. Eur. Heart J. 2001, 22:1343-1352.
49. Grytli H.H., Fagerland M.W., Fossa S.D., Tasken K.A., Haheim L.L. Use of beta-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy. Prostate 2012, (Epub ahead of print).
50. Gu L., Lau S.K., Loera S., Somlo G., Kane S.E. Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines. Clin. Cancer Res. 2009, 15:7196-7206.
51. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
52. Hanke M.L., Powell N.D., Stiner L.M., Bailey M.T., Sheridan J.F. Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress. Brain Behav. Immun. 2012, (Epub ahead of print).
53. Hara M.R., Kovacs J.J., Whalen E.J., Rajagopal S., Strachan R.T., Grant W., Towers A.J., Williams B., Lam C.M., Xiao K., Shenoy S.K., Gregory S.G., Ahn S., Duckett D.R., Lefkowitz R.J. A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature 2011, 477:349-353.
54. Henry J.P. Biological basis of the stress response. Integr. Physiol. Behav. Sci. 1992, 27:66-83.
55. Hermes G.L., Delgado B., Tretiakova M., Cavigelli S.A., Krausz T., Conzen S.D., McClintock M.K. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:22393-22398.
56. Irwin M.R., Cole S.W. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 2011, 11:625-632.
57. Irwin M.R., Wang M., Campomayor C.O., Collado-Hidalgo A., Cole S. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch. Intern. Med. 2006, 166:1756-1762.
58. Jenkins F.J., Baum A. Stress and reactivation of latent herpes simplex virus: a fusion of behavioral medicine and molecular biology. Ann. Behav. Med. 1995, 17:116-123.
59. Kamradt M.C., Mohideen N., Krueger E., Walter S., Vaughan A.T. Inhibition of radiation-induced apoptosis by dexamethasone in cervical carcinoma cell lines depends upon increased HPV E6/E7. Br. J. Cancer 2000, 82:1709-1716.
60. Kamradt M.C., Mohideen N., Vaughan A.T. RU486 increases radiosensitivity and restores apoptosis through modulation of HPV E6/E7 in dexamethasone-treated cervical carcinoma cells. Gynecol. Oncol. 2000, 77:177-182.
61. Karelina K., Norman G.J., Zhang N., Morris J.S., Peng H., DeVries A.C. Social isolation alters neuroinflammatory response to stroke. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:5895-5900. (Epub 2009 Mar 5823).
62. Karssen A.M., Her S., Li J.Z., Patel P.D., Meng F., Bunney W.E., Jones E.G., Watson S.J., Akil H., Myers R.M., Schatzberg A.F., Lyons D.M. Stress-induced changes in primate prefrontal profiles of gene expression. Mol. Psychiatry 2007, 12:1089-1102. (Epub 2007 Sep 1025).
63. Kim C., Paik S. Gene-expression-based prognostic assays for breast cancer. Nat. Rev. Clin. Oncol. 2010, 7:340-347.
64. Kinzler K.W., Vogelstein B. The Genetic Basis of Human Cancer 1998, McGraw-Hill, Toronto.
65. Kinzler K.W., Vogelstein B. Cancer genes and the pathways they control. Nat. Med. 2004, 10:789-799.
66. Kupfer S.R., Summers W.C. Identification of a glucocorticoid-responsive element in Epstein-Barr virus. J. Virol. 1990, 64:1984-1990.
67. Lamkin D.M., Sloan E.K., Patel A.J., Chiang B.S., Pimentel M.A., Ma J.C., Arevalo J.M., Morizono K., Cole S.W. Chronic stress enhances progression of acute lymphoblastic leukemia via beta-adrenergic signaling. Brain Behav. Immun. 2012, 26:635-641.
68. Landen C.N., Lin Y.G., Armaiz Pena G.N., Das P.D., Arevalo J.M., Kamat A.A., Han L.Y., Jennings N.B., Spannuth W.A., Thaker P.H., Lutgendorf S.K., Savary C.A., Sanguino A.M., Lopez-Berestein G., Cole S.W., Sood A.K. Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res. 2007, 67:10389-10396.
69. Landmark-Hoyvik H., Reinertsen K.V., Loge J.H., Fossa S.D., Borresen-Dale A.L., Dumeaux V. Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors. Pharmacogenomics J. 2009, 9:333-340.
70. Lang K., Drell T.L.t., Lindecke A., Niggemann B., Kaltschmidt C., Zaenker K.S., Entschladen F. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int. J. Cancer 2004, 112:231-238.
