-
1
-
-
50549121134
-
The distribution of secondary growths in cancer of the breast
-
Paget S. The distribution of secondary growths in cancer of the breast. The Lancet. 1889;133:571-73.
-
(1889)
The Lancet.
, vol.133
, pp. 571-573
-
-
Paget, S.1
-
3
-
-
34248141223
-
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
-
Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2007;6:1,186-97.
-
(2007)
Mol Cancer Ther.
, vol.6
, pp. 1186-1197
-
-
Mahadevan, D.1
von Hoff, D.D.2
-
4
-
-
0036186862
-
Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas
-
Yen TW, Aardal NP, Bronner MP, Thorning DR, Savard CE, Lee SP, Bell RH Jr. Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas. Surgery. 2002;131:129-34.
-
(2002)
Surgery.
, vol.131
, pp. 129-134
-
-
Yen, T.W.1
Aardal, N.P.2
Bronner, M.P.3
Thorning, D.R.4
Savard, C.E.5
Lee, S.P.6
Bell Jr., R.H.7
-
5
-
-
38049156416
-
Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin
-
Magzoub M, Jin S, Verkman AS. Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 2008;22:276-84.
-
(2008)
FASEB J.
, vol.22
, pp. 276-284
-
-
Magzoub, M.1
Jin, S.2
Verkman, A.S.3
-
6
-
-
0034193258
-
Role of extracellular matrix assembly in interstitial transport in solid tumors
-
Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res. 2000;60:2,497-2,503.
-
(2000)
Cancer Res.
, vol.60
, pp. 2497-2503
-
-
Netti, P.A.1
Berk, D.A.2
Swartz, M.A.3
Grodzinsky, A.J.4
Jain, R.K.5
-
8
-
-
69949109921
-
Decreased blood flow with increased metabolic activity: A novel sign of pancreatic tumor aggressiveness
-
Komar G, Kauhanen S, Liukko K, Seppanen M, Kajander S, Ovaska J, Nuutila P, Minn H. Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res. 2009;15:5,511-17.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 5511-5517
-
-
Komar, G.1
Kauhanen, S.2
Liukko, K.3
Seppanen, M.4
Kajander, S.5
Ovaska, J.6
Nuutila, P.7
Minn, H.8
-
9
-
-
0014816552
-
Differential problems in the angiographic diagnosis of carcinoma of the pancreas
-
Reuter SR, Redman HC, Bookstein JJ. Differential problems in the angiographic diagnosis of carcinoma of the pancreas. Radiology. 1970;96:93-99.
-
(1970)
Radiology.
, vol.96
, pp. 93-99
-
-
Reuter, S.R.1
Redman, H.C.2
Bookstein, J.J.3
-
10
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5:816-26.
-
(2004)
Nat Rev Mol Cell Biol.
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
13
-
-
0034776908
-
Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma
-
Linder S, Castanos-Velez E, von Rosen A, Biberfeld P. Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma. Hepatogastroenterology2001;48:1,321-27.
-
(2001)
Hepatogastroenterology
, vol.48
, pp. 1321-1327
-
-
Linder, S.1
Castanos-Velez, E.2
von Rosen, A.3
Biberfeld, P.4
-
14
-
-
37349018272
-
The integrin-extracellular matrix axis in pancreatic cancer
-
Grzesiak JJ, Ho JC, Moossa AR, Bouvet M. The integrin-extracellular matrix axis in pancreatic cancer. Pancreas. 2007;35:293-301.
-
(2007)
Pancreas.
, vol.35
, pp. 293-301
-
-
Grzesiak, J.J.1
Ho, J.C.2
Moossa, A.R.3
Bouvet, M.4
-
15
-
-
84858980393
-
Integrin beta4 regulates SPARC protein to promote invasion
-
Gerson KD, Shearstone JR, Maddula VS, Selig-mann BE, Mercurio AM. Integrin beta4 regulates SPARC protein to promote invasion. J Biol Chem. 2012;287:9,835-44.
-
(2012)
J Biol Chem.
, vol.287
, pp. 9835-9844
-
-
Gerson, K.D.1
Shearstone, J.R.2
Maddula, V.S.3
Selig-mann, B.E.4
Mercurio, A.M.5
-
16
-
-
33846916208
-
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
-
Infante JR, Matsubayashi H, Sato N, Tonascia J, Klein AP, Riall TA, Yeo C, Iacobuzio-Donahue C, Goggins M. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol. 2007;25:319-25.
-
(2007)
J Clin Oncol.
, vol.25
, pp. 319-325
-
-
Infante, J.R.1
Matsubayashi, H.2
Sato, N.3
Tonascia, J.4
Klein, A.P.5
Riall, T.A.6
Yeo, C.7
Iacobuzio-Donahue, C.8
Goggins, M.9
-
17
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
-
Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, Korn RL, Desai N, Trieu V, Iglesias JL, Zhang H, Soon-Shiong P, Shi T, Rajeshkumar NV, Maitra A, Hidalgo M. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011;29:4,548-54.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 4548-4554
-
-
von Hoff, D.D.1
Ramanathan, R.K.2
Borad, M.J.3
Laheru, D.A.4
Smith, L.S.5
Wood, T.E.6
Korn, R.L.7
Desai, N.8
Trieu, V.9
Iglesias, J.L.10
Zhang, H.11
Soon-Shiong, P.12
Shi, T.13
Rajeshkumar, N.V.14
Maitra, A.15
Hidalgo, M.16
-
18
-
-
0035958902
-
A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
-
Matter ML, Ruoslahti E. A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J Biol Chem. 2001;276:27,757-63.
-
(2001)
J Biol Chem.
, vol.276
, pp. 27757-27763
-
-
Matter, M.L.1
Ruoslahti, E.2
-
19
-
-
0033021996
-
Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death
-
Uhm JH, Dooley NP, Kyritsis AP, Rao JS, Gladson CL. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin Cancer Res. 1999;5:1,587-94.
