MGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment

Neuroscience Research

Volumn 75, Issue 2, 2013, Pages 160-166

  Liu, Bin ^a   Dong, Qi ^a   Zhang, Shuyan ^a   Su, Danying ^a   Yang, Zichao ^a   Lv, Manhua ^a   Zhang, Shuangyan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Action potential; Astrocyte; GABA neuron; Glutamate transporter; Ischemia; MGluR; Synaptic transmission

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR;

ACTION POTENTIAL; ARTICLE; BRAIN CELL; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITOTOXICITY; FUNCTIONAL DISEASE; HUMAN; HUMAN CELL; ISCHEMIA; NERVOUS TISSUE; NEUROPROTECTION; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; ANIMAL; ASTROCYTE; BRAIN ISCHEMIA; DRUG ANTAGONISM; METABOLISM; MOUSE; PHYSIOLOGY; ANTAGONISTS AND INHIBITORS;

ANIMALS; ASTROCYTES; BRAIN ISCHEMIA; GABAERGIC NEURONS; MICE; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPTIC TRANSMISSION;

EID: 84875309842     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.12.002     Document Type: Article

References (60)

1. Albrecht J., Sonnewald U., et al. Glutamine in the central nervous system: function and dysfunction. Front. Biosci. 2007, 12:332-343.
2. Bergles D.E., Jahr C.E. Synaptic activation of glutamate transporters in hippocampal astrocytes. Neuron 1997, 19:1297-1308.
3. Block F. Global ischemia and behavioural deficits. Prog. Neurobiol. 1999, 58:279-295.
4. Bridges R.J., Esslinger C.S. The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. Pharmacol. Ther. 2005, 107(3):271-285.
5. Bruno V., Battaglia G., et al. An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors. Eur. J. Neurosci. 2001, 13(8):1469-1478.
6. Camacho A., Massieu L. Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death. Arch. Med. Res. 2006, 37(1):11-18.
7. Candelario-Jalil E. Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics. Curr. Opin. Investig. Drugs 2009, 10(7):644-654.
8. Centonze D., Saulle E., et al. Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischemia. Brain 2001, 124(Pt9):1855-1865.
9. Chen N., Chen X., et al. Homeostasis established by coordination of subcellular compartment plasticity improves spike encoding. J. Cell Sci. 2008, 121(17):2961-2971.
10. Chen N., Chen X., et al. After-hyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels. Biochem. Biophys. Res. Commun. 2006, 346:938-945.
11. Chen N., Yu J., et al. Axons amplify somatic incomplete spikes into uniform amplitudes in mouse cortical pyramidal neurons. PLoS ONE 2010, 5(7):e11868.
12. Chen N., Zhu Y., et al. Sodium channel-mediated intrinsic mechanisms underlying the differences of spike programming among GABAergic neurons. Biochem. Biophys. Res. Commun. 2006, 346:281-287.
13. Chen X., Numata T., et al. The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Mol. Brain 2010, 3:38.
14. Chen Y., Swanson R.A. Astrocytes and brain injury. J. Cereb. Blood Flow Metab. 2003, 23(2):137-149.
15. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988, 11(10):465-469.
16. Dronne M.A., Grenier E., et al. Role of astrocytes in grey matter during stroke: a modelling approach. Brain Res. 2007, 1138:231-242.
17. Ferraguti F., Crepaldi L., et al. Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol. Rev. 2008, 60(4):536-581.
18. Freund T.F., Buzsaki G. Interneurons of the hippocampus. Hippocampus 1996, 6:347-470.
19. Ge R., Qian H., et al. Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons. Mol. Brain 2011, 4(1):19.
20. Homola A., Zoremba N., et al. Changes in diffusion parameters, energy-related metabolites and glutamate in the rat cortex after transient hypoxia/ischemia. Neurosci. Lett. 2006, 404(1-2):137-142.
21. 2+ and acidosis synergistically lead to the dysfunction of cortical GABAergic neurons during ischemia. Biochem. Biophys. Res. Commun. 2010, 394:709-714.
22. Inage Y.W., Itoh M., et al. Expression of two glutamate transporters, GLAST and EAAT4, in the human cerebellum: their correlation in development and neonatal hypoxia-ischemic damage. J. Neuropathol. Exp. Neurol. 1998, 57(6):554-562.
23. Johansen F.F., Diemer N.H. Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells. Acta Neurol. Scand. 1991, 84(1):1-6.
24. Kageyama T., Ishikawa A., et al. Glutamate elevation in rabbit vitreous during transient ischemia-reperfusion. Jpn. J. Ophthalmol. 2000, 44(2):110-114.
25. Kanai Y., Hediger M.A. The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur. J. Pharmacol. 2003, 479(1-3):237-247.