71. Leib D.A., Nadeau K.C., Rundle S.A., Schaffer P.A. The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:48-52.
72. Lemeshow S., Sorensen H.T., Phillips G., Yang E.V., Antonsen S., Riis A.H., Lesinski G.B., Jackson R., Glaser R. Beta-blockers and survival among danish patients with malignant melanoma: a population-based cohort study. Cancer Epidemiol. Biomarkers Prev. 2011, 20:2273-2279.
73. Lundberg U., Frankenhaeuser M. Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort. J. Psychosom. Res. 1980, 24:125-130.
74. Lutgendorf S.K., Cole S., Costanzo E., Bradley S., Coffin J., Jabbari S., Rainwater K., Ritchie J.M., Yang M., Sood A.K. Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin. Cancer Res. 2003, 9:4514-4521.
75. Lutgendorf S.K., Degeest K., Sung C.Y., Arevalo J.M., Penedo F., Lucci J., Goodheart M., Lubaroff D., Farley D.M., Sood A.K., Cole S.W. Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav. Immun. 2009, 23:176-183.
76. Lutgendorf S.K., Degeest K., Dahmoush L., Farley D., Penedo F., Bender D., Goodheart M., Buekers T.E., Mendez L., Krueger G., Clevenger L., Lubaroff D.M., Sood A.K., Cole S.W. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain Behav. Immun 2011.
77. McClintock M.K., Conzen S.D., Gehlert S., Masi C., Olopade F. Mammary cancer and social interactions: identifying multiple environments that regulate gene expression throughout the life span. J. Gerontol. B Psychol. Sci. Soc. Sci. 2005, 60:32-41.
78. Melhem-Bertrandt A., Chavez-Macgregor M., Lei X., Brown E.N., Lee R.T., Meric-Bernstam F., Sood A.K., Conzen S.D., Hortobagyi G.N., Gonzalez-Angulo A.M. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J. Clin. Oncol. 2011, 29:2645-2652.
79. Mikosz C.A., Brickley D.R., Sharkey M.S., Moran T.W., Conzen S.D. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J. Biol. Chem. 2001, 276:16649-16654. (Epub 12001 Feb 16613).
80. Miller A.H., Ancoli-Israel S., Bower J.E., Capuron L., Irwin M.R. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J. Clin. Oncol. 2008, 26:971-982.
81. Miller G.E., Chen E., Sze J., Marin T., Arevalo J.M., Doll R., Ma R., Cole S.W. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol. Psychiatry 2008, 64:266-272. (Epub 2008 Apr 2028).
82. Miller G., Chen E., Cole S.W. Health psychology: developing biologically plausible models linking the social world and physical health. Annu. Rev. Psychol. 2009, 60:501-524.
83. Miller G.E., Chen E., Fok A.K., Walker H., Lim A., Nicholls E.F., Cole S., Kobor M.S. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:14716-14721.
84. Mittal R., Pater A., Pater M.M. Multiple human papillomavirus type 16 glucocorticoid response elements functional for transformation, transient expression, and DNA-protein interactions. J. Virol. 1993, 67:5656-5659.
85. Moran T.J., Gray S., Mikosz C.A., Conzen S.D. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000, 60:867-872.
86. Nilsson M.B., Armaiz-Pena G., Takahashi R., Lin Y.G., Trevino J., Li Y., Jennings N., Arevalo J., Lutgendorf S.K., Gallick G.E., Sanguino A.M., Lopez-Berestein G., Cole S.W., Sood A.K. Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J. Biol. Chem. 2007, 282:29919-29926. (Epub 22007 Aug 29923).
87. Nkontchou G., Aout M., Mahmoudi A., Roulot D., Bourcier V., Grando-Lemaire V., Ganne-Carrie N., Trinchet J.C., Vicaut E., Beaugrand M. Effect of long-term propranolol treatment on hepatocellular carcinoma incidence in patients with HCV-associated cirrhosis. Cancer Prev. Res. (Phila) 2012, 5:1007-1014.
88. O'Donovan A., Sun B., Cole S., Rempel H., Lenoci M., Pulliam L., Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis. Markers 2011, 30:123-132.
89. Ohmori T., Morita K., Saito T., Ohta M., Ueno S., Rokutan K. Assessment of human stress and depression by DNA microarray analysis. J. Med. Invest. 2005, 52:266-271.
90. Ornish D., Magbanua M.J., Weidner G., Weinberg V., Kemp C., Green C., Mattie M.D., Marlin R., Simko J., Shinohara K., Haqq C.M., Carroll P.R. Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:8369-8374. (Epub 2008 Jun 8316).