-
(1999)
Clin Cancer Res.
, vol.5
, pp. 1587-1594
-
-
Uhm, J.H.1
Dooley, N.P.2
Kyritsis, A.P.3
Rao, J.S.4
Gladson, C.L.5
-
20
-
-
0031596991
-
NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival
-
Scatena M, Almeida M, Chaisson ML, Fausto N, Nicosia RF, Giachelli CM. NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. J Cell Biol. 1998;141:1,083-93.
-
(1998)
J Cell Biol.
, vol.141
, pp. 1083-1093
-
-
Scatena, M.1
Almeida, M.2
Chaisson, M.L.3
Fausto, N.4
Nicosia, R.F.5
Giachelli, C.M.6
-
21
-
-
0035899331
-
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
-
Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene. 2001;20:4,995-5,004.
-
(2001)
Oncogene.
, vol.20
, pp. 4995-5004
-
-
Aoudjit, F.1
Vuori, K.2
-
22
-
-
16844377086
-
Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
-
Courter DL, Lomas L, Scatena M, Giachelli CM. Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. J Biol Chem. 2005;280:12,145-51.
-
(2005)
J Biol Chem.
, vol.280
, pp. 12145-12151
-
-
Courter, D.L.1
Lomas, L.2
Scatena, M.3
Giachelli, C.M.4
-
23
-
-
9444251067
-
Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
-
Bao W, Stromblad S. Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen. J Cell Biol. 2004;167:745-56.
-
(2004)
J Cell Biol.
, vol.167
, pp. 745-756
-
-
Bao, W.1
Stromblad, S.2
-
24
-
-
0028983407
-
The alpha 5 beta 1 integrin supports survival of cells on fibro-nectin and up-regulates Bcl-2 expression
-
Zhang Z, Vuori K, Reed JC, Ruoslahti E. The alpha 5 beta 1 integrin supports survival of cells on fibro-nectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci U S A. 1995;92:6,161-65.
-
(1995)
Proc Natl Acad Sci U S A.
, vol.92
, pp. 6161-6165
-
-
Zhang, Z.1
Vuori, K.2
Reed, J.C.3
Ruoslahti, E.4
-
25
-
-
0042696985
-
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
-
Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003;5:733-40.
-
(2003)
Nat Cell Biol.
, vol.5
, pp. 733-740
-
-
Reginato, M.J.1
Mills, K.R.2
Paulus, J.K.3
Lynch, D.K.4
Sgroi, D.C.5
Debnath, J.6
Muthuswamy, S.K.7
Brugge, J.S.8
-
26
-
-
33845877722
-
Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells
-
Hazlehurst LA, Argilagos RF, Dalton WS. Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells. Br J Haematol. 2007;136:269-75.
-
(2007)
Br J Haematol.
, vol.136
, pp. 269-275
-
-
Hazlehurst, L.A.1
Argilagos, R.F.2
Dalton, W.S.3
-
27
-
-
84859983619
-
Targeting the tumor microenvironment in cancer: Why hyaluronidase deserves a second look
-
Whatcott CJ, Han H, Posner RG, Hostetter G, Von Hoff DD. Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov. 2011;1:291-96.
-
(2011)
Cancer Discov.
, vol.1
, pp. 291-296
-
-
Whatcott, C.J.1
Han, H.2
Posner, R.G.3
Hostetter, G.4
von Hoff, D.D.5
-
28
-
-
79955063673
-
Hyaluronan-CD44 interactions as potential targets for cancer therapy
-
Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S. Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J. 2011;278:1,429-43.
-
(2011)
FEBS J.
, vol.278
, pp. 1429-1443
-
-
Misra, S.1
Heldin, P.2
Hascall, V.C.3
Karamanos, N.K.4
Skandalis, S.S.5
Markwald, R.R.6
Ghatak, S.7
-
29
-
-
0032926177
-
Localization of matrix metal-loproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
-
Yu Q Stamenkovic I. Localization of matrix metal-loproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev. 1999;13:35-48.
-
(1999)
Genes Dev.
, vol.13
, pp. 35-48
-
-
Yu, Q.1
Stamenkovic, I.2
-
30
-
-
79955541291
-
CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance
-
Jung T, Gross W, Zoller M. CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance. J Biol Chem. 2011;286:15,862-74.
-
(2011)
J Biol Chem.
, vol.286
, pp. 15862-15874
-
-
Jung, T.1
Gross, W.2
Zoller, M.3
-
31
-
-
79955966781
-
Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction
-
Meran S, Luo DD, Simpson R, Martin J, Wells A, Steadman R, Phillips AO. Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. J Biol Chem. 2011;286:17,618-30.
-
(2011)
J Biol Chem.
, vol.286
, pp. 17618-17630
-
-
Meran, S.1
Luo, D.D.2
Simpson, R.3
Martin, J.4
Wells, A.5
Steadman, R.6
Phillips, A.O.7
-
32
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418-29.
-
(2012)
Cancer Cell.
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
Cuevas, C.2
Chang, A.E.3
Goel, V.K.4
von Hoff, D.D.5
Hingorani, S.R.6
-
33
-
-
84870909412
-
Hyaluro-nan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
[Epub ahead of print]
-
Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, Lolkema MP, Jiang P, Kultti A, Thompson CB, Maneval DC, Jodrell DI, Frost GI, Shepard HM, Skepper JN, Tuveson DA. Hyaluro-nan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut. 2012. [Epub ahead of print]
-
(2012)
Gut
-
-
Jacobetz, M.A.1
Chan, D.S.2
Neesse, A.3
Bapiro, T.E.4
Cook, N.5
Frese, K.K.6
Feig, C.7
Nakagawa, T.8
Caldwell, M.E.9
Zecchini, H.I.10
Lolkema, M.P.11
Jiang, P.12
Kultti, A.13
Thompson, C.B.14
Maneval, D.C.15
Jodrell, D.I.16
Frost, G.I.17
Shepard, H.M.18
Skepper, J.N.19
Tuveson, D.A.20
more..
