N-acetylcysteine inhibits TNF-α, sTNFR, and TGF-β 1 release by alveolar macrophages in idiopathic pulmonary fibrosis in vitro

Sarcoidosis Vasculitis and Diffuse Lung Diseases

Volumn 26, Issue 2, 2009, Pages 147-154

  Cui, A ^a,b   Ye, Q ^a,b   Sarria, R ^c   Nakamura, S ^d   Guzman, J ^e   Costabel, Ulrich ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d NARA MEDICAL UNIVERSITY   (Japan)

^e RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Alveolar macrophage; Cytokine; Idiopathic pulmonary fibrosis; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG SARCOIDOSIS; PRIORITY JOURNAL;

ACETYLCYSTEINE; AGED; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MACROPHAGES, ALVEOLAR; MALE; RECEPTORS, TUMOR NECROSIS FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77649253590     PISSN: 11240490     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Cotgreave IA. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-77.
2. Blesa S, Cortijo J, Mata M, et al. Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen. Eur Respir J 2003; 21: 394-400.
3. American Thoracic Society/European Respiratory Society. International multidisciplinary consensus classification of idiopathic interstitial pneumonias: general principles and recommendations. Am J Respir Crit Care Med 2002; 165: 277-304.
4. Cantin AM, North SL, Fells GA, Hubbard RC, Crystal RG. Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis. J Clin Invest 1987; 79: 1165-73.
5. Cortijo J, Cerda-Nicolas M, Serrano A, et al. Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur Respir J 2001; 17: 1228-35.
6. Meyer A, Buhl R, Kampf S, Magnussen H. Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals. Am J Respir Crit Care Med 1995; 152: 1055-60.
7. Demedts M, Behr J, Buhl R, et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 2005; 353: 2229-42.
8. Tomioka H, Kuwata Y, Imanaka K, et al. A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis. Respirology 2005; 10: 449-55.
9. American Thoracic Society/European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS) and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000; 161: 646-64.
10. Tong ZH, Dai HP, Chen B, Abdoh Z, Guzman J, Costabel U. Inhibition of cytokine release from alveolar macrophages in pulmonary sarcoidosis by pentoxifylline: comparison with dexamethasone. Chest 2003; 124: 1526-32.
11. Theiss AL, Simmons JG, Jobin C, Lund PK. Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 2005; 280: 36099-109.
12. Sime PJ, Marr RA, Gauldie D, et al. Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta and myodibroblasts. Am J Pathol 1998; 153: 825-32.
13. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 1989; 170: 655-63.
14. Gharaee-Kermani M, Phan SH. Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Curr Pharm Des 2001; 7: 1083-103.
15. Piguet PF, Ribaux C, Karpuz V, Grau GE,Kapanci Y. Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis. Am J Pathol 1993; 143: 651-5.
16. Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G. Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Crit Care Med 1995; 152: 2163-9.
17. Homolka J,Ziegenhagen MW, Gaede KI, Entzian P,Zissel G, Müller-Quernheim J. Systemic immune cell activation in a subgroup of patients with idiopathic pulmonary fibrosis. Respiration 2003; 70: 262-9.
18. Raghu G, Brown KK, Costabel U, et al. Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial. Am J Respir Crit Care Med 2008; 178 : 948-55.
19. Glosli H, Tronstad KJ, Wergedal H, et al. Human TNF-alpha in transgenic mice induces differential changes in redox status and glutathione-regulating enzymes. FASEB J 2002; 16: 1450-2.
20. Townsend DM,Tew KD,Tapiero, H. The importance of glutathione in human disease. Pharmacother 2003; 57: 145-55.
21. Ullmann KS, Northrop JP, Verweij CL, Crabtree GR. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol 1990; 8: 421-52.
22. Hulten LM, Lindmark H, Schersten H,Wiklund O,Nilsson FN, Riise GC. Butylated hydroxytoluene and N-acetylcysteine, attenuates tumor necrosis factor-alpha secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro. Transplantation 1998; 66: 364-9.