91. Padgett D.A., Sheridan J.F., Dorne J., Berntson G.G., Candelora J., Glaser R. Social stress and the reactivation of latent herpes simplex virus type 1. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:7231-7235.
92. Palm D., Lang K., Niggemann B., Drell T.L., Masur K., Zaenker K.S., Entschladen F. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int. J. Cancer 2006, 118:2744-2749.
93. Pang D., Kocherginsky M., Krausz T., Kim S.Y., Conzen S.D. Dexamethasone decreases xenograft response to paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol. Ther. 2006, 5:933-940. (Epub 2006 Aug 2002).
94. Parker J., Klein S.L., McClintock M.K., Morison W.L., Ye X., Conti C.J., Peterson N., Nousari C.H., Tausk F.A. Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis. J. Am. Acad. Dermatol. 2004, 51:919-922.
95. Pater M.M., Hughes G.A., Hyslop D.E., Nakshatri H., Pater A. Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA. Nature 1988, 335:832-835.
96. Petrella A., Ercolino S.F., Festa M., Gentilella A., Tosco A., Conzen S.D., Parente L. Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur. J. Cancer 2006, 42:3287-3293. (Epub 2006 Oct 3227).
97. Powe D.G., Voss M.J., Zanker K.S., Habashy H.O., Green A.R., Ellis I.O., Entschladen F. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget 2010, 1:628-638.
98. Prosch S., Wendt C.E.C., Reinke P., Priemer C., Pooert M., Kruger D.H., Volk H.-D., Docke W.-D. A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation. Virology 2000, 272:357-365.
99. Rasmussen A.F., Marsh J.T., Brill N.Q. Increases susceptibility to hepres simplex in mice subjected to avoidance-learning stress or restraint. Proc. Soc. Exp. Biol. Med. 1957, 96:183.
100. Saligan L.N., Kim H.S. A systematic review of the association between immunogenomic markers and cancer-related fatigue. Brain Behav. Immun. 2012, 26:830-848.
101. Sanders V.M., Straub R.H. Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav. Immun. 2002, 16:290-332.
102. Sastry K.S., Karpova Y., Prokopovich S., Smith A.J., Essau B., Gersappe A., Carson J.P., Weber M.J., Register T.C., Chen Y.Q., Penn R.B., Kulik G. Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation. J. Biol. Chem. 2007, 282:14094-14100.
103. Saul A.N., Oberyszyn T.M., Daugherty C., Kusewitt D., Jones S., Jewell S., Malarkey W.B., Lehman A., Lemeshow S., Dhabhar F.S. Chronic stress and susceptibility to skin cancer. J. Natl Cancer Inst. 2005, 97:1760-1767.
104. Schuster C., Chasserot-Golaz S., Urier G., Beck G., Sergeant A. Evidence for a functional glucocorticoid responsive element in the Epstein-Barr virus genome. Mol. Endocrinol. 1991, 5:267-272.
105. Segman R.H., Shefi N., Goltser-Dubner T., Friedman N., Kaminski N., Shalev A.Y. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol. Psychiatry 2005, 10(500-513):425.
106. Shah S.M., Carey I.M., Owen C.G., Harris T., Dewilde S., Cook D.G. Does beta-adrenoceptor blocker therapy improve cancer survival? Findings from a population-based retrospective cohort study. Br. J. Clin. Pharmacol. 2011, 72:157-161.
107. Shahzad M.M., Arevalo J.M., Armaiz-Pena G.N., Lu C., Stone R.L., Moreno-Smith M., Nishimura M., Lee J.W., Jennings N.B., Bottsford-Miller J., Vivas-Mejia P., Lutgendorf S.K., Lopez-Berestein G., Bar-Eli M., Cole S.W., Sood A.K. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J. Biol. Chem. 2010, 285:35462-35470.
108. Shi M., Liu D., Duan H., Qian L., Wang L., Niu L., Zhang H., Yong Z., Gong Z., Song L., Yu M., Hu M., Xia Q., Shen B., Guo N. The beta2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Breast Cancer Res. Treat. 2011, 125:351-362.
109. Sloan E.K., Capitanio J.P., Tarara R.P., Mendoza S.P., Mason W.A., Cole S.W. Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J. Neurosci. 2007, 27:8857-8865.
110. Sloan E.K., Priceman S.J., Cox B.F., Yu S., Pimentel M.A., Tangkanangnukul V., Arevalo J.M., Morizono K., Karanikolas B.D., Wu L., Sood A.K., Cole S.W. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res. 2010, 70:7042-7052.
