메뉴 건너뛰기




Volumn 18, Issue 1-2, 2013, Pages 97-113

Cell fusion is a potent inducer of aneuploidy and drug resistance in tumor cell/ normal cell hybrids

Author keywords

Adult stem cells; Breast cancer; Cell fusion; Drug resistance; Hybrid cells; Tumor progression

Indexed keywords

ALVESPIMYCIN; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 1B1; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DOXORUBICIN; DOXORUBICIN DERIVATIVE; ETOPOSIDE; GEFITINIB; MICRORNA; MICRORNA 125B; PACLITAXEL; PROTEIN BAX; PROTEIN MAD2; TAMOXIFEN; TEMOZOLOMIDE; VERAPAMIL;

EID: 84875310730     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v18.i1-2.60     Document Type: Article
Times cited : (52)

References (114)
  • 2
    • 79960964524 scopus 로고    scopus 로고
    • Membrane fusions during Mammalian fertilization
    • Gadella BM, Evans JP. Membrane fusions during Mammalian fertilization. Adv Exp Med Biol. 2011;713:65-80.
    • (2011) Adv Exp Med Biol. , vol.713 , pp. 65-80
    • Gadella, B.M.1    Evans, J.P.2
  • 4
    • 79960960616 scopus 로고    scopus 로고
    • Cell-fusion-mediated reprogramming: Pluripotency or transdifferentiation? Implications for regenerative medicine
    • Sanges D, Lluis F, Cosma MP. Cell-fusion-mediated reprogramming: pluripotency or transdifferentiation? Implications for regenerative medicine. Adv Exp Med Biol. 2011;713:137-59.
    • (2011) Adv Exp Med Biol. , vol.713 , pp. 137-159
    • Sanges, D.1    Lluis, F.2    Cosma, M.P.3
  • 5
    • 79960946728 scopus 로고    scopus 로고
    • Molecular mechanisms of myoblast fusion across species
    • Simionescu A, Pavlath GK. Molecular mechanisms of myoblast fusion across species. Adv Exp Med Biol. 2011;713:113-35.
    • (2011) Adv Exp Med Biol. , vol.713 , pp. 113-135
    • Simionescu, A.1    Pavlath, G.K.2
  • 7
    • 79960903181 scopus 로고    scopus 로고
    • Class III viral membrane fusion proteins
    • Backovic M, Jardetzky TS. Class III viral membrane fusion proteins. Adv Exp Med Biol. 2011;714:91-101.
    • (2011) Adv Exp Med Biol. , vol.714 , pp. 91-101
    • Backovic, M.1    Jardetzky, T.S.2
  • 8
    • 79951825045 scopus 로고    scopus 로고
    • Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming
    • Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, Wong MH. Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res. 2011;71:1,497-505.
    • (2011) Cancer Res. , vol.71 , pp. 1497-1505
    • Powell, A.E.1    Anderson, E.C.2    Davies, P.S.3    Silk, A.D.4    Pelz, C.5    Impey, S.6    Wong, M.H.7
  • 10
    • 0015111747 scopus 로고
    • In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydrogenase and lactate dehydrogenase profiles
    • Goldenberg DM, Bhan RD, Pavia RA. In vivo human-hamster somatic cell fusion indicated by glucose 6-phosphate dehydrogenase and lactate dehydrogenase profiles. Cancer Res. 1971;31:1,148-52.
    • (1971) Cancer Res. , vol.31 , pp. 1148-1152
    • Goldenberg, D.M.1    Bhan, R.D.2    Pavia, R.A.3
  • 11
    • 0016139097 scopus 로고
    • In vivo hybridisation of human tumour and normal hamster cells
    • Goldenberg DM, Pavia RA, Tsao MC. In vivo hybridisation of human tumour and normal hamster cells. Nature. 1974;250:649-51.
    • (1974) Nature. , vol.250 , pp. 649-651
    • Goldenberg, D.M.1    Pavia, R.A.2    Tsao, M.C.3
  • 13
    • 0036681286 scopus 로고    scopus 로고
    • Spontaneously formed tumorigenic hybrids of Meth A sarcoma and macrophages grow faster and are better vascularized than the parental tumor
    • Busund LT, Killie MK, Bartnes K, Seljelid R. Spontaneously formed tumorigenic hybrids of Meth A sarcoma and macrophages grow faster and are better vascularized than the parental tumor. Int J Cancer. 2002;100:407-13.
