Chronic restraint stress attenuates p53 function and promotes tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 18, 2012, Pages 7013-7018

  Feng, Zhaohui ^a   Liu, Lianxin ^b   Zhang, Cen ^a   Zheng, Tongsen ^a   Wang, Jiabei ^a   Lin, Meihua ^a   Zhao, Yuhan ^a   Wang, Xiaowen ^a   Levine, Arnold J ^c   Hu, Wenwei ^a  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC STRESS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMOBILIZATION STRESS; IN VIVO STUDY; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; COCARCINOGENESIS; CORTICOSTERONE; DISEASE MODELS, ANIMAL; GENES, P53; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; IMMEDIATE-EARLY PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, RADIATION-INDUCED; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; RESTRAINT, PHYSICAL; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 84860802435     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203930109     Document Type: Article

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