111. Sood A.K., Bhatty R., Kamat A.A., Landen C.N., Han L., Thaker P.H., Li Y., Gershenson D.M., Lutgendorf S., Cole S.W. Stress hormone-mediated invasion of ovarian cancer cells. Clin. Cancer Res. 2006, 12:369-375.
112. Sood A.K., Armaiz-Pena G.N., Halder J., Nick A.M., Stone R.L., Hu W., Carroll A.R., Spannuth W.A., Deavers M.T., Allen J.K., Han L.Y., Kamat A.A., Shahzad M.M., McIntyre B.W., Diaz-Montero C.M., Jennings N.B., Lin Y.G., Merritt W.M., DeGeest K., Vivas-Mejia P.E., Lopez-Berestein G., Schaller M.D., Cole S.W., Lutgendorf S.K. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J. Clin. Invest. 2010, 120:1515-1523.
113. Thaker P.H., Han L.Y., Kamat A.A., Arevalo J.M., Takahashi R., Lu C., Jennings N.B., Armaiz-Pena G., Bankson J.A., Ravoori M., Merritt W.M., Lin Y.G., Mangala L.S., Kim T.J., Coleman R.L., Landen C.N., Li Y., Felix E., Sanguino A.M., Newman R.A., Lloyd M., Gershenson D.M., Kundra V., Lopez-Berestein G., Lutgendorf S.K., Cole S.W., Sood A.K. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat. Med. 2006, 12:939-944. (Epub 2006 Jul 2023).
114. Tomlins S.A., Rhodes D.R., Perner S., Dhanasekaran S.M., Mehra R., Sun X.W., Varambally S., Cao X., Tchinda J., Kuefer R., Lee C., Montie J.E., Shah R.B., Pienta K.J., Rubin M.A., Chinnaiyan A.M. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005, 310:644-648.
115. Tung J., Barreiro L.B., Johnson Z.P., Hansen K.D., Michopoulos V., Toufexis D., Michelini K., Wilson M.E., Gilad Y. Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:6490-6495.
116. Weaver I.C., Meaney M.J., Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:3480-3485. (Epub 2006 Feb 3416).
117. Williams J.B., Pang D., Delgado B., Kocherginsky M., Tretiakova M., Krausz T., Pan D., He J., McClintock M.K., Conzen S.D. A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev. Res. (Phila) 2009, 2:850-861.
118. Wood L.D., Parsons D.W., Jones S., Lin J., Sjoblom T., Leary R.J., Shen D., Boca S.M., Barber T., Ptak J., Silliman N., Szabo S., Dezso Z., Ustyanksky V., Nikolskaya T., Nikolsky Y., Karchin R., Wilson P.A., Kaminker J.S., Zhang Z., Croshaw R., Willis J., Dawson D., Shipitsin M., Willson J.K., Sukumar S., Polyak K., Park B.H., Pethiyagoda C.L., Pant P.V., Ballinger D.G., Sparks A.B., Hartigan J., Smith D.R., Suh E., Papadopoulos N., Buckhaults P., Markowitz S.D., Parmigiani G., Kinzler K.W., Velculescu V.E., Vogelstein B. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113.
119. Wu W., Chaudhuri S., Brickley D.R., Pang D., Karrison T., Conzen S.D. Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res. 2004, 64:1757-1764.
120. Wu W., Pew T., Zou M., Pang D., Conzen S.D. Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J. Biol. Chem. 2005, 280:4117-4124. (Epub 2004 Dec 4117).
121. Yang E.V., Sood A.K., Chen M., Li Y., Eubank T.D., Marsh C.B., Jewell S., Flavahan N.A., Morrison C., Yeh P.E., Lemeshow S., Glaser R. Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res. 2006, 66:10357-10364.
122. Yang E.V., Webster Marketon J.I., Chen M., Lo K.W., Kim S.J., Glaser R. Glucocorticoids activate Epstein Barr virus lytic replication through the upregulation of immediate early BZLF1 gene expression. Brain Behav. Immun. 2010, 24:1089-1096.
123. Zhang X., Odom D.T., Koo S.H., Conkright M.D., Canettieri G., Best J., Chen H., Jenner R., Herbolsheimer E., Jacobsen E., Kadam S., Ecker J.R., Emerson B., Hogenesch J.B., Unterman T., Young R.A., Montminy M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4459-4464. (Epub 2005 Mar 4457).
124. Zieker D., Fehrenbach E., Dietzsch J., Fliegner J., Waidmann M., Nieselt K., Gebicke-Haerter P., Spanagel R., Simon P., Niess A.M., Northoff H. cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiol. Genomics 2005, 23:287-294. (Epub 2005 Aug 2023).