    • (2002) Int J Cancer. , vol.100 , pp. 407-413
    • Busund, L.T.1    Killie, M.K.2    Bartnes, K.3    Seljelid, R.4
  • 15
    • 67249120052 scopus 로고    scopus 로고
    • Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
    • Lu X, Kang Y. Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci U S A. 2009;106:9,385-90.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 9385-9390
    • Lu, X.1    Kang, Y.2
  • 16
    • 0033769681 scopus 로고    scopus 로고
    • Primary cells suppress oncogene-dependent apoptosis
    • Duelli DM, Lazebnik YA. Primary cells suppress oncogene-dependent apoptosis. Nat Cell Biol. 2000;2:859-62.
    • (2000) Nat Cell Biol. , vol.2 , pp. 859-862
    • Duelli, D.M.1    Lazebnik, Y.A.2
  • 17
    • 0842320021 scopus 로고    scopus 로고
    • Cell fusion: A hidden enemy?
    • Duelli D, Lazebnik Y. Cell fusion: a hidden enemy? Cancer Cell. 2003;3:445-8.
    • (2003) Cancer Cell. , vol.3 , pp. 445-448
    • Duelli, D.1    Lazebnik, Y.2
  • 19
    • 79959613246 scopus 로고    scopus 로고
    • Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant hybrid cells
    • Nagler C, Hardt C, Zänker KS, Dittmar T. Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant hybrid cells. Cancer Cell International. 2011;11:21-34.
    • (2011) Cancer Cell International. , vol.11 , pp. 21-34
    • Nagler, C.1    Hardt, C.2    Zänker, K.S.3    Dittmar, T.4
  • 20
    • 79960937293 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of Mammalian cell fusion
    • Zhou X, Platt JL. Molecular and cellular mechanisms of Mammalian cell fusion. Adv Exp Med Biol. 2011;713:33-64.
    • (2011) Adv Exp Med Biol. , vol.713 , pp. 33-64
    • Zhou, X.1    Platt, J.L.2
  • 21
    • 36448937162 scopus 로고    scopus 로고
    • Cell-to-cell fusion as a link between viruses and cancer
    • Duelli D, Lazebnik Y. Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer. 2007;7:968-76.
    • (2007) Nat Rev Cancer. , vol.7 , pp. 968-976
    • Duelli, D.1    Lazebnik, Y.2
  • 22
    • 26944431659 scopus 로고    scopus 로고
    • Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury
    • Fang TC, Alison MR, Cook HT, Jeffery R, Wright NA, Poulsom R. Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury. J Am Soc Nephrol. 2005;16:1,723-32.
    • (2005) J Am Soc Nephrol. , vol.16 , pp. 1723-1732
    • Fang, T.C.1    Alison, M.R.2    Cook, H.T.3    Jeffery, R.4    Wright, N.A.5    Poulsom, R.6
  • 25
    • 68449085032 scopus 로고    scopus 로고
    • Inflammation and proliferation act together to mediate intestinal cell fusion
    • Davies PS, Powell AE, Swain JR, Wong MH. Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS ONE. 2009;4:e6530.
    • (2009) PLoS ONE. , vol.4
    • Davies, P.S.1    Powell, A.E.2    Swain, J.R.3    Wong, M.H.4
  • 27
    • 85047690939 scopus 로고    scopus 로고
    • Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
    • Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest. 2004;113:1,266-70.
    • (2004) J Clin Invest. , vol.113 , pp. 1266-1270
    • Camargo, F.D.1    Finegold, M.2    Goodell, M.A.3
  • 28
    • 0037464545 scopus 로고    scopus 로고
    • Transplanted bone marrow regenerates liver by cell fusion
    • Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature. 2003;422:901-4.
    • (2003) Nature. , vol.422 , pp. 901-904
    • Vassilopoulos, G.1    Wang, P.R.2    Russell, D.W.3
  • 33
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539-45.
    • (2001) Lancet. , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 34
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 1986;315:1,650-9.
    • (1986) N Engl J Med. , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 37
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 1996;56:4,625-9.
    • (1996) Cancer Res. , vol.56 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 38
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis C, Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol. 2005;167:627-35.
    • (2005) Am J Pathol. , vol.167 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 39
    • 34249338002 scopus 로고    scopus 로고
    • Tumor-associated macrophage: Its role in cancer invasion and metastasis
    • Shih JY, Yuan A, Chen JJW, Yang PC. Tumor-associated macrophage: its role in cancer invasion and metastasis. J Cancer Mol. 2006;2:101-6.