-
34
-
-
0242268883
-
Tumor reversion: Correction of malignant behavior by microenvironmental cues
-
Kenny PA, Bissell MJ. Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer. 2003;107:688-95.
-
(2003)
Int J Cancer.
, vol.107
, pp. 688-695
-
-
Kenny, P.A.1
Bissell, M.J.2
-
35
-
-
0032954505
-
Pancreatic stellate cells are activated by proin-flammatory cytokines: Implications for pancreatic fibrogenesis
-
Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Wilson JS. Pancreatic stellate cells are activated by proin-flammatory cytokines: implications for pancreatic fibrogenesis. Gut. 1999;44:534-41.
-
(1999)
Gut.
, vol.44
, pp. 534-541
-
-
Apte, M.V.1
Haber, P.S.2
Darby, S.J.3
Rodgers, S.C.4
McCaughan, G.W.5
Korsten, M.A.6
Pirola, R.C.7
Wilson, J.S.8
-
36
-
-
0345251977
-
Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: An in vivo and in vitro study
-
Faouzi S, Le Bail B, Neaud V, Boussarie L, Saric J, Bioulac-Sage P, Balabaud C, Rosenbaum J. Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol. 1999;30:275-84.
-
(1999)
J Hepatol.
, vol.30
, pp. 275-284
-
-
Faouzi, S.1
Le Bail, B.2
Neaud, V.3
Boussarie, L.4
Saric, J.5
Bioulac-Sage, P.6
Balabaud, C.7
Rosenbaum, J.8
-
37
-
-
0026425624
-
Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions
-
Cullen KJ, Smith HS, Hill S, Rosen N, Lippman ME. Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions. Cancer Res. 1991;51:4,978-85.
-
(1991)
Cancer Res.
, vol.51
, pp. 4978-4985
-
-
Cullen, K.J.1
Smith, H.S.2
Hill, S.3
Rosen, N.4
Lippman, M.E.5
-
39
-
-
33745515023
-
Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer
-
Bierie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 2006;6:506-20.
-
(2006)
Nat Rev Cancer.
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
40
-
-
0036467496
-
TGF-beta signaling: Positive and negative effects on tumorigenesis
-
Wakefield LM, Roberts AB. TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev. 2002;12:22-29.
-
(2002)
Curr Opin Genet Dev.
, vol.12
, pp. 22-29
-
-
Wakefield, L.M.1
Roberts, A.B.2
-
41
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350-3.
-
(1996)
Science.
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
Moskaluk, C.A.4
da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
42
-
-
68049115773
-
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
-
Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15:4,674-9.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 4674-4679
-
-
Blackford, A.1
Serrano, O.K.2
Wolfgang, C.L.3
Parmigiani, G.4
Jones, S.5
Zhang, X.6
Parsons, D.W.7
Lin, J.C.8
Leary, R.J.9
Eshleman, J.R.10
Goggins, M.11
Jaffee, E.M.12
Iacobuzio-Donahue, C.A.13
Maitra, A.14
Cameron, J.L.15
Olino, K.16
Schulick, R.17
Winter, J.18
Herman, J.M.19
Laheru, D.20
Klein, A.P.21
Vogelstein, B.22
Kinzler, K.W.23
Velculescu, V.E.24
Hruban, R.H.25
more..
-
43
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1,806-13.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 1806-1813
-
-
Iacobuzio-Donahue, C.A.1
Fu, B.2
Yachida, S.3
Luo, M.4
Abe, H.5
Henderson, C.M.6
Vilardell, F.7
Wang, Z.8
Keller, J.W.9
Banerjee, P.10
Herman, J.M.11
Cameron, J.L.12
Yeo, C.J.13
Halushka, M.K.14
Eshleman, J.R.15
Raben, M.16
Klein, A.P.17
Hruban, R.H.18
Hidalgo, M.19
Laheru, D.20
more..
-
44
-
-
15444372825
-
Type I transforming growth factor beta receptor binds to and activates phosphati-dylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphati-dylinositol 3-kinase. J Biol Chem. 2005;280:10,870-6.
-
(2005)
J Biol Chem.
, vol.280
, pp. 10870-10876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
45
-
-
0035185853
-
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell. 2001;12:27-36.
-
(2001)
Mol Biol Cell.
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
Aakre, M.4
Lundquist, C.A.5
Engel, M.E.6
Arteaga, C.L.7
Moses, H.L.8
-
46
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator ofTGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. Identification of a member of the MAPKKK family as a potential mediator ofTGF-beta signal transduction. Science. 1995;270:2,008-11.
-
(1995)
Science.
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
47
-
-
0026612306
-
Activation of p21ras by transforming growth factor beta in epithelial cells
-
Mulder KM, Morris SL. Activation of p21ras by transforming growth factor beta in epithelial cells. J Biol Chem. 1992;267:5,029-31.
-
(1992)
J Biol Chem.
, vol.267
, pp. 5029-5031
-
-
Mulder, K.M.1
Morris, S.L.2
-
48
-
-
10844224603
-
Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors
-
Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH, Moody SE, Chodosh LA, Arteaga CL. Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res. 2004;64:9,002-11.
-
(2004)
Cancer Res.
, vol.64
, pp. 9002-9011
-
-
Muraoka-Cook, R.S.1
Kurokawa, H.2
Koh, Y.3
Forbes, J.T.4
Roebuck, L.R.5
Barcellos-Hoff, M.H.6
Moody, S.E.7
Chodosh, L.A.8
Arteaga, C.L.9
-
49
-
-
0036086409
-
Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest. 2002;109:1,551-9.
