Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats

Journal of Neuroinflammation

Volumn 10, Issue , 2013, Pages

  Aldbass, Abeer M ^a   Bhat, Ramesa Shafi ^a   El Ansary, Afaf ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Comet DNA; Glutathione s transferase; Interferon ; N acetyl cysteine; Propionic acid; Serotonin

Indexed keywords

ACETYLCYSTEINE; GAMMA INTERFERON; GLUTATHIONE TRANSFERASE; PROPIONIC ACID; SEROTONIN; DNA; NEUROPROTECTIVE AGENT; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; AUTISM; BRAIN PROTECTION; BRAIN TOXICITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; MALE; NONHUMAN; RAT; ANALYSIS OF VARIANCE; ANIMAL; AUTISTIC DISORDER; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; RECEIVER OPERATING CHARACTERISTIC; TOXICITY;

ACETYLCYSTEINE; ANALYSIS OF VARIANCE; ANIMALS; AUTISTIC DISORDER; BRAIN; COMET ASSAY; DISEASE MODELS, ANIMAL; DNA; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; INTERFERON-GAMMA; MALE; NEUROPROTECTIVE AGENTS; PROPIONATES; RATS; ROC CURVE; SEROTONIN;

EID: 84875323020     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-42     Document Type: Article

References (43)