    • (2006) J Cancer Mol. , vol.2 , pp. 101-106
    • Shih, J.Y.1    Yuan, A.2    Chen, J.J.W.3    Yang, P.C.4
  • 40
    • 0034650795 scopus 로고    scopus 로고
    • Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFalpha and IL-1alpha
    • Torisu H, Ono M, Kiryu H, Furue M, Ohmoto Y, Nakayama J, Nishioka Y, Sone S, Kuwano M. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha. Int J Cancer. 2000;85:182-8.
    • (2000) Int J Cancer. , vol.85 , pp. 182-188
    • Torisu, H.1    Ono, M.2    Kiryu, H.3    Furue, M.4    Ohmoto, Y.5    Nakayama, J.6    Nishioka, Y.7    Sone, S.8    Kuwano, M.9
  • 44
    • 0342737671 scopus 로고
    • Über Zellverschmelzung mit quantitativ abnormer Chromosomenverteilung als Ursache der Geschwulstbildung
    • In: Roux W, editor, Leipzig, Germany: Wilhelm Engelmann
    • Aichel O. Über Zellverschmelzung mit quantitativ abnormer Chromosomenverteilung als Ursache der Geschwulstbildung. In: Roux W, editor. Vorträge und Aufsätze über Entwicklungsmechanik der Organismen. Leipzig, Germany: Wilhelm Engelmann;1911:1-115.
    • (1911) Vorträge und Aufsätze über Entwicklungsmechanik der Organismen , pp. 1-115
    • Aichel, O.1
  • 45
    • 33746069082 scopus 로고    scopus 로고
    • In memoriam of Rudolf Virchow: A historical retrospective including aspects of inflammation, infection and neoplasia
    • Schmidt A, Weber OF. In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia. Contrib Microbiol. 2006;13:1-15.
    • (2006) Contrib Microbiol. , vol.13 , pp. 1-15
    • Schmidt, A.1    Weber, O.F.2
  • 48
    • 0014417721 scopus 로고
    • On the progression of malignity: A hypothesis
    • Goldenberg DM. [On the progression of malignity: a hypothesis]. Klin Wochenschr. 1968;46:898-9.
    • (1968) Klin Wochenschr. , vol.46 , pp. 898-899
    • Goldenberg, D.M.1
  • 49
    • 0014993802 scopus 로고
    • Transformation of a normal differentiated cell of an adult organism, induced by the fusion of this cell with another normal cell of the same organism but with different organ or tissue specificity
    • Mekler LB, Drize OB, Osechinskii IV, Shliankevich MA. [Transformation of a normal differentiated cell of an adult organism, induced by the fusion of this cell with another normal cell of the same organism but with different organ or tissue specificity]. Vestn Akad Med Nauk SSSR. 1971;26:75-80.
    • (1971) Vestn Akad Med Nauk SSSR. , vol.26 , pp. 75-80
    • Mekler, L.B.1    Drize, O.B.2    Osechinskii, I.V.3    Shliankevich, M.A.4
  • 50
    • 17144455288 scopus 로고
    • Hybridization of transformed cells with lymphocytes as 1 of the probable causes of the progression leading to the development of metastatic malignant cells
    • Mekler LB. [Hybridization of transformed cells with lymphocytes as 1 of the probable causes of the progression leading to the development of metastatic malignant cells]. Vestn Akad Med Nauk SSSR. 1971;26:80-9.
    • (1971) Vestn Akad Med Nauk SSSR. , vol.26 , pp. 80-89
    • Mekler, L.B.1
  • 51
    • 84860223175 scopus 로고    scopus 로고
    • Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells In Vivo
    • Goldenberg DM, Zagzag D, Heselmeyer-Haddad KM, Berroa Garcia LY, Ried T, Loo M, Chang CH, Gold DV. Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells In Vivo. Int J Cancer. 2012:131:49-58.
    • (2012) Int J Cancer , vol.131 , pp. 49-58
    • Goldenberg, D.M.1    Zagzag, D.2    Heselmeyer-Haddad, K.M.3    Berroa Garcia, L.Y.4    Ried, T.5    Loo, M.6    Chang, C.H.7    Gold, D.V.8
  • 54
    • 0032764342 scopus 로고    scopus 로고
    • Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells
    • Rachkovsky M, Pawelek J. Acquired melanocyte stimulating hormone-inducible chemotaxis following macrophage fusion with Cloudman S91 melanoma cells. Cell Growth Differ. 1999;10:517-24.