-
(2002)
J Clin Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
50
-
-
0036087521
-
Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
-
Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR, Merlino G, Wakefield LM. Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. J Clin Invest. 2002;109:1,607-15.
-
(2002)
J Clin Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
Dukhanina, O.2
Tang, B.3
Mamura, M.4
Letterio, J.J.5
McGregor, J.6
Patel, S.C.7
Khozin, S.8
Liu, Z.Y.9
Green, J.10
Anver, M.R.11
Merlino, G.12
Wakefield, L.M.13
-
51
-
-
66149156949
-
Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention
-
Zion O, Genin O, Kawada N, Yoshizato K, Roffe S, Nagler A, Iovanna JL, Halevy O, Pines M. Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas. 2009;38:427-35.
-
(2009)
Pancreas.
, vol.38
, pp. 427-435
-
-
Zion, O.1
Genin, O.2
Kawada, N.3
Yoshizato, K.4
Roffe, S.5
Nagler, A.6
Iovanna, J.L.7
Halevy, O.8
Pines, M.9
-
52
-
-
73649096622
-
Tgfbr1 hap-loinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer
-
Adrian K, Strouch MJ, Zeng Q, Barron MR, Cheon EC, Honasoge A, Xu Y, Phukan S, Sadim M, Bentrem DJ, Pasche B, Grippo PJ. Tgfbr1 hap-loinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer. Cancer Res. 2009;69:9,169-74.
-
(2009)
Cancer Res.
, vol.69
, pp. 9169-9174
-
-
Adrian, K.1
Strouch, M.J.2
Zeng, Q.3
Barron, M.R.4
Cheon, E.C.5
Honasoge, A.6
Xu, Y.7
Phukan, S.8
Sadim, M.9
Bentrem, D.J.10
Pasche, B.11
Grippo, P.J.12
-
53
-
-
10044284417
-
Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice
-
Nagashio Y, Ueno H, Imamura M, Asaumi H, Wata-nabe S, Yamaguchi T, Taguchi M, Tashiro M, Otsuki M. Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice. Lab Invest. 2004;84:1,610-8.
-
(2004)
Lab Invest.
, vol.84
, pp. 1610-1618
-
-
Nagashio, Y.1
Ueno, H.2
Imamura, M.3
Asaumi, H.4
Wata-nabe, S.5
Yamaguchi, T.6
Taguchi, M.7
Tashiro, M.8
Otsuki, M.9
-
54
-
-
0346157370
-
Tumor-stroma interaction of human pancreatic cancer: Acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins
-
Miyamoto H, Murakami T, Tsuchida K, Sugino H, Miyake H, Tashiro S. Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas. 2004;28:38-44.
-
(2004)
Pancreas.
, vol.28
, pp. 38-44
-
-
Miyamoto, H.1
Murakami, T.2
Tsuchida, K.3
Sugino, H.4
Miyake, H.5
Tashiro, S.6
-
55
-
-
47549089080
-
Matrix metallopro-teinases stimulate epithelial-mesenchymal transition during tumor development
-
Orlichenko LS, Radisky DC. Matrix metallopro-teinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis. 2008;25:593-600.
-
(2008)
Clin Exp Metastasis.
, vol.25
, pp. 593-600
-
-
Orlichenko, L.S.1
Radisky, D.C.2
-
56
-
-
0038324071
-
Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway
-
Postigo AA. Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J. 2003;22:2,443-52.
-
(2003)
EMBO J.
, vol.22
, pp. 2443-2452
-
-
Postigo, A.A.1
-
57
-
-
59449092007
-
Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines
-
Haddad Y, Choi W, McConkey DJ. Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines. Clin Cancer Res. 2009;15:532-42.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 532-542
-
-
Haddad, Y.1
Choi, W.2
McConkey, D.J.3
-
58
-
-
37549037486
-
PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma
-
Gold DV, Karanjawala Z, Modrak DE, Goldenberg DM, Hruban RH. PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma. Clin Cancer Res. 2007;13:7,380-7.
-
(2007)
Clin Cancer Res.
, vol.13
, pp. 7380-7387
-
-
Gold, D.V.1
Karanjawala, Z.2
Modrak, D.E.3
Goldenberg, D.M.4
Hruban, R.H.5
-
59
-
-
33644815924
-
New MUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis
-
Gold DV, Modrak DE, Ying Z, Cardillo TM, Sharkey RM, Goldenberg DM. New MUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis. J Clin Oncol. 2006;24:252-8.
-
(2006)
J Clin Oncol.
, vol.24
, pp. 252-258
-
-
Gold, D.V.1
Modrak, D.E.2
Ying, Z.3
Cardillo, T.M.4
Sharkey, R.M.5
Goldenberg, D.M.6
-
60
-
-
84868191187
-
Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial
-
[Epub ahead of print]
-
Ocean AJ, Pennington KL, Guarino MJ, Sheikh A, Bekaii-Saab T, Serafini AN, Lee D, Sung MW, Gulec SA, Goldsmith SJ, Manzone T, Holt M, O'Neil BH, Hall N, Montero AJ, Kauh J, Gold DV, Horne H, Wegener WA, Goldenberg DM. Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial. Cancer. 2012. [Epub ahead of print]
-
(2012)
Cancer
-
-
Ocean, A.J.1
Pennington, K.L.2
Guarino, M.J.3
Sheikh, A.4
Bekaii-Saab, T.5
Serafini, A.N.6
Lee, D.7
Sung, M.W.8
Gulec, S.A.9
Goldsmith, S.J.10
Manzone, T.11
Holt, M.12
O'Neil, B.H.13
Hall, N.14
Montero, A.J.15
Kauh, J.16
Gold, D.V.17
Horne, H.18
Wegener, W.A.19
Goldenberg, D.M.20
more..