1. Bellinger DCA. Strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children. Environ Health Perspect 2012, 120(4):501-507. 3339460, 22182676.
2. Winneke G. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J Neurol Sci 2011, 308(1-2):9-15.
3. Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987, 28:1221-1227. 10.1136/gut.28.10.1221, 1433442, 3678950.
4. Karuri AR, Dobrowsky E, Tannock IF. Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. Br J Cancer 1993, 68:1080-1087. 10.1038/bjc.1993.485, 1968646, 8260358.
5. Sziray N, Leveleki C, Levay G, Marko B, Harsing LG, Mikics E, Barsy B, Haller J. Mechanisms underlying the long-term behavioural effects of traumatic experience in rats: the role of serotonin/noradrenaline balance and NMDA receptors. Brain Res Bull 2007, 71:376-385. 10.1016/j.brainresbull.2006.10.006, 17208655.
6. Neuhaus E, Beauchaine TP, Bernier R. Neurobiological correlates of social functioning in autism. Clin Psychol Rev 2010, 30:733-748. 10.1016/j.cpr.2010.05.007, 20570622.
7. El-Ansary AK, Ben BA, Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid. J Neuroinflammation 2012, 9:74. 10.1186/1742-2094-9-74, 3425128, 22531301.
8. Bonnet U, Bingmann D, Wiemann M. Intracellular pH modulates spontaneous and epileptiform bioelectric activity of hippocampal CA3-neurones. Eur Neuropsychopharmacol 2000, 10:97-103. 10.1016/S0924-977X(99)00063-2, 10706990.
9. Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB. Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 2003, 6:1139-1140. 10.1038/nn1130, 14517544.
10. Moore H, Grace AA. A role for electrotonic coupling in thestriatum in the expression of dopamine receptor-mediated stereotypies. Neuropsychopharmacology 2002, 27:980-992. 10.1016/S0893-133X(02)00383-4, 12464455.
11. MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boond F, Taylor AR, Kavaliers M, Ossenkopp KP. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res 2007, 176:149-169. 10.1016/j.bbr.2006.07.025, 16950524.
12. Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry 2012, 71(11):956-961. 10.1016/j.biopsych.2012.01.014, 22342106.
13. Rigo FK, Pasquetti L, Malfatti CR, Fighera MR, Coelho RC, Petri CZ, Mello CF. Propionic acid induces convulsions and protein carbonylation in rats. Neurosci Lett 2006, 408:151-154. 10.1016/j.neulet.2006.08.075, 16997462.
14. Gogolla N, Leblanc JJ, Quast KB, Sudhof T, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord 2009, 1:172-181. 10.1007/s11689-009-9023-x, 2906812,2906812, 20664807.
15. Monks TJ, Ghersi-Egea JF, Philbert M, Cooper AJ, Lock EA. Symposium overview: the role of glutathione in neuroprotection and neurotoxicity. Toxicol Sci 1999, 51:161-177. 10.1093/toxsci/51.2.161, 10543018.
16. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004, 80:1611-1617.
17. Li N, Wand M, Oberley TD, Sempf JM, Nel AE. Comparisons of the pro-oxidant and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 2002, 169:4531-4541.
18. Fahey RC. Glutathione analogs in prokaryotes. Biochim Biophys Acta 2012, 2012:2012. [Epub ahead of print].
19. Bellomo G, Offhenius S. Altered thiol and calcium homeostasis in oxidative hepatocellular injury. Hepatology 1985, 5:876-882. 10.1002/hep.1840050529, 4029898.
20. Al-Gadani Y, El-Ansary A, Attas O, Al-Ayadhi L. Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children. Clin Biochem 2009, 42:1032-1040. 10.1016/j.clinbiochem.2009.03.011, 19306862.
21. Rossignol DA, Frye RE. A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Mol Psychiatry 2012, 17:389-401. 10.1038/mp.2011.165, 3317062, 22143005.
22. Al-Yafee YA, Al- Ayadhi LY, Haq SH, El-Ansary AK. Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia. BMC Neurol 2011, 11:139. 10.1186/1471-2377-11-139, 3217885, 22051046.
23. Hrycaj P, Stratz T, Mennet P, Muller W. Pathogenetic aspects of responsiveness to ordansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome - a preliminary study. J Rheumatol 1996, 23:1418-1423.
24. Trotta R, Dal Col J, Yu J, Ciarlariello D, Thomas B, Zhang X, Allard J, Wei M, Mao H, Byrd JC, Perrotti D, Caligiuri MA. TGF-β utilizes SMAD3 to inhibit CD16-mediated IFNγ production and antibody-dependent cellular cytotoxicity in human NK cells. J Immunol 2008, 181(6):3784-3792. 2924753, 18768831.
25. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 1988, 175:184-191. 10.1016/0014-4827(88)90265-0, 3345800.
26. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K, Boris M, Bradstreet JJ, Baker SM, Gaylor DW. Metabolic end phenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006, B(8):947.
27. Zachwieja J, Zaniew M, Bobkowski W, Stefaniak E, Warzywoda A, Ostalska-Nowicka D, Dobrowolska-Zachwieja A, Lewandowska-Stachowiak M, Siwińska A. Beneficial in vitro effect of N-acetyl-cysteine on oxidative stress and apoptosis. Pediatr Nephrol 2005, 20:725-731. 10.1007/s00467-004-1806-4, 15809833.
28. Farshid AA, Tamaddonfard E, Yahyaee F. Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats. Indian J Exp Biol 2010, 48(11):1136-1142.
29. Cui A, Ye Q, Sarria R, Nakamura S, Guzman J, Costabel U. N-acetylcysteine inhibits TNF-α, TNFR, and TGF-B 1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro. Sarcoidosis Vasc Diffuse Lung Dis 2009, 26:147-154.
30. Lante F, Meunier J, Guiramand J, De Jesus Ferreira MC, Cambonie G, Aimar R, Cohen-Solal C, Maurice T, Vignes M, Barbanel G. Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation. Hippocampus 2008, 18(6):602-609. 10.1002/hipo.20421, 18306297.
31. Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipo-polysaccharide stimulated mixed glial cultures. J Neurochem 2008, 105:956-970. 10.1111/j.1471-4159.2007.05199.x, 2659629, 18205750.
32. Giovanni S, Sergio D, Filippo D, Antonino D, Giovannangelo O. Antioxidants as antidepressants: fact or fiction?. CNS Drugs 2012, 26(6):477-490. 10.2165/11633190-000000000-00000, 22668245.
33. Janaky R, Dohovics R, Saransaari P, Oja SS. Modulation of [3H]dopamine release by glutathione in mouse striatal slices. Neurochem Res 2007, 32:1357-1364. 10.1007/s11064-007-9315-z, 17401648.
34. Himi T, Ikeda M, Yasuhara T, Murota SI. Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons. J Neurosci Res 2003, 71:679-688. 10.1002/jnr.10510, 12584726.
35. Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci 2002, 22:9134-9141.
36. Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 2005, 25:6389-6393. 10.1523/JNEUROSCI.1007-05.2005, 1413952, 16000629.
37. Ogita K, Kitago T, Nakamuta H, Fukuda Y, Koida M, Ogawa Y, Yoneda Y. Glutathione-induced inhibition of Na + independent and -dependent bindings of L-[3H]glutamate in rat brain. Life Sci 1986, 39:2411-2418. 10.1016/0024-3205(86)90482-0, 3796201.
38. Varga V, Jenei Z, Janaky R, Saransaari P, Oja SS. Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. Neurochem Res 1997, 22:1165-1171. 10.1023/A:1027377605054, 9251108.
39. Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl) 2006, 184:254-256.
40. Reliene R, Pollard JM, Sobol Z, Trouiller B, Gatti RA, Schiestl RH. N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals. Mutat Res 2009, 665(1-2):37-43.
41. Yang Q, Hergenhahn M, Weninger A, Bartsch H. Cigarette smoke induces direct DNA damage in the human B-lymphoid cell line Raji. Carcinogenesis 1999, 20:1769-1775. 10.1093/carcin/20.9.1769, 10469623.
42. Yedjou CG, Tchounwou PB. N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health 2007, 4(2):132-137. 10.3390/ijerph2007040007, 17617676.
43. MacFabe DF. Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microb Ecol Heal Dis 2012, 23:19260.