    • (1999) Cell Growth Differ. , vol.10 , pp. 517-524
    • Rachkovsky, M.1    Pawelek, J.2
  • 56
    • 72249120354 scopus 로고    scopus 로고
    • Cell fusion as a hidden force in tumor progression
    • Lu X, Kang Y. Cell fusion as a hidden force in tumor progression. Cancer Res. 2009;69:8,536-9.
    • (2009) Cancer Res. , vol.69 , pp. 8536-8539
    • Lu, X.1    Kang, Y.2
  • 58
    • 70349235320 scopus 로고    scopus 로고
    • Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion
    • Hu L, Ceresa BP. Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion. Virology. 2009;393:135-43.
    • (2009) Virology. , vol.393 , pp. 135-143
    • Hu, L.1    Ceresa, B.P.2
  • 60
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: The origin of the cancer stem cell: Current controversies and new insights
    • Bjerkvig R, Tysnes BB, Aboody KS, Najbauer J, Terzis AJ. Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat Rev Cancer. 2005;5:899-904.
    • (2005) Nat Rev Cancer. , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3    Najbauer, J.4    Terzis, A.J.5
  • 63
    • 84875289990 scopus 로고    scopus 로고
    • The dark side of stem cells: Triggering cancer progression by cell fusion
    • accepted
    • Dittmar T, Nagler C, Niggemann B, Zänker KS. The dark side of stem cells: triggering cancer progression by cell fusion. Curr Mol Med. 2012; accepted.
    • (2012) Curr Mol Med.
    • Dittmar, T.1    Nagler, C.2    Niggemann, B.3    Zänker, K.S.4
  • 66
    • 42549167207 scopus 로고    scopus 로고
    • Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis
    • Pawelek JM, Chakraborty AK. Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer. 2008;8:377-86.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 377-386
    • Pawelek, J.M.1    Chakraborty, A.K.2
  • 67
    • 0024311905 scopus 로고
    • Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations
    • Miller FR, Mohamed AN, McEachern D. Production of a more aggressive tumor cell variant by spontaneous fusion of two mouse tumor subpopulations. Cancer Res. 1989;49:4,316-21.
    • (1989) Cancer Res. , vol.49 , pp. 4316-4321
    • Miller, F.R.1    Mohamed, A.N.2    McEachern, D.3
  • 68
    • 0032531141 scopus 로고    scopus 로고
    • Cell fusion studies to examine the mechanism for etoposide resistance in Chinese hamster V79 spheroids
    • Luo C, Johnston PJ, MacPhail SH, Banath JP, Oloumi A, Olive PL. Cell fusion studies to examine the mechanism for etoposide resistance in Chinese hamster V79 spheroids. Exp Cell Res. 1998;243:282-9.
    • (1998) Exp Cell Res. , vol.243 , pp. 282-289
    • Luo, C.1    Johnston, P.J.2    McPhail, S.H.3    Banath, J.P.4    Oloumi, A.5    Olive, P.L.6
  • 69
    • 77954765542 scopus 로고    scopus 로고
    • p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: Correlations with cell fusion and doxorubicin resistance
    • Yang JY, Ha SA, Yang YS, Kim JW. p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. BMC Cancer. 2010;10:388.
    • (2010) BMC Cancer. , vol.10 , pp. 388
    • Yang, J.Y.1    Ha, S.A.2    Yang, Y.S.3    Kim, J.W.4
  • 74
    • 73449113932 scopus 로고    scopus 로고
    • Role of microRNA in anticancer drug resistance
    • Zheng T, Wang J, Chen X, Liu L. Role of microRNA in anticancer drug resistance. Int J Cancer. 2010;126:2-10.
    • (2010) Int J Cancer. , vol.126 , pp. 2-10
    • Zheng, T.1    Wang, J.2    Chen, X.3    Liu, L.4
  • 75
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet. 2008;9:102-14.
    • (2008) Nat Rev Genet. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 77
    • 49149114863 scopus 로고    scopus 로고
    • Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells
    • Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol. 2008;76:582-8.
    • (2008) Biochem Pharmacol. , vol.76 , pp. 582-588
    • Zhu, H.1    Wu, H.2    Liu, X.3    Evans, B.R.4    Medina, D.J.5    Liu, C.G.6    Yang, J.M.7
  • 78
    • 66849113786 scopus 로고    scopus 로고
    • MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells
    • Pan YZ, Morris ME, Yu AM. MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol. 2009;75:1,374-9.