-
61
-
-
85172042987
-
The EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin
-
Abstract nr LB-297
-
Tremblay GB, Viau E, Filion M. The EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin. Cancer Res. 2012;72(8 Suppl):Abstract nr LB-297.
-
(2012)
Cancer Res.
, vol.72
, Issue.8 SUPPL.
-
-
Tremblay, G.B.1
Viau, E.2
Filion, M.3
-
62
-
-
0024549349
-
Induction of angiogenesis during the transition from hyperplasia to neoplasia
-
Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature. 1989;339:58-61.
-
(1989)
Nature.
, vol.339
, pp. 58-61
-
-
Folkman, J.1
Watson, K.2
Ingber, D.3
Hanahan, D.4
-
63
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182-6.
-
(1971)
N Engl J Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
64
-
-
53049099678
-
Bevacizumab in advanced cancer, too much or too little?
-
Jirillo A, Vascon F, Giacobbo M. Bevacizumab in advanced cancer, too much or too little? Ann Oncol. 2008;19:1,817-8.
-
(2008)
Ann Oncol.
, vol.19
, pp. 1817-1818
-
-
Jirillo, A.1
Vascon, F.2
Giacobbo, M.3
-
65
-
-
34548439322
-
Gemcitabine plus bevacizumab no better than gemcitabine alone in clinical study of 600 patients with pancreatic cancer
-
Gemcitabine plus bevacizumab no better than gemcitabine alone in clinical study of 600 patients with pancreatic cancer. Cancer Biol Ther. 2007;6:132-140.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 132-140
-
-
-
66
-
-
65549150854
-
Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
-
Van Cutsem E, Vervenne WL, Bennouna J, Humblet Y, Gill S, Van Laethem JL, Verslype C, Scheithauer W, Shang A, Cosaert J, Moore MJ. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol. 2009;27:2,231-7.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 2231-2237
-
-
van Cutsem, E.1
Vervenne, W.L.2
Bennouna, J.3
Humblet, Y.4
Gill, S.5
van Laethem, J.L.6
Verslype, C.7
Scheithauer, W.8
Shang, A.9
Cosaert, J.10
Moore, M.J.11
-
67
-
-
53549092538
-
Targeting angiogenesis in pancreatic cancer: Rationale and pitfalls
-
Whipple C, Korc M. Targeting angiogenesis in pancreatic cancer: rationale and pitfalls. Langenbecks Arch Surg. 2008;393:901-10.
-
(2008)
Langenbecks Arch Surg.
, vol.393
, pp. 901-910
-
-
Whipple, C.1
Korc, M.2
-
68
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 2009;324:1,457-61.
-
(2009)
Science.
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
Frese, K.K.11
Denicola, G.12
Feig, C.13
Combs, C.14
Winter, S.P.15
Ireland-Zecchini, H.16
Reichelt, S.17
Howat, W.J.18
Chang, A.19
Dhara, M.20
Wang, L.21
Rückert, F.22
Grützmann, R.23
Pilarsky, C.24
Izeradjene, K.25
Hingorani, S.R.26
Huang, P.27
Davies, S.E.28
Plunkett, W.29
Egorin, M.30
Hruban, R.H.31
Whitebread, N.32
McGovern, K.33
Adams, J.34
Iacobuzio-Donahue, C.35
Griffiths, J.36
Tuveson, D.A.37
more..
-
69
-
-
0034960583
-
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
-
Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, Blake Pepinsky R, Shapiro R, Taylor FR, Baker DP, Asahara T, Isner JM. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. N at Med.2001;7:706-11.
-
(2001)
Nat Med.
, vol.7
, pp. 706-711
-
-
Pola, R.1
Ling, L.E.2
Silver, M.3
Corbley, M.J.4
Kearney, M.5
Blake Pepinsky, R.6
Shapiro, R.7
Taylor, F.R.8
Baker, D.P.9
Asahara, T.10
Isner, J.M.11
-
70
-
-
20844441940
-
Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
-
Kusano KF, Allendoerfer KL, Munger W, Pola R, Bosch-Marce M, Kirchmair R, Yoon YS, Curry C, Silver M, Kearney M, Asahara T, Losordo DW. Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol. 2004;24:2,102-7.
-
(2004)
Arterioscler Thromb Vasc Biol.
, vol.24
, pp. 2102-2107
-
-
Kusano, K.F.1
Allendoerfer, K.L.2
Munger, W.3
Pola, R.4
Bosch-Marce, M.5
Kirchmair, R.6
Yoon, Y.S.7
Curry, C.8
Silver, M.9
Kearney, M.10
Asahara, T.11
Losordo, D.W.12
-
71
-
-
84860112131
-
What we have learned about pancreatic cancer from mouse models
-
Perez-Mancera PA, Guerra C, Barbacid M, Tuve-son DA. What we have learned about pancreatic cancer from mouse models. Gastroenterology. 2012;142:1,079-92.
-
(2012)
Gastroenterology.
, vol.142
, pp. 1079-1092
-
-
Perez-Mancera, P.A.1
Guerra, C.2
Barbacid, M.3
Tuve-son, D.A.4
-
73
-
-
0035901090
-
Inflammation and cancer: Back to Virchow?
-
Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539-45.
-
(2001)
Lancet.
, vol.357
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
74
-
-
0028907428
-
Role of schistosomiasis in human bladder cancer: Evidence of association, aetiological factors, and basic mechanisms of carcinogenesis
-
Badawi AF, Mostafa MH, Probert A, O'Connor PJ. Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis. Eur J Cancer Prev. 1995;4:45-59.
-
(1995)
Eur J Cancer Prev.
, vol.4
, pp. 45-59
-
-
Badawi, A.F.1
Mostafa, M.H.2
Probert, A.3
O'Connor, P.J.4
-
75
-
-
0032719646
-
Helicobacter pylori: From the benign to the malignant
-
Williams MP, Pounder RE. Helicobacter pylori: from the benign to the malignant. Am J Gastroenterol. 1999;94:S11-6.