23. Hu S, Zhao H, Al-Humadi NH, Yin XJ, Ma JK. Silica-induced apoptosis in alveolar macrophages: evidence on depletion and the activation of mitochondrial pathway. J Toxicol Environ Health A 2006; 69: 11261-84.
24. Jansson AH, Eriksson C, Wang X. Effects of budesonide and Nacetylcysteine on acute lung hyperinflation, inflammation and injury in rats. Vascul Pharmacol 2005; 43: 101-11.
25. Gosset P,Wallaert B,Tonnel AB, Fourneau C. Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by alveolar macrophages. Eur Respir J 1999; 14: 98-105.
26. Aderka D, Engelmann H, Shemer-Avni Y, et al. Variation in serum levels of the soluble TNF receptors among healthy individuals. Lymphokine Cytokine Res 1992; 11: 157-9.
27. Cope AP, Aderka D, Doherty M, et al. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthr Rheum 1992; 35: 1160-8.
28. Dai HP, Guzman J, Bauer PC, Costabel U. Elevated levels of soluble TNF receptors in BAL fluid in extrinsic allergic alveolitis. Clin Exp Allergy 1999; 29: 1209-13.
29. Ziegenhagen MW, Fitschen J, Martinet N, Schlaak M, Müller-Quernheim J. Serum level of soluble tumour necrosis factor receptor II (75 kDa) indicates inflammatory activity of sarcoidosis. J Intern Med 2000; 248: 33-41.
30. Bemelmans MHA, Gouma DJ, Buurrman WA. LPS-induced sTNFreceptor release in vivo in a murine model: Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-γ. J Immunol 1993; 151: 5554-62.
31. Coker RK, Laurent GJ, Shahzeidi S, et al. Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 1997; 150: 981-91.
32. Zhang HY, Phan SH. Inhibition of myofibroblast apoptosis by transforming growth factor b1.Am J Respir Cell Mol Biol 1999; 21: 658-65.
33. Ignotz RA, Massague J.Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986; 261: 4337-45.
34. Dubaybo BA, Thet LA. Effect of transforming growth factor b on synthesis of glycosaminoglycans by human lung fibroblasts. Exp Lung Res 1990; 16: 389-403.
35. Wahl SM, Hunt DA,Wakefield LM, et al.Transforming growth factor type γ induces chemotaxis and growth factor production. Proc Natl Acad Sci USA 1987; 84: 5788-92.
36. Giri SN, Hyde DM, Hollinger MA. Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice. Thorax 1993; 48: 959-66.
37. Li J, He B,Weng B. The therapeutic effect of TGF-beta monoclonal antibody to bleomycin-induced pulmonary fibrosis in rats. Chung Hua Chich Ho Hu His Tsa Chih 1997; 20: 347-9.
38. Wang Q,Wang Y, Hyde DM, et al. Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamster. Thorax 1999; 54: 805-12.
39. Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G. Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor b and tumor necrosis factor a. Am J Respir Crit Care Med 1995; 152: 2163-9.
40. Pan LH, Ohtani H. Yamauchi K, Nagura H. Co-expression of TNF-α and IL-1β in human acute pulmonary fibrotic diseases: an immunohistochemical analysis. Pathol Int 1996; 46: 91-9.
41. Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN. Enhanced IL-1β and tumor necrosis factor-a release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol 1993; 150: 4188-96.
42. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J. Transient expression of IL-1b induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 2001; 107: 1529-36.
43. Serlin DM, Kuang PP, Subramanian M, et al. Interleukin-1b induces osteopontin expression in pulmonary fibroblasts. J Cell Biochem 2006; 97: 519-29.
44. Losa Garcia JE, Rodriguez FM, Martin de Cabo MR, et al. Evaluation of inflammatory cytokine secretion by human alveolar macrophages. Mediators Inflamm 1999; 8: 43-51.
45. Asada K, Ogushi F, Tani K, Yasuoka S, Sone S, Ogura T. Cell-associated interleukin 1 production of alveolar macrophages from bleomycin-induced pulmonary fibrosis in rats. Nihon Kyobu Shikkan Gakkai Zasshi 1993; 31: 853-8.
46. Piguet PF, Vesin C, Grau GE, Thompson RC. Interleukin 1 receptor antagonist (IL-1 ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine 1993; 35: 57-61.
47. Haddad JE, Safieh-Garabedion B, Saade NE, Land SC. Thiol regulation of pro-inflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. Pharmacol 2001; 296: 996-1005.