    • (2009) Mol Pharmacol. , vol.75 , pp. 1374-1379
    • Pan, Y.Z.1    Morris, M.E.2    Yu, A.M.3
  • 79
    • 50249188925 scopus 로고    scopus 로고
    • Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line
    • To KK, Zhan Z, Litman T, Bates SE. Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line. Mol Cell Biol. 2008;28:5,147-61.
    • (2008) Mol Cell Biol. , vol.28 , pp. 5147-5161
    • To, K.K.1    Zhan, Z.2    Litman, T.3    Bates, S.E.4
  • 80
    • 79955501601 scopus 로고    scopus 로고
    • ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2
    • Jeon HM, Sohn YW, Oh SY, Kim SH, Beck S, Kim S, Kim H. ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Res. 2011;71:3,410-21.
    • (2011) Cancer Res. , vol.71 , pp. 3410-3421
    • Jeon, H.M.1    Sohn, Y.W.2    Oh, S.Y.3    Kim, S.H.4    Beck, S.5    Kim, S.6    Kim, H.7
  • 82
    • 84856225885 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice
    • Giovannetti E, Erozenci A, Smit J, Danesi R, Peters GJ. Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice. Crit Rev Oncol Hematol. 2012;81:103-22.
    • (2012) Crit Rev Oncol Hematol. , vol.81 , pp. 103-122
    • Giovannetti, E.1    Erozenci, A.2    Smit, J.3    Danesi, R.4    Peters, G.J.5
  • 83
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer. 2011;11:849-64.
    • (2011) Nat Rev Cancer. , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 84
    • 84862971827 scopus 로고    scopus 로고
    • Fusion of human umbilical cord mesenchymal stem cells with esophageal cells
    • Wang Y, Fan H, Zhou B, Ju Z, Yu L, Guo L, Han J, Lu S. Fusion of human umbilical cord mesenchymal stem cells with esophageal cells. Int J Oncol. 2012;40:370-7.
    • (2012) Int J Oncol. , vol.40 , pp. 370-377
    • Wang, Y.1    Fan, H.2    Zhou, B.3    Ju, Z.4    Yu, L.5    Guo, L.6    Han, J.7    Lu, S.8
  • 85
    • 42549114180 scopus 로고    scopus 로고
    • Mesenchymal stem cells: An emerging tool for cancer targeting and therapy
    • Fritz V, Jorgensen C. Mesenchymal stem cells: an emerging tool for cancer targeting and therapy. Curr Stem Cell Res Ther. 2008;3:32-42.
    • (2008) Curr Stem Cell Res Ther. , vol.3 , pp. 32-42
    • Fritz, V.1    Jorgensen, C.2
  • 86
    • 80052672888 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Angels or demons?
    • Wong RS. Mesenchymal stem cells: angels or demons? J Biomed Biotechnol. 2011;2011: 459,510-8.
    • (2011) J Biomed Biotechnol. , vol.2011 , pp. 459510-8
    • Wong, R.S.1
  • 88
    • 0030825508 scopus 로고    scopus 로고
    • Chromosomal imbalance maps of malignant solid tumors: A cytogenetic survey of 3185 neoplasms
    • Mertens F, Johansson B, Hoglund M, Mitelman F. Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms. Cancer Res. 1997;57:2,765-80.
    • (1997) Cancer Res. , vol.57 , pp. 2765-2780
    • Mertens, F.1    Johansson, B.2    Hoglund, M.3    Mitelman, F.4
  • 90
    • 0033815915 scopus 로고    scopus 로고
    • Aneuploidy, the somatic mutation that makes cancer a species of its own
    • Duesberg P, Rasnick D. Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil Cytoskeleton. 2000;47:81-107.
    • (2000) Cell Motil Cytoskeleton. , vol.47 , pp. 81-107
    • Duesberg, P.1    Rasnick, D.2
  • 91
    • 0032506125 scopus 로고    scopus 로고
    • Genetic instability of cancer cells is proportional to their degree of aneuploidy
    • Duesberg P, Rausch C, Rasnick D, Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci USA. 1998; 95: 13,692-7.