-
(1999)
Am J Gastroenterol.
, vol.94
-
-
Williams, M.P.1
Pounder, R.E.2
-
76
-
-
0022234804
-
Human papillomaviruses and cancer
-
McCance DJ. Human papillomaviruses and cancer. Biochim Biophys Acta. 1986;823:195-205.
-
(1986)
Biochim Biophys Acta.
, vol.823
, pp. 195-205
-
-
McCance, D.J.1
-
77
-
-
0030975440
-
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group
-
Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK, Jr., Perrault J, Whitcomb DC. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst. 1997;89:442-6.
-
(1997)
J Natl Cancer Inst.
, vol.89
, pp. 442-446
-
-
Lowenfels, A.B.1
Maisonneuve, P.2
DiMagno, E.P.3
Elitsur, Y.4
Gates Jr., L.K.5
Perrault, J.6
Whitcomb, D.C.7
-
78
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
-
(2011)
Cell.
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
79
-
-
33749598665
-
Neutrophils and respiratory tract DNA damage and mutagenesis: A review
-
Knaapen AM, Gungor N, Schins RP, Borm PJ, Van Schooten FJ. Neutrophils and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis. 2006;21:225-36.
-
(2006)
Mutagenesis.
, vol.21
, pp. 225-236
-
-
Knaapen, A.M.1
Gungor, N.2
Schins, R.P.3
Borm, P.J.4
van Schooten, F.J.5
-
80
-
-
0031821387
-
Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of benzene genotoxicity
-
Tuo J, Wolff SP, Loft S, Poulsen HE. Formation of nitrated and hydroxylated aromatic compounds from benzene and peroxynitrite, a possible mechanism of benzene genotoxicity. Free Radic Res. 1998;28:369-75.
-
(1998)
Free Radic Res.
, vol.28
, pp. 369-375
-
-
Tuo, J.1
Wolff, S.P.2
Loft, S.3
Poulsen, H.E.4
-
81
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernandez-Porras I, Cañamero M, Rodriguez-Justo M, Serrano M, Barbacid M. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell. 2011;19:728-39.
-
(2011)
Cancer Cell.
, vol.19
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
Schuhmacher, A.J.4
Hernandez-Porras, I.5
Cañamero, M.6
Rodriguez-Justo, M.7
Serrano, M.8
Barbacid, M.9
-
82
-
-
0030944928
-
Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines
-
Negus RP, Stamp GW, Hadley J, Balkwill FR. Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am J Pathol. 1997;150:1,723-34.
-
(1997)
Am J Pathol.
, vol.150
, pp. 1723-1734
-
-
Negus, R.P.1
Stamp, G.W.2
Hadley, J.3
Balkwill, F.R.4
-
83
-
-
35148814410
-
Dynamics of the immune reaction to pancreatic cancer from inception to invasion
-
Clark CE, Hingorani SR, Mick R, Combs C, Tuveson DA, Vonderheide RH. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 2007;67:9,518-27.
-
(2007)
Cancer Res.
, vol.67
, pp. 9518-9527
-
-
Clark, C.E.1
Hingorani, S.R.2
Mick, R.3
Combs, C.4
Tuveson, D.A.5
Vonderheide, R.H.6
-
84
-
-
4944244259
-
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
-
Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104:2,224-34.
-
(2004)
Blood.
, vol.104
, pp. 2224-2234
-
-
Murdoch, C.1
Giannoudis, A.2
Lewis, C.E.3
-
85
-
-
68949114117
-
Tumor-associated macrophages: Effectors of angiogenesis and tumor progression
-
Coffelt SB, Hughes R, Lewis CE. Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta. 2009;1796:11-18.
-
(2009)
Biochim Biophys Acta.
, vol.1796
, pp. 11-18
-
-
Coffelt, S.B.1
Hughes, R.2
Lewis, C.E.3
-
86
-
-
52049083001
-
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells
-
Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, Roberts DD. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 2008;68:7,090-9.
-
(2008)
Cancer Res.
, vol.68
, pp. 7090-7099
-
-
Martin-Manso, G.1
Galli, S.2
Ridnour, L.A.3
Tsokos, M.4
Wink, D.A.5
Roberts, D.D.6
-
87
-
-
0033780453
-
Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
-
Lewis JS, Landers RJ, Underwood JC, Harris AL, Lewis CE. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol. 2000;192:150-8.
-
(2000)
J Pathol.
, vol.192
, pp. 150-158
-
-
Lewis, J.S.1
Landers, R.J.2
Underwood, J.C.3
Harris, A.L.4
Lewis, C.E.5
-
88
-
-
0036493984
-
Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
-
Leek RD, Talks KL, Pezzella F, Turley H, Campo L, Brown NS, Bicknell R, Taylor M, Gatter KC, Harris AL. Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res. 2002;62:1,326-9.
-
(2002)
Cancer Res.
, vol.62
, pp. 1326-1329
-
-
Leek, R.D.1
Talks, K.L.2
Pezzella, F.3
Turley, H.4
Campo, L.5
Brown, N.S.6
Bicknell, R.7
Taylor, M.8
Gatter, K.C.9
Harris, A.L.10
-
89
-
-
0031906876
-
Transforming growth factor-beta stimulates urokinase expression in tumor-associated macrophages of the breast
-
Hildenbrand R, Jansen C, Wolf G, Bohme B, Berger S, von Minckwitz G, Hörlin A, Kaufmann M, Stutte HJ. Transforming growth factor-beta stimulates urokinase expression in tumor-associated macrophages of the breast. Lab Invest. 1998;78:59-71.
-
(1998)
Lab Invest.