26. Li P.A., Shuaib A., et al. Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke 2000, 31(1):183-192.
27. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79(4):1431-1568.
28. Marcoli M., Bonfanti A., et al. Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade. Neuropharmacology 2004, 47(6):884-891.
29. McKay B.E., Turner R.W. Physiological and morphological development of the rat cerebellar Purkinje cell. J. Physiol. (London) 2005, 567(Pt3):829-850.
30. McNamara J.O., Huang Y.Z., et al. Molecular signaling mechanisms underlying epileptogenesis. Sci. STKE 2006, 2006(356):re12.
31. Metha S.L., Manhas N., et al. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. 2007, 54(1):34-66.
32. 2+ elevation in cerebellar slices: a comparative study with the values found in hippocampal slices. Acta Neuropathol. (Berl.) 1995, 89(1):2-7.
33. Muller G.J., Moller A., et al. Stereological cell counts of GABAergic neurons in rat dentate hilus following transient cerebral ischemia. Exp. Brain Res. 2001, 141(3):380-388.
34. Nagy J.I., Dudek F.E., et al. Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res. Brain Res. Rev. 2004, 47(1-3):191-215.
35. Ni H., Huang L., et al. Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deficit. PLoS ONE 2010, 5(10):e13736.
36. Pellegrini-Giampietro D.E., Cozzi A., et al. 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. Eur. J. Neurosci. 1999, 11(10):3637-3647.
37. Saji M., Cohen M., et al. Transient forebrain ischemia induces delayed injury in the substantia nigra reticulata: degeneration of GABA neurons, compensatory expression of GAD mRNA. Brain Res. 1994, 643(1-2):234-244.
38. Schwartz-Bloom R.D., Sah R. r-aminobutyric acid A neurotransmission and cerebral ischemia. J. Neurochem. 2001, 77:353-371.
39. Shimamoto K., Lebrun B. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol. Pharmacol. 1998, 53(2):195-201.
40. Simon R., Xiong Z. Acidotoxicity in brain ischemia. Biochem. Soc. Trans. 2006, 34:1356-1361.
41. Sonnewald U., Qu H., et al. Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling. J. Pharmacol. Exp. Ther. 2002, 301(1):1-6.
42. Strasser U., Lobner D., et al. Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures. Eur. J. Neurosci. 1998, 10(9):2848-2855.
43. Swanson R.A., Ying W., et al. Astrocyte influences on ischemic neuronal death. Curr. Mol. Med. 2004, 4(2):193-205.
44. Taoufik E., Probert L. Ischemic neuronal damage. Curr. Pharm. Des. 2008, 14(33):3565-3573.
45. Wang J.-H. Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons. Brain Res. Bull. 2003, 60(1-2):53-58.
46. 2+/CaM signalling pathway up-regulates glutamatergic synaptic function in non-pyramidal fast-spiking neurons of hippocampal CA1. J. Physiol. (London) 2001, 533(2):407-422.
47. Wang J., Zhang M. Differential modulation of glutamatergic and cholinergic synapses by calcineurin in hippocampal CA1 fast-spiking interneurons. Brain Res. 2004, 1004(1-2):125-135.
48. Wang J.H., Wei J., et al. The gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding. J. Cell Sci. 2008, 121(17):2951-2960.
49. Wang Q., Liu X., et al. The postnatal development of intrinsic properties and spike encoding at cortical GABAergic neurons. Biochem. Biophys. Res. Commun. 2009, 378:706-710.
50. Welsh J.P., Yuen G., et al. Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv. Neurol. 2002, 89:331-359.
51. Werner C.G., Scartabelli T., et al. Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of ischemic tolerance. Eur. J. Neurosci. 2007, 25(12):3597-3604.
52. White B.C., Sullivan J.M., et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J. Neurol. Sci. 2000, 179:1-33.
53. Wisniewski K., Car H. (S)-3,5-DHPG: a review. CNS Drug Rev. 2002, 8(1):101-116.
54. Won S.J., Kim D.Y., et al. Cellular and molecular pathways of ischemic neuronal death. J. Biochem. Mol. Biol. 2002, 35(1):67-86.
55. Yamashita A., Makita K., et al. Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4. Neurosci. Res. 2006, 55(3):264-270.
56. Yu J., Qian H., et al. Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PLoS ONE 2011, 6(9):e25219.
57. Yu J., Qian H., et al. Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Mol. Brain 2012, 5(1):26.
58. Zhang F., Liu B., et al. mGluR1,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice. Mol. Brain 2012, 5(1):20.
59. 2+. Biochem. Biophys. Res. Commun. 2008, 366:401-407.
60. Zoli M., Agnati L.F. Wiring and volume transmission in the central nervous system: the concept of closed and open synapses. Prog. Neurobiol. 1996, 49(4):363-380.