    • (1998) Proc Natl Acad Sci USA. , vol.95 , pp. 13692-13697
    • Duesberg, P.1    Rausch, C.2    Rasnick, D.3    Hehlmann, R.4
  • 95
    • 0034724312 scopus 로고    scopus 로고
    • Aneuploidy versus gene mutation hypothesis of cancer: Recent study claims mutation, but is found to support aneuploidy
    • Li R, Sonik A, Stindl R, Rasnick D, Duesberg P. Aneuploidy versus gene mutation hypothesis of cancer: recent study claims mutation, but is found to support aneuploidy. Proc Natl Acad Sci USA. 2000;97:3,236-41.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , pp. 3236-3241
    • Li, R.1    Sonik, A.2    Stindl, R.3    Rasnick, D.4    Duesberg, P.5
  • 96
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495-7.
    • (1975) Nature. , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 99
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • Li F, Tiede B, Massague J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 2007;17:3-14.
    • (2007) Cell Res. , vol.17 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 100
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker AK, Allan AL. Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med. 2008;12:374-90.
    • (2008) J Cell Mol Med. , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 101
    • 72949118673 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
    • Croker AK, Goodale D, Chu J, Postenka C, Hedley BD, Hess DA, Allan AL. High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med. 2009;(8B):2236.52.
    • (2009) J Cell Mol Med. , Issue.8 B , pp. 2236-2252
    • Croker, A.K.1    Goodale, D.2    Chu, J.3    Postenka, C.4    Hedley, B.D.5    Hess, D.A.6    Allan, A.L.7
  • 103
    • 79960900961 scopus 로고    scopus 로고
    • Cell Fusion, Drug Resistance and Recurrence CSCs
    • Nagler C, Zanker KS, Dittmar T. Cell Fusion, Drug Resistance and Recurrence CSCs. Adv Exp Med Biol. 2011;714:173-82.
    • (2011) Adv Exp Med Biol. , vol.714 , pp. 173-182
    • Nagler, C.1    Zanker, K.S.2    Dittmar, T.3
  • 104
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol. 2008;26:2,839-45.
    • (2008) J Clin Oncol. , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 105
    • 35148888629 scopus 로고    scopus 로고
    • Cancer stem cells in radiation resistance
    • Rich JN. Cancer stem cells in radiation resistance. Cancer Res. 2007;67:8,980-4.
    • (2007) Cancer Res. , vol.67 , pp. 8980-8984
    • Rich, J.N.1
  • 106
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer. 2005;5:275-84.
    • (2005) Nat Rev Cancer. , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 107
    • 45949101159 scopus 로고    scopus 로고
    • Expression of multidrug resistance genes in normal and cancer stem cells
    • Shervington A, Lu C. Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Invest. 2008;26:535-42.
    • (2008) Cancer Invest. , vol.26 , pp. 535-542
    • Shervington, A.1    Lu, C.2
  • 108
    • 30444446406 scopus 로고    scopus 로고
    • The paradox of response and survival in cancer therapeutics
    • Huff CA, Matsui W, Smith BD, Jones RJ. The paradox of response and survival in cancer therapeutics. Blood. 2006;107:431-34.
    • (2006) Blood. , vol.107 , pp. 431-434
    • Huff, C.A.1    Matsui, W.2    Smith, B.D.3    Jones, R.J.4
  • 110
    • 33745712636 scopus 로고    scopus 로고
    • Cancer stem cells: Redefining the paradigm of cancer treatment strategies
    • Dean M. Cancer stem cells: redefining the paradigm of cancer treatment strategies. Mol Interv. 2006;6:140-8.
    • (2006) Mol Interv. , vol.6 , pp. 140-148
    • Dean, M.1
  • 112
    • 44649107292 scopus 로고    scopus 로고
    • Mechanisms of Disease: Cancer stem cells-targeting the evil twin
    • Trumpp A, Wiestler OD. Mechanisms of Disease: cancer stem cells-targeting the evil twin. Nat Clin Pract Oncol. 2008;5:337-47.
    • (2008) Nat Clin Pract Oncol. , vol.5 , pp. 337-347
    • Trumpp, A.1    Wiestler, O.D.2
  • 113
    • 29244479554 scopus 로고    scopus 로고
    • Why therapeutic response may not prolong the life of a cancer patient: Selection for oncogenic resistance
    • Blagosklonny MV. Why therapeutic response may not prolong the life of a cancer patient: selection for oncogenic resistance. Cell Cycle. 2005;4:1,693-8.
    • (2005) Cell Cycle. , vol.4 , pp. 1693-1698
    • Blagosklonny, M.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.