, vol.78
, pp. 59-71
-
-
Hildenbrand, R.1
Jansen, C.2
Wolf, G.3
Bohme, B.4
Berger, S.5
von Minckwitz, G.6
Hörlin, A.7
Kaufmann, M.8
Stutte, H.J.9
-
90
-
-
0031974687
-
IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
-
Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L, Mantovani A. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol. 1998;28:359-69.
-
(1998)
Eur J Immunol.
, vol.28
, pp. 359-369
-
-
Allavena, P.1
Piemonti, L.2
Longoni, D.3
Bernasconi, S.4
Stoppacciaro, A.5
Ruco, L.6
Mantovani, A.7
-
91
-
-
0032704154
-
Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells
-
Schmid-Kotsas A, Gross HJ, Menke A, Weiden-bach H, Adler G, Siech M, Beger H, Grünert A, Bachem MG. Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells. Am J Pathol. 1999;155:1,749-58.
-
(1999)
Am J Pathol.
, vol.155
, pp. 1749-1758
-
-
Schmid-Kotsas, A.1
Gross, H.J.2
Menke, A.3
Weiden-bach, H.4
Adler, G.5
Siech, M.6
Beger, H.7
Grünert, A.8
Bachem, M.G.9
-
92
-
-
33747602354
-
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
-
Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci U S A. 2006;103:12,493-8.
-
(2006)
Proc Natl Acad Sci U S A.
, vol.103
, pp. 12493-12498
-
-
Nozawa, H.1
Chiu, C.2
Hanahan, D.3
-
93
-
-
0345707663
-
Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: Implication of inflammation-associated carcinogenesis and tumor progression
-
Tazawa H, Okada F, Kobayashi T, Tada M, Mori Y, Une Y, Sendo F, Kobayashi M, Hosokawa M. Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression. Am J Pathol. 2003;163:2,221-32.
-
(2003)
Am J Pathol.
, vol.163
, pp. 2221-2232
-
-
Tazawa, H.1
Okada, F.2
Kobayashi, T.3
Tada, M.4
Mori, Y.5
Une, Y.6
Sendo, F.7
Kobayashi, M.8
Hosokawa, M.9
-
94
-
-
0036721629
-
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
-
Liyanage UK, Moore TT, Joo HG, Tanaka Y, Herrmann V, Doherty G, Drebin JA, Strasberg SM, Eberlein TJ, Goedegebuure PS, Linehan DC. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol. 2002;169:2,756-61.
-
(2002)
J Immunol.
, vol.169
, pp. 2756-2761
-
-
Liyanage, U.K.1
Moore, T.T.2
Joo, H.G.3
Tanaka, Y.4
Herrmann, V.5
Doherty, G.6
Drebin, J.A.7
Strasberg, S.M.8
Eberlein, T.J.9
Goedegebuure, P.S.10
Linehan, D.C.11
-
95
-
-
33747893112
-
Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma
-
Liyanage UK, Goedegebuure PS, Moore TT, Viehl CT, Moo-Young TA, Larson JW, Frey DM, Ehlers JP, Eberlein TJ, Linehan DC. Increased prevalence of regulatory T cells (Treg) is induced by pancreas adenocarcinoma. J Immunother. 2006;29:416-24.
-
(2006)
J Immunother.
, vol.29
, pp. 416-424
-
-
Liyanage, U.K.1
Goedegebuure, P.S.2
Moore, T.T.3
Viehl, C.T.4
Moo-Young, T.A.5
Larson, J.W.6
Frey, D.M.7
Ehlers, J.P.8
Eberlein, T.J.9
Linehan, D.C.10
-
96
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1,057-61.
-
(2003)
Science.
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
97
-
-
33748448717
-
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms
-
Li MO, Sanjabi S, Flavell RA. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms. Immunity. 2006;25:455-71.
-
(2006)
Immunity.
, vol.25
, pp. 455-471
-
-
Li, M.O.1
Sanjabi, S.2
Flavell, R.A.3
-
98
-
-
33646164362
-
Transforming growth factor-beta regulation of immune responses
-
Li MO, Wan YY, Sanjabi S, Robertson AK, Fla-vell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 2006;24:99-146.
-
(2006)
Annu Rev Immunol.
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
Robertson, A.K.4
Fla-vell, R.A.5
-
100
-
-
33847415066
-
Natural regulatory T cells: Mechanisms of suppression
-
Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 2007;13:108-16.
-
(2007)
Trends Mol Med.
, vol.13
, pp. 108-116
-
-
Miyara, M.1
Sakaguchi, S.2
-
101
-
-
77958050577
-
Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
Royal RE, Levy C, Turner K, Mathur A, Hughes M, Kammula US, Sherry RM, Topalian SL, Yang JC, Lowy I, Rosenberg SA. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 2010;33:828-33.
-
(2010)
J Immunother.
, vol.33
, pp. 828-833
-
-
Royal, R.E.1
Levy, C.2
Turner, K.3
Mathur, A.4
Hughes, M.5
Kammula, U.S.6
Sherry, R.M.7
Topalian, S.L.8
Yang, J.C.9
Lowy, I.10
Rosenberg, S.A.11
-
102
-
-
0034280315
-
DAB(389)IL-2 (ONTAK): A novel fusion toxin therapy for lymphoma
-
discussion 7
-
Foss FM. DAB(389)IL-2 (ONTAK): a novel fusion toxin therapy for lymphoma. Clin Lymphoma. 2000;1:110-6; discussion 7.
-
(2000)
Clin Lymphoma.
, vol.1
, pp. 110-116
-
-
Foss, F.M.1
-
103
-
-
3242736641
-
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice
-
Jones E, Dahm-Vicker M, Simon AK, Green A, Powrie F, Cerundolo V, Gallimore A. Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice. Cancer Immun. 2002;2:1-12.
-
(2002)
Cancer Immun.
, vol.2
, pp. 1-12
-
-
Jones, E.1
Dahm-Vicker, M.2
Simon, A.K.3
Green, A.4
Powrie, F.5
Cerundolo, V.6
Gallimore, A.7
-
104
-
-
0036858838
-
Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens
-
Golgher D, Jones E, Powrie F, Elliott T, Gallimore A. Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur J Immunol. 2002;32:3,267-75.
-
(2002)
Eur J Immunol.
, vol.32
, pp. 3267-3275
-
-
Golgher, D.1
Jones, E.2
Powrie, F.3
Elliott, T.4
Gallimore, A.5
-
105
-
-
0036123178
-
Treatment of refractory peripheral T-cell lymphoma with denileukin diftitox (ONTAK)
-
Talpur R, Apisarnthanarax N, Ward S, Duvic M. Treatment of refractory peripheral T-cell lymphoma with denileukin diftitox (ONTAK). Leuk Lymphoma. 2002;43:121-6.
-
(2002)
Leuk Lymphoma.
, vol.43
, pp. 121-126
-
-
Talpur, R.1
Apisarnthanarax, N.2
Ward, S.3
Duvic, M.4
-
106
-
-
0036282371
-
Denileukin diftitox for the treatment of panniculitic lymphoma
-
McGinnis KS, Shapiro M, Junkins-Hopkins JM, Smith M, Lessin SR, Vittorio CC, Rook AH. Denileukin diftitox for the treatment of panniculitic lymphoma. Arch Dermatol. 2002;138:740-2.
-
(2002)
Arch Dermatol.
, vol.138
, pp. 740-742
-
-
McGinnis, K.S.1
Shapiro, M.2
Junkins-Hopkins, J.M.3
Smith, M.4
Lessin, S.R.5
Vittorio, C.C.6
Rook, A.H.7
-
107
-
-
64349108724
-
Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
-
Kreitman RJ. Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. BioDrugs. 2009;23:1-13.
-
(2009)
BioDrugs.
, vol.23
, pp. 1-13
-
-
Kreitman, R.J.1
-
108
-
-
35548950221
-
Regulatory-T-cell inhibition versus depletion: The right choice in cancer immunotherapy
-
Colombo MP, Piconese S. Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy. Nat Rev Cancer. 2007;7:880-7.
-
(2007)
Nat Rev Cancer.
, vol.7
, pp. 880-887
-
-
Colombo, M.P.1
Piconese, S.2
-
109
-
-
0035005707
-
Glypicans in growth control and cancer
-
Filmus J. Glypicans in growth control and cancer. Glycobiology. 2001;11:19R-23R.
-
(2001)
Glycobiology.
, vol.11
-
-
Filmus, J.1
-
110
-
-
38449095557
-
Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer
-
Ishiwata T, Cho K, Kawahara K, Yamamoto T, Fuji-wara Y, Uchida E, Tajiri T, Naito Z. Role of lumican in cancer cells and adjacent stromal tissues in human pancreatic cancer. Oncol Rep. 2007;18:537-43.
-
(2007)
Oncol Rep.
, vol.18
, pp. 537-543
-
-
Ishiwata, T.1
Cho, K.2
Kawahara, K.3
Yamamoto, T.4
Fuji-wara, Y.5
Uchida, E.6
Tajiri, T.7
Naito, Z.8
-
111
-
-
44749083565
-
Association between cancer and "acid mucopolysaccharides": An old concept comes of age, finally
-
Stern R. Association between cancer and "acid mucopolysaccharides": an old concept comes of age, finally. Semin Cancer Biol. 2008;18:238-43.
-
(2008)
Semin Cancer Biol.
, vol.18
, pp. 238-243
-
-
Stern, R.1
-
112
-
-
48549097841
-
Extracellular matrix: A matter of life and death
-
Marastoni S, Ligresti G, Lorenzon E, Colombatti A, Mongiat M. Extracellular matrix: a matter of life and death. Connect Tissue Res. 2008;49:203-6.
-
(2008)
Connect Tissue Res.
, vol.49
, pp. 203-206
-
-
Marastoni, S.1
Ligresti, G.2
Lorenzon, E.3
Colombatti, A.4
Mongiat, M.5
-
113
-
-
0033032317
-
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
-
Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, Chilvers ER, Dransfield I, Donnelly SC, Strieter R, Haslett C. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med. 1999;5:662-8.
-
(1999)
Nat Med.
, vol.5
, pp. 662-668
-
-
Sethi, T.1
Rintoul, R.C.2
Moore, S.M.3
McKinnon, A.C.4
Salter, D.5
Choo, C.6
Chilvers, E.R.7
Dransfield, I.8
Donnelly, S.C.9
Strieter, R.10
Haslett, C.11
-
114
-
-
68549130675
-
The biological role and regulation of versican levels in cancer
-
Ricciardelli C, Sakko AJ, Ween MP, Russell DL, Horsfall DJ. The biological role and regulation of versican levels in cancer. Cancer Metastasis Rev. 2009;28:233-45.
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 233-245
-
-
Ricciardelli, C.1
Sakko, A.J.2
Ween, M.P.3
Russell, D.L.4
Horsfall, D.J.5
-
115
-
-
56649114152
-
Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis
-
Shimizu K. Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis. J Gastroenterol. 2008;43:823-32.
-
(2008)
J Gastroenterol.
, vol.43
, pp. 823-832
-
-
Shimizu, K.1
-
116
-
-
33847216148
-
Endothelial cell adhesion molecules and cancer progression
-
Kobayashi H, Boelte KC, Lin PC. Endothelial cell adhesion molecules and cancer progression. Curr Med Chem. 2007;14:377-86.
-
(2007)
Curr Med Chem.
, vol.14
, pp. 377-386
-
-
Kobayashi, H.1
Boelte, K.C.2
Lin, P